HUP0401145A3 - Process for the preparation of intermediates useful in the synthesis of statin derivatives especially 7-amino 3,5-dihydroxy heptanoic acid derivatives, and intermediates thereof - Google Patents
Process for the preparation of intermediates useful in the synthesis of statin derivatives especially 7-amino 3,5-dihydroxy heptanoic acid derivatives, and intermediates thereofInfo
- Publication number
- HUP0401145A3 HUP0401145A3 HU0401145A HUP0401145A HUP0401145A3 HU P0401145 A3 HUP0401145 A3 HU P0401145A3 HU 0401145 A HU0401145 A HU 0401145A HU P0401145 A HUP0401145 A HU P0401145A HU P0401145 A3 HUP0401145 A3 HU P0401145A3
- Authority
- HU
- Hungary
- Prior art keywords
- intermediates
- synthesis
- amino
- preparation
- derivatives
- Prior art date
Links
- 239000000543 intermediate Substances 0.000 title 2
- XAPGSJPBBUEOEQ-UHFFFAOYSA-N 7-amino-3,5-dihydroxyheptanoic acid Chemical class NCCC(O)CC(O)CC(O)=O XAPGSJPBBUEOEQ-UHFFFAOYSA-N 0.000 title 1
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/30—Preparation of optical isomers
- C07C227/32—Preparation of optical isomers by stereospecific synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
- C07C235/74—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of a saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/716—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01810670 | 2001-07-06 | ||
PCT/EP2002/007307 WO2003004450A1 (en) | 2001-07-06 | 2002-07-02 | Process for the preparation of intermediates useful in the synthesis of statin derivatives especially 7-amino 3,5-dihydroxy heptanoic acid derivatives, and intermediates thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0401145A2 HUP0401145A2 (hu) | 2004-09-28 |
HUP0401145A3 true HUP0401145A3 (en) | 2008-08-28 |
Family
ID=8184014
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0401145A HUP0401145A3 (en) | 2001-07-06 | 2002-07-02 | Process for the preparation of intermediates useful in the synthesis of statin derivatives especially 7-amino 3,5-dihydroxy heptanoic acid derivatives, and intermediates thereof |
Country Status (17)
Country | Link |
---|---|
US (3) | US7420078B2 (hu) |
EP (2) | EP2161250A1 (hu) |
JP (1) | JP2004533479A (hu) |
KR (2) | KR20040017277A (hu) |
CN (2) | CN101880227A (hu) |
AR (3) | AR034735A1 (hu) |
AU (1) | AU2002354701B2 (hu) |
BR (1) | BR0210842A (hu) |
CA (1) | CA2448917A1 (hu) |
CZ (1) | CZ2004150A3 (hu) |
ES (1) | ES2340260T3 (hu) |
HR (1) | HRPK20040119B3 (hu) |
HU (1) | HUP0401145A3 (hu) |
IL (3) | IL159050A0 (hu) |
PL (1) | PL366392A1 (hu) |
PT (1) | PT1404642E (hu) |
WO (1) | WO2003004450A1 (hu) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6101484A (en) | 1999-03-31 | 2000-08-08 | Mercata, Inc. | Dynamic market equilibrium management system, process and article of manufacture |
WO2002057229A1 (en) | 2001-01-19 | 2002-07-25 | Biocon India Limited | FORM V CRYSTALLINE [R-(R*,R*)]-2-(4-FLUOROPHENYL)-ß,$G(D)-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1- HEPTANOIC ACID HEMI CALCIUM SALT. (ATORVASTATIN) |
KR20040017277A (ko) * | 2001-07-06 | 2004-02-26 | 테바 파마슈티컬 인더스트리즈 리미티드 | 6-시아노 신 3,5-디히드록시 헥산산 유도체를 매개로 한7-아미노 신 3,5-디히드록시 헵탄산 유도체의 제조 방법 |
JP4359141B2 (ja) | 2001-07-13 | 2009-11-04 | アストラゼネカ・ユーケイ・リミテッド | アミノピリミジン化合物の製造 |
US7361772B2 (en) | 2001-08-16 | 2008-04-22 | Biocon Limited | Process for the production of atorvastatin calcium |
ATE452871T1 (de) | 2002-03-18 | 2010-01-15 | Biocon Ltd | Amorphe hmg-coa-reduktase-inhibitoren mit gewünschter teilchengrösse |
US7179942B2 (en) | 2002-07-05 | 2007-02-20 | Bicon Limited | Halo-substituted active methylene compounds |
AU2003295684A1 (en) * | 2002-11-15 | 2004-06-15 | Teva Pharmaceutical Industries Ltd. | Synthesis of 3,5-dihydroxy-7-pyrrol-1-yl heptanoic acids |
DK1631533T3 (da) | 2003-04-22 | 2009-06-02 | Biocon Ltd | Hidtil ukendt fremgangsmåde til stereoselektiv reduktion af beta-ketoestre |
AU2003272080A1 (en) | 2003-09-18 | 2005-04-06 | Biocon Limited | Novel process for the preparation of tert-butyl 6-cyano-5-hydroxy-3-oxohexanoate |
GB0428328D0 (en) | 2004-12-24 | 2005-02-02 | Astrazeneca Uk Ltd | Chemical process |
WO2007034909A1 (ja) * | 2005-09-22 | 2007-03-29 | Kaneka Corporation | (3r,5r)-7-アミノ-3,5-ジヒドロキシヘプタン酸誘導体の製造法 |
KR20100080432A (ko) * | 2008-12-29 | 2010-07-08 | 한미약품 주식회사 | 스타틴 화합물의 신규 제조방법 및 이에 사용되는 벤조티아졸릴 술폰 화합물 |
US20130178636A1 (en) * | 2010-09-16 | 2013-07-11 | Dsm Sinochem Pharmaceuticals Netherlands B.V. | Esters of hexanoic acids as intermediates for the preparation of atorvastatin |
JP6073292B2 (ja) | 2011-05-06 | 2017-02-01 | ビーエーエスエフ ソシエタス・ヨーロピアBasf Se | 吸水性ポリマー粒子の製造法 |
US8420773B2 (en) | 2011-05-06 | 2013-04-16 | Basf Se | Process for producing water-absorbing polymer particles |
WO2013080219A2 (en) * | 2011-11-28 | 2013-06-06 | Mylan Laboratories Ltd | NOVEL PROCESS FOR THE PREPARATION OF INTERMEDIATES OF HMG-CoA REDUCTASE INHIBITORS |
US10149720B2 (en) | 2013-03-08 | 2018-12-11 | Auris Health, Inc. | Method, apparatus, and a system for facilitating bending of an instrument in a surgical or medical robotic environment |
EP2778229A1 (de) * | 2013-03-11 | 2014-09-17 | Sandoz Ag | Verfahren zur enantioselektiven Herstellung von 3-Hydroxyglutarsäuremonoestern und deren Verwendung |
US10376672B2 (en) | 2013-03-15 | 2019-08-13 | Auris Health, Inc. | Catheter insertion system and method of fabrication |
WO2014168933A1 (en) | 2013-04-08 | 2014-10-16 | Cytodyn Inc. | Felinized antibodies and methods of treating retroviral infections in felines |
CN104230879B (zh) * | 2014-08-15 | 2016-08-24 | 新发药业有限公司 | 一种2-((4r, 6s)-6-甲酰基-2,2-二取代基-1,3-二氧六环-4-基)乙酸酯制备方法 |
CN108033899B (zh) * | 2017-12-06 | 2020-04-10 | 浙江科技学院 | 一种(r)-6-氰基-5-羟基-3-羰基己酸叔丁酯的制备方法 |
CN108997324A (zh) * | 2018-08-21 | 2018-12-14 | 南京欧信医药技术有限公司 | 瑞舒伐他汀钙中间体的制备方法 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4677211A (en) * | 1984-06-29 | 1987-06-30 | Sandoz Pharmaceuticals Corp. | Preparation of lactones |
US4950775A (en) * | 1985-10-11 | 1990-08-21 | University Of California | Antihypercholesterolemic compounds and synthesis thereof |
US5003080A (en) | 1988-02-22 | 1991-03-26 | Warner-Lambert Company | Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pryan-2-one inhibitors of cholesterol synthesis |
IT1226726B (it) * | 1988-07-29 | 1991-02-05 | Zambon Spa | Composti attivi come inibitori della biosintesi del colesterolo. |
US5196440A (en) * | 1988-07-29 | 1993-03-23 | Zambon Group S.P.A. | Compounds active as inhibitors of the cholesterol biosynthesis |
IT1224795B (it) * | 1988-12-01 | 1990-10-24 | Sigma Tau Ind Farmaceuti | Uso dell'acetil d-carnitina nel trattamento terapeutico del glaucoma e composizioni farmaceutiche utili in tale trattamento |
IT1237792B (it) * | 1989-12-21 | 1993-06-17 | Zambon Spa | Composti attivi come inibitori dell'enzima hmg-coa reduttasi |
US5155251A (en) | 1991-10-11 | 1992-10-13 | Warner-Lambert Company | Process for the synthesis of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate |
JP3652394B2 (ja) | 1995-01-27 | 2005-05-25 | 高砂香料工業株式会社 | N−置換−7−アミノ−5−ヒドロキシ−3−オキソヘプタン酸誘導体およびその製造法 |
EP1284964A1 (en) | 2000-05-26 | 2003-02-26 | Ciba SC Holding AG | Process for the preparation of indole derivatives and intermediates of the process |
KR20040017277A (ko) | 2001-07-06 | 2004-02-26 | 테바 파마슈티컬 인더스트리즈 리미티드 | 6-시아노 신 3,5-디히드록시 헥산산 유도체를 매개로 한7-아미노 신 3,5-디히드록시 헵탄산 유도체의 제조 방법 |
IL159719A0 (en) | 2001-07-06 | 2004-06-20 | Teva Pharma | Process for the preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives via 6-cyano syn 3,5-dihydroxy hexanoic acid derivatives |
WO2003004455A2 (en) | 2001-07-06 | 2003-01-16 | Teva Pharmaceutical Industries Ltd. | Process for the preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives, intermediates thereof and methods for their preparation |
-
2002
- 2002-07-02 KR KR20047000160A patent/KR20040017277A/ko not_active Application Discontinuation
- 2002-07-02 EP EP09176993A patent/EP2161250A1/en not_active Withdrawn
- 2002-07-02 CA CA002448917A patent/CA2448917A1/en not_active Abandoned
- 2002-07-02 AU AU2002354701A patent/AU2002354701B2/en not_active Ceased
- 2002-07-02 CN CN201010004468XA patent/CN101880227A/zh active Pending
- 2002-07-02 BR BR0210842-9A patent/BR0210842A/pt not_active IP Right Cessation
- 2002-07-02 HU HU0401145A patent/HUP0401145A3/hu unknown
- 2002-07-02 US US10/482,463 patent/US7420078B2/en not_active Expired - Fee Related
- 2002-07-02 JP JP2003510418A patent/JP2004533479A/ja active Pending
- 2002-07-02 EP EP02782448A patent/EP1404639A1/en not_active Withdrawn
- 2002-07-02 PT PT02764615T patent/PT1404642E/pt unknown
- 2002-07-02 CN CNA028135342A patent/CN1610657A/zh active Pending
- 2002-07-02 CZ CZ2004150A patent/CZ2004150A3/cs unknown
- 2002-07-02 IL IL15905002A patent/IL159050A0/xx not_active IP Right Cessation
- 2002-07-02 ES ES02764615T patent/ES2340260T3/es not_active Expired - Lifetime
- 2002-07-02 KR KR20047000163A patent/KR20040017278A/ko not_active Application Discontinuation
- 2002-07-02 PL PL02366392A patent/PL366392A1/xx not_active Application Discontinuation
- 2002-07-02 WO PCT/EP2002/007307 patent/WO2003004450A1/en active Application Filing
- 2002-07-05 AR ARP020102537A patent/AR034735A1/es not_active Application Discontinuation
- 2002-07-05 AR ARP020102535A patent/AR034733A1/es unknown
- 2002-07-05 AR ARP020102536A patent/AR034734A1/es not_active Application Discontinuation
-
2004
- 2004-02-05 HR HR20040119A patent/HRPK20040119B3/xx not_active IP Right Cessation
-
2008
- 2008-07-24 US US12/220,390 patent/US7855302B2/en not_active Expired - Fee Related
-
2010
- 2010-11-04 US US12/939,401 patent/US8026383B2/en not_active Expired - Fee Related
-
2011
- 2011-07-19 IL IL214165A patent/IL214165A0/en unknown
- 2011-07-19 IL IL214164A patent/IL214164A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
AR034733A1 (es) | 2004-03-17 |
CN101880227A (zh) | 2010-11-10 |
AR034734A1 (es) | 2004-03-17 |
EP1404639A1 (en) | 2004-04-07 |
IL159050A0 (en) | 2004-05-12 |
US20110046411A1 (en) | 2011-02-24 |
KR20040017278A (ko) | 2004-02-26 |
ES2340260T3 (es) | 2010-06-01 |
US20080312466A1 (en) | 2008-12-18 |
JP2004533479A (ja) | 2004-11-04 |
PL366392A1 (en) | 2005-01-24 |
PT1404642E (pt) | 2010-03-29 |
CN1610657A (zh) | 2005-04-27 |
AR034735A1 (es) | 2004-03-17 |
IL214164A0 (en) | 2011-08-31 |
WO2003004450A1 (en) | 2003-01-16 |
US7855302B2 (en) | 2010-12-21 |
BR0210842A (pt) | 2004-07-13 |
US7420078B2 (en) | 2008-09-02 |
HRPK20040119B3 (en) | 2006-07-31 |
HRP20040119A2 (en) | 2005-04-30 |
KR20040017277A (ko) | 2004-02-26 |
CA2448917A1 (en) | 2003-01-16 |
IL214165A0 (en) | 2011-08-31 |
CZ2004150A3 (cs) | 2004-09-15 |
EP2161250A1 (en) | 2010-03-10 |
HUP0401145A2 (hu) | 2004-09-28 |
AU2002354701B2 (en) | 2007-11-22 |
US20040186313A1 (en) | 2004-09-23 |
US8026383B2 (en) | 2011-09-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD9A | Lapse of provisional protection due to non-payment of fees |