JP2012041338A5 - - Google Patents

Info

Publication number

JP2012041338A5

JP2012041338A5 JP2011162428A JP2011162428A JP2012041338A5 JP 2012041338 A5 JP2012041338 A5 JP 2012041338A5 JP 2011162428 A JP2011162428 A JP 2011162428A JP 2011162428 A JP2011162428 A JP 2011162428A JP 2012041338 A5 JP2012041338 A5 JP 2012041338A5

Authority

JP

Japan

Prior art keywords

synuclein

pharmaceutical composition

antibody

composition according

disease

Prior art date

2011-07-25

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

• Espacenet
• Global Dossier
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• 239000008194 pharmaceutical composition Substances 0.000 claims 10
• 102000003802 alpha-Synuclein Human genes 0.000 claims 9
• 108090000185 alpha-Synuclein Proteins 0.000 claims 9
• 201000010099 disease Diseases 0.000 claims 6
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
• 239000000126 substance Substances 0.000 claims 6
• 239000012634 fragment Substances 0.000 claims 4
• 210000004558 lewy body Anatomy 0.000 claims 4
• 238000000034 method Methods 0.000 claims 4
• 150000001413 amino acids Chemical class 0.000 claims 3
• 230000009261 transgenic effect Effects 0.000 claims 3
• 102000019355 Synuclein Human genes 0.000 claims 2
• 108050006783 Synuclein Proteins 0.000 claims 2
• 108700019146 Transgenes Proteins 0.000 claims 2
• 230000002776 aggregation Effects 0.000 claims 2
• 238000004220 aggregation Methods 0.000 claims 2
• 210000004556 brain Anatomy 0.000 claims 2
• 210000004027 cell Anatomy 0.000 claims 2
• 230000000694 effects Effects 0.000 claims 2
• 230000002163 immunogen Effects 0.000 claims 2
• 238000012216 screening Methods 0.000 claims 2
• 208000024827 Alzheimer disease Diseases 0.000 claims 1
• 101710137189 Amyloid-beta A4 protein Proteins 0.000 claims 1
• 101710151993 Amyloid-beta precursor protein Proteins 0.000 claims 1
• 102100022704 Amyloid-beta precursor protein Human genes 0.000 claims 1
• 208000009829 Lewy Body Disease Diseases 0.000 claims 1
• 201000002832 Lewy body dementia Diseases 0.000 claims 1
• 208000018737 Parkinson disease Diseases 0.000 claims 1
• 238000009825 accumulation Methods 0.000 claims 1
• 239000002671 adjuvant Substances 0.000 claims 1
• DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 claims 1
• 230000003941 amyloidogenesis Effects 0.000 claims 1
• 230000028993 immune response Effects 0.000 claims 1
• 210000002569 neuron Anatomy 0.000 claims 1
• 208000024891 symptom Diseases 0.000 claims 1