JP2005503557A5 - - Google Patents
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- JP2005503557A5 JP2005503557A5 JP2003529154A JP2003529154A JP2005503557A5 JP 2005503557 A5 JP2005503557 A5 JP 2005503557A5 JP 2003529154 A JP2003529154 A JP 2003529154A JP 2003529154 A JP2003529154 A JP 2003529154A JP 2005503557 A5 JP2005503557 A5 JP 2005503557A5
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- Prior art keywords
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- analysis method
- Prior art date
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Links
- 238000004458 analytical method Methods 0.000 claims 35
- 239000003550 marker Substances 0.000 claims 19
- 239000000523 sample Substances 0.000 claims 14
- 239000012491 analyte Substances 0.000 claims 11
- 238000010606 normalization Methods 0.000 claims 10
- 239000013076 target substance Substances 0.000 claims 10
- 238000004949 mass spectrometry Methods 0.000 claims 8
- 238000000034 method Methods 0.000 claims 8
- 150000002500 ions Chemical class 0.000 claims 7
- 235000001014 amino acid Nutrition 0.000 claims 5
- 150000001413 amino acids Chemical class 0.000 claims 5
- 239000003446 ligand Substances 0.000 claims 4
- 125000001424 substituent group Chemical group 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 238000010494 dissociation reaction Methods 0.000 claims 2
- 230000005593 dissociations Effects 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 238000000926 separation method Methods 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 1
- 235000003704 aspartic acid Nutrition 0.000 claims 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 1
- 238000004587 chromatography analysis Methods 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 238000001360 collision-induced dissociation Methods 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 238000001962 electrophoresis Methods 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 238000010195 expression analysis Methods 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 239000011737 fluorine Substances 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 238000011223 gene expression profiling Methods 0.000 claims 1
- 238000009396 hybridization Methods 0.000 claims 1
- 235000018102 proteins Nutrition 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
- 230000035945 sensitivity Effects 0.000 claims 1
- 238000012163 sequencing technique Methods 0.000 claims 1
- 238000000539 two dimensional gel electrophoresis Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01307830 | 2001-09-14 | ||
| PCT/GB2002/004240 WO2003025576A2 (en) | 2001-09-14 | 2002-09-16 | Mass labels |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005503557A JP2005503557A (ja) | 2005-02-03 |
| JP2005503557A5 true JP2005503557A5 (https=) | 2005-12-22 |
| JP4290003B2 JP4290003B2 (ja) | 2009-07-01 |
Family
ID=8182269
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003529154A Expired - Lifetime JP4290003B2 (ja) | 2001-09-14 | 2002-09-16 | 質量標識体 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7732378B2 (https=) |
| EP (1) | EP1425586B1 (https=) |
| JP (1) | JP4290003B2 (https=) |
| CA (1) | CA2460131C (https=) |
| DE (1) | DE60223696T2 (https=) |
| DK (1) | DK1425586T3 (https=) |
| ES (1) | ES2296996T3 (https=) |
| PT (1) | PT1425586E (https=) |
| WO (1) | WO2003025576A2 (https=) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002014867A2 (en) * | 2000-08-11 | 2002-02-21 | Agilix Corporation | Ultra-sensitive detection systems |
| JP2005514603A (ja) * | 2001-11-06 | 2005-05-19 | アジリックス・コーポレイション | 高感度コード化検出システム |
| US7556969B2 (en) | 2002-12-19 | 2009-07-07 | Northeastern University | Intensified neutral loss tags and use thereof in mass spectrometry |
| JP4613299B2 (ja) | 2003-01-30 | 2011-01-12 | ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド | 分析物分析に関する方法、混合物、キット、および組成物 |
| GB0306756D0 (en) | 2003-03-24 | 2003-04-30 | Xzillion Gmbh & Co Kg | Mass labels |
| JP2005140755A (ja) * | 2003-11-10 | 2005-06-02 | Japan Science & Technology Agency | 質量分析用プローブ及びそれを用いた質量分析方法 |
| CA2542941C (en) * | 2003-11-26 | 2013-02-12 | Applera Corporation | Analysis of mass spectral data in the quiet zones and label selection therefor |
| US7105806B2 (en) * | 2003-11-26 | 2006-09-12 | Applera Corporation | Method and apparatus for de-convoluting a convoluted spectrum |
| EP1916527A1 (en) * | 2003-11-26 | 2008-04-30 | Applera Corporation | Analysis of mass spectral data in the quiet zones |
| US7355045B2 (en) | 2004-01-05 | 2008-04-08 | Applera Corporation | Isotopically enriched N-substituted piperazine acetic acids and methods for the preparation thereof |
| US7307169B2 (en) | 2004-01-05 | 2007-12-11 | Applera Corporation | Isotopically enriched N-substituted piperazines and methods for the preparation thereof |
| JP2007519910A (ja) | 2004-01-28 | 2007-07-19 | イマティクス バイオテクノロジーズ ゲーエムベーハー | 腫瘍関連ペプチドの同定および定量方法 |
| US20070054345A1 (en) * | 2004-05-19 | 2007-03-08 | Hunter Christie L | Expression quantification using mass spectrometry |
| US20080206737A1 (en) * | 2004-05-19 | 2008-08-28 | Hunter Christie L | Expression quantification using mass spectrometry |
| US7618780B2 (en) | 2004-05-20 | 2009-11-17 | Trillion Genomics Limited | Use of mass labelled probes to detect target nucleic acids using mass spectrometry |
| US20070048752A1 (en) | 2004-07-12 | 2007-03-01 | Applera Corporation | Mass tags for quantitative analyses |
| WO2006017208A1 (en) * | 2004-07-12 | 2006-02-16 | Applera Corporation | Mass tags for quantitative analyses |
| WO2006023398A2 (en) * | 2004-08-16 | 2006-03-02 | Ludwig Institute For Cancer Research | Modular isotope labelled mass spectrometry reagents and methods for quantitation of amino acids, peptides and proteins |
| US20060134710A1 (en) * | 2004-10-30 | 2006-06-22 | Viorica Lopez-Avila | WDR11 protein assay |
| US20070207555A1 (en) * | 2005-02-03 | 2007-09-06 | Cesar Guerra | Ultra-sensitive detection systems using multidimension signals |
| US20060183238A1 (en) | 2005-02-09 | 2006-08-17 | Applera Corporation | Amine-containing compound analysis methods |
| US20070134802A1 (en) * | 2005-06-30 | 2007-06-14 | Heinz Doebeli | Ionization modifier for mass spectrometry |
| GB0515323D0 (en) * | 2005-07-26 | 2005-08-31 | Electrophoretics Ltd | Mass labels |
| US8889423B2 (en) | 2005-07-29 | 2014-11-18 | Eisai R & D Management Co., Ltd. | Method for analysis of compound-binding ability of protein |
| GB0518585D0 (en) * | 2005-09-12 | 2005-10-19 | Electrophoretics Ltd | Mass labels |
| EP1921081A1 (en) * | 2006-11-06 | 2008-05-14 | Koninklijke Philips Electronics N.V. | Use of arylboronic acids in protein labelling |
| GB0704764D0 (en) * | 2007-03-12 | 2007-04-18 | Electrophoretics Ltd | Isobarically labelled reagents and methods of their use |
| EP2160752A4 (en) * | 2007-05-23 | 2012-11-07 | Nicholas A Williamson | METHOD FOR MASS ANALYSIS OF TARGET MOLECULES IN COMPLEX MIXTURES |
| GB0809488D0 (en) | 2008-05-23 | 2008-07-02 | Electrophoretics Ltd | Mass spectrometric analysis |
| GB0811574D0 (en) * | 2008-06-24 | 2008-07-30 | Trillion Genomics Ltd | Characterising planar samples by mass spectrometry |
| KR101081053B1 (ko) * | 2008-07-18 | 2011-11-07 | 포항공과대학교 산학협력단 | 가변질량 라벨링제와 이를 이용한 아미노산 서열 및 단백질정량 동시 분석방법 |
| GB0916881D0 (en) * | 2009-09-25 | 2009-11-11 | Electrophoretics Ltd | Mass labels |
| GB0921665D0 (en) | 2009-12-10 | 2010-01-27 | Trillion Genomics Ltd | Phobes |
| EP2528443B1 (en) * | 2010-01-25 | 2017-01-11 | DH Technologies Development Pte. Ltd. | Quantitative analysis of vitamin d3, vitamin d2, and metabolites thereof |
| DE102011017084B4 (de) | 2010-04-14 | 2020-07-09 | Wisconsin Alumni Research Foundation | Massenspektrometriedaten-Erfassungsmodus zur Erzielung einer zuverlässigeren Proteinquantifizierung |
| GB201006360D0 (en) | 2010-04-16 | 2010-06-02 | Immatics Biotechnologies Gmbh | Method for differentially quantifying naturally processed HLA-restricted peptides for cancer, autoimmune and infectious diseases immunotherapy development |
| EP2588144B1 (en) | 2010-07-02 | 2018-05-09 | Ventana Medical Systems, Inc. | Detecting targets using mass tags and mass spectrometry |
| US8589084B2 (en) * | 2010-10-08 | 2013-11-19 | Massachusetts Institute Of Technology | Detection of ethanol emission from a spark ignition engine operating on gasohols |
| US20140017797A1 (en) * | 2010-12-13 | 2014-01-16 | De Staadt der Nederlanden, vert doorde minister van VWS | Protein affinity tag and uses thereof |
| US9040903B2 (en) | 2011-04-04 | 2015-05-26 | Wisconsin Alumni Research Foundation | Precursor selection using an artificial intelligence algorithm increases proteomic sample coverage and reproducibility |
| US9388132B2 (en) | 2011-09-15 | 2016-07-12 | Wisconsin Alumni Research Foundation | Isobaric tandem mass tags for quantitative proteomics and peptidomics |
| US10436790B2 (en) | 2011-09-28 | 2019-10-08 | Waters Technologies Corporation | Rapid fluorescence tagging of glycans and other biomolecules with enhanced MS signals |
| CN104508487B (zh) * | 2012-05-10 | 2017-04-19 | 萨默费尼根有限公司 | 用于通过质谱法高度多路复用地定量肽类的方法以及用于其的标记试剂 |
| JP6285917B2 (ja) * | 2012-05-22 | 2018-02-28 | バイオジェン・エムエイ・インコーポレイテッドＢｉｏｇｅｎ ＭＡ Ｉｎｃ． | 反応性代謝物質のスクリーニングのための捕獲剤 |
| GB201322567D0 (en) | 2013-12-19 | 2014-02-05 | Electrophoretics Ltd | Mass labels |
| US10269550B2 (en) | 2014-02-21 | 2019-04-23 | Purdue Research Foundation | Systems and methods for quantifying an analyte extracted from a sample |
| US11495448B2 (en) | 2014-02-21 | 2022-11-08 | Purdue Research Foundation | Systems and methods for quantifying an analyte extracted from a sample |
| EP3108496B1 (en) * | 2014-02-21 | 2021-04-28 | Purdue Research Foundation | Analyzing an extracted sample using an immiscible extraction solvent |
| WO2016069764A1 (en) | 2014-10-30 | 2016-05-06 | Waters Technologies Corporation | Methods for the rapid preparation of labeled glycosylamines and for the analysis of glycosylated biomolecules producing the same |
| WO2016077548A1 (en) | 2014-11-13 | 2016-05-19 | Waters Technologies Corporation | Methods for liquid chromatography calibration for rapid labeled n-glycans |
| GB201423361D0 (en) | 2014-12-30 | 2015-02-11 | Immatics Biotechnologies Gmbh | Method for the absolute Quantification of naturally processed HLA-Restricted cancer peptides |
| CN109641846A (zh) | 2016-06-21 | 2019-04-16 | 沃特世科技公司 | 通过用于增强的ms信号的还原胺化的聚糖和其他生物分子的荧光标记 |
| US11035832B2 (en) | 2016-06-21 | 2021-06-15 | Waters Technologies Corporation | Methods of electrospray ionization of glycans modified with amphipathic, strongly basic moieties |
| EP3479103B1 (en) | 2016-07-01 | 2022-04-20 | Waters Technologies Corporation | Methods for the rapid preparation of labeled glycosylamines from complex matrices using molecular weight cut off filtration and on-filter deglycosylation |
| CN110609103A (zh) * | 2018-06-15 | 2019-12-24 | 中国科学院大连化学物理研究所 | 基于化学标记和质谱的蛋白与材料相互作用结构分析方法 |
| KR102362170B1 (ko) * | 2019-04-08 | 2022-02-11 | 주식회사 엘지화학 | Maldi 질량분석을 이용한 고분자의 상대적 정량분석방법 |
| CA3165068A1 (en) | 2020-01-30 | 2021-08-05 | John E. Blume | Lung biomarkers and methods of use thereof |
| WO2021163467A1 (en) * | 2020-02-14 | 2021-08-19 | Temple University-Of The Commonwealth System Of Higher Education | Linking amino acid sequences, manufacturing method thereof, and use thereof |
| US12334190B2 (en) | 2021-03-31 | 2025-06-17 | PrognomIQ, Inc. | Multi-omic assessment using proteins and nucleic acids |
| WO2023019148A1 (en) * | 2021-08-10 | 2023-02-16 | PrognomIQ, Inc. | Macromolecule enrichment |
| US12387508B2 (en) | 2021-09-10 | 2025-08-12 | PrognomIQ, Inc. | Direct classification of raw biomolecule measurement data |
| US12007397B2 (en) | 2021-09-13 | 2024-06-11 | PrognomIQ, Inc. | Enhanced detection and quantitation of biomolecules |
| US20240036055A1 (en) * | 2022-06-15 | 2024-02-01 | Wisconsin Alumni Research Foundation | Multiplexed DiLeu-Biotin-Azide (DBA) Tag Enabled Isobaric Tandem Orthogonal Proteolysis Activity-Based Protein Profiling (isoBOP-ABPP) Platform For High-Throughput Quantitative Pan-PTM Analysis |
| EP4639171A2 (en) * | 2022-12-21 | 2025-10-29 | Roche Diagnostics GmbH | (poly)label signal enhancer |
| EP4667939A1 (en) | 2024-06-21 | 2025-12-24 | Commissariat à l'Energie Atomique et aux Energies Alternatives | Multiplex cancer cell profiling using ms-tagged probes containing an iminosydnone cleavable linker |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5258498A (en) * | 1987-05-21 | 1993-11-02 | Creative Biomolecules, Inc. | Polypeptide linkers for production of biosynthetic proteins |
| GB9315847D0 (en) * | 1993-07-30 | 1993-09-15 | Isis Innovation | Tag reagent and assay method |
| US6027890A (en) * | 1996-01-23 | 2000-02-22 | Rapigene, Inc. | Methods and compositions for enhancing sensitivity in the analysis of biological-based assays |
| DE69739304D1 (de) * | 1996-01-23 | 2009-04-23 | Operon Biotechnologies Inc | Verfahren und Zusammensetzungen zur Bestimmung von Sequenzen von Nukleinsäure-Molekülen |
| EP0863858B1 (en) | 1996-04-08 | 2004-02-04 | Glaxo Group Limited | Mass-based encoding and qualitative analysis of combinatorial libraries |
| DE69735445T2 (de) * | 1996-12-10 | 2006-08-10 | Sequenom, Inc., San Diego | Abspaltbare, nicht-flüchtige moleküle zur massenmarkierung |
| ATE374836T1 (de) | 1997-01-15 | 2007-10-15 | Xzillion Gmbh & Co Kg | Massenmarkierte hybridisierungssonden |
| IL133948A0 (en) | 1997-07-11 | 2001-04-30 | Brax Group Ltd | Characterising nucleic acids |
| CA2303790A1 (en) | 1997-09-15 | 1999-03-25 | Brax Group Limited | Characterising nucleic acid by mass spectrometry |
| GB9823646D0 (en) | 1997-12-19 | 1998-12-23 | Brax Genomics Ltd | Compounds for mass spectrometry |
| GB0006141D0 (en) * | 2000-03-14 | 2000-05-03 | Brax Group Ltd | Mass labels |
| WO2002014867A2 (en) | 2000-08-11 | 2002-02-21 | Agilix Corporation | Ultra-sensitive detection systems |
-
2002
- 2002-09-16 CA CA002460131A patent/CA2460131C/en not_active Expired - Lifetime
- 2002-09-16 DK DK02767650T patent/DK1425586T3/da active
- 2002-09-16 JP JP2003529154A patent/JP4290003B2/ja not_active Expired - Lifetime
- 2002-09-16 ES ES02767650T patent/ES2296996T3/es not_active Expired - Lifetime
- 2002-09-16 EP EP02767650A patent/EP1425586B1/en not_active Expired - Lifetime
- 2002-09-16 DE DE60223696T patent/DE60223696T2/de not_active Expired - Lifetime
- 2002-09-16 US US10/489,341 patent/US7732378B2/en not_active Expired - Lifetime
- 2002-09-16 PT PT02767650T patent/PT1425586E/pt unknown
- 2002-09-16 WO PCT/GB2002/004240 patent/WO2003025576A2/en not_active Ceased
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