JP2004533479A5 - - Google Patents
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- Publication number
- JP2004533479A5 JP2004533479A5 JP2003510418A JP2003510418A JP2004533479A5 JP 2004533479 A5 JP2004533479 A5 JP 2004533479A5 JP 2003510418 A JP2003510418 A JP 2003510418A JP 2003510418 A JP2003510418 A JP 2003510418A JP 2004533479 A5 JP2004533479 A5 JP 2004533479A5
- Authority
- JP
- Japan
- Prior art keywords
- protecting group
- formula
- hydrogen
- compound
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CC=C[C@](C[C@](CC(*)=O)O)OCCNC Chemical compound CC=C[C@](C[C@](CC(*)=O)O)OCCNC 0.000 description 3
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01810670 | 2001-07-06 | ||
| PCT/EP2002/007307 WO2003004450A1 (en) | 2001-07-06 | 2002-07-02 | Process for the preparation of intermediates useful in the synthesis of statin derivatives especially 7-amino 3,5-dihydroxy heptanoic acid derivatives, and intermediates thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004533479A JP2004533479A (ja) | 2004-11-04 |
| JP2004533479A5 true JP2004533479A5 (enExample) | 2006-01-05 |
Family
ID=8184014
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003510418A Pending JP2004533479A (ja) | 2001-07-06 | 2002-07-02 | スタチン誘導体、特に７−アミノ３，５−ジヒドロキシヘプタン酸誘導体及びその中間体の合成に有用な中間体の調製方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US7420078B2 (enExample) |
| EP (2) | EP2161250A1 (enExample) |
| JP (1) | JP2004533479A (enExample) |
| KR (2) | KR20040017278A (enExample) |
| CN (2) | CN101880227A (enExample) |
| AR (3) | AR034735A1 (enExample) |
| AU (1) | AU2002354701B2 (enExample) |
| BR (1) | BR0210842A (enExample) |
| CA (1) | CA2448917A1 (enExample) |
| CZ (1) | CZ2004150A3 (enExample) |
| ES (1) | ES2340260T3 (enExample) |
| HR (1) | HRPK20040119B3 (enExample) |
| HU (1) | HUP0401145A3 (enExample) |
| IL (3) | IL159050A0 (enExample) |
| PL (1) | PL366392A1 (enExample) |
| PT (1) | PT1404642E (enExample) |
| WO (1) | WO2003004450A1 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6101484A (en) | 1999-03-31 | 2000-08-08 | Mercata, Inc. | Dynamic market equilibrium management system, process and article of manufacture |
| WO2002057229A1 (en) | 2001-01-19 | 2002-07-25 | Biocon India Limited | FORM V CRYSTALLINE [R-(R*,R*)]-2-(4-FLUOROPHENYL)-ß,$G(D)-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1- HEPTANOIC ACID HEMI CALCIUM SALT. (ATORVASTATIN) |
| PL366392A1 (en) * | 2001-07-06 | 2005-01-24 | Ciba Specialty Chemicals Holding Inc. | Process for the preparation of intermediates useful in the synthesis of statin derivatives especially 7-amino 3,5-dihydroxy heptanoic acid derivatives, and intermediates thereof |
| EP1417180B1 (en) | 2001-07-13 | 2006-12-27 | AstraZeneca UK Limited | Preparation of aminopyrimidine compounds |
| US7361772B2 (en) | 2001-08-16 | 2008-04-22 | Biocon Limited | Process for the production of atorvastatin calcium |
| IL164020A0 (en) | 2002-03-18 | 2005-12-18 | Biocon Ltd | A process for the preparation of amorphous hmg-coareductase inhibitors |
| US7179942B2 (en) | 2002-07-05 | 2007-02-20 | Bicon Limited | Halo-substituted active methylene compounds |
| AU2003295684A1 (en) * | 2002-11-15 | 2004-06-15 | Teva Pharmaceutical Industries Ltd. | Synthesis of 3,5-dihydroxy-7-pyrrol-1-yl heptanoic acids |
| ATE425132T1 (de) | 2003-04-22 | 2009-03-15 | Biocon Ltd | Neues verfahren zur stereoselektiven reduktion von beta-ketoestern |
| WO2005026107A1 (en) | 2003-09-18 | 2005-03-24 | Biocon Limited | Novel process for the preparation of tert-butyl 6-cyano-5-hydroxy-3-oxohexanoate |
| GB0428328D0 (en) | 2004-12-24 | 2005-02-02 | Astrazeneca Uk Ltd | Chemical process |
| WO2007034909A1 (ja) * | 2005-09-22 | 2007-03-29 | Kaneka Corporation | （３ｒ，５ｒ）－７－アミノ－３，５－ジヒドロキシヘプタン酸誘導体の製造法 |
| WO2010077062A2 (en) * | 2008-12-29 | 2010-07-08 | Hanmi Pharm. Co., Ltd. | Preparation method of statin compound and benzothiazolyl sulfone compound used therein |
| CN103108870A (zh) * | 2010-09-16 | 2013-05-15 | 中化帝斯曼制药有限公司荷兰公司 | 作为制备阿托伐他汀的中间体的己酸的酯 |
| US8420773B2 (en) | 2011-05-06 | 2013-04-16 | Basf Se | Process for producing water-absorbing polymer particles |
| CN103502324B (zh) | 2011-05-06 | 2015-12-23 | 巴斯夫欧洲公司 | 制备吸水聚合物颗粒的方法 |
| EP2785851A2 (en) * | 2011-11-28 | 2014-10-08 | Mylan Laboratories, Limited | Process for producing chiral statin side chain intermediates employing candida antarctica lipase b |
| US10149720B2 (en) | 2013-03-08 | 2018-12-11 | Auris Health, Inc. | Method, apparatus, and a system for facilitating bending of an instrument in a surgical or medical robotic environment |
| EP2778229A1 (de) * | 2013-03-11 | 2014-09-17 | Sandoz Ag | Verfahren zur enantioselektiven Herstellung von 3-Hydroxyglutarsäuremonoestern und deren Verwendung |
| US10376672B2 (en) | 2013-03-15 | 2019-08-13 | Auris Health, Inc. | Catheter insertion system and method of fabrication |
| CA2944989A1 (en) | 2013-04-08 | 2014-10-16 | Cytodyn Inc. | Felinized antibodies and methods of treating retroviral infections in felines |
| CN104230879B (zh) * | 2014-08-15 | 2016-08-24 | 新发药业有限公司 | 一种2-((4r, 6s)-6-甲酰基-2,2-二取代基-1,3-二氧六环-4-基)乙酸酯制备方法 |
| CN108033899B (zh) * | 2017-12-06 | 2020-04-10 | 浙江科技学院 | 一种(r)-6-氰基-5-羟基-3-羰基己酸叔丁酯的制备方法 |
| CN108997324A (zh) * | 2018-08-21 | 2018-12-14 | 南京欧信医药技术有限公司 | 瑞舒伐他汀钙中间体的制备方法 |
| CN118772052A (zh) * | 2024-09-10 | 2024-10-15 | 湖南九维生物医药有限公司 | 一种医药中间体及其制备方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4677211A (en) * | 1984-06-29 | 1987-06-30 | Sandoz Pharmaceuticals Corp. | Preparation of lactones |
| US4950775A (en) * | 1985-10-11 | 1990-08-21 | University Of California | Antihypercholesterolemic compounds and synthesis thereof |
| US5003080A (en) | 1988-02-22 | 1991-03-26 | Warner-Lambert Company | Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pryan-2-one inhibitors of cholesterol synthesis |
| IT1226726B (it) * | 1988-07-29 | 1991-02-05 | Zambon Spa | Composti attivi come inibitori della biosintesi del colesterolo. |
| US5196440A (en) * | 1988-07-29 | 1993-03-23 | Zambon Group S.P.A. | Compounds active as inhibitors of the cholesterol biosynthesis |
| IT1224795B (it) * | 1988-12-01 | 1990-10-24 | Sigma Tau Ind Farmaceuti | Uso dell'acetil d-carnitina nel trattamento terapeutico del glaucoma e composizioni farmaceutiche utili in tale trattamento |
| IT1237792B (it) | 1989-12-21 | 1993-06-17 | Zambon Spa | Composti attivi come inibitori dell'enzima hmg-coa reduttasi |
| US5155251A (en) | 1991-10-11 | 1992-10-13 | Warner-Lambert Company | Process for the synthesis of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate |
| JP3652394B2 (ja) | 1995-01-27 | 2005-05-25 | 高砂香料工業株式会社 | Ｎ−置換−７−アミノ−５−ヒドロキシ−３−オキソヘプタン酸誘導体およびその製造法 |
| IL152580A0 (en) | 2000-05-26 | 2003-05-29 | Ciba Sc Holding Ag | Process for the preparation of indole derivatives and intermediates of the process |
| WO2003004456A1 (en) | 2001-07-06 | 2003-01-16 | Teva Pharmaceutical Industries Ltd. | Process for the preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives via 6-cyano syn 3,5-dihydroxy hexanoic acid derivatives |
| PL366392A1 (en) | 2001-07-06 | 2005-01-24 | Ciba Specialty Chemicals Holding Inc. | Process for the preparation of intermediates useful in the synthesis of statin derivatives especially 7-amino 3,5-dihydroxy heptanoic acid derivatives, and intermediates thereof |
| SK792004A3 (sk) | 2001-07-06 | 2005-03-04 | Teva Pharmaceutical Industries Ltd. | Syntéza a medziprodukty derivátov 3,5-dihydroxyheptánovej kyseliny |
-
2002
- 2002-07-02 PL PL02366392A patent/PL366392A1/xx not_active Application Discontinuation
- 2002-07-02 KR KR20047000163A patent/KR20040017278A/ko not_active Withdrawn
- 2002-07-02 WO PCT/EP2002/007307 patent/WO2003004450A1/en not_active Ceased
- 2002-07-02 EP EP09176993A patent/EP2161250A1/en not_active Withdrawn
- 2002-07-02 BR BR0210842-9A patent/BR0210842A/pt not_active IP Right Cessation
- 2002-07-02 KR KR20047000160A patent/KR20040017277A/ko not_active Withdrawn
- 2002-07-02 CA CA002448917A patent/CA2448917A1/en not_active Abandoned
- 2002-07-02 AU AU2002354701A patent/AU2002354701B2/en not_active Ceased
- 2002-07-02 IL IL15905002A patent/IL159050A0/xx not_active IP Right Cessation
- 2002-07-02 HU HU0401145A patent/HUP0401145A3/hu unknown
- 2002-07-02 CN CN201010004468XA patent/CN101880227A/zh active Pending
- 2002-07-02 CZ CZ2004150A patent/CZ2004150A3/cs unknown
- 2002-07-02 HR HR20040119A patent/HRPK20040119B3/xx not_active IP Right Cessation
- 2002-07-02 JP JP2003510418A patent/JP2004533479A/ja active Pending
- 2002-07-02 PT PT02764615T patent/PT1404642E/pt unknown
- 2002-07-02 EP EP02782448A patent/EP1404639A1/en not_active Withdrawn
- 2002-07-02 US US10/482,463 patent/US7420078B2/en not_active Expired - Fee Related
- 2002-07-02 ES ES02764615T patent/ES2340260T3/es not_active Expired - Lifetime
- 2002-07-02 CN CNA028135342A patent/CN1610657A/zh active Pending
- 2002-07-05 AR ARP020102537A patent/AR034735A1/es not_active Application Discontinuation
- 2002-07-05 AR ARP020102536A patent/AR034734A1/es not_active Application Discontinuation
- 2002-07-05 AR ARP020102535A patent/AR034733A1/es unknown
-
2008
- 2008-07-24 US US12/220,390 patent/US7855302B2/en not_active Expired - Fee Related
-
2010
- 2010-11-04 US US12/939,401 patent/US8026383B2/en not_active Expired - Fee Related
-
2011
- 2011-07-19 IL IL214165A patent/IL214165A0/en unknown
- 2011-07-19 IL IL214164A patent/IL214164A0/en unknown
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