AU2002333336A1 - Protected 3.5-dihydroxy -2.2-dimethyl-valeronitriles for the synthesis of epothilones and derivatives and method for the production and use thereof - Google Patents

Protected 3.5-dihydroxy -2.2-dimethyl-valeronitriles for the synthesis of epothilones and derivatives and method for the production and use thereof

Info

Publication number
AU2002333336A1
AU2002333336A1 AU2002333336A AU2002333336A AU2002333336A1 AU 2002333336 A1 AU2002333336 A1 AU 2002333336A1 AU 2002333336 A AU2002333336 A AU 2002333336A AU 2002333336 A AU2002333336 A AU 2002333336A AU 2002333336 A1 AU2002333336 A1 AU 2002333336A1
Authority
AU
Australia
Prior art keywords
valeronitriles
epothilones
dihydroxy
dimethyl
synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU2002333336A
Other versions
AU2002333336B2 (en
Inventor
Orlin Petrov
Johannes Platzek
Jurgen Westermann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Bayer Schering Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10138347A external-priority patent/DE10138347A1/en
Application filed by Bayer Schering Pharma AG filed Critical Bayer Schering Pharma AG
Publication of AU2002333336A1 publication Critical patent/AU2002333336A1/en
Application granted granted Critical
Publication of AU2002333336B2 publication Critical patent/AU2002333336B2/en
Assigned to BAYER SCHERING PHARMA ATIENGESELLSCHAFT reassignment BAYER SCHERING PHARMA ATIENGESELLSCHAFT Alteration of Name(s) of Applicant(s) under S113 Assignors: SCHERING ATIENGESELLSCHAFT
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

AU2002333336A 2001-08-03 2002-08-05 Protected 3.5-dihydroxy -2.2-dimethyl-valeronitriles for the synthesis of epothilones and derivatives and method for the production and use thereof Expired - Fee Related AU2002333336B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10138347A DE10138347A1 (en) 2001-08-03 2001-08-03 Protected 3,5-dihydroxy-2,2-dimethyl-valeronitriles for the synthesis of epothilones and derivatives and methods of preparation
DE10138347.9 2001-08-03
PCT/EP2002/008730 WO2003014068A1 (en) 2001-08-03 2002-08-05 Protected 3.5-dihydroxy-2.2-dimethyl-valeronitriles for the synthesis of epothilones and derivatives and method for the production and use thereof

Publications (2)

Publication Number Publication Date
AU2002333336A1 true AU2002333336A1 (en) 2003-06-19
AU2002333336B2 AU2002333336B2 (en) 2008-05-29

Family

ID=7694414

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002333336A Expired - Fee Related AU2002333336B2 (en) 2001-08-03 2002-08-05 Protected 3.5-dihydroxy -2.2-dimethyl-valeronitriles for the synthesis of epothilones and derivatives and method for the production and use thereof

Country Status (21)

Country Link
US (2) US7034165B2 (en)
EP (1) EP1412323B1 (en)
JP (1) JP4620346B2 (en)
KR (1) KR100876036B1 (en)
CN (1) CN100482641C (en)
AR (1) AR036206A1 (en)
AT (1) ATE444283T1 (en)
AU (1) AU2002333336B2 (en)
BR (1) BR0211651A (en)
CA (1) CA2455797C (en)
DE (2) DE10138347A1 (en)
ES (1) ES2331468T3 (en)
HK (1) HK1070350A1 (en)
IL (1) IL159726A0 (en)
MX (1) MXPA04001060A (en)
NO (1) NO20040911L (en)
PE (1) PE20030327A1 (en)
PL (1) PL367429A1 (en)
RU (1) RU2303590C2 (en)
WO (1) WO2003014068A1 (en)
ZA (1) ZA200401722B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6242469B1 (en) 1996-12-03 2001-06-05 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto, analogues and uses thereof
US6204388B1 (en) * 1996-12-03 2001-03-20 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
US6867305B2 (en) 1996-12-03 2005-03-15 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
US7368568B2 (en) * 2001-08-03 2008-05-06 Bayer Schering Pharma Ag Protected 3,5-dihydroxy-2,2-dimethyl-valeroamides for the synthesis of epothilones and derivatives and process for production and the use
WO2003029195A1 (en) 2001-09-28 2003-04-10 Sumika Fine Chemicals Co., Ltd. Intermediates for epothilone derivative and process for producing these
US7649006B2 (en) 2002-08-23 2010-01-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
NZ538522A (en) 2002-08-23 2008-03-28 Sloan Kettering Inst Cancer Synthesis of epothilones, intermediates thereto, analogues and uses thereof
WO2007086879A2 (en) 2005-02-11 2007-08-02 University Of Southern California Method of expressing proteins with disulfide bridges
WO2007130501A2 (en) * 2006-05-01 2007-11-15 University Of Southern California Combination therapy for treatment of cancer
US8802394B2 (en) 2008-11-13 2014-08-12 Radu O. Minea Method of expressing proteins with disulfide bridges with enhanced yields and activity

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19701758A1 (en) * 1997-01-20 1998-07-23 Wessjohann Ludgar A Dr New beta-keto-alcohol derivatives
US6211412B1 (en) 1999-03-29 2001-04-03 The University Of Kansas Synthesis of epothilones
US6603015B2 (en) * 1999-03-29 2003-08-05 University Of Kansas Synthesis of epothilones
WO2003029195A1 (en) * 2001-09-28 2003-04-10 Sumika Fine Chemicals Co., Ltd. Intermediates for epothilone derivative and process for producing these

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