AU2002333336A1 - Protected 3.5-dihydroxy -2.2-dimethyl-valeronitriles for the synthesis of epothilones and derivatives and method for the production and use thereof - Google Patents
Protected 3.5-dihydroxy -2.2-dimethyl-valeronitriles for the synthesis of epothilones and derivatives and method for the production and use thereofInfo
- Publication number
- AU2002333336A1 AU2002333336A1 AU2002333336A AU2002333336A AU2002333336A1 AU 2002333336 A1 AU2002333336 A1 AU 2002333336A1 AU 2002333336 A AU2002333336 A AU 2002333336A AU 2002333336 A AU2002333336 A AU 2002333336A AU 2002333336 A1 AU2002333336 A1 AU 2002333336A1
- Authority
- AU
- Australia
- Prior art keywords
- valeronitriles
- epothilones
- dihydroxy
- dimethyl
- synthesis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- 229930013356 epothilones Natural products 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 230000002194 synthesizing Effects 0.000 title 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10138347.9 | 2001-08-03 | ||
| DE10138347A DE10138347A1 (en) | 2001-08-03 | 2001-08-03 | Protected 3,5-dihydroxy-2,2-dimethyl-valeronitriles for the synthesis of epothilones and derivatives and methods of preparation |
| PCT/EP2002/008730 WO2003014068A1 (en) | 2001-08-03 | 2002-08-05 | Protected 3.5-dihydroxy-2.2-dimethyl-valeronitriles for the synthesis of epothilones and derivatives and method for the production and use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2002333336A1 true AU2002333336A1 (en) | 2003-06-19 |
| AU2002333336B2 AU2002333336B2 (en) | 2008-05-29 |
Family
ID=7694414
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2002333336A Expired - Fee Related AU2002333336B2 (en) | 2001-08-03 | 2002-08-05 | Protected 3.5-dihydroxy -2.2-dimethyl-valeronitriles for the synthesis of epothilones and derivatives and method for the production and use thereof |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US7034165B2 (en) |
| EP (1) | EP1412323B1 (en) |
| JP (1) | JP4620346B2 (en) |
| KR (1) | KR100876036B1 (en) |
| CN (1) | CN100482641C (en) |
| AR (1) | AR036206A1 (en) |
| AT (1) | ATE444283T1 (en) |
| AU (1) | AU2002333336B2 (en) |
| BR (1) | BR0211651A (en) |
| CA (1) | CA2455797C (en) |
| DE (2) | DE10138347A1 (en) |
| ES (1) | ES2331468T3 (en) |
| HK (1) | HK1070350A1 (en) |
| IL (1) | IL159726A0 (en) |
| MX (1) | MXPA04001060A (en) |
| NO (1) | NO20040911L (en) |
| PE (1) | PE20030327A1 (en) |
| PL (1) | PL367429A1 (en) |
| RU (1) | RU2303590C2 (en) |
| WO (1) | WO2003014068A1 (en) |
| ZA (1) | ZA200401722B (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6867305B2 (en) | 1996-12-03 | 2005-03-15 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| US6204388B1 (en) * | 1996-12-03 | 2001-03-20 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| EP1386922B1 (en) | 1996-12-03 | 2012-04-11 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereof, analogues and uses thereof |
| US7368568B2 (en) * | 2001-08-03 | 2008-05-06 | Bayer Schering Pharma Ag | Protected 3,5-dihydroxy-2,2-dimethyl-valeroamides for the synthesis of epothilones and derivatives and process for production and the use |
| WO2003029195A1 (en) | 2001-09-28 | 2003-04-10 | Sumika Fine Chemicals Co., Ltd. | Intermediates for epothilone derivative and process for producing these |
| US7649006B2 (en) | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| WO2004018478A2 (en) | 2002-08-23 | 2004-03-04 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| JP2008536479A (en) | 2005-02-11 | 2008-09-11 | ユニバーシティ オブ サザン カリフォルニア | Expression method of protein having disulfide bridge |
| US8008256B2 (en) * | 2006-05-01 | 2011-08-30 | University Of Southern California | Combination therapy for treatment of cancer |
| WO2010056901A2 (en) | 2008-11-13 | 2010-05-20 | University Of Southern California | Method of expressing proteins with disulfide bridges with enhanced yields and activity |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19701758A1 (en) * | 1997-01-20 | 1998-07-23 | Wessjohann Ludgar A Dr | New beta-keto-alcohol derivatives |
| US6211412B1 (en) * | 1999-03-29 | 2001-04-03 | The University Of Kansas | Synthesis of epothilones |
| US6603015B2 (en) * | 1999-03-29 | 2003-08-05 | University Of Kansas | Synthesis of epothilones |
| WO2003029195A1 (en) * | 2001-09-28 | 2003-04-10 | Sumika Fine Chemicals Co., Ltd. | Intermediates for epothilone derivative and process for producing these |
-
2001
- 2001-08-03 DE DE10138347A patent/DE10138347A1/en not_active Withdrawn
-
2002
- 2002-08-02 AR ARP020102939A patent/AR036206A1/en unknown
- 2002-08-02 PE PE2002000703A patent/PE20030327A1/en not_active Application Discontinuation
- 2002-08-05 CA CA2455797A patent/CA2455797C/en not_active Expired - Fee Related
- 2002-08-05 WO PCT/EP2002/008730 patent/WO2003014068A1/en active Application Filing
- 2002-08-05 EP EP02794553A patent/EP1412323B1/en not_active Expired - Lifetime
- 2002-08-05 MX MXPA04001060A patent/MXPA04001060A/en active IP Right Grant
- 2002-08-05 AU AU2002333336A patent/AU2002333336B2/en not_active Expired - Fee Related
- 2002-08-05 ES ES02794553T patent/ES2331468T3/en not_active Expired - Lifetime
- 2002-08-05 DE DE50213889T patent/DE50213889D1/en not_active Expired - Lifetime
- 2002-08-05 BR BR0211651-0A patent/BR0211651A/en not_active IP Right Cessation
- 2002-08-05 KR KR1020047001709A patent/KR100876036B1/en not_active IP Right Cessation
- 2002-08-05 RU RU2004106532/04A patent/RU2303590C2/en not_active IP Right Cessation
- 2002-08-05 CN CNB028152395A patent/CN100482641C/en not_active Expired - Fee Related
- 2002-08-05 PL PL02367429A patent/PL367429A1/en unknown
- 2002-08-05 IL IL15972602A patent/IL159726A0/en unknown
- 2002-08-05 JP JP2003519018A patent/JP4620346B2/en not_active Expired - Fee Related
- 2002-08-05 US US10/211,236 patent/US7034165B2/en not_active Expired - Fee Related
- 2002-08-05 AT AT02794553T patent/ATE444283T1/en not_active IP Right Cessation
-
2004
- 2004-03-02 NO NO20040911A patent/NO20040911L/en not_active Application Discontinuation
- 2004-03-02 ZA ZA200401722A patent/ZA200401722B/en unknown
-
2005
- 2005-04-12 HK HK05103081.9A patent/HK1070350A1/en not_active IP Right Cessation
- 2005-07-26 US US11/188,991 patent/US7358382B2/en not_active Expired - Fee Related
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