JP2006500032A5 - - Google Patents
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- Publication number
- JP2006500032A5 JP2006500032A5 JP2004538310A JP2004538310A JP2006500032A5 JP 2006500032 A5 JP2006500032 A5 JP 2006500032A5 JP 2004538310 A JP2004538310 A JP 2004538310A JP 2004538310 A JP2004538310 A JP 2004538310A JP 2006500032 A5 JP2006500032 A5 JP 2006500032A5
- Authority
- JP
- Japan
- Prior art keywords
- nfat
- receptor
- antibody
- seq
- activated receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108020003175 receptors Proteins 0.000 claims 38
- 102000005962 receptors Human genes 0.000 claims 36
- 238000000034 method Methods 0.000 claims 11
- 230000003213 activating effect Effects 0.000 claims 10
- 239000002773 nucleotide Substances 0.000 claims 10
- 125000003729 nucleotide group Chemical group 0.000 claims 10
- 229920001184 polypeptide Polymers 0.000 claims 10
- 102000004196 processed proteins & peptides Human genes 0.000 claims 10
- 108090000765 processed proteins & peptides Proteins 0.000 claims 10
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 8
- 239000005557 antagonist Substances 0.000 claims 8
- 239000012634 fragment Substances 0.000 claims 7
- 210000001124 body fluid Anatomy 0.000 claims 6
- 239000010839 body fluid Substances 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 6
- 108020004414 DNA Proteins 0.000 claims 5
- 125000003275 alpha amino acid group Chemical group 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 4
- 102000004127 Cytokines Human genes 0.000 claims 4
- 108090000695 Cytokines Proteins 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 108091033319 polynucleotide Proteins 0.000 claims 4
- 102000040430 polynucleotide Human genes 0.000 claims 4
- 239000002157 polynucleotide Substances 0.000 claims 4
- 238000013518 transcription Methods 0.000 claims 4
- 230000035897 transcription Effects 0.000 claims 4
- 238000013519 translation Methods 0.000 claims 4
- 239000000556 agonist Substances 0.000 claims 3
- 239000000427 antigen Substances 0.000 claims 3
- 102000036639 antigens Human genes 0.000 claims 3
- 108091007433 antigens Proteins 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
- 239000013604 expression vector Substances 0.000 claims 3
- 230000001939 inductive effect Effects 0.000 claims 3
- 230000003449 preventive effect Effects 0.000 claims 3
- 239000002464 receptor antagonist Substances 0.000 claims 3
- 229940044551 receptor antagonist Drugs 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 230000000692 anti-sense effect Effects 0.000 claims 2
- 239000000356 contaminant Substances 0.000 claims 2
- 239000012530 fluid Substances 0.000 claims 2
- 208000026278 immune system disease Diseases 0.000 claims 2
- 239000000018 receptor agonist Substances 0.000 claims 2
- 229940044601 receptor agonist Drugs 0.000 claims 2
- 238000012216 screening Methods 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 102000053642 Catalytic RNA Human genes 0.000 claims 1
- 108090000994 Catalytic RNA Proteins 0.000 claims 1
- 241000282412 Homo Species 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 108010018525 NFATC Transcription Factors Proteins 0.000 claims 1
- 102000002673 NFATC Transcription Factors Human genes 0.000 claims 1
- 108091030071 RNAI Chemical class 0.000 claims 1
- 230000009471 action Effects 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 230000007815 allergy Effects 0.000 claims 1
- 230000000890 antigenic effect Effects 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 230000008827 biological function Effects 0.000 claims 1
- 230000000903 blocking effect Effects 0.000 claims 1
- 230000001413 cellular effect Effects 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000009368 gene silencing by RNA Effects 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 230000002452 interceptive effect Effects 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 108091092562 ribozyme Proteins 0.000 claims 1
- 230000009261 transgenic effect Effects 0.000 claims 1
- 230000007704 transition Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41215702P | 2002-09-19 | 2002-09-19 | |
| PCT/US2003/029643 WO2004027079A2 (en) | 2002-09-19 | 2003-09-19 | Nuclear factor of activated t cells receptor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006500032A JP2006500032A (ja) | 2006-01-05 |
| JP2006500032A5 true JP2006500032A5 (enExample) | 2006-03-09 |
Family
ID=32030815
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004538310A Pending JP2006500032A (ja) | 2002-09-19 | 2003-09-19 | 活性化t細胞受容体の核因子 |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US20060292668A1 (enExample) |
| EP (1) | EP1562980A4 (enExample) |
| JP (1) | JP2006500032A (enExample) |
| CN (1) | CN1688601A (enExample) |
| AU (1) | AU2003287008A1 (enExample) |
| CA (1) | CA2497937A1 (enExample) |
| MX (1) | MXPA05002818A (enExample) |
| WO (1) | WO2004027079A2 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2329636B2 (es) | 2006-02-17 | 2010-07-26 | Universitat De Valencia, Estudi General (Participa Con El 70%) | Uso del factor pedf para inducir la auto-renovacion de celulas madre. |
| CN105177031B (zh) * | 2015-06-12 | 2018-04-24 | 北京艺妙神州医疗科技有限公司 | 嵌合抗原受体修饰的t细胞及其用途 |
| US10573722B2 (en) * | 2016-02-17 | 2020-02-25 | General Electric Company | Systems and methods for in-situ doped semiconductor gate electrodes for wide bandgap semiconductor power devices |
| CN106519005B (zh) * | 2016-11-14 | 2019-12-24 | 深圳大学 | 磷酸化nfat3突变体及其应用 |
| CN120290711A (zh) * | 2020-04-14 | 2025-07-11 | 北京英朗超显医疗科技有限公司 | Nfam1在制备评估冠心病风险试剂盒中的应用 |
| CN111454952A (zh) * | 2020-04-14 | 2020-07-28 | 台州市立医院 | 一种可抑制nfat基因的靶序列的筛选方法及其应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5837840A (en) * | 1993-09-20 | 1998-11-17 | Board Of Trustees Of Leland Stanford Jr. University | NF-AT polypeptides and polynucleotides |
| US6352830B1 (en) * | 1991-08-22 | 2002-03-05 | The Board Of Trustees Of The Leland Stanford Junior University | NF-AT polypeptides and polynucleotides and screening methods for immunosuppressive agents |
| US6197925B1 (en) * | 1991-08-22 | 2001-03-06 | Sara Lee Corporation | NF-AT polypeptides and polynucleotides |
| US6436703B1 (en) * | 2000-03-31 | 2002-08-20 | Hyseq, Inc. | Nucleic acids and polypeptides |
| WO2002028999A2 (en) * | 2000-10-03 | 2002-04-11 | Gene Logic, Inc. | Gene expression profiles in granulocytic cells |
| WO2003016506A2 (en) * | 2001-08-17 | 2003-02-27 | Incyte Genomics, Inc. | Secreted proteins |
-
2003
- 2003-09-19 JP JP2004538310A patent/JP2006500032A/ja active Pending
- 2003-09-19 CN CNA038221330A patent/CN1688601A/zh active Pending
- 2003-09-19 WO PCT/US2003/029643 patent/WO2004027079A2/en not_active Ceased
- 2003-09-19 CA CA002497937A patent/CA2497937A1/en not_active Abandoned
- 2003-09-19 MX MXPA05002818A patent/MXPA05002818A/es unknown
- 2003-09-19 EP EP03777528A patent/EP1562980A4/en not_active Withdrawn
- 2003-09-19 US US10/528,326 patent/US20060292668A1/en not_active Abandoned
- 2003-09-19 AU AU2003287008A patent/AU2003287008A1/en not_active Abandoned
-
2008
- 2008-01-18 US US12/016,447 patent/US20090022710A1/en not_active Abandoned
-
2009
- 2009-12-11 US US12/636,541 patent/US20100173383A1/en not_active Abandoned
-
2010
- 2010-11-04 US US12/939,385 patent/US20110124081A1/en not_active Abandoned
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