JP2010534828A5 - - Google Patents
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- Publication number
- JP2010534828A5 JP2010534828A5 JP2010517399A JP2010517399A JP2010534828A5 JP 2010534828 A5 JP2010534828 A5 JP 2010534828A5 JP 2010517399 A JP2010517399 A JP 2010517399A JP 2010517399 A JP2010517399 A JP 2010517399A JP 2010534828 A5 JP2010534828 A5 JP 2010534828A5
- Authority
- JP
- Japan
- Prior art keywords
- trem
- ligand
- antibody
- binding
- receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000003446 ligand Substances 0.000 claims 30
- 102000018368 Triggering Receptor Expressed on Myeloid Cells-1 Human genes 0.000 claims 28
- 108010066451 Triggering Receptor Expressed on Myeloid Cells-1 Proteins 0.000 claims 28
- 150000001875 compounds Chemical class 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 150000007523 nucleic acids Chemical class 0.000 claims 6
- 102000039446 nucleic acids Human genes 0.000 claims 6
- 108020004707 nucleic acids Proteins 0.000 claims 6
- 210000004408 hybridoma Anatomy 0.000 claims 4
- 102000019034 Chemokines Human genes 0.000 claims 2
- 108010012236 Chemokines Proteins 0.000 claims 2
- 102000004127 Cytokines Human genes 0.000 claims 2
- 108090000695 Cytokines Proteins 0.000 claims 2
- 210000003719 b-lymphocyte Anatomy 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 230000000770 proinflammatory effect Effects 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 1
- 230000000903 blocking effect Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 210000004881 tumor cell Anatomy 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96161507P | 2007-07-23 | 2007-07-23 | |
| PCT/EP2008/059668 WO2009013319A1 (en) | 2007-07-23 | 2008-07-23 | Screening, therapy and diagnosis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010534828A JP2010534828A (ja) | 2010-11-11 |
| JP2010534828A5 true JP2010534828A5 (enExample) | 2011-09-01 |
Family
ID=39816994
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010517399A Abandoned JP2010534828A (ja) | 2007-07-23 | 2008-07-23 | スクリーニング、療法及び診断 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20100306863A1 (enExample) |
| EP (1) | EP2174131A1 (enExample) |
| JP (1) | JP2010534828A (enExample) |
| CN (1) | CN101821621A (enExample) |
| WO (1) | WO2009013319A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8393201B2 (en) | 2010-09-21 | 2013-03-12 | Webtech Wireless Inc. | Sensing ignition by voltage monitoring |
| RU2463606C1 (ru) * | 2011-08-17 | 2012-10-10 | Учреждение Российской академии медицинских наук Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний Сибирского отделения Российской академии медицинских наук (УРАМН НИИ КПССЗ СО РАМН) | Способ ранней диагностики осложненного системного воспалительного ответа у пациентов, оперированных в условиях искусственного кровообращения |
| CN102517287B (zh) * | 2012-01-10 | 2013-09-11 | 广西大学 | 抑制水牛TREM1基因表达的shRNA、慢病毒表达载体及其构建方法和应用 |
| EP3456742A1 (en) | 2012-02-15 | 2019-03-20 | Novo Nordisk A/S | Antibodies that bind peptidoglycan recognition protein 1 |
| ES2797625T3 (es) | 2012-09-07 | 2020-12-03 | Inst Nat Sante Rech Med | Péptidos inhibitorios derivados del receptor desencadenante expresado en células mieloides-1 (TREM-1) y del transcrito similar a TREM 1 (TLT-1) y sus usos |
| EP2835641A1 (en) * | 2013-08-09 | 2015-02-11 | Inotrem | Methods and kits for predicting the risk of having a cardiovascular disease or event |
| SG10202103445QA (en) * | 2015-04-13 | 2021-05-28 | Regeneron Pharma | Humanized sirpa-il15 knockin mice and methods of use thereof |
| US12091455B2 (en) | 2018-02-14 | 2024-09-17 | Yale University | Compositions for modulation of a TREM or TREML protein and methods of use |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| WO2020179700A1 (ja) * | 2019-03-01 | 2020-09-10 | 国立大学法人筑波大学 | アレルギー疾患を処置することに用いるための組成物 |
| WO2021011678A1 (en) * | 2019-07-15 | 2021-01-21 | Bristol-Myers Squibb Company | Anti-trem-1 antibodies and uses thereof |
| CN111157741B (zh) * | 2019-12-30 | 2022-08-16 | 广州市妇女儿童医疗中心 | 髓系细胞触发受体1在制备胃炎诊断或治疗试剂中的应用及试剂盒 |
| CN112526143B (zh) * | 2020-12-03 | 2021-08-03 | 中山大学附属第五医院 | 髓系细胞触发受体2作为新型冠状病毒肺炎诊断或治疗靶点的应用 |
| CN113687081A (zh) * | 2021-05-19 | 2021-11-23 | 大汉生物科技(广东)有限公司 | 髓系细胞触发受体2在制备脓毒症相关功能产品中的应用 |
| WO2023023125A1 (en) * | 2021-08-17 | 2023-02-23 | Predigen, Inc. | Methods for characterizing infections and methods for developing tests for the same |
| CN114736957B (zh) * | 2022-04-15 | 2024-03-12 | 中国人民解放军空军军医大学 | 外泌体介导rna casc15干预阿尔茨海默症突触损失的应用 |
| CN116908446B (zh) * | 2023-06-27 | 2024-05-07 | 广州市妇女儿童医疗中心 | 用于诊断川崎病冠状动脉瘤的生物标志物及其应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4444887A (en) * | 1979-12-10 | 1984-04-24 | Sloan-Kettering Institute | Process for making human antibody producing B-lymphocytes |
| US4522811A (en) * | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US4716111A (en) * | 1982-08-11 | 1987-12-29 | Trustees Of Boston University | Process for producing human antibodies |
| IT1164225B (it) * | 1983-05-13 | 1987-04-08 | Anic Spa | Analoghi retro-invertiti del pentapeptide potenziante la bradichina bpp5a e metodi per la loro preparazione |
| US5413923A (en) * | 1989-07-25 | 1995-05-09 | Cell Genesys, Inc. | Homologous recombination for universal donor cells and chimeric mammalian hosts |
| DE69133566T2 (de) * | 1990-01-12 | 2007-12-06 | Amgen Fremont Inc. | Bildung von xenogenen Antikörpern |
| US5814318A (en) * | 1990-08-29 | 1998-09-29 | Genpharm International Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5633425A (en) * | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5545806A (en) * | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5661016A (en) * | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5625126A (en) * | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| KR100272077B1 (ko) * | 1990-08-29 | 2000-11-15 | 젠팜인터내셔날,인코포레이티드 | 이종 항체를 생산할 수 있는 전이유전자를 가진 인간이외의 동물 |
| ATE408012T1 (de) * | 1991-12-02 | 2008-09-15 | Medical Res Council | Herstellung von autoantikörpern auf phagenoberflächen ausgehend von antikörpersegmentbibliotheken |
| US5916771A (en) * | 1996-10-11 | 1999-06-29 | Abgenix, Inc. | Production of a multimeric protein by cell fusion method |
| US20090081199A1 (en) * | 2001-03-20 | 2009-03-26 | Bioxell S.P.A. | Novel receptor trem (triggering receptor expressed on myeloid cells) and uses thereof |
| CA2342376C (en) * | 2001-03-20 | 2013-11-12 | Marco Colonna | A receptor trem (triggering receptor expressed on myeloid cells) and uses thereof |
| GB0305478D0 (en) * | 2003-03-10 | 2003-04-16 | Bioxell Spa | Diagnostic and prognostic compounds and method |
-
2008
- 2008-07-23 WO PCT/EP2008/059668 patent/WO2009013319A1/en not_active Ceased
- 2008-07-23 EP EP08786360A patent/EP2174131A1/en not_active Withdrawn
- 2008-07-23 JP JP2010517399A patent/JP2010534828A/ja not_active Abandoned
- 2008-07-23 US US12/452,813 patent/US20100306863A1/en not_active Abandoned
- 2008-07-23 CN CN200880106081A patent/CN101821621A/zh not_active Withdrawn
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