JP2004534769A - 抗ウイルスヌクレオシド誘導体 - Google Patents
抗ウイルスヌクレオシド誘導体 Download PDFInfo
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- JP2004534769A JP2004534769A JP2002591006A JP2002591006A JP2004534769A JP 2004534769 A JP2004534769 A JP 2004534769A JP 2002591006 A JP2002591006 A JP 2002591006A JP 2002591006 A JP2002591006 A JP 2002591006A JP 2004534769 A JP2004534769 A JP 2004534769A
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- 239000011654 magnesium acetate Substances 0.000 description 1
- 229940069446 magnesium acetate Drugs 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
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- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
- A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Molecular Biology (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0112617.6A GB0112617D0 (en) | 2001-05-23 | 2001-05-23 | Antiviral nucleoside derivatives |
| PCT/EP2002/005340 WO2002094289A1 (en) | 2001-05-23 | 2002-05-15 | Antiviral nucleoside derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004534769A true JP2004534769A (ja) | 2004-11-18 |
| JP2004534769A5 JP2004534769A5 (enExample) | 2005-08-18 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002591006A Pending JP2004534769A (ja) | 2001-05-23 | 2002-05-15 | 抗ウイルスヌクレオシド誘導体 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6660721B2 (enExample) |
| EP (1) | EP1395266B1 (enExample) |
| JP (1) | JP2004534769A (enExample) |
| CA (1) | CA2445744C (enExample) |
| DE (1) | DE60215157T2 (enExample) |
| ES (1) | ES2272732T3 (enExample) |
| GB (1) | GB0112617D0 (enExample) |
| WO (1) | WO2002094289A1 (enExample) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010515680A (ja) * | 2007-01-05 | 2010-05-13 | メルク・シャープ・エンド・ドーム・コーポレイション | Ｒｎａ依存性ｒｎａウイルス感染症の治療用としてのヌクレオシドアリールホスホロアミデート |
| JP2015509983A (ja) * | 2012-03-13 | 2015-04-02 | ギリアード サイエンシーズ， インコーポレイテッド | 抗ウイルス処置のための２’−置換カルバヌクレオシド類似体 |
| WO2017155082A1 (ja) * | 2016-03-11 | 2017-09-14 | 国立大学法人鹿児島大学 | 抗肝腫瘍ウイルス剤 |
| WO2020158951A1 (ja) * | 2019-02-01 | 2020-08-06 | ダイキン工業株式会社 | 抗ｃ型肝炎ウイルス剤 |
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| BR0110023A (pt) * | 2000-04-13 | 2003-12-30 | Pharmasset Ltd | Derivados de nucleosìdeo 3'-ou-2' substituìdos para tratamento de infecções por vìrus da hepatite |
| MY164523A (en) * | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
| IL153020A0 (en) | 2000-05-26 | 2003-06-24 | Idenix Cayman Ltd | Methods and compositions for treating flaviviruses and pestiviruses |
| US7105499B2 (en) | 2001-01-22 | 2006-09-12 | Merck & Co., Inc. | Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase |
| US8481712B2 (en) | 2001-01-22 | 2013-07-09 | Merck Sharp & Dohme Corp. | Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase |
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| EP1435974A4 (en) * | 2001-09-28 | 2006-09-06 | Idenix Cayman Ltd | METHODS AND COMPOSITIONS FOR THE TREATMENT OF HEPATITIS C VIRUS USING 4 'MODIFIED NUCLEOSIDES |
| CN101172993A (zh) | 2002-06-28 | 2008-05-07 | 埃迪尼克斯(开曼)有限公司 | 用于治疗黄病毒感染的2′－c－甲基－3′－o－l－缬氨酸酯核糖呋喃基胞苷 |
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| KR20050035194A (ko) | 2002-06-28 | 2005-04-15 | 이데닉스 (케이만) 리미티드 | 플라비비리다에 감염 치료용 2'-ｃ-메틸-3'-ｏ-ｌ-발린에스테르 리보푸라노실 사이티딘 |
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| US20040067877A1 (en) * | 2002-08-01 | 2004-04-08 | Schinazi Raymond F. | 2', 3'-Dideoxynucleoside analogues for the treatment or prevention of Flaviviridae infections |
| KR20050059199A (ko) * | 2002-09-30 | 2005-06-17 | 제네랩스 테크놀로지스, 인코포레이티드 | Ｃ형 간염 바이러스 감염 치료용의 뉴클레오시드 유도체 |
| US7094768B2 (en) * | 2002-09-30 | 2006-08-22 | Genelabs Technologies, Inc. | Nucleoside derivatives for treating hepatitis C virus infection |
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| US5587362A (en) | 1994-01-28 | 1996-12-24 | Univ. Of Ga Research Foundation | L-nucleosides |
| ATE344271T1 (de) * | 1998-02-25 | 2006-11-15 | Univ Emory | 2'-fluoronukleoside |
| US5968826A (en) | 1998-10-05 | 1999-10-19 | Isis Pharmaceuticals Inc. | Antisense inhibition of integrin α4 expression |
| BR0114837A (pt) | 2000-10-18 | 2006-05-09 | Pharmasset Ltd | nucleosìdeos modificados para tratamento de infecções viróticas e proliferação celular anormal |
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- 2001-05-23 GB GBGB0112617.6A patent/GB0112617D0/en not_active Ceased
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- 2002-05-15 DE DE60215157T patent/DE60215157T2/de not_active Expired - Lifetime
- 2002-05-15 EP EP02743012A patent/EP1395266B1/en not_active Expired - Lifetime
- 2002-05-15 WO PCT/EP2002/005340 patent/WO2002094289A1/en not_active Ceased
- 2002-05-15 CA CA002445744A patent/CA2445744C/en not_active Expired - Fee Related
- 2002-05-15 ES ES02743012T patent/ES2272732T3/es not_active Expired - Lifetime
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010515680A (ja) * | 2007-01-05 | 2010-05-13 | メルク・シャープ・エンド・ドーム・コーポレイション | Ｒｎａ依存性ｒｎａウイルス感染症の治療用としてのヌクレオシドアリールホスホロアミデート |
| JP2015509983A (ja) * | 2012-03-13 | 2015-04-02 | ギリアード サイエンシーズ， インコーポレイテッド | 抗ウイルス処置のための２’−置換カルバヌクレオシド類似体 |
| JP2017206528A (ja) * | 2012-03-13 | 2017-11-24 | ギリアード サイエンシーズ， インコーポレイテッド | 抗ウイルス処置のための２’−置換カルバヌクレオシド類似体 |
| WO2017155082A1 (ja) * | 2016-03-11 | 2017-09-14 | 国立大学法人鹿児島大学 | 抗肝腫瘍ウイルス剤 |
| JPWO2017155082A1 (ja) * | 2016-03-11 | 2019-01-31 | 国立大学法人 鹿児島大学 | 抗肝腫瘍ウイルス剤 |
| US10987372B2 (en) | 2016-03-11 | 2021-04-27 | Kagoshima University | Anti-hepatoma-virus agent |
| WO2020158951A1 (ja) * | 2019-02-01 | 2020-08-06 | ダイキン工業株式会社 | 抗ｃ型肝炎ウイルス剤 |
| JP2020125245A (ja) * | 2019-02-01 | 2020-08-20 | ダイキン工業株式会社 | 抗ｃ型肝炎ウイルス剤 |
Also Published As
| Publication number | Publication date |
|---|---|
| DE60215157D1 (de) | 2006-11-16 |
| US20030083307A1 (en) | 2003-05-01 |
| EP1395266B1 (en) | 2006-10-04 |
| US6660721B2 (en) | 2003-12-09 |
| CA2445744A1 (en) | 2002-11-28 |
| EP1395266A1 (en) | 2004-03-10 |
| WO2002094289A1 (en) | 2002-11-28 |
| CA2445744C (en) | 2007-12-04 |
| DE60215157T2 (de) | 2007-08-23 |
| GB0112617D0 (en) | 2001-07-18 |
| ES2272732T3 (es) | 2007-05-01 |
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