JP2004536096A5 - - Google Patents
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- Publication number
- JP2004536096A5 JP2004536096A5 JP2003508332A JP2003508332A JP2004536096A5 JP 2004536096 A5 JP2004536096 A5 JP 2004536096A5 JP 2003508332 A JP2003508332 A JP 2003508332A JP 2003508332 A JP2003508332 A JP 2003508332A JP 2004536096 A5 JP2004536096 A5 JP 2004536096A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- solution
- polyvinylpyrrolidone
- olopatadine
- solution according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000243 solution Substances 0.000 claims 24
- 239000000203 mixture Substances 0.000 claims 16
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 14
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 14
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 14
- JBIMVDZLSHOPLA-LSCVHKIXSA-N olopatadine Chemical compound C1OC2=CC=C(CC(O)=O)C=C2C(=C/CCN(C)C)\C2=CC=CC=C21 JBIMVDZLSHOPLA-LSCVHKIXSA-N 0.000 claims 8
- 229960004114 olopatadine Drugs 0.000 claims 8
- 229920000172 poly(styrenesulfonic acid) Polymers 0.000 claims 6
- 229940005642 polystyrene sulfonic acid Drugs 0.000 claims 6
- 238000000034 method Methods 0.000 claims 5
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims 3
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 3
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 3
- 239000007864 aqueous solution Substances 0.000 claims 3
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 3
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 3
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 3
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 3
- 229920000642 polymer Polymers 0.000 claims 3
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 3
- 229920002554 vinyl polymer Polymers 0.000 claims 3
- 239000000230 xanthan gum Substances 0.000 claims 3
- 229920001285 xanthan gum Polymers 0.000 claims 3
- 235000010493 xanthan gum Nutrition 0.000 claims 3
- 229940082509 xanthan gum Drugs 0.000 claims 3
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 2
- 230000000172 allergic effect Effects 0.000 claims 2
- 208000010668 atopic eczema Diseases 0.000 claims 2
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 2
- 229920001577 copolymer Polymers 0.000 claims 2
- 230000004968 inflammatory condition Effects 0.000 claims 2
- AGBXYHCHUYARJY-UHFFFAOYSA-N 2-phenylethenesulfonic acid Chemical compound OS(=O)(=O)C=CC1=CC=CC=C1 AGBXYHCHUYARJY-UHFFFAOYSA-N 0.000 claims 1
- 206010027654 Allergic conditions Diseases 0.000 claims 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 1
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 1
- 229920003123 carboxymethyl cellulose sodium Polymers 0.000 claims 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims 1
- 229940105329 carboxymethylcellulose Drugs 0.000 claims 1
- 229940063834 carboxymethylcellulose sodium Drugs 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 claims 1
- 150000002978 peroxides Chemical class 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30131501P | 2001-06-27 | 2001-06-27 | |
| US60/301,315 | 2001-06-27 | ||
| PCT/US2002/019417 WO2003002093A1 (en) | 2001-06-27 | 2002-06-19 | Olopatadine formulations for topical administration |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009048628A Division JP2009114213A (ja) | 2001-06-27 | 2009-03-02 | 局所投与のためのオロパタジン処方物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004536096A JP2004536096A (ja) | 2004-12-02 |
| JP2004536096A5 true JP2004536096A5 (enExample) | 2005-12-22 |
| JP4827374B2 JP4827374B2 (ja) | 2011-11-30 |
Family
ID=23162841
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003508332A Expired - Lifetime JP4827374B2 (ja) | 2001-06-27 | 2002-06-19 | 局所投与のためのオロパタジン処方物 |
| JP2009048628A Withdrawn JP2009114213A (ja) | 2001-06-27 | 2009-03-02 | 局所投与のためのオロパタジン処方物 |
| JP2010069010A Withdrawn JP2010150292A (ja) | 2001-06-27 | 2010-03-24 | 局所投与のためのオロパタジン処方物 |
| JP2012035170A Expired - Lifetime JP5328947B2 (ja) | 2001-06-27 | 2012-02-21 | 局所投与のためのオロパタジン処方物 |
| JP2013061887A Withdrawn JP2013127005A (ja) | 2001-06-27 | 2013-03-25 | 局所投与のためのオロパタジン処方物 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009048628A Withdrawn JP2009114213A (ja) | 2001-06-27 | 2009-03-02 | 局所投与のためのオロパタジン処方物 |
| JP2010069010A Withdrawn JP2010150292A (ja) | 2001-06-27 | 2010-03-24 | 局所投与のためのオロパタジン処方物 |
| JP2012035170A Expired - Lifetime JP5328947B2 (ja) | 2001-06-27 | 2012-02-21 | 局所投与のためのオロパタジン処方物 |
| JP2013061887A Withdrawn JP2013127005A (ja) | 2001-06-27 | 2013-03-25 | 局所投与のためのオロパタジン処方物 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US6995186B2 (enExample) |
| EP (1) | EP1399127B1 (enExample) |
| JP (5) | JP4827374B2 (enExample) |
| KR (1) | KR100884711B1 (enExample) |
| CN (1) | CN1211125C (enExample) |
| AR (1) | AR034619A1 (enExample) |
| AT (1) | ATE295149T1 (enExample) |
| AU (1) | AU2002310461B2 (enExample) |
| BR (1) | BRPI0210707B8 (enExample) |
| CA (1) | CA2447924C (enExample) |
| DE (1) | DE60204142T2 (enExample) |
| DK (1) | DK1399127T3 (enExample) |
| ES (1) | ES2238574T3 (enExample) |
| GC (1) | GC0000397A (enExample) |
| MX (1) | MXPA03011947A (enExample) |
| PL (1) | PL205565B1 (enExample) |
| PT (1) | PT1399127E (enExample) |
| TW (1) | TWI231759B (enExample) |
| WO (1) | WO2003002093A1 (enExample) |
| ZA (1) | ZA200308771B (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100055152A1 (en) * | 2008-08-26 | 2010-03-04 | Trutek Corporation | Antihistamine and antihistamine-like nasal application, products, and method |
| TWI231759B (en) * | 2001-06-27 | 2005-05-01 | Alcon Inc | Olopatadine formulations for topical administration |
| US7977376B2 (en) | 2001-06-27 | 2011-07-12 | Novartis Ag | Olopatadine formulations for topical nasal administration |
| US20050209312A1 (en) * | 2004-03-19 | 2005-09-22 | Bausch & Lomb Incorporated | Carboxylic acid derivatives of doxepin formulations preserved with low-irritation preservative |
| CN1942173B (zh) * | 2004-04-08 | 2012-05-09 | 协和发酵麒麟株式会社 | 稳定性提高的固体制剂及其制造方法 |
| US20070225356A1 (en) * | 2004-04-21 | 2007-09-27 | Kyowa Hakko Kogo Co., Ltd | Preventive and/or Therapeutic Agent for Chronic Sinusitis |
| AU2005259911A1 (en) * | 2004-06-28 | 2006-01-12 | Alcon, Inc. | Topical formulations for treating allergic diseases |
| AU2005309951B2 (en) * | 2004-11-24 | 2011-07-07 | Alcon, Inc. | Method of delivering nasal spray |
| WO2006097458A1 (en) * | 2005-03-15 | 2006-09-21 | Nycomed Gmbh | Novel combination |
| EP1901708B1 (en) | 2005-07-08 | 2013-09-11 | Senju Pharmaceutical Co., Ltd. | Percutaneously absorptive ophthalmic preparation comprising olopatadine |
| US20070077302A1 (en) * | 2005-09-30 | 2007-04-05 | Azaam Alli | Methods for stabilizing ophthalmic compositions |
| US20080114076A1 (en) * | 2006-11-09 | 2008-05-15 | Alcon Manufacturing Ltd. | Punctal plug comprising a water-insoluble polymeric matrix |
| ZA200902587B (en) | 2006-11-09 | 2010-06-30 | Alcon Res Ltd | Water insoluble polymer matrix for drug delivery |
| JP5323720B2 (ja) * | 2006-12-18 | 2013-10-23 | アルコン リサーチ， リミテッド | 眼用薬物送達のためのデバイスおよび方法 |
| WO2008093358A2 (en) * | 2007-01-29 | 2008-08-07 | Sun Pharmaceutical Industries Limited | Aqueous topical solution containing olopatadine |
| HUE026162T2 (en) * | 2007-02-07 | 2016-05-30 | Novartis Ag | Olopatadine preparation for topical nasal administration |
| WO2008120249A1 (en) * | 2007-03-30 | 2008-10-09 | Sifi S.P.A. | Pharmaceutical formulations based on apolar and polar lipids for ophthalmic use |
| US20080254029A1 (en) * | 2007-04-11 | 2008-10-16 | Alcon Research, Ltd. | Use of an Inhibitor of TNFa Plus an Antihistamine to Treat Allergic Rhinitis and Allergic Conjunctivitis |
| US20100227917A1 (en) * | 2007-09-06 | 2010-09-09 | Masashi Nakakura | EYE DROP CONTAINING DIBENZ[b,e]OXEPIN DERIVATIVE |
| WO2009142950A1 (en) * | 2008-05-19 | 2009-11-26 | Alcon Research, Ltd. | Pharmaceutical compositions having carboxyvinyl polymer and povidone polymer |
| CN102089039B (zh) * | 2008-08-26 | 2013-10-23 | 博磊科技股份有限公司 | 带静电荷口罩过滤产品和用于增加过滤效率的方法 |
| JP2012509250A (ja) * | 2008-08-28 | 2012-04-19 | トルテック コーポレーション | 抗ヒスタミン及び抗ヒスタミン様経鼻適用製品及び方法 |
| US9458198B1 (en) | 2009-06-26 | 2016-10-04 | Shire Orphan Therapies Gmbh | Cyclic peptide-based NPR-B agonists |
| PT2453872E (pt) * | 2009-07-17 | 2013-10-30 | Alcon Res Ltd | Regime de pulverização nasal de olopatadina para crianças |
| WO2011027322A1 (en) | 2009-09-03 | 2011-03-10 | Ranbaxy Laboratories Limited | Extended release dosage form containing olopatadine for oral administration |
| US8551938B2 (en) * | 2009-09-25 | 2013-10-08 | Alcon Research, Ltd. | NPR-B agonists |
| UY32902A (es) | 2009-09-25 | 2011-02-28 | Alcon Res Ltd | Nuevos agonistas de npr-b |
| CN102548536A (zh) * | 2009-10-01 | 2012-07-04 | 爱尔康研究有限公司 | 奥洛他定组合物及其用途 |
| AR078446A1 (es) | 2009-12-18 | 2011-11-09 | Alcon Res Ltd | Agonistas de npr-b. uso. |
| WO2011075471A2 (en) | 2009-12-18 | 2011-06-23 | Alcon Research, Ltd. | Novel npr-b agonists and methods of use for the treatment of c-type natriuretic peptide-mediated disorders |
| CN103140215A (zh) * | 2010-07-21 | 2013-06-05 | 爱尔康研究有限公司 | 具有提高的溶解度特征的药物组合物 |
| WO2012063237A2 (en) * | 2010-11-08 | 2012-05-18 | Healor Ltd. | Buffered ophthalmic compositions and methods of use thereof |
| TWI544922B (zh) | 2011-05-19 | 2016-08-11 | 愛爾康研究有限公司 | 高濃度歐羅派特錠（ｏｌｏｐａｔａｄｉｎｅ）眼用組成物 |
| CN102885767A (zh) * | 2012-11-02 | 2013-01-23 | 江苏吉贝尔药业有限公司 | 一种新的盐酸奥洛他定滴眼液及其制备方法 |
| WO2018144742A1 (en) | 2017-02-01 | 2018-08-09 | Shire Human Genetic Therapies, Inc. | Compounds and compositions for the treatment of ophthalmic disorders |
| WO2018235935A1 (ja) * | 2017-06-23 | 2018-12-27 | 参天製薬株式会社 | 水溶性粘稠化剤を含有する医薬組成物 |
| JP7037349B2 (ja) * | 2017-06-23 | 2022-03-16 | 参天製薬株式会社 | 水溶性粘稠化剤を含有する医薬組成物 |
| CN114980881A (zh) * | 2019-12-06 | 2022-08-30 | 东兴药品工业株式会社 | 包含奥洛他定的鼻用组合物 |
| KR102705675B1 (ko) * | 2020-03-31 | 2024-09-11 | 산텐 세이야꾸 가부시키가이샤 | 수지제 용기에 충전된 은염 함유 안과용 수성 조성물 |
| CN111700860A (zh) * | 2020-07-09 | 2020-09-25 | 浙江尖峰药业有限公司 | 盐酸奥洛他定滴眼液及其制备方法 |
| CN119318630B (zh) * | 2024-10-16 | 2025-08-22 | 苏州欧康维视生物科技有限公司 | 一种阿托品药物组合物 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4370324A (en) | 1980-09-17 | 1983-01-25 | Bernstein Joel E | Method and composition for treating and preventing irritation of the eyes |
| US4407791A (en) | 1981-09-28 | 1983-10-04 | Alcon Laboratories, Inc. | Ophthalmic solutions |
| US4749700A (en) | 1984-10-23 | 1988-06-07 | Nastech Pharmaceutical Co, Inc. | Novel methods of administering antihistamines, antinausea and antiemetic pharmaceutical agents and novel dosage forms containing same |
| GB8520662D0 (en) | 1985-08-17 | 1985-09-25 | Wellcome Found | Tricyclic aromatic compounds |
| US4923892A (en) | 1985-08-17 | 1990-05-08 | Burroughs Wellcome Co. | Tricyclic aromatic compounds |
| JPS6310784A (ja) | 1986-03-03 | 1988-01-18 | Kyowa Hakko Kogyo Co Ltd | 抗アレルギー剤 |
| DE3877904D1 (de) | 1987-11-13 | 1993-03-11 | Asta Pharma Ag | Azelastin enthaltende arzneimittel zur anwendung in der nase und/oder am auge. |
| IT1250691B (it) | 1991-07-22 | 1995-04-21 | Giancarlo Santus | Composizioni terapeutiche per somministrazione intranasale comprendenti ketorolac. |
| JP3662944B2 (ja) | 1993-08-24 | 2005-06-22 | 協和醗酵工業株式会社 | 点鼻剤 |
| US5897858A (en) | 1994-02-03 | 1999-04-27 | Schering-Plough Healthcare Products, Inc. | Nasal spray compositions exhibiting increased retention in the nasal cavity |
| US5641805A (en) | 1995-06-06 | 1997-06-24 | Alcon Laboratories, Inc. | Topical ophthalmic formulations for treating allergic eye diseases |
| US6207684B1 (en) | 1997-06-09 | 2001-03-27 | Bridge Pharma, Inc. | Compounds with combined antihistaminic and mast cell stabilizing activities, intended for ophthalmic use |
| CN1114401C (zh) | 1998-07-14 | 2003-07-16 | 阿尔康实验室公司 | 11－(3－二甲氨基亚丙基)－6,11－二氢二苯并[b,e]噁庚英－2－乙酸用于制药的新用途 |
| CA2340225A1 (en) * | 1998-10-27 | 2000-05-04 | Wesley Wehsin Han | Preservative system for topically administrable pharmaceutical compositions containing a fatty acid/amino acid soap |
| US6146622A (en) * | 1998-10-27 | 2000-11-14 | Alcon Laboratories, Inc. | Use of certain anionic amino acid based surfactants to enhance antimicrobial effectiveness of topically administrable pharmaceutical compositions |
| US6274626B1 (en) * | 1998-12-22 | 2001-08-14 | Bausch & Lomb Incorporated | Pheniramine-containing compositions and method for treating allergic responses |
| US6174914B1 (en) | 1999-06-15 | 2001-01-16 | Alcon Laboratories, Inc. | Method of inhibiting cytokine release from human ocular cells |
| BR0014117A (pt) | 1999-09-21 | 2002-05-14 | Alcon Lab Inc | Uso de sabÈes de acido graxo/aminoácido para aumentar a eficácia antimicrobiana de composições farmacêutica tópicas |
| CN1376066A (zh) | 1999-11-18 | 2002-10-23 | 爱尔康公司 | H1拮抗剂和安全类固醇的治疗眼病的用途 |
| PT1250133E (pt) * | 2000-01-25 | 2005-05-31 | Alcon Inc | Composicoes antialergicas oftalmicas adequadas a utilizacao com lentes de contacto |
| AR031135A1 (es) | 2000-10-10 | 2003-09-10 | Upjohn Co | Composiciones de antibiotico topico para el tratamiento de infecciones oculares |
| TWI231759B (en) * | 2001-06-27 | 2005-05-01 | Alcon Inc | Olopatadine formulations for topical administration |
| CN1297275C (zh) | 2002-11-12 | 2007-01-31 | 爱尔康公司 | 抗过敏剂和类固醇用于治疗过敏性鼻炎的用途 |
-
2002
- 2002-06-18 TW TW091113234A patent/TWI231759B/zh not_active IP Right Cessation
- 2002-06-19 ES ES02737539T patent/ES2238574T3/es not_active Expired - Lifetime
- 2002-06-19 AT AT02737539T patent/ATE295149T1/de active
- 2002-06-19 WO PCT/US2002/019417 patent/WO2003002093A1/en not_active Ceased
- 2002-06-19 MX MXPA03011947A patent/MXPA03011947A/es active IP Right Grant
- 2002-06-19 EP EP02737539A patent/EP1399127B1/en not_active Expired - Lifetime
- 2002-06-19 CN CNB028120434A patent/CN1211125C/zh not_active Expired - Lifetime
- 2002-06-19 DE DE60204142T patent/DE60204142T2/de not_active Expired - Lifetime
- 2002-06-19 KR KR1020037014821A patent/KR100884711B1/ko not_active Expired - Lifetime
- 2002-06-19 CA CA002447924A patent/CA2447924C/en not_active Expired - Lifetime
- 2002-06-19 BR BRPI0210707A patent/BRPI0210707B8/pt not_active IP Right Cessation
- 2002-06-19 AU AU2002310461A patent/AU2002310461B2/en not_active Expired
- 2002-06-19 JP JP2003508332A patent/JP4827374B2/ja not_active Expired - Lifetime
- 2002-06-19 US US10/175,106 patent/US6995186B2/en not_active Expired - Lifetime
- 2002-06-19 PT PT02737539T patent/PT1399127E/pt unknown
- 2002-06-19 DK DK02737539T patent/DK1399127T3/da active
- 2002-06-19 PL PL367780A patent/PL205565B1/pl unknown
- 2002-06-22 GC GCP20022092 patent/GC0000397A/en active
- 2002-06-24 AR ARP020102365A patent/AR034619A1/es not_active Application Discontinuation
-
2003
- 2003-11-11 ZA ZA2003/08771A patent/ZA200308771B/en unknown
-
2005
- 2005-03-15 US US11/079,996 patent/US7402609B2/en not_active Expired - Lifetime
-
2009
- 2009-03-02 JP JP2009048628A patent/JP2009114213A/ja not_active Withdrawn
-
2010
- 2010-03-24 JP JP2010069010A patent/JP2010150292A/ja not_active Withdrawn
-
2012
- 2012-02-21 JP JP2012035170A patent/JP5328947B2/ja not_active Expired - Lifetime
-
2013
- 2013-03-25 JP JP2013061887A patent/JP2013127005A/ja not_active Withdrawn
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