JP2004536929A5 - - Google Patents
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- Publication number
- JP2004536929A5 JP2004536929A5 JP2003516444A JP2003516444A JP2004536929A5 JP 2004536929 A5 JP2004536929 A5 JP 2004536929A5 JP 2003516444 A JP2003516444 A JP 2003516444A JP 2003516444 A JP2003516444 A JP 2003516444A JP 2004536929 A5 JP2004536929 A5 JP 2004536929A5
- Authority
- JP
- Japan
- Prior art keywords
- polyhydric alcohol
- biodegradable
- ester
- alcohol ester
- moiety
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000002148 esters Chemical class 0.000 claims description 33
- 150000005846 sugar alcohols Polymers 0.000 claims description 24
- -1 2-carboxyethenyl group Chemical group 0.000 claims description 15
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 12
- 238000006243 chemical reaction Methods 0.000 claims description 11
- 229940079593 drug Drugs 0.000 claims description 11
- 239000003814 drug Substances 0.000 claims description 11
- 125000002252 acyl group Chemical group 0.000 claims description 10
- 229920001282 polysaccharide Polymers 0.000 claims description 10
- 239000005017 polysaccharide Substances 0.000 claims description 10
- 230000000975 bioactive effect Effects 0.000 claims description 7
- 150000004676 glycans Chemical class 0.000 claims description 7
- 239000000017 hydrogel Substances 0.000 claims description 7
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 6
- 239000000126 substance Substances 0.000 claims description 6
- 238000012377 drug delivery Methods 0.000 claims description 5
- PAPBSGBWRJIAAV-UHFFFAOYSA-N ε-Caprolactone Chemical group O=C1CCCCCO1 PAPBSGBWRJIAAV-UHFFFAOYSA-N 0.000 claims description 5
- 238000000576 coating method Methods 0.000 claims description 3
- 150000001875 compounds Chemical class 0.000 claims description 3
- 229920000728 polyester Polymers 0.000 claims description 3
- 238000006116 polymerization reaction Methods 0.000 claims description 3
- 230000002792 vascular Effects 0.000 claims description 3
- 229920002307 Dextran Polymers 0.000 claims description 2
- 125000001931 aliphatic group Chemical group 0.000 claims description 2
- 239000012867 bioactive agent Substances 0.000 claims description 2
- 229920001577 copolymer Polymers 0.000 claims description 2
- 238000007306 functionalization reaction Methods 0.000 claims description 2
- 229920001519 homopolymer Polymers 0.000 claims description 2
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 claims description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 239000011248 coating agent Substances 0.000 claims 2
- RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 claims 1
- 125000003158 alcohol group Chemical group 0.000 claims 1
- 229920000229 biodegradable polyester Polymers 0.000 claims 1
- 239000004622 biodegradable polyester Substances 0.000 claims 1
- 239000007795 chemical reaction product Substances 0.000 claims 1
- JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical compound CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000000178 monomer Substances 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 238000005227 gel permeation chromatography Methods 0.000 description 7
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 description 7
- 239000004793 Polystyrene Substances 0.000 description 5
- YLFIGGHWWPSIEG-UHFFFAOYSA-N aminoxyl Chemical group [O]N YLFIGGHWWPSIEG-UHFFFAOYSA-N 0.000 description 5
- 229920002223 polystyrene Polymers 0.000 description 5
- 150000003254 radicals Chemical class 0.000 description 5
- 239000002243 precursor Substances 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 2
- 150000007942 carboxylates Chemical class 0.000 description 2
- 125000001841 imino group Chemical group [H]N=* 0.000 description 2
- DNXHEGUUPJUMQT-UHFFFAOYSA-N (+)-estrone Natural products OC1=CC=C2C3CCC(C)(C(CC4)=O)C4C3CCC2=C1 DNXHEGUUPJUMQT-UHFFFAOYSA-N 0.000 description 1
- VPVXHAANQNHFSF-UHFFFAOYSA-N 1,4-dioxan-2-one Chemical compound O=C1COCCO1 VPVXHAANQNHFSF-UHFFFAOYSA-N 0.000 description 1
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 1
- 229920002845 Poly(methacrylic acid) Polymers 0.000 description 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical compound C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 description 1
- 229940127093 camptothecin Drugs 0.000 description 1
- 150000001735 carboxylic acids Chemical class 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 description 1
- 229960004679 doxorubicin Drugs 0.000 description 1
- 229960003399 estrone Drugs 0.000 description 1
- 125000003719 estrone group Chemical group 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000005865 ionizing radiation Effects 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 description 1
- 229920001610 polycaprolactone Polymers 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 238000010526 radical polymerization reaction Methods 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 238000007634 remodeling Methods 0.000 description 1
- 238000007151 ring opening polymerisation reaction Methods 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30918001P | 2001-08-02 | 2001-08-02 | |
| PCT/US2002/019816 WO2003011212A2 (en) | 2001-08-02 | 2002-07-15 | Biodegradable polyhydric alcohol esters |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009064455A Division JP2009167418A (ja) | 2001-08-02 | 2009-03-17 | 生分解性多価アルコールエステル |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004536929A JP2004536929A (ja) | 2004-12-09 |
| JP2004536929A5 true JP2004536929A5 (cg-RX-API-DMAC7.html) | 2006-01-05 |
| JP4335002B2 JP4335002B2 (ja) | 2009-09-30 |
Family
ID=23197041
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003516444A Expired - Fee Related JP4335002B2 (ja) | 2001-08-02 | 2002-07-15 | 生分解性多価アルコールエステル |
| JP2009064455A Pending JP2009167418A (ja) | 2001-08-02 | 2009-03-17 | 生分解性多価アルコールエステル |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009064455A Pending JP2009167418A (ja) | 2001-08-02 | 2009-03-17 | 生分解性多価アルコールエステル |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6592895B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1411903A4 (cg-RX-API-DMAC7.html) |
| JP (2) | JP4335002B2 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2002316340B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2450123C (cg-RX-API-DMAC7.html) |
| WO (1) | WO2003011212A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6716445B2 (en) * | 1999-04-12 | 2004-04-06 | Cornell Research Foundation, Inc. | Hydrogel entrapping therapeutic agent and stent with coating comprising this |
| ES2298135T3 (es) * | 1999-04-12 | 2008-05-16 | Cornell Research Foundation, Inc. | Sistema formador de hidrogel con componentes hidrofobos e hidrofilos. |
| US7229979B2 (en) | 2003-06-23 | 2007-06-12 | Immune Modulation, Inc. | Hypoestoxides, derivatives and agonists thereof for use as stent-coating agents |
| KR100578737B1 (ko) * | 2003-06-25 | 2006-05-12 | 학교법인 포항공과대학교 | 반응성 방사구조 고분자 및 이를 이용한 저유전성 고분자복합체 박막 |
| JP2005046611A (ja) * | 2003-07-01 | 2005-02-24 | Medtronic Vascular Inc | 薬剤含有ポリマーが塗布されたステント用のエネルギーで活性化された接着剤層 |
| US7169404B2 (en) | 2003-07-30 | 2007-01-30 | Advanced Cardiovasular Systems, Inc. | Biologically absorbable coatings for implantable devices and methods for fabricating the same |
| US20050074453A1 (en) * | 2003-10-02 | 2005-04-07 | Ferree Bret A. | Methods of preventing adhesions following laminectomies and other surgical procedures |
| US7670616B2 (en) * | 2004-03-11 | 2010-03-02 | Cornell Research Foundation, Inc. | Hydrogel forming system comprising PEG derivative precursor |
| EP2329852A1 (en) | 2004-03-26 | 2011-06-08 | SurModics, Inc. | Composition and method for preparing biocompatible surfaces |
| ATE442822T1 (de) * | 2004-04-02 | 2009-10-15 | Arterial Remodelling Technolog | Stentanordnung auf polymerbasis |
| US20050220853A1 (en) * | 2004-04-02 | 2005-10-06 | Kinh-Luan Dao | Controlled delivery of therapeutic agents from medical articles |
| US8246993B2 (en) * | 2004-06-10 | 2012-08-21 | Cytogel Pharma, Llc | Advantageous hydrogel composition |
| US20060013886A1 (en) | 2004-06-28 | 2006-01-19 | Daqing Wu | Injectable microspheres |
| AU2005267536B8 (en) * | 2004-06-28 | 2010-12-16 | Cornell Research Foundation, Inc. | Injectable microspheres from unsaturated functionalized polyhydric alcohol esters |
| FI122108B (fi) * | 2004-11-17 | 2011-08-31 | Jvs Polymers Oy | Silloittuva biopolymeeri |
| WO2006138719A2 (en) | 2005-06-17 | 2006-12-28 | Georgia Tech Research Corporation | Coated microstructures and method of manufacture thereof |
| WO2007065074A2 (en) * | 2005-11-29 | 2007-06-07 | Indiana University Research And Technology Corporation | Biodegradable implant polymers and composites |
| US8399012B2 (en) * | 2006-04-17 | 2013-03-19 | Kimberly-Clark Worldwide, Inc. | Degradable therapeutic delivery device |
| EP2076211A4 (en) * | 2006-10-20 | 2015-07-22 | Elixir Medical Corp | LUMINOUS PROSTHESES AND METHODS OF COATING THEREOF |
| WO2009120361A2 (en) | 2008-03-28 | 2009-10-01 | Surmodics, Inc. | Insertable medical devices having microparticulate-associated elastic substrates and methods for drug delivery |
| CN107033368A (zh) | 2009-11-09 | 2017-08-11 | 聚光灯技术合伙有限责任公司 | 碎裂水凝胶 |
| CA2780294C (en) | 2009-11-09 | 2018-01-16 | Spotlight Technology Partners Llc | Polysaccharide based hydrogels |
| AU2011255258B2 (en) | 2010-05-21 | 2015-07-09 | Cytogel Pharma, Llc | Materials and methods for treatment of inflammation |
| AU2012284097B2 (en) | 2011-07-18 | 2017-08-03 | President And Fellows Of Harvard College | Engineered microbe-targeting molecules and uses thereof |
| JP6649250B2 (ja) | 2013-05-21 | 2020-02-19 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | 操作されたヘム結合性構成物およびその使用 |
| EP3083658B1 (en) | 2013-12-18 | 2019-05-08 | President and Fellows of Harvard College | Crp capture/detection of gram positive bacteria |
| ES2782428T3 (es) | 2014-04-18 | 2020-09-15 | Univ Auburn | Formulaciones vacunales de partículas para la inducción de inmunidad innata y adaptativa |
| US10293044B2 (en) | 2014-04-18 | 2019-05-21 | Auburn University | Particulate formulations for improving feed conversion rate in a subject |
| WO2016040347A2 (en) | 2014-09-08 | 2016-03-17 | University Of Iowa Research Foundation | Microrna inhibitor system and methods of use thereof |
| JP2017535645A (ja) * | 2014-12-16 | 2017-11-30 | ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． | 生分解性ポリマー組成物 |
| US10435457B2 (en) | 2015-08-06 | 2019-10-08 | President And Fellows Of Harvard College | Microbe-binding molecules and uses thereof |
| US10583199B2 (en) | 2016-04-26 | 2020-03-10 | Northwestern University | Nanocarriers having surface conjugated peptides and uses thereof for sustained local release of drugs |
| US10273476B2 (en) | 2016-04-30 | 2019-04-30 | University Of Iowa Research Foundation | MicroRNA-200 based approaches for modulating bone formation inhibition and bone regeneration |
| US10975121B2 (en) | 2017-06-24 | 2021-04-13 | Cytogel Pharma, Llc | Analgesic mu-opioid receptor binding peptide pharmaceutical formulations and uses thereof |
| CN110698656A (zh) * | 2019-10-12 | 2020-01-17 | 西安交通大学 | 一种低温熔融药物缓释医用高分子材料合成方法及应用 |
| KR102769424B1 (ko) * | 2020-06-23 | 2025-02-19 | 주식회사 티엠디랩 | 온도 기반 형상기억 고분자 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0616799A (ja) * | 1992-02-19 | 1994-01-25 | Sagami Chem Res Center | ポリエステル系多官能性マクロモノマー、ゲルおよび温度変化に応答する薬物放出制御材料 |
| JPH0733844A (ja) * | 1993-07-23 | 1995-02-03 | Sagami Chem Res Center | 脂肪族ポリエステルを主成分とするゲルおよび温度変化に応答する薬物放出制御材料 |
| JP3772426B2 (ja) * | 1995-11-28 | 2006-05-10 | 大日本インキ化学工業株式会社 | 発泡体及び積層体 |
| US6476204B1 (en) | 1998-08-31 | 2002-11-05 | Cornell Research Foundation, Inc. | Dextran-maleic acid monoesters and hydrogels based thereon |
| ES2298135T3 (es) * | 1999-04-12 | 2008-05-16 | Cornell Research Foundation, Inc. | Sistema formador de hidrogel con componentes hidrofobos e hidrofilos. |
| JP4565290B2 (ja) * | 1999-12-01 | 2010-10-20 | 東洋紡績株式会社 | 高水酸基濃度を有するオキシ酸系脂肪族ポリエステルおよびオキシ酸系脂肪族ポリエステル組成物 |
| US6503538B1 (en) | 2000-08-30 | 2003-01-07 | Cornell Research Foundation, Inc. | Elastomeric functional biodegradable copolyester amides and copolyester urethanes |
-
2002
- 2002-07-15 JP JP2003516444A patent/JP4335002B2/ja not_active Expired - Fee Related
- 2002-07-15 EP EP02746633A patent/EP1411903A4/en not_active Withdrawn
- 2002-07-15 AU AU2002316340A patent/AU2002316340B2/en not_active Ceased
- 2002-07-15 US US10/194,965 patent/US6592895B2/en not_active Expired - Lifetime
- 2002-07-15 WO PCT/US2002/019816 patent/WO2003011212A2/en not_active Ceased
- 2002-07-15 CA CA2450123A patent/CA2450123C/en not_active Expired - Fee Related
-
2009
- 2009-03-17 JP JP2009064455A patent/JP2009167418A/ja active Pending
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