JP2004533449A - Cd26を発現している細胞に関連する疾患の治療としての抗cd26モノクローナル抗体 - Google Patents

Cd26を発現している細胞に関連する疾患の治療としての抗cd26モノクローナル抗体 Download PDF

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JP2004533449A
JP2004533449A JP2002589043A JP2002589043A JP2004533449A JP 2004533449 A JP2004533449 A JP 2004533449A JP 2002589043 A JP2002589043 A JP 2002589043A JP 2002589043 A JP2002589043 A JP 2002589043A JP 2004533449 A JP2004533449 A JP 2004533449A
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ナム エイチ. ダン,
幾夫 森本
スチュアート シュロスマン,
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    • C07K16/40Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
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    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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JP2002589043A 2001-05-11 2002-05-08 Cd26を発現している細胞に関連する疾患の治療としての抗cd26モノクローナル抗体 Pending JP2004533449A (ja)

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US29053101P 2001-05-11 2001-05-11
PCT/US2002/014462 WO2002092127A1 (en) 2001-05-11 2002-05-08 Anti-cd26 monoclonal antibodies as therapy for diseases associated with cells expressing cd26

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JP2004533449A true JP2004533449A (ja) 2004-11-04
JP2004533449A5 JP2004533449A5 (enExample) 2005-12-22

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US (2) US7198788B2 (enExample)
EP (1) EP1392361A4 (enExample)
JP (1) JP2004533449A (enExample)
KR (1) KR100863624B1 (enExample)
CN (2) CN101172158A (enExample)
AU (1) AU2002308637B2 (enExample)
CA (1) CA2446806A1 (enExample)
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WO2008114876A1 (en) * 2007-03-14 2008-09-25 The University Of Tokyo A method of treating malignant mesothelioma
JP2009502139A (ja) * 2005-07-22 2009-01-29 ワイズセラピューティックス株式会社 抗cd26抗体およびその使用方法
WO2011118804A1 (ja) * 2010-03-26 2011-09-29 国立大学法人徳島大学 新規抗cd98抗体とその用途
JP2013521287A (ja) * 2010-03-01 2013-06-10 ティーエーユー・セラピューティクス・エルエルシー 癌診断および撮像
JP2018502577A (ja) * 2015-01-09 2018-02-01 メディミューン,エルエルシー ヒトdpp−4を検出するためのアッセイ
JP2021508834A (ja) * 2017-12-22 2021-03-11 アディエンネ エス.エー. 抗cd26リガンドの生物活性を決定するための細胞内定量法
WO2022220232A1 (ja) * 2021-04-12 2022-10-20 国立大学法人 東京大学 すい臓がん検出用蛍光プローブ

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2344653A1 (en) * 1998-09-29 2000-04-06 Gamida Cell Ltd. Methods of controlling proliferation and differentiation of stem and progenitor cells
IL152904A0 (en) * 2002-01-24 2003-06-24 Gamida Cell Ltd Utilization of retinoid and vitamin d receptor antagonists for expansion of renewable stem cell populations
EP1465982A4 (en) * 2002-01-25 2006-06-07 Gamida Cell Ltd PROCESS FOR EXPANSION OF STEM AND PRESERVATIVE CELLS AND EXPANDED CELL POPULATIONS THEREWITH OBTAINED
CA2479679A1 (en) * 2002-03-18 2003-09-25 Gamida-Cell Ltd. Methods of inducing differentiation in ex vivo expanded stem cells
JP4596916B2 (ja) * 2002-09-05 2010-12-15 メディミューン,エルエルシー Cd2拮抗薬を投与することによりt細胞悪性腫瘍を予防または治療する方法
US20050054097A1 (en) * 2002-11-17 2005-03-10 Tony Peled EX-VIVO expansion of hematopoietic system cell populations in mononuclear cell cultures
JP5717937B2 (ja) * 2002-12-06 2015-05-13 ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. プロテアソーム阻害療法を用いた患者の同定、判定および治療方法
US20040202666A1 (en) * 2003-01-24 2004-10-14 Immunomedics, Inc. Anti-cancer anthracycline drug-antibody conjugates
US7550590B2 (en) 2003-03-25 2009-06-23 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
JP2007511467A (ja) 2003-05-14 2007-05-10 タケダ サン ディエゴ インコーポレイテッド ジペプチジルペプチダーゼインヒビター
CN1816356A (zh) 2003-05-14 2006-08-09 免疫原公司 药物缀合物组合物
WO2005016911A1 (en) 2003-08-13 2005-02-24 Takeda Pharmaceutical Company Limited 4-pyrimidone derivatives and their use as peptidyl peptidase inhibitors
WO2006030442A2 (en) * 2004-09-16 2006-03-23 Gamida-Cell Ltd. Methods of ex vivo progenitor and stem cell expansion by co-culture with mesenchymal cells
CA2597407C (en) 2005-02-11 2013-09-10 Immunogen, Inc. Process for preparing stable drug conjugates
AU2006278573A1 (en) 2005-08-03 2007-02-15 Immunogen, Inc. Immunoconjugate formulations
NZ595430A (en) 2005-08-24 2013-05-31 Immunogen Inc Process for preparing maytansinoid antibody conjugates
WO2007033350A1 (en) 2005-09-14 2007-03-22 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors for treating diabetes
EP1924567B1 (en) 2005-09-16 2012-08-22 Takeda Pharmaceutical Company Limited Process for the preparation of pyrimidinedione derivatives
US20090162405A1 (en) * 2006-12-14 2009-06-25 Yong Qian Proteinase-engineered cancer vaccine induces immune responses to prevent cancer and to systemically kill cancer cells
US8846393B2 (en) 2005-11-29 2014-09-30 Gamida-Cell Ltd. Methods of improving stem cell homing and engraftment
TW200838536A (en) 2006-11-29 2008-10-01 Takeda Pharmaceutical Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor
KR101334934B1 (ko) * 2006-12-27 2013-11-29 삼성디스플레이 주식회사 유기발광표시장치의 에이징 방법
KR200450480Y1 (ko) * 2008-09-22 2010-10-07 대우조선해양 주식회사 앵글 취부장치
WO2010099918A1 (en) * 2009-03-06 2010-09-10 Klaus Tschira Stiftung Ggmbh Pharmaceutical composition and method for identifying a cancerous and/or an inflammatory disease in a patient
WO2010141566A1 (en) 2009-06-03 2010-12-09 Immunogen, Inc. Conjugation methods
US8321012B2 (en) * 2009-12-22 2012-11-27 The Invention Science Fund I, Llc Device, method, and system for neural modulation as vaccine adjuvant in a vertebrate subject
RS58367B1 (sr) 2011-03-29 2019-03-29 Immunogen Inc Priprema konjugata antitela i majtanzinoida jednostepenim postupkom
AU2013216863B2 (en) * 2012-02-10 2018-09-06 Seagen Inc. Detection and treatment of CD30+ cancers
JP6348848B2 (ja) 2012-02-13 2018-06-27 ガミダ セル リミテッド 間葉系幹細胞の増殖
US9567569B2 (en) 2012-07-23 2017-02-14 Gamida Cell Ltd. Methods of culturing and expanding mesenchymal stem cells
US9175266B2 (en) 2012-07-23 2015-11-03 Gamida Cell Ltd. Enhancement of natural killer (NK) cell proliferation and activity
IN2015DN03202A (enExample) 2012-10-04 2015-10-02 Immunogen Inc
EP2767549A1 (en) 2013-02-19 2014-08-20 Adienne S.A. Anti-CD26 antibodies and uses thereof
US11242399B2 (en) 2013-02-19 2022-02-08 Adienne S.A. Anti-CD26 antibodies
CN107417691B (zh) * 2013-03-15 2020-06-26 G1治疗公司 高效的抗赘生剂和抗增生剂
US9464092B2 (en) 2013-03-15 2016-10-11 G1 Therapeutics, Inc. Transient protection of normal cells during chemotherapy
JP2015030666A (ja) 2013-07-31 2015-02-16 学校法人順天堂 抗ヒトcd26モノクローナル抗体又はその抗原結合性断片
CN103694352B (zh) * 2013-12-19 2015-12-09 江苏众红生物工程创药研究院有限公司 一种抗 cd26 抗体及其制备方法
CN103709251B (zh) * 2013-12-19 2016-04-13 江苏众红生物工程创药研究院有限公司 全人源抗cd26抗体及其应用
TWI677505B (zh) * 2014-08-18 2019-11-21 瑞士商艾迪安納股份有限公司 抗cd26抗體及其用途
EP3191098A4 (en) 2014-09-12 2018-04-25 G1 Therapeutics, Inc. Combinations and dosing regimes to treat rb-positive tumors
WO2016040848A1 (en) 2014-09-12 2016-03-17 G1 Therapeutics, Inc. Treatment of rb-negative tumors using topoisomerase inhibitors in combination with cyclin dependent kinase 4/6 inhibitors
CN107406463A (zh) 2014-12-04 2017-11-28 细胞基因公司 生物分子共轭物
SG11201802915WA (en) * 2015-09-11 2018-05-30 Ys Ac Co Ltd Cancer treatment composition combining anti-cd26 antibody and other anticancer agent
JP2019501139A (ja) 2015-11-25 2019-01-17 イミュノジェン・インコーポレーテッド 医薬製剤及びその使用
WO2017189526A1 (en) * 2016-04-25 2017-11-02 Musc Foundation For Research Development Activated cd26-high immune cells and cd26-negative immune cells and uses thereof
CN109709337B (zh) * 2018-12-28 2021-09-14 江苏众红生物工程创药研究院有限公司 人cd26的免疫组化检测试剂盒及其临床应用
CN109535255B (zh) * 2018-12-28 2020-10-27 江苏众红生物工程创药研究院有限公司 一种抗人cd26抗体及其在检测试剂盒中的应用
WO2020236890A1 (en) * 2019-05-20 2020-11-26 Mayo Foundation For Medical Education And Research Treating chronic liver disease
CA3155930A1 (en) * 2019-09-27 2021-04-01 Starkage Therapeutics Senescent cell-associated antigen-binding domains, antibodies and chimeric antigen receptors comprising the same, and uses thereof
US11723926B2 (en) 2019-09-27 2023-08-15 Starkage Therapeutics Senescent cell-associated antigen-binding domains, antibodies and chimeric antigen receptors comprising the same, and uses thereof
US10988479B1 (en) 2020-06-15 2021-04-27 G1 Therapeutics, Inc. Morphic forms of trilaciclib and methods of manufacture thereof
BR112023022312A2 (pt) 2021-05-13 2023-12-26 Adienne S A Métodos de tratamento de dermatomiosite
IL308373A (en) 2021-05-13 2024-01-01 Adienne S A Methods for treating graft versus host disease
CN116023491A (zh) * 2021-10-25 2023-04-28 江苏众红生物工程创药研究院有限公司 抗cd26抗体及其应用
CN116549629A (zh) * 2022-01-30 2023-08-08 江苏众红生物工程创药研究院有限公司 Cd45作为生物标志物在筛查cd26抗体或其衍生物治疗肿瘤有效性和精准性中的应用
CN114878820A (zh) * 2022-05-30 2022-08-09 湛江中心人民医院 肺腺癌病理诊断标志物及其应用
WO2025027529A1 (en) 2023-07-31 2025-02-06 Advesya Anti-il-1rap antibody drug conjugates and methods of use thereof
CN117568477B (zh) * 2023-10-17 2024-11-19 中山大学肿瘤防治中心(中山大学附属肿瘤医院、中山大学肿瘤研究所) Dpp4作为nk/t细胞淋巴瘤肿瘤标志物的应用
TW202530255A (zh) 2023-12-15 2025-08-01 法商亞維西亞有限公司 抗il-1rap結合結構域及其抗體-藥物偶聯物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5120642A (en) * 1989-11-28 1992-06-09 Coulter Corporation Monoclonal antibody which distinguishes helper inducer and suppressor inducer cd4+ lymphocytes
US5863904A (en) 1995-09-26 1999-01-26 The University Of Michigan Methods for treating cancers and restenosis with P21
US6951924B2 (en) * 1997-03-14 2005-10-04 Human Genome Sciences, Inc. Antibodies against secreted protein HTEBYII
US6573096B1 (en) * 2000-04-01 2003-06-03 The Research Foundation At State University Of New York Compositions and methods for inhibition of cancer invasion and angiogenesis
AU2001269123A1 (en) * 2000-07-10 2002-01-21 Bayer Aktiengesellschaft Regulation of human dipeptidyl-peptidase iv-like enzyme
IL155245A0 (en) * 2000-10-12 2003-11-23 Ferring Bv Novel serine protease genes related to dppiv

Cited By (14)

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Publication number Priority date Publication date Assignee Title
JP2009502139A (ja) * 2005-07-22 2009-01-29 ワイズセラピューティックス株式会社 抗cd26抗体およびその使用方法
US8771688B2 (en) 2007-03-14 2014-07-08 The University Of Tokyo Method of treating malignant mesothelioma
JP4865868B2 (ja) * 2007-03-14 2012-02-01 国立大学法人 東京大学 悪性中皮種の治療方法
WO2008114876A1 (en) * 2007-03-14 2008-09-25 The University Of Tokyo A method of treating malignant mesothelioma
JP2013521287A (ja) * 2010-03-01 2013-06-10 ティーエーユー・セラピューティクス・エルエルシー 癌診断および撮像
WO2011118804A1 (ja) * 2010-03-26 2011-09-29 国立大学法人徳島大学 新規抗cd98抗体とその用途
JPWO2011118804A1 (ja) * 2010-03-26 2013-07-04 国立大学法人徳島大学 新規抗cd98抗体とその用途
JP2018502577A (ja) * 2015-01-09 2018-02-01 メディミューン,エルエルシー ヒトdpp−4を検出するためのアッセイ
JP2021508834A (ja) * 2017-12-22 2021-03-11 アディエンネ エス.エー. 抗cd26リガンドの生物活性を決定するための細胞内定量法
JP7366925B2 (ja) 2017-12-22 2023-10-23 アディエンネ エス.エー. 抗cd26リガンドの生物活性を決定するための細胞内定量法
JP2024020200A (ja) * 2017-12-22 2024-02-14 アディエンネ エス.エー. 抗cd26リガンドの生物活性を決定するための細胞内定量法
JP7529373B2 (ja) 2017-12-22 2024-08-06 アディエンネ エス.エー. 抗cd26リガンドの生物活性を決定するための細胞内定量法
WO2022220232A1 (ja) * 2021-04-12 2022-10-20 国立大学法人 東京大学 すい臓がん検出用蛍光プローブ
JPWO2022220232A1 (enExample) * 2021-04-12 2022-10-20

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KR20040029984A (ko) 2004-04-08
US20030031665A1 (en) 2003-02-13
AU2002308637B2 (en) 2007-05-17
US7198788B2 (en) 2007-04-03
US7658923B2 (en) 2010-02-09
KR100863624B1 (ko) 2008-10-15
EP1392361A4 (en) 2009-08-05
EP1392361A1 (en) 2004-03-03
CN100341572C (zh) 2007-10-10
CN1671415A (zh) 2005-09-21
WO2002092127A1 (en) 2002-11-21
CA2446806A1 (en) 2002-11-21
US20070207143A1 (en) 2007-09-06
CN101172158A (zh) 2008-05-07

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