JP2004532038A5 - - Google Patents

Info

Publication number

JP2004532038A5

JP2004532038A5 JP2002589648A JP2002589648A JP2004532038A5 JP 2004532038 A5 JP2004532038 A5 JP 2004532038A5 JP 2002589648 A JP2002589648 A JP 2002589648A JP 2002589648 A JP2002589648 A JP 2002589648A JP 2004532038 A5 JP2004532038 A5 JP 2004532038A5

Authority

JP

Japan

Prior art keywords

antigen binding

amino acid

mutated

nucleic acid

encoding

Prior art date

2002-05-17

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 108020004707 nucleic acids Proteins 0.000 claims 44
• 102000039446 nucleic acids Human genes 0.000 claims 44
• 150000007523 nucleic acids Chemical class 0.000 claims 44
• 239000000427 antigen Substances 0.000 claims 36
• 108091007433 antigens Proteins 0.000 claims 36
• 102000036639 antigens Human genes 0.000 claims 36
• 150000001413 amino acids Chemical class 0.000 claims 24
• 238000000034 method Methods 0.000 claims 20
• 108020004705 Codon Proteins 0.000 claims 14
• 108091034117 Oligonucleotide Proteins 0.000 claims 14
• JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 13
• 108700018351 Major Histocompatibility Complex Proteins 0.000 claims 10
• 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 claims 10
• 229920001184 polypeptide Polymers 0.000 claims 9
• 102000004196 processed proteins & peptides Human genes 0.000 claims 9
• 108090000765 processed proteins & peptides Proteins 0.000 claims 9
• 108091008874 T cell receptors Proteins 0.000 claims 6
• 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 6
• 238000004519 manufacturing process Methods 0.000 claims 4
• 125000003275 alpha amino acid group Chemical group 0.000 claims 3
• 230000035772 mutation Effects 0.000 claims 3
• 238000012216 screening Methods 0.000 claims 3
• 238000006467 substitution reaction Methods 0.000 claims 3
• 108091033319 polynucleotide Proteins 0.000 claims 2
• 102000040430 polynucleotide Human genes 0.000 claims 2
• 239000002157 polynucleotide Substances 0.000 claims 2
• 125000000539 amino acid group Chemical group 0.000 claims 1
• 230000003247 decreasing effect Effects 0.000 claims 1