JP2004532044A - 検出システム - Google Patents

検出システム Download PDF

Info

Publication number
JP2004532044A
JP2004532044A JP2003500296A JP2003500296A JP2004532044A JP 2004532044 A JP2004532044 A JP 2004532044A JP 2003500296 A JP2003500296 A JP 2003500296A JP 2003500296 A JP2003500296 A JP 2003500296A JP 2004532044 A JP2004532044 A JP 2004532044A
Authority
JP
Japan
Prior art keywords
probe
label
amplification
sequence
nucleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2003500296A
Other languages
English (en)
Japanese (ja)
Other versions
JP2004532044A5 (enExample
Inventor
マーティン アラン リー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UK Secretary of State for Defence
Original Assignee
UK Secretary of State for Defence
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UK Secretary of State for Defence filed Critical UK Secretary of State for Defence
Publication of JP2004532044A publication Critical patent/JP2004532044A/ja
Publication of JP2004532044A5 publication Critical patent/JP2004532044A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6851Quantitative amplification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Geophysics And Detection Of Objects (AREA)
  • Eye Examination Apparatus (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2003500296A 2001-05-25 2002-05-24 検出システム Pending JP2004532044A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0112868.5A GB0112868D0 (en) 2001-05-25 2001-05-25 Detection system
PCT/GB2002/002443 WO2002097132A2 (en) 2001-05-25 2002-05-24 Nucleic acid detection method

Publications (2)

Publication Number Publication Date
JP2004532044A true JP2004532044A (ja) 2004-10-21
JP2004532044A5 JP2004532044A5 (enExample) 2009-01-08

Family

ID=9915364

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003500296A Pending JP2004532044A (ja) 2001-05-25 2002-05-24 検出システム

Country Status (14)

Country Link
US (2) US7700275B2 (enExample)
EP (1) EP1390542B1 (enExample)
JP (1) JP2004532044A (enExample)
KR (1) KR20040024556A (enExample)
CN (1) CN1304596C (enExample)
AT (1) ATE298804T1 (enExample)
AU (1) AU2002311414B2 (enExample)
CA (1) CA2448211C (enExample)
DE (1) DE60204874T2 (enExample)
DK (1) DK1390542T3 (enExample)
ES (1) ES2240753T3 (enExample)
GB (1) GB0112868D0 (enExample)
PT (1) PT1390542E (enExample)
WO (1) WO2002097132A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006501836A (ja) * 2002-10-10 2006-01-19 イギリス国 検出システム
JP2012502638A (ja) * 2008-09-18 2012-02-02 エフ.ホフマン−ラ ロシュ アーゲー 蛍光標識及び可溶性消光体を使用する標的変異体の検出

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0112868D0 (en) * 2001-05-25 2001-07-18 Secr Defence Detection system
ES2529204T3 (es) * 2004-10-18 2015-02-17 Brandeis University Métodos para la amplificación de ácido nucleico
WO2006121277A1 (en) * 2005-05-09 2006-11-16 Korea Research Institute Of Standards And Science Fret probes for fluorescent detection of the epsps gene
KR100764559B1 (ko) * 2005-05-09 2007-10-08 한국표준과학연구원 Epsps 유전자 검색에 활용할 수 있는 fret형광검출용 프로브
CN100420943C (zh) * 2005-06-23 2008-09-24 李卫 Dna分子内杂交-聚丙烯酰胺凝胶电泳方法
US8968700B2 (en) * 2005-08-11 2015-03-03 The Board Of Trustees Of The Leland Stanford Junior University Imaging of protease activity in live cells using activity based probes
US7785786B2 (en) 2006-01-23 2010-08-31 Quest Diagnostics Investments Incorporated Methods for detecting nucleic acids using multiple signals
CN100526461C (zh) * 2006-07-10 2009-08-12 中国农业科学院棉花研究所 获得植物内含子序列扩增多态性的方法及其专用引物
JP2009044967A (ja) * 2007-08-14 2009-03-05 Sony Corp 二本鎖核酸の形成に係る情報を得る方法
US20100129796A1 (en) * 2008-11-24 2010-05-27 Micah Halpern Dye probe fluorescence resonance energy transfer genotyping
GB201004339D0 (en) 2010-03-16 2010-04-28 Enigma Diagnostics Ltd Sequence detection assay
GB201007868D0 (en) 2010-05-11 2010-06-23 Enigma Diagnostics Ltd Sequence detection assay
WO2012118715A2 (en) 2011-02-28 2012-09-07 The Board Of Trustees Of Leland Stanford Junior University Non-peptidic quenched fluorescent imaging probes
DE102011117520A1 (de) * 2011-11-03 2013-05-08 Frank Schleifenbaum Sensorsystem für nicht intrusive Druckmessungen
WO2014145257A2 (en) 2013-03-15 2014-09-18 The Board Of Trustees Of The Leland Stanford Junior University Activity-based probe compounds, compositions, and methods of use
EP3347714B1 (en) * 2015-09-10 2021-03-10 InSilixa Inc. Methods for multiplex quantitative nucleic acid amplification
EP3510380B1 (en) 2016-12-23 2023-11-08 The Board of Trustees of the Leland Stanford Junior University Activity-based probe compounds, compositions, and methods of use
EP3601261A4 (en) 2017-03-30 2021-07-14 The Board of Trustees of the Leland Stanford Junior University CONTRAST AGENTS ACTIVATED BY A PROTEASE FOR IN VIVO IMAGING

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1533151A (fr) * 1962-05-18 1968-07-19 Rhone Poulenc Sa Nouvel antibiotique et sa préparation
US4012284A (en) * 1962-11-16 1977-03-15 Societa' Farmaceutici Italia, S.p.A. Process of preparation of antibiotic F.I. 1762 derivatives
US3183157A (en) * 1963-02-01 1965-05-11 Upjohn Co Antibiotic nogalamycin and method of producing
US4197249A (en) * 1977-08-15 1980-04-08 American Cyanamid Company 1,4-Bis(substituted-amino)-5,8-dihydroxyanthraquinones and leuco bases thereof
US4469863A (en) * 1980-11-12 1984-09-04 Ts O Paul O P Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof
CA1219824A (en) 1981-04-17 1987-03-31 David C. Ward Modified nucleotides and methods of preparing and using same
US5200313A (en) * 1983-08-05 1993-04-06 Miles Inc. Nucleic acid hybridization assay employing detectable anti-hybrid antibodies
US4757141A (en) 1985-08-26 1988-07-12 Applied Biosystems, Incorporated Amino-derivatized phosphite and phosphate linking agents, phosphoramidite precursors, and useful conjugates thereof
US4868103A (en) * 1986-02-19 1989-09-19 Enzo Biochem, Inc. Analyte detection by means of energy transfer
US5208323A (en) * 1989-08-10 1993-05-04 Universite Laval Coupling of an anti-tumor to an antibody using glutaraldehyde preactivated anti-tumor agent
HU201626B (en) 1989-09-05 1990-11-28 Magyar Kabel Muevek Device for making surface layer on work pieces moving longitudinally particularly by use of dusty integumentary material in cable industry
GB8923075D0 (en) * 1989-10-13 1989-11-29 Patterson Laurence H Anti-cancer compounds
US5994056A (en) * 1991-05-02 1999-11-30 Roche Molecular Systems, Inc. Homogeneous methods for nucleic acid amplification and detection
US5849486A (en) 1993-11-01 1998-12-15 Nanogen, Inc. Methods for hybridization analysis utilizing electrically controlled hybridization
US5567583A (en) * 1991-12-16 1996-10-22 Biotronics Corporation Methods for reducing non-specific priming in DNA detection
ES2082256T3 (es) 1992-03-23 1996-03-16 Hoffmann La Roche Metodo de deteccion del adn.
AU689815B2 (en) * 1993-08-30 1998-04-09 Promega Corporation Nucleic acid purification compositions and methods
AU7662794A (en) 1993-09-23 1995-04-10 Zeneca Limited Nucleic acid detection with energy transfer
US5925517A (en) 1993-11-12 1999-07-20 The Public Health Research Institute Of The City Of New York, Inc. Detectably labeled dual conformation oligonucleotide probes, assays and kits
US5491063A (en) * 1994-09-01 1996-02-13 Hoffmann-La Roche Inc. Methods for in-solution quenching of fluorescently labeled oligonucleotide probes
DE69527125T2 (de) * 1994-11-09 2003-02-27 Hitachi, Ltd. Verfahren und Vorrichtung zur DNS Analyse
US5858397A (en) * 1995-10-11 1999-01-12 University Of British Columbia Liposomal formulations of mitoxantrone
EP2369007B1 (en) * 1996-05-29 2015-07-29 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions
AU726501B2 (en) 1996-06-04 2000-11-09 University Of Utah Research Foundation Monitoring hybridization during PCR
US6117635A (en) 1996-07-16 2000-09-12 Intergen Company Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon
GB9716052D0 (en) 1996-12-06 1997-10-01 Secr Defence Reaction vessels
US6403311B1 (en) * 1997-02-12 2002-06-11 Us Genomics Methods of analyzing polymers using ordered label strategies
ATE273381T1 (de) * 1997-02-12 2004-08-15 Eugene Y Chan Verfahren zur analyse von polymeren
GB9725237D0 (en) 1997-11-29 1998-01-28 Secr Defence Amplification system
GB9725197D0 (en) * 1997-11-29 1998-01-28 Secr Defence Detection system
GB9803382D0 (en) * 1998-02-19 1998-04-15 Secr Defence Detection system
GB9812768D0 (en) 1998-06-13 1998-08-12 Zeneca Ltd Methods
GB9918237D0 (en) * 1999-08-04 1999-10-06 Secr Defence Detection system
US7019129B1 (en) 2000-05-09 2006-03-28 Biosearch Technologies, Inc. Dark quenchers for donor-acceptor energy transfer
US6323337B1 (en) 2000-05-12 2001-11-27 Molecular Probes, Inc. Quenching oligonucleotides
KR100386606B1 (ko) * 2001-02-03 2003-06-02 엘지전자 주식회사 Dna 검출 방법 및 그 장치
GB0110501D0 (en) 2001-04-30 2001-06-20 Secr Defence Brit Amplification process
GB0112868D0 (en) 2001-05-25 2001-07-18 Secr Defence Detection system
KR100459394B1 (ko) * 2001-10-30 2004-12-03 엘지전자 주식회사 인터컬레이터를 이용한 핵산의 전기화학발광 검출방법
AU2002351193A1 (en) * 2001-11-28 2003-06-10 Mj Bioworks Incorporated Parallel polymorphism scoring by amplification and error correction
CA2500129C (en) * 2002-09-30 2011-03-29 F. Hoffmann-La Roche Ag Oligonucleotides for genotyping thymidylate synthase gene
GB0223563D0 (en) 2002-10-10 2002-11-20 Secr Defence Detection system
US7354706B2 (en) * 2003-09-09 2008-04-08 The Regents Of The University Of Colorado, A Body Corporate Use of photopolymerization for amplification and detection of a molecular recognition event
EP1694869A2 (en) * 2003-11-10 2006-08-30 Investigen, Inc. Methods of preparing nucleic acid for detection

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006501836A (ja) * 2002-10-10 2006-01-19 イギリス国 検出システム
JP2012502638A (ja) * 2008-09-18 2012-02-02 エフ.ホフマン−ラ ロシュ アーゲー 蛍光標識及び可溶性消光体を使用する標的変異体の検出

Also Published As

Publication number Publication date
CN1304596C (zh) 2007-03-14
DK1390542T3 (da) 2005-08-08
DE60204874T2 (de) 2006-04-27
HK1068651A1 (en) 2005-04-29
ES2240753T3 (es) 2005-10-16
US20040241679A1 (en) 2004-12-02
AU2002311414B2 (en) 2006-11-09
GB0112868D0 (en) 2001-07-18
ATE298804T1 (de) 2005-07-15
PT1390542E (pt) 2005-11-30
US20100227326A1 (en) 2010-09-09
EP1390542B1 (en) 2005-06-29
CA2448211C (en) 2010-12-07
CA2448211A1 (en) 2002-12-05
WO2002097132A3 (en) 2003-09-12
WO2002097132A2 (en) 2002-12-05
KR20040024556A (ko) 2004-03-20
EP1390542A2 (en) 2004-02-25
US7700275B2 (en) 2010-04-20
CN1527885A (zh) 2004-09-08
DE60204874D1 (de) 2005-08-04

Similar Documents

Publication Publication Date Title
CN1203186C (zh) 用pcr检测目标核酸的方法
US20100227326A1 (en) Detection System
JP4540844B2 (ja) 核酸の蛍光定量的検出システム
JP5685561B2 (ja) 核酸の検出用物質及び検出方法
JP4457001B2 (ja) ドナー/アクセプター部分が相補鎖上となる標的核酸検出のmet/fretに基づく方法
JP6166342B2 (ja) ホスホロチオエート基を含むオリゴヌクレオチドを用いる、ポリメラーゼ連鎖反応による検出システム
AU2002311414A1 (en) Nucleic acid detection method
JP2004532044A5 (enExample)
JP4628625B2 (ja) 蛍光エネルギー移動を含む標的核酸を検出するための増幅方法
KR20090052227A (ko) 경쟁적 증폭 반응을 이용하여 표적 핵산을 검출하는 방법
HK1068651B (en) Detection system

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20050524

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20080512

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20080812

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20080819

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20081111

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20090126