|
CH652145A5
(de)
|
1982-01-22 |
1985-10-31 |
Sandoz Ag |
Verfahren zur in vitro-herstellung von hybridomen welche humane monoklonale antikoerper erzeugen.
|
|
US4634666A
(en)
|
1984-01-06 |
1987-01-06 |
The Board Of Trustees Of The Leland Stanford Junior University |
Human-murine hybridoma fusion partner
|
|
IL77243A
(en)
*
|
1984-12-21 |
1996-11-14 |
Procter & Gamble |
Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds
|
|
DE3521994A1
(de)
|
1985-06-20 |
1987-01-02 |
Bayer Ag |
N-(2-aminoacylamido-2-desoxy-hexosyl)-amide-, -carbamate und -harnstoffe, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
US4883666A
(en)
*
|
1987-04-29 |
1989-11-28 |
Massachusetts Institute Of Technology |
Controlled drug delivery system for treatment of neural disorders
|
|
US5583112A
(en)
|
1987-05-29 |
1996-12-10 |
Cambridge Biotech Corporation |
Saponin-antigen conjugates and the use thereof
|
|
US5057540A
(en)
|
1987-05-29 |
1991-10-15 |
Cambridge Biotech Corporation |
Saponin adjuvant
|
|
US6093406A
(en)
*
|
1988-06-02 |
2000-07-25 |
The United States Of America As Represented By The Secretary Of The Army |
Vaccine for induction of immunity to malaria
|
|
US4912094B1
(en)
|
1988-06-29 |
1994-02-15 |
Ribi Immunochem Research Inc. |
Modified lipopolysaccharides and process of preparation
|
|
US5576184A
(en)
*
|
1988-09-06 |
1996-11-19 |
Xoma Corporation |
Production of chimeric mouse-human antibodies with specificity to human tumor antigens
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
IL162181A
(en)
|
1988-12-28 |
2006-04-10 |
Pdl Biopharma Inc |
A method of producing humanized immunoglubulin, and polynucleotides encoding the same
|
|
CA2017507C
(en)
|
1989-05-25 |
1996-11-12 |
Gary Van Nest |
Adjuvant formulation comprising a submicron oil droplet emulsion
|
|
US5196511A
(en)
*
|
1989-12-01 |
1993-03-23 |
The Scripps Research Institute |
Peptides and antibodies that inhibit integrin-ligand binding
|
|
EP1690935A3
(en)
|
1990-01-12 |
2008-07-30 |
Abgenix, Inc. |
Generation of xenogeneic antibodies
|
|
JP2980677B2
(ja)
|
1990-04-27 |
1999-11-22 |
マクマイケル,ジョン |
不正常なアミロイドβタンパク質と関連する中枢神経系疾患状態の治療のための方法および組成物
|
|
US5753624A
(en)
*
|
1990-04-27 |
1998-05-19 |
Milkhaus Laboratory, Inc. |
Materials and methods for treatment of plaquing disease
|
|
US5427908A
(en)
|
1990-05-01 |
1995-06-27 |
Affymax Technologies N.V. |
Recombinant library screening methods
|
|
EP0600866B1
(en)
|
1990-06-01 |
1997-12-03 |
Chiron Corporation |
Compositions and methods for identifying biologically active molecules
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
US5780587A
(en)
*
|
1990-08-24 |
1998-07-14 |
President And Fellows Of Harvard College |
Compounds and methods for inhibiting β-protein filament formation and neurotoxicity
|
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
WO1993012227A1
(en)
|
1991-12-17 |
1993-06-24 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5814318A
(en)
|
1990-08-29 |
1998-09-29 |
Genpharm International Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5770429A
(en)
|
1990-08-29 |
1998-06-23 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
JP2938569B2
(ja)
|
1990-08-29 |
1999-08-23 |
ジェンファーム インターナショナル,インコーポレイティド |
異種免疫グロブリンを作る方法及びトランスジェニックマウス
|
|
US5874299A
(en)
|
1990-08-29 |
1999-02-23 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
US5877397A
(en)
|
1990-08-29 |
1999-03-02 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
US5789650A
(en)
|
1990-08-29 |
1998-08-04 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5858657A
(en)
|
1992-05-15 |
1999-01-12 |
Medical Research Council |
Methods for producing members of specific binding pairs
|
|
US5871907A
(en)
|
1991-05-15 |
1999-02-16 |
Medical Research Council |
Methods for producing members of specific binding pairs
|
|
CA2103059C
(en)
|
1991-06-14 |
2005-03-22 |
Paul J. Carter |
Method for making humanized antibodies
|
|
WO1993001222A1
(fr)
|
1991-07-03 |
1993-01-21 |
Kanebo, Ltd. |
Elastomere de polyurethane thermoplastique, procede et dispositif de production, et fibre elastique realisee a partir de cet elastomere
|
|
EP0773227A1
(en)
|
1991-09-18 |
1997-05-14 |
Affymax Technologies N.V. |
Diverse collections of oligomers in use to prepare drugs, diagnostic reagents, pesticides or herbicides
|
|
US5565332A
(en)
|
1991-09-23 |
1996-10-15 |
Medical Research Council |
Production of chimeric antibodies - a combinatorial approach
|
|
ATE243746T1
(de)
|
1992-01-07 |
2003-07-15 |
Elan Pharm Inc |
Transgene tiermodelle fur alzheimer-krankheit
|
|
US5733743A
(en)
|
1992-03-24 |
1998-03-31 |
Cambridge Antibody Technology Limited |
Methods for producing members of specific binding pairs
|
|
US5604102A
(en)
|
1992-04-15 |
1997-02-18 |
Athena Neurosciences, Inc. |
Methods of screening for β-amyloid peptide production inhibitors
|
|
US5958883A
(en)
*
|
1992-09-23 |
1999-09-28 |
Board Of Regents Of The University Of Washington Office Of Technology |
Animal models of human amyloidoses
|
|
KR100310939B1
(ko)
|
1992-10-01 |
2002-06-20 |
추후제출 |
태그로암호화한복합조합화학라이브러리
|
|
EP0672142B1
(en)
|
1992-12-04 |
2001-02-28 |
Medical Research Council |
Multivalent and multispecific binding proteins, their manufacture and use
|
|
CA2115900A1
(en)
|
1993-02-22 |
1994-08-23 |
Gerald W. Becker |
Pharmaceutical screens and antibodies
|
|
WO1995006407A1
(en)
*
|
1993-08-30 |
1995-03-09 |
The Regents Of The University Of California |
Novel component of amyloid in alzheimer's disease and methods for use of same
|
|
CN1134156A
(zh)
|
1993-11-02 |
1996-10-23 |
阿菲马克斯技术公司 |
合成和筛选多种分子
|
|
US5877218A
(en)
|
1994-01-10 |
1999-03-02 |
Teva Pharmaceutical Industries, Ltd. |
Compositions containing and methods of using 1-aminoindan and derivatives thereof and process for preparing optically active 1-aminoindan derivatives
|
|
US7473423B2
(en)
*
|
1994-04-29 |
2009-01-06 |
Mayo Foundation For Medical Education And Research |
Human IgM antibodies, and diagnostic and therapeutic uses thereof particularly in the central nervous system
|
|
CA2189634A1
(en)
|
1994-05-06 |
1995-11-16 |
John J. Baldwin |
Combinatorial dihydrobenzopyran library
|
|
US5663046A
(en)
|
1994-06-22 |
1997-09-02 |
Pharmacopeia, Inc. |
Synthesis of combinatorial libraries
|
|
EP1181937A3
(en)
*
|
1994-08-09 |
2004-02-04 |
Cytrx Corporation |
Novel vaccine adjuvant and vaccine
|
|
US5589154A
(en)
*
|
1994-11-22 |
1996-12-31 |
Rutgers, The State University Of New Jersey |
Methods for the prevention or treatment of vascular hemorrhaging and Alzheimer's disease
|
|
US5807741A
(en)
*
|
1995-07-20 |
1998-09-15 |
Brown; Douglas Richard |
Neutralizing monoclonal antibody against botulinum neurotoxin serotype F
|
|
AU5508798A
(en)
|
1996-11-19 |
1998-06-10 |
Trustees Of The University Of Pennsylvania, The |
Diagnostic and therapeutic reagents for alzheimer's disease
|
|
EP2172216A3
(en)
|
1997-03-10 |
2010-11-24 |
Ottawa Hospital Research Institute |
Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
|
|
DE69842048D1
(de)
|
1997-08-01 |
2011-01-27 |
Max Planck Gesellschaft |
Zusammensetzung und verfahren zum nachweis von krankheiten in zusammenhang mit der bildung von amyloid-ähnlichen fibrillen oder protein-aggregaten
|
|
US7964192B1
(en)
|
1997-12-02 |
2011-06-21 |
Janssen Alzheimer Immunotherapy |
Prevention and treatment of amyloidgenic disease
|
|
TWI239847B
(en)
*
|
1997-12-02 |
2005-09-21 |
Elan Pharm Inc |
N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
|
|
US6923964B1
(en)
*
|
1997-12-02 |
2005-08-02 |
Neuralab Limited |
Active immunization of AScr for prion disorders
|
|
US6710226B1
(en)
*
|
1997-12-02 |
2004-03-23 |
Neuralab Limited |
Transgenic mouse assay to determine the effect of Aβ antibodies and Aβ Fragments on alzheimer's disease characteristics
|
|
US6787523B1
(en)
*
|
1997-12-02 |
2004-09-07 |
Neuralab Limited |
Prevention and treatment of amyloidogenic disease
|
|
US6913745B1
(en)
*
|
1997-12-02 |
2005-07-05 |
Neuralab Limited |
Passive immunization of Alzheimer's disease
|
|
US6761888B1
(en)
*
|
2000-05-26 |
2004-07-13 |
Neuralab Limited |
Passive immunization treatment of Alzheimer's disease
|
|
US6743427B1
(en)
*
|
1997-12-02 |
2004-06-01 |
Neuralab Limited |
Prevention and treatment of amyloidogenic disease
|
|
JP4430815B2
(ja)
|
1998-02-09 |
2010-03-10 |
ベーリンガー インゲルハイム インターナショナルゲゼルシャフト ミット ベシュレンクテル ハフツング |
パーキンソン病に関与するdnaまたは遺伝子
|
|
WO1999050300A1
(en)
*
|
1998-03-30 |
1999-10-07 |
The Trustees Of The University Of Pennsylvania |
Method of identifying, diagnosing and treating synuclein positive neurodegenerative disorders
|
|
WO1999060024A1
(en)
|
1998-05-21 |
1999-11-25 |
The University Of Tennessee Research Corporation |
Methods for amyloid removal using anti-amyloid antibodies
|
|
US6184351B1
(en)
*
|
1998-09-25 |
2001-02-06 |
Amgen Inc. |
α-synuclein super-mutants accelerate α-synuclein aggregation
|
|
AU6288499A
(en)
|
1998-10-06 |
2000-04-26 |
Regents Of The University Of California, The |
Method for screening for anti-amyloidogenic properties and method for treatment of neurodegenerative disease
|
|
US6172122B1
(en)
*
|
1998-12-17 |
2001-01-09 |
The Lubrizol Corporation |
Stable emulsions from gelled overbased substrates with surfactants and aqueous liquids
|
|
UA81216C2
(en)
|
1999-06-01 |
2007-12-25 |
|
Prevention and treatment of amyloid disease
|
|
US20040146521A1
(en)
*
|
1999-06-01 |
2004-07-29 |
Schenk Dale B. |
Prevention and treatment of synucleinopathic disease
|
|
JP2003531570A
(ja)
*
|
1999-07-27 |
2003-10-28 |
アブジェニックス インク. |
神経障害に関連したポリペプチド蓄積を阻害する方法および組成物
|
|
GB9924513D0
(en)
*
|
1999-10-15 |
1999-12-15 |
Novartis Ag |
Organic compounds
|
|
US20020094335A1
(en)
*
|
1999-11-29 |
2002-07-18 |
Robert Chalifour |
Vaccine for the prevention and treatment of alzheimer's and amyloid related diseases
|
|
WO2001053457A2
(en)
|
2000-01-21 |
2001-07-26 |
University Of Connecticut Health Center |
Vaccines against neurodegenerative disorders
|
|
AU2001238612A1
(en)
|
2000-02-18 |
2001-08-27 |
The Regents Of The University Of California |
Method for screening for anti-amyloidogenic properties and method for treatment of neurodegenerative disease
|
|
ES2248283T3
(es)
*
|
2000-02-21 |
2006-03-16 |
Pharmexa A/S |
Nuevo procedimiento para reducir los niveles de amiloide.
|
|
AU783144B2
(en)
*
|
2000-02-21 |
2005-09-29 |
H. Lundbeck A/S |
Novel method for down-regulation of amyloid
|
|
WO2001079283A1
(en)
|
2000-04-13 |
2001-10-25 |
University Of British Columbia |
Modulating cell survival by modulating huntingtin function
|
|
US6784291B2
(en)
*
|
2000-05-04 |
2004-08-31 |
Avi Biopharma, Inc. |
Splice-region antisense composition and method
|
|
JP2004502781A
(ja)
*
|
2000-07-07 |
2004-01-29 |
パナシア ファーマシューティカルズ インコーポレーテッド |
神経組織の損傷を予防するため、およびα−シヌクレイン疾患を処置するための方法
|
|
EP1309341A2
(en)
|
2000-07-07 |
2003-05-14 |
Lars Lannfelt |
Prevention and treatment of alzheimer's disease
|
|
TWI255272B
(en)
*
|
2000-12-06 |
2006-05-21 |
Guriq Basi |
Humanized antibodies that recognize beta amyloid peptide
|
|
JP4055579B2
(ja)
*
|
2000-12-13 |
2008-03-05 |
大正製薬株式会社 |
新規抗体
|
|
US20020160394A1
(en)
*
|
2001-01-24 |
2002-10-31 |
Bayer Corporation |
Regulation of transthyretin to treat obesity
|
|
US6815175B2
(en)
*
|
2001-03-16 |
2004-11-09 |
Cornell Research Foundation, Inc. |
Anti-amyloid peptide antibody based diagnosis and treatment of a neurological disease or disorder
|
|
WO2003000714A2
(en)
|
2001-06-22 |
2003-01-03 |
Panacea Pharmaceuticals, Inc. |
Compositions and methods for preventing protein aggregation in neurodegenerative diseases
|
|
MY144532A
(en)
*
|
2001-08-20 |
2011-09-30 |
Lundbeck & Co As H |
Novel method for down-regulation of amyloid
|
|
KR100506766B1
(ko)
*
|
2001-11-20 |
2005-08-05 |
(주)에이티젠 |
환경 스트레스에 내성을 부여하는 신규한 펩타이드 및이를 포함하는 융합단백질
|
|
US7479482B2
(en)
*
|
2001-11-21 |
2009-01-20 |
New York University |
Synthetic immunogenic but non-deposit-forming polypeptides and peptides homologous to amyloid β, prion protein, amylin, α-synuclein, or polyglutamine repeats for induction of an immune response thereto
|
|
GB0203446D0
(en)
*
|
2002-02-14 |
2002-04-03 |
Univ Lancaster |
Detection and/or monitoring of synuclein-related diseases
|
|
GB0216972D0
(en)
|
2002-07-22 |
2002-08-28 |
Univ Lancaster |
Peptides and peptide derivaties for the treatment of &-synuclein-related diseases
|
|
ATE429639T1
(de)
*
|
2002-09-30 |
2009-05-15 |
Univ Auburn |
Verfahren und isolierung zur selbstzusammenlagerung kleiner proteinpartikel aus blut und anderen biologischen materialien
|
|
US8506959B2
(en)
*
|
2002-11-01 |
2013-08-13 |
Neotope Biosciences Limited |
Prevention and treatment of synucleinopathic and amyloidogenic disease
|
|
US8697082B2
(en)
*
|
2002-11-01 |
2014-04-15 |
Neotope Biosciences Limited |
Prevention and treatment of synucleinopathic and amyloidogenic disease
|
|
TW200509968A
(en)
*
|
2002-11-01 |
2005-03-16 |
Elan Pharm Inc |
Prevention and treatment of synucleinopathic disease
|
|
US9034337B2
(en)
*
|
2003-10-31 |
2015-05-19 |
Prothena Biosciences Limited |
Treatment and delay of outset of synucleinopathic and amyloidogenic disease
|
|
US20080014194A1
(en)
*
|
2003-10-31 |
2008-01-17 |
Elan Pharmaceuticals, Inc. |
Prevention and Treatment of Synucleinopathic and Amyloidogenic Disease
|
|
US7358331B2
(en)
|
2003-05-19 |
2008-04-15 |
Elan Pharmaceuticals, Inc. |
Truncated fragments of alpha-synuclein in Lewy body disease
|
|
HUE035044T2
(en)
*
|
2003-05-19 |
2018-05-02 |
Prothena Biosciences Ltd |
Truncated fragments of alpha-synuclein in Lewy-body disease
|
|
US7674599B2
(en)
*
|
2003-11-08 |
2010-03-09 |
Elan Pharmaceuticals, Inc. |
Methods of using antibodies to detect alpha-synuclein in fluid samples
|
|
US20050203010A1
(en)
*
|
2003-11-14 |
2005-09-15 |
Atgen Co., Ltd. |
Novel peptides conferring environmental stress resistance
and fusion proteins including said peptides
|
|
MX2007001679A
(es)
|
2004-08-09 |
2007-05-23 |
Elan Pharm Inc |
Prevencion y tratamiento de la enfermedad sinucleinopatica y amiloidogenica.
|
|
CA2657953A1
(en)
|
2005-07-19 |
2007-01-25 |
University Of Rochester |
Alpha-synuclein antibodies and methods related thereto
|
|
WO2007021255A1
(en)
|
2005-08-09 |
2007-02-22 |
Elan Pharmaceuticals, Inc. |
Antibodies to alpha-synuclein
|
|
JP5558834B2
(ja)
|
2007-02-23 |
2014-07-23 |
ヤンセン アルツハイマー イミュノセラピー |
シヌクレイノパチーおよびアミロイド形成疾患(amyloidogenicdisease)の予防および処置
|
|
US8147833B2
(en)
*
|
2007-02-23 |
2012-04-03 |
Neotope Biosciences Limited |
Prevention and treatment of synucleinopathic and amyloidogenic disease
|