JP4335002B2 - 生分解性多価アルコールエステル - Google Patents

生分解性多価アルコールエステル Download PDF

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Publication number
JP4335002B2
JP4335002B2 JP2003516444A JP2003516444A JP4335002B2 JP 4335002 B2 JP4335002 B2 JP 4335002B2 JP 2003516444 A JP2003516444 A JP 2003516444A JP 2003516444 A JP2003516444 A JP 2003516444A JP 4335002 B2 JP4335002 B2 JP 4335002B2
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JP
Japan
Prior art keywords
polyhydric alcohol
caprolactone
biodegradable
ppcl
pgcl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2003516444A
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English (en)
Japanese (ja)
Other versions
JP2004536929A5 (cg-RX-API-DMAC7.html
JP2004536929A (ja
Inventor
ラン・メイドン
チ−チャン・チュ
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Cornell Research Foundation Inc
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Cornell Research Foundation Inc
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Filing date
Publication date
Application filed by Cornell Research Foundation Inc filed Critical Cornell Research Foundation Inc
Publication of JP2004536929A publication Critical patent/JP2004536929A/ja
Publication of JP2004536929A5 publication Critical patent/JP2004536929A5/ja
Application granted granted Critical
Publication of JP4335002B2 publication Critical patent/JP4335002B2/ja
Anticipated expiration legal-status Critical
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • C08G63/08—Lactones or lactides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/042—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/145—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow
    • A61L2300/604—Biodegradation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606—Coatings

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Materials For Medical Uses (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Medicinal Preparation (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
JP2003516444A 2001-08-02 2002-07-15 生分解性多価アルコールエステル Expired - Fee Related JP4335002B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30918001P 2001-08-02 2001-08-02
PCT/US2002/019816 WO2003011212A2 (en) 2001-08-02 2002-07-15 Biodegradable polyhydric alcohol esters

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2009064455A Division JP2009167418A (ja) 2001-08-02 2009-03-17 生分解性多価アルコールエステル

Publications (3)

Publication Number Publication Date
JP2004536929A JP2004536929A (ja) 2004-12-09
JP2004536929A5 JP2004536929A5 (cg-RX-API-DMAC7.html) 2006-01-05
JP4335002B2 true JP4335002B2 (ja) 2009-09-30

Family

ID=23197041

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2003516444A Expired - Fee Related JP4335002B2 (ja) 2001-08-02 2002-07-15 生分解性多価アルコールエステル
JP2009064455A Pending JP2009167418A (ja) 2001-08-02 2009-03-17 生分解性多価アルコールエステル

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2009064455A Pending JP2009167418A (ja) 2001-08-02 2009-03-17 生分解性多価アルコールエステル

Country Status (6)

Country Link
US (1) US6592895B2 (cg-RX-API-DMAC7.html)
EP (1) EP1411903A4 (cg-RX-API-DMAC7.html)
JP (2) JP4335002B2 (cg-RX-API-DMAC7.html)
AU (1) AU2002316340B2 (cg-RX-API-DMAC7.html)
CA (1) CA2450123C (cg-RX-API-DMAC7.html)
WO (1) WO2003011212A2 (cg-RX-API-DMAC7.html)

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US6716445B2 (en) * 1999-04-12 2004-04-06 Cornell Research Foundation, Inc. Hydrogel entrapping therapeutic agent and stent with coating comprising this
ES2298135T3 (es) * 1999-04-12 2008-05-16 Cornell Research Foundation, Inc. Sistema formador de hidrogel con componentes hidrofobos e hidrofilos.
US7229979B2 (en) 2003-06-23 2007-06-12 Immune Modulation, Inc. Hypoestoxides, derivatives and agonists thereof for use as stent-coating agents
KR100578737B1 (ko) * 2003-06-25 2006-05-12 학교법인 포항공과대학교 반응성 방사구조 고분자 및 이를 이용한 저유전성 고분자복합체 박막
JP2005046611A (ja) * 2003-07-01 2005-02-24 Medtronic Vascular Inc 薬剤含有ポリマーが塗布されたステント用のエネルギーで活性化された接着剤層
US7169404B2 (en) 2003-07-30 2007-01-30 Advanced Cardiovasular Systems, Inc. Biologically absorbable coatings for implantable devices and methods for fabricating the same
US20050074453A1 (en) * 2003-10-02 2005-04-07 Ferree Bret A. Methods of preventing adhesions following laminectomies and other surgical procedures
US7670616B2 (en) * 2004-03-11 2010-03-02 Cornell Research Foundation, Inc. Hydrogel forming system comprising PEG derivative precursor
EP2329852A1 (en) 2004-03-26 2011-06-08 SurModics, Inc. Composition and method for preparing biocompatible surfaces
ATE442822T1 (de) * 2004-04-02 2009-10-15 Arterial Remodelling Technolog Stentanordnung auf polymerbasis
US20050220853A1 (en) * 2004-04-02 2005-10-06 Kinh-Luan Dao Controlled delivery of therapeutic agents from medical articles
US8246993B2 (en) * 2004-06-10 2012-08-21 Cytogel Pharma, Llc Advantageous hydrogel composition
US20060013886A1 (en) 2004-06-28 2006-01-19 Daqing Wu Injectable microspheres
AU2005267536B8 (en) * 2004-06-28 2010-12-16 Cornell Research Foundation, Inc. Injectable microspheres from unsaturated functionalized polyhydric alcohol esters
FI122108B (fi) * 2004-11-17 2011-08-31 Jvs Polymers Oy Silloittuva biopolymeeri
WO2006138719A2 (en) 2005-06-17 2006-12-28 Georgia Tech Research Corporation Coated microstructures and method of manufacture thereof
WO2007065074A2 (en) * 2005-11-29 2007-06-07 Indiana University Research And Technology Corporation Biodegradable implant polymers and composites
US8399012B2 (en) * 2006-04-17 2013-03-19 Kimberly-Clark Worldwide, Inc. Degradable therapeutic delivery device
EP2076211A4 (en) * 2006-10-20 2015-07-22 Elixir Medical Corp LUMINOUS PROSTHESES AND METHODS OF COATING THEREOF
WO2009120361A2 (en) 2008-03-28 2009-10-01 Surmodics, Inc. Insertable medical devices having microparticulate-associated elastic substrates and methods for drug delivery
CN107033368A (zh) 2009-11-09 2017-08-11 聚光灯技术合伙有限责任公司 碎裂水凝胶
CA2780294C (en) 2009-11-09 2018-01-16 Spotlight Technology Partners Llc Polysaccharide based hydrogels
AU2011255258B2 (en) 2010-05-21 2015-07-09 Cytogel Pharma, Llc Materials and methods for treatment of inflammation
AU2012284097B2 (en) 2011-07-18 2017-08-03 President And Fellows Of Harvard College Engineered microbe-targeting molecules and uses thereof
JP6649250B2 (ja) 2013-05-21 2020-02-19 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 操作されたヘム結合性構成物およびその使用
EP3083658B1 (en) 2013-12-18 2019-05-08 President and Fellows of Harvard College Crp capture/detection of gram positive bacteria
ES2782428T3 (es) 2014-04-18 2020-09-15 Univ Auburn Formulaciones vacunales de partículas para la inducción de inmunidad innata y adaptativa
US10293044B2 (en) 2014-04-18 2019-05-21 Auburn University Particulate formulations for improving feed conversion rate in a subject
WO2016040347A2 (en) 2014-09-08 2016-03-17 University Of Iowa Research Foundation Microrna inhibitor system and methods of use thereof
JP2017535645A (ja) * 2014-12-16 2017-11-30 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． 生分解性ポリマー組成物
US10435457B2 (en) 2015-08-06 2019-10-08 President And Fellows Of Harvard College Microbe-binding molecules and uses thereof
US10583199B2 (en) 2016-04-26 2020-03-10 Northwestern University Nanocarriers having surface conjugated peptides and uses thereof for sustained local release of drugs
US10273476B2 (en) 2016-04-30 2019-04-30 University Of Iowa Research Foundation MicroRNA-200 based approaches for modulating bone formation inhibition and bone regeneration
US10975121B2 (en) 2017-06-24 2021-04-13 Cytogel Pharma, Llc Analgesic mu-opioid receptor binding peptide pharmaceutical formulations and uses thereof
CN110698656A (zh) * 2019-10-12 2020-01-17 西安交通大学 一种低温熔融药物缓释医用高分子材料合成方法及应用
KR102769424B1 (ko) * 2020-06-23 2025-02-19 주식회사 티엠디랩 온도 기반 형상기억 고분자

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JPH0616799A (ja) * 1992-02-19 1994-01-25 Sagami Chem Res Center ポリエステル系多官能性マクロモノマー、ゲルおよび温度変化に応答する薬物放出制御材料
JPH0733844A (ja) * 1993-07-23 1995-02-03 Sagami Chem Res Center 脂肪族ポリエステルを主成分とするゲルおよび温度変化に応答する薬物放出制御材料
JP3772426B2 (ja) * 1995-11-28 2006-05-10 大日本インキ化学工業株式会社 発泡体及び積層体
US6476204B1 (en) 1998-08-31 2002-11-05 Cornell Research Foundation, Inc. Dextran-maleic acid monoesters and hydrogels based thereon
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JP4565290B2 (ja) * 1999-12-01 2010-10-20 東洋紡績株式会社 高水酸基濃度を有するオキシ酸系脂肪族ポリエステルおよびオキシ酸系脂肪族ポリエステル組成物
US6503538B1 (en) 2000-08-30 2003-01-07 Cornell Research Foundation, Inc. Elastomeric functional biodegradable copolyester amides and copolyester urethanes

Also Published As

Publication number Publication date
WO2003011212A2 (en) 2003-02-13
WO2003011212A3 (en) 2003-08-07
AU2002316340B2 (en) 2006-09-07
JP2009167418A (ja) 2009-07-30
US6592895B2 (en) 2003-07-15
EP1411903A4 (en) 2007-01-03
US20030109647A1 (en) 2003-06-12
CA2450123A1 (en) 2003-02-13
CA2450123C (en) 2013-01-29
JP2004536929A (ja) 2004-12-09
EP1411903A2 (en) 2004-04-28

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