DK1425586T3 - Massemarkörer - Google Patents
MassemarkörerInfo
- Publication number
- DK1425586T3 DK1425586T3 DK02767650T DK02767650T DK1425586T3 DK 1425586 T3 DK1425586 T3 DK 1425586T3 DK 02767650 T DK02767650 T DK 02767650T DK 02767650 T DK02767650 T DK 02767650T DK 1425586 T3 DK1425586 T3 DK 1425586T3
- Authority
- DK
- Denmark
- Prior art keywords
- mass markers
- markers
- mass
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
- G01N33/6851—Methods of protein analysis involving laser desorption ionisation mass spectrometry
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2458/00—Labels used in chemical analysis of biological material
- G01N2458/15—Non-radioactive isotope labels, e.g. for detection by mass spectrometry
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Biophysics (AREA)
- Optics & Photonics (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01307830 | 2001-09-14 | ||
| PCT/GB2002/004240 WO2003025576A2 (en) | 2001-09-14 | 2002-09-16 | Mass labels |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1425586T3 true DK1425586T3 (da) | 2008-02-11 |
Family
ID=8182269
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK02767650T DK1425586T3 (da) | 2001-09-14 | 2002-09-16 | Massemarkörer |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7732378B2 (https=) |
| EP (1) | EP1425586B1 (https=) |
| JP (1) | JP4290003B2 (https=) |
| CA (1) | CA2460131C (https=) |
| DE (1) | DE60223696T2 (https=) |
| DK (1) | DK1425586T3 (https=) |
| ES (1) | ES2296996T3 (https=) |
| PT (1) | PT1425586E (https=) |
| WO (1) | WO2003025576A2 (https=) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002014867A2 (en) * | 2000-08-11 | 2002-02-21 | Agilix Corporation | Ultra-sensitive detection systems |
| JP2005514603A (ja) * | 2001-11-06 | 2005-05-19 | アジリックス・コーポレイション | 高感度コード化検出システム |
| US7556969B2 (en) | 2002-12-19 | 2009-07-07 | Northeastern University | Intensified neutral loss tags and use thereof in mass spectrometry |
| JP4613299B2 (ja) | 2003-01-30 | 2011-01-12 | ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド | 分析物分析に関する方法、混合物、キット、および組成物 |
| GB0306756D0 (en) | 2003-03-24 | 2003-04-30 | Xzillion Gmbh & Co Kg | Mass labels |
| JP2005140755A (ja) * | 2003-11-10 | 2005-06-02 | Japan Science & Technology Agency | 質量分析用プローブ及びそれを用いた質量分析方法 |
| CA2542941C (en) * | 2003-11-26 | 2013-02-12 | Applera Corporation | Analysis of mass spectral data in the quiet zones and label selection therefor |
| US7105806B2 (en) * | 2003-11-26 | 2006-09-12 | Applera Corporation | Method and apparatus for de-convoluting a convoluted spectrum |
| EP1916527A1 (en) * | 2003-11-26 | 2008-04-30 | Applera Corporation | Analysis of mass spectral data in the quiet zones |
| US7355045B2 (en) | 2004-01-05 | 2008-04-08 | Applera Corporation | Isotopically enriched N-substituted piperazine acetic acids and methods for the preparation thereof |
| US7307169B2 (en) | 2004-01-05 | 2007-12-11 | Applera Corporation | Isotopically enriched N-substituted piperazines and methods for the preparation thereof |
| JP2007519910A (ja) | 2004-01-28 | 2007-07-19 | イマティクス バイオテクノロジーズ ゲーエムベーハー | 腫瘍関連ペプチドの同定および定量方法 |
| US20070054345A1 (en) * | 2004-05-19 | 2007-03-08 | Hunter Christie L | Expression quantification using mass spectrometry |
| US20080206737A1 (en) * | 2004-05-19 | 2008-08-28 | Hunter Christie L | Expression quantification using mass spectrometry |
| US7618780B2 (en) | 2004-05-20 | 2009-11-17 | Trillion Genomics Limited | Use of mass labelled probes to detect target nucleic acids using mass spectrometry |
| US20070048752A1 (en) | 2004-07-12 | 2007-03-01 | Applera Corporation | Mass tags for quantitative analyses |
| WO2006017208A1 (en) * | 2004-07-12 | 2006-02-16 | Applera Corporation | Mass tags for quantitative analyses |
| WO2006023398A2 (en) * | 2004-08-16 | 2006-03-02 | Ludwig Institute For Cancer Research | Modular isotope labelled mass spectrometry reagents and methods for quantitation of amino acids, peptides and proteins |
| US20060134710A1 (en) * | 2004-10-30 | 2006-06-22 | Viorica Lopez-Avila | WDR11 protein assay |
| US20070207555A1 (en) * | 2005-02-03 | 2007-09-06 | Cesar Guerra | Ultra-sensitive detection systems using multidimension signals |
| US20060183238A1 (en) | 2005-02-09 | 2006-08-17 | Applera Corporation | Amine-containing compound analysis methods |
| US20070134802A1 (en) * | 2005-06-30 | 2007-06-14 | Heinz Doebeli | Ionization modifier for mass spectrometry |
| GB0515323D0 (en) * | 2005-07-26 | 2005-08-31 | Electrophoretics Ltd | Mass labels |
| US8889423B2 (en) | 2005-07-29 | 2014-11-18 | Eisai R & D Management Co., Ltd. | Method for analysis of compound-binding ability of protein |
| GB0518585D0 (en) * | 2005-09-12 | 2005-10-19 | Electrophoretics Ltd | Mass labels |
| EP1921081A1 (en) * | 2006-11-06 | 2008-05-14 | Koninklijke Philips Electronics N.V. | Use of arylboronic acids in protein labelling |
| GB0704764D0 (en) * | 2007-03-12 | 2007-04-18 | Electrophoretics Ltd | Isobarically labelled reagents and methods of their use |
| EP2160752A4 (en) * | 2007-05-23 | 2012-11-07 | Nicholas A Williamson | METHOD FOR MASS ANALYSIS OF TARGET MOLECULES IN COMPLEX MIXTURES |
| GB0809488D0 (en) | 2008-05-23 | 2008-07-02 | Electrophoretics Ltd | Mass spectrometric analysis |
| GB0811574D0 (en) * | 2008-06-24 | 2008-07-30 | Trillion Genomics Ltd | Characterising planar samples by mass spectrometry |
| KR101081053B1 (ko) * | 2008-07-18 | 2011-11-07 | 포항공과대학교 산학협력단 | 가변질량 라벨링제와 이를 이용한 아미노산 서열 및 단백질정량 동시 분석방법 |
| GB0916881D0 (en) * | 2009-09-25 | 2009-11-11 | Electrophoretics Ltd | Mass labels |
| GB0921665D0 (en) | 2009-12-10 | 2010-01-27 | Trillion Genomics Ltd | Phobes |
| EP2528443B1 (en) * | 2010-01-25 | 2017-01-11 | DH Technologies Development Pte. Ltd. | Quantitative analysis of vitamin d3, vitamin d2, and metabolites thereof |
| DE102011017084B4 (de) | 2010-04-14 | 2020-07-09 | Wisconsin Alumni Research Foundation | Massenspektrometriedaten-Erfassungsmodus zur Erzielung einer zuverlässigeren Proteinquantifizierung |
| GB201006360D0 (en) | 2010-04-16 | 2010-06-02 | Immatics Biotechnologies Gmbh | Method for differentially quantifying naturally processed HLA-restricted peptides for cancer, autoimmune and infectious diseases immunotherapy development |
| EP2588144B1 (en) | 2010-07-02 | 2018-05-09 | Ventana Medical Systems, Inc. | Detecting targets using mass tags and mass spectrometry |
| US8589084B2 (en) * | 2010-10-08 | 2013-11-19 | Massachusetts Institute Of Technology | Detection of ethanol emission from a spark ignition engine operating on gasohols |
| US20140017797A1 (en) * | 2010-12-13 | 2014-01-16 | De Staadt der Nederlanden, vert doorde minister van VWS | Protein affinity tag and uses thereof |
| US9040903B2 (en) | 2011-04-04 | 2015-05-26 | Wisconsin Alumni Research Foundation | Precursor selection using an artificial intelligence algorithm increases proteomic sample coverage and reproducibility |
| US9388132B2 (en) | 2011-09-15 | 2016-07-12 | Wisconsin Alumni Research Foundation | Isobaric tandem mass tags for quantitative proteomics and peptidomics |
| US10436790B2 (en) | 2011-09-28 | 2019-10-08 | Waters Technologies Corporation | Rapid fluorescence tagging of glycans and other biomolecules with enhanced MS signals |
| CN104508487B (zh) * | 2012-05-10 | 2017-04-19 | 萨默费尼根有限公司 | 用于通过质谱法高度多路复用地定量肽类的方法以及用于其的标记试剂 |
| JP6285917B2 (ja) * | 2012-05-22 | 2018-02-28 | バイオジェン・エムエイ・インコーポレイテッドBiogen MA Inc. | 反応性代謝物質のスクリーニングのための捕獲剤 |
| GB201322567D0 (en) | 2013-12-19 | 2014-02-05 | Electrophoretics Ltd | Mass labels |
| US10269550B2 (en) | 2014-02-21 | 2019-04-23 | Purdue Research Foundation | Systems and methods for quantifying an analyte extracted from a sample |
| US11495448B2 (en) | 2014-02-21 | 2022-11-08 | Purdue Research Foundation | Systems and methods for quantifying an analyte extracted from a sample |
| EP3108496B1 (en) * | 2014-02-21 | 2021-04-28 | Purdue Research Foundation | Analyzing an extracted sample using an immiscible extraction solvent |
| WO2016069764A1 (en) | 2014-10-30 | 2016-05-06 | Waters Technologies Corporation | Methods for the rapid preparation of labeled glycosylamines and for the analysis of glycosylated biomolecules producing the same |
| WO2016077548A1 (en) | 2014-11-13 | 2016-05-19 | Waters Technologies Corporation | Methods for liquid chromatography calibration for rapid labeled n-glycans |
| GB201423361D0 (en) | 2014-12-30 | 2015-02-11 | Immatics Biotechnologies Gmbh | Method for the absolute Quantification of naturally processed HLA-Restricted cancer peptides |
| CN109641846A (zh) | 2016-06-21 | 2019-04-16 | 沃特世科技公司 | 通过用于增强的ms信号的还原胺化的聚糖和其他生物分子的荧光标记 |
| US11035832B2 (en) | 2016-06-21 | 2021-06-15 | Waters Technologies Corporation | Methods of electrospray ionization of glycans modified with amphipathic, strongly basic moieties |
| EP3479103B1 (en) | 2016-07-01 | 2022-04-20 | Waters Technologies Corporation | Methods for the rapid preparation of labeled glycosylamines from complex matrices using molecular weight cut off filtration and on-filter deglycosylation |
| CN110609103A (zh) * | 2018-06-15 | 2019-12-24 | 中国科学院大连化学物理研究所 | 基于化学标记和质谱的蛋白与材料相互作用结构分析方法 |
| KR102362170B1 (ko) * | 2019-04-08 | 2022-02-11 | 주식회사 엘지화학 | Maldi 질량분석을 이용한 고분자의 상대적 정량분석방법 |
| CA3165068A1 (en) | 2020-01-30 | 2021-08-05 | John E. Blume | Lung biomarkers and methods of use thereof |
| WO2021163467A1 (en) * | 2020-02-14 | 2021-08-19 | Temple University-Of The Commonwealth System Of Higher Education | Linking amino acid sequences, manufacturing method thereof, and use thereof |
| US12334190B2 (en) | 2021-03-31 | 2025-06-17 | PrognomIQ, Inc. | Multi-omic assessment using proteins and nucleic acids |
| WO2023019148A1 (en) * | 2021-08-10 | 2023-02-16 | PrognomIQ, Inc. | Macromolecule enrichment |
| US12387508B2 (en) | 2021-09-10 | 2025-08-12 | PrognomIQ, Inc. | Direct classification of raw biomolecule measurement data |
| US12007397B2 (en) | 2021-09-13 | 2024-06-11 | PrognomIQ, Inc. | Enhanced detection and quantitation of biomolecules |
| US20240036055A1 (en) * | 2022-06-15 | 2024-02-01 | Wisconsin Alumni Research Foundation | Multiplexed DiLeu-Biotin-Azide (DBA) Tag Enabled Isobaric Tandem Orthogonal Proteolysis Activity-Based Protein Profiling (isoBOP-ABPP) Platform For High-Throughput Quantitative Pan-PTM Analysis |
| EP4639171A2 (en) * | 2022-12-21 | 2025-10-29 | Roche Diagnostics GmbH | (poly)label signal enhancer |
| EP4667939A1 (en) | 2024-06-21 | 2025-12-24 | Commissariat à l'Energie Atomique et aux Energies Alternatives | Multiplex cancer cell profiling using ms-tagged probes containing an iminosydnone cleavable linker |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5258498A (en) * | 1987-05-21 | 1993-11-02 | Creative Biomolecules, Inc. | Polypeptide linkers for production of biosynthetic proteins |
| GB9315847D0 (en) * | 1993-07-30 | 1993-09-15 | Isis Innovation | Tag reagent and assay method |
| US6027890A (en) * | 1996-01-23 | 2000-02-22 | Rapigene, Inc. | Methods and compositions for enhancing sensitivity in the analysis of biological-based assays |
| DE69739304D1 (de) * | 1996-01-23 | 2009-04-23 | Operon Biotechnologies Inc | Verfahren und Zusammensetzungen zur Bestimmung von Sequenzen von Nukleinsäure-Molekülen |
| EP0863858B1 (en) | 1996-04-08 | 2004-02-04 | Glaxo Group Limited | Mass-based encoding and qualitative analysis of combinatorial libraries |
| DE69735445T2 (de) * | 1996-12-10 | 2006-08-10 | Sequenom, Inc., San Diego | Abspaltbare, nicht-flüchtige moleküle zur massenmarkierung |
| ATE374836T1 (de) | 1997-01-15 | 2007-10-15 | Xzillion Gmbh & Co Kg | Massenmarkierte hybridisierungssonden |
| IL133948A0 (en) | 1997-07-11 | 2001-04-30 | Brax Group Ltd | Characterising nucleic acids |
| CA2303790A1 (en) | 1997-09-15 | 1999-03-25 | Brax Group Limited | Characterising nucleic acid by mass spectrometry |
| GB9823646D0 (en) | 1997-12-19 | 1998-12-23 | Brax Genomics Ltd | Compounds for mass spectrometry |
| GB0006141D0 (en) * | 2000-03-14 | 2000-05-03 | Brax Group Ltd | Mass labels |
| WO2002014867A2 (en) | 2000-08-11 | 2002-02-21 | Agilix Corporation | Ultra-sensitive detection systems |
-
2002
- 2002-09-16 CA CA002460131A patent/CA2460131C/en not_active Expired - Lifetime
- 2002-09-16 DK DK02767650T patent/DK1425586T3/da active
- 2002-09-16 JP JP2003529154A patent/JP4290003B2/ja not_active Expired - Lifetime
- 2002-09-16 ES ES02767650T patent/ES2296996T3/es not_active Expired - Lifetime
- 2002-09-16 EP EP02767650A patent/EP1425586B1/en not_active Expired - Lifetime
- 2002-09-16 DE DE60223696T patent/DE60223696T2/de not_active Expired - Lifetime
- 2002-09-16 US US10/489,341 patent/US7732378B2/en not_active Expired - Lifetime
- 2002-09-16 PT PT02767650T patent/PT1425586E/pt unknown
- 2002-09-16 WO PCT/GB2002/004240 patent/WO2003025576A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP1425586A2 (en) | 2004-06-09 |
| US20050048489A1 (en) | 2005-03-03 |
| JP4290003B2 (ja) | 2009-07-01 |
| ES2296996T3 (es) | 2008-05-01 |
| EP1425586B1 (en) | 2007-11-21 |
| DE60223696D1 (de) | 2008-01-03 |
| CA2460131C (en) | 2006-11-21 |
| PT1425586E (pt) | 2007-12-31 |
| WO2003025576A3 (en) | 2003-07-31 |
| JP2005503557A (ja) | 2005-02-03 |
| WO2003025576A2 (en) | 2003-03-27 |
| DE60223696T2 (de) | 2009-01-29 |
| CA2460131A1 (en) | 2003-03-27 |
| US7732378B2 (en) | 2010-06-08 |
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