JP2002542157A5 - - Google Patents
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- Publication number
- JP2002542157A5 JP2002542157A5 JP2000604070A JP2000604070A JP2002542157A5 JP 2002542157 A5 JP2002542157 A5 JP 2002542157A5 JP 2000604070 A JP2000604070 A JP 2000604070A JP 2000604070 A JP2000604070 A JP 2000604070A JP 2002542157 A5 JP2002542157 A5 JP 2002542157A5
- Authority
- JP
- Japan
- Prior art keywords
- gpr
- antigen
- antibody
- binding
- binding fragment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102100036303 C-C chemokine receptor type 9 Human genes 0.000 description 51
- 101000716070 Homo sapiens C-C chemokine receptor type 9 Proteins 0.000 description 51
- 239000000427 antigen Substances 0.000 description 47
- 102000036639 antigens Human genes 0.000 description 47
- 108091007433 antigens Proteins 0.000 description 47
- 239000012634 fragment Substances 0.000 description 42
- 239000003446 ligand Substances 0.000 description 24
- 238000000034 method Methods 0.000 description 24
- 101000897486 Homo sapiens C-C motif chemokine 25 Proteins 0.000 description 22
- 210000004027 cell Anatomy 0.000 description 21
- 239000003814 drug Substances 0.000 description 14
- 102000005962 receptors Human genes 0.000 description 14
- 108020003175 receptors Proteins 0.000 description 14
- 239000003795 chemical substances by application Substances 0.000 description 13
- 239000005557 antagonist Substances 0.000 description 7
- 239000012472 biological sample Substances 0.000 description 7
- 238000004519 manufacturing process Methods 0.000 description 7
- 230000004044 response Effects 0.000 description 6
- 229940124597 therapeutic agent Drugs 0.000 description 5
- 206010028980 Neoplasm Diseases 0.000 description 3
- 201000011510 cancer Diseases 0.000 description 3
- 108020001507 fusion proteins Proteins 0.000 description 3
- 102000037865 fusion proteins Human genes 0.000 description 3
- 210000004408 hybridoma Anatomy 0.000 description 3
- 229940127121 immunoconjugate Drugs 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
- 208000011231 Crohn disease Diseases 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 230000035605 chemotaxis Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000004907 flux Effects 0.000 description 2
- 102000046956 human CCL25 Human genes 0.000 description 2
- 208000027866 inflammatory disease Diseases 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 210000000265 leukocyte Anatomy 0.000 description 2
- 230000001404 mediated effect Effects 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 102000004900 CC chemokine receptor 9 Human genes 0.000 description 1
- 108090001026 CC chemokine receptor 9 Proteins 0.000 description 1
- 208000014997 Crohn colitis Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 description 1
- 239000007801 affinity label Substances 0.000 description 1
- 125000003275 alpha amino acid group Chemical group 0.000 description 1
- 210000003719 b-lymphocyte Anatomy 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 229940127089 cytotoxic agent Drugs 0.000 description 1
- 239000002254 cytotoxic agent Substances 0.000 description 1
- 231100000599 cytotoxic agent Toxicity 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 210000004379 membrane Anatomy 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/266,464 | 1999-03-11 | ||
| US09/266,464 US6329159B1 (en) | 1999-03-11 | 1999-03-11 | Anti-GPR-9-6 antibodies and methods of identifying agents which modulate GPR-9-6 function |
| PCT/US2000/006240 WO2000053635A1 (en) | 1999-03-11 | 2000-03-10 | Anti-gpr-9-6 and anti-teck antibodies and methods of identifying modulators of gpr-9-6 and teck functions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011178577A Division JP5933204B2 (ja) | 1999-03-11 | 2011-08-17 | 抗ｇｐｒ−９−６および抗ｔｅｃｋ抗体ならびにｇｐｒ−９−６およびｔｅｃｋの機能の調節因子の同定方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002542157A JP2002542157A (ja) | 2002-12-10 |
| JP2002542157A5 true JP2002542157A5 (enExample) | 2007-04-05 |
| JP5112578B2 JP5112578B2 (ja) | 2013-01-09 |
Family
ID=23014693
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000604070A Expired - Lifetime JP5112578B2 (ja) | 1999-03-11 | 2000-03-10 | 抗ｇｐｒ−９−６および抗ｔｅｃｋ抗体ならびにｇｐｒ−９−６およびｔｅｃｋの機能の調節因子の同定方法。 |
| JP2011178577A Expired - Lifetime JP5933204B2 (ja) | 1999-03-11 | 2011-08-17 | 抗ｇｐｒ−９−６および抗ｔｅｃｋ抗体ならびにｇｐｒ−９−６およびｔｅｃｋの機能の調節因子の同定方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011178577A Expired - Lifetime JP5933204B2 (ja) | 1999-03-11 | 2011-08-17 | 抗ｇｐｒ−９−６および抗ｔｅｃｋ抗体ならびにｇｐｒ−９−６およびｔｅｃｋの機能の調節因子の同定方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (6) | US6329159B1 (enExample) |
| EP (1) | EP1157043B2 (enExample) |
| JP (2) | JP5112578B2 (enExample) |
| AT (1) | ATE517123T1 (enExample) |
| AU (1) | AU771603B2 (enExample) |
| CA (1) | CA2365230C (enExample) |
| WO (1) | WO2000053635A1 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE255888T1 (de) * | 1998-06-01 | 2003-12-15 | Ortho Mcneil Pharm Inc | Tetrahydronaphtalene verbindungen und deren verwendung zur behandlung von neurodegenerativen krankheiten |
| US20050100548A1 (en) * | 2001-07-24 | 2005-05-12 | Biogen Idec Ma Inc. | BAFF, inhibitors thereof and their use in the modulation of B-cell response |
| US6329159B1 (en) | 1999-03-11 | 2001-12-11 | Millennium Pharmaceuticals, Inc. | Anti-GPR-9-6 antibodies and methods of identifying agents which modulate GPR-9-6 function |
| US6698636B2 (en) * | 2000-09-28 | 2004-03-02 | June Angus | Waist pouch |
| US7468253B2 (en) * | 2001-06-07 | 2008-12-23 | Chemocentryx, Inc. | Method for multiple chemokine receptor screening for antagonists using RAM assay |
| EP1717583A3 (en) * | 2001-06-07 | 2007-10-10 | ChemoCentryx Inc | Cell migration assay |
| NO20013192L (no) * | 2001-06-25 | 2002-12-27 | Medinnova As | Metode for monitering av T-celler |
| US7413866B2 (en) * | 2001-11-30 | 2008-08-19 | Chemocentryx, Inc. | Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors |
| US7871619B2 (en) * | 2001-11-30 | 2011-01-18 | Chemocentryx, Inc. | Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors |
| US7442512B2 (en) * | 2001-11-30 | 2008-10-28 | Chemocentryx, Inc. | Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors |
| US7253007B2 (en) * | 2001-11-30 | 2007-08-07 | Chemocentryx, Inc. | Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors |
| WO2003095967A2 (en) * | 2002-05-14 | 2003-11-20 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with chemokine receptor 9(ccr9) |
| EP1507756B1 (en) * | 2002-05-24 | 2015-07-22 | Millennium Pharmaceuticals, Inc. | Ccr9 inhibitors and methods of use thereof |
| US7964194B2 (en) * | 2002-11-15 | 2011-06-21 | Morehouse School Of Medicine | Anti-chemokine and associated receptor antibodies and uses for inhibition of inflammation |
| US9233120B2 (en) * | 2002-11-15 | 2016-01-12 | Jyant Technologies | Anti-CCL25 and anti-CCR9 antibodies for the prevention and treatment of cancer and cancer cell migration |
| US7919083B2 (en) * | 2002-11-15 | 2011-04-05 | Morehouse School Of Medicine | Anti-chemokine and associated receptors antibodies for inhibition of growth of neoplasms |
| US8512701B2 (en) | 2002-11-15 | 2013-08-20 | Morehouse School Of Medicine | Anti-CXCL13 and anti-CXCR5 antibodies for the prevention and treatment of cancer and cancer cell migration |
| US20120135415A1 (en) * | 2002-11-15 | 2012-05-31 | Morehouse School Of Medicine | Detecting cancer with anti-cxcl13 and anti-cxcr5 antibodies |
| US8658377B2 (en) | 2002-11-15 | 2014-02-25 | Morehouse School Of Medicine | Detecting cancer with anti-CCL25 and anti-CCR9 antibodies |
| CA2511242C (en) * | 2002-12-20 | 2010-01-12 | Anita Melikian | Inhibitors of human tumor-expressed ccxckr2 |
| MXPA05011409A (es) | 2003-04-23 | 2005-12-12 | Medarex Inc | Composiciones y metodos para la terapia de enfermedad inflamatoria intestinal. |
| US20100247540A1 (en) * | 2003-10-30 | 2010-09-30 | Chemocentryx, Inc. | Methods and Compositions For Modulating Angiogenesis |
| ZA200608572B (en) * | 2004-04-16 | 2008-06-25 | Genentech Inc | Assay for antibodies |
| PT1781705E (pt) | 2004-06-21 | 2014-12-23 | Medarex Llc | Anticorpos contra recetor i do interferão alfa e as suas utilizações |
| EP1871804B1 (en) * | 2005-04-21 | 2013-08-28 | ChemoCentryx, Inc. | Antibodies that bind ccx-ckr2 |
| CA2883711A1 (en) | 2012-09-07 | 2014-03-13 | The Governors Of The University Of Alberta | Methods and compositions for diagnosis of inflammatory liver disease |
| EP2876114A1 (en) * | 2013-11-25 | 2015-05-27 | Consejo Superior De Investigaciones Científicas | Antibodies against CCR9 and applications thereof |
| EP3416641A1 (en) | 2016-02-16 | 2018-12-26 | Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts | Modulators of ccr9 for treating tumor resistance to immune responses |
| EP3416640A1 (en) | 2016-02-16 | 2018-12-26 | Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts | Modulators of tumor immune resistance for the treatment of cancer |
| WO2018106931A1 (en) | 2016-12-07 | 2018-06-14 | Progenity Inc. | Gastrointestinal tract detection methods, devices and systems |
| CA3045310A1 (en) | 2016-12-14 | 2018-06-21 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with a chemokine/chemokine receptor inhibitor |
| CN116726361A (zh) | 2018-11-19 | 2023-09-12 | 比奥拉治疗股份有限公司 | 用生物治疗剂治疗疾病的方法和装置 |
| US11707610B2 (en) | 2019-12-13 | 2023-07-25 | Biora Therapeutics, Inc. | Ingestible device for delivery of therapeutic agent to the gastrointestinal tract |
| JP2025505543A (ja) | 2022-02-03 | 2025-02-28 | サンロック・バイオファルマ・ソシエダッド・リミターダ | 抗ｃｃｒ９抗体およびビンクリスチンを含むがんの併用療法 |
| JP7368678B1 (ja) | 2023-04-26 | 2023-10-25 | イミュニティリサーチ株式会社 | Ｃｄ４＋ｔ細胞集団中の特定の細胞亜集団の相対量の測定方法 |
| EP4578874A1 (en) * | 2023-12-29 | 2025-07-02 | SunRock Biopharma S.L. | Anti-ccr9 antibody |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US18167A (en) * | 1857-09-08 | Improvement in blast-furnaces | ||
| US5440021A (en) * | 1991-03-29 | 1995-08-08 | Chuntharapai; Anan | Antibodies to human IL-8 type B receptor |
| US5652133A (en) | 1993-01-28 | 1997-07-29 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Cloning and expression of the human macrophage inflammatory protein-1.alpha.α) /rantes receptor |
| EP2034023A1 (en) * | 1996-03-01 | 2009-03-11 | Euroscreen S.A. | C-C CKR-5 ,CC-Chemikines receptor, derivatives thereof and their uses |
| US5981231A (en) | 1996-06-17 | 1999-11-09 | Human Genome Sciences, Inc. | Polynucleotides encoding chemokine β-15 |
| JP2000515733A (ja) | 1996-06-17 | 2000-11-28 | ヒューマン・ジェノム・サイエンシズ・インコーポレイテッド | ケモカインβ―１５ |
| US6723520B2 (en) | 1996-07-05 | 2004-04-20 | Schering Corporation | Antibodies that bind chemokine teck |
| EP0909321A2 (en) | 1996-07-05 | 1999-04-21 | Schering Corporation | Mammalian chemokine reagents |
| DE69737656T2 (de) * | 1996-09-10 | 2008-01-03 | Theodor Kocher Institut | Cxcr3 chemokine rezeptor, antikoerper, nukleinsaeure und deren verfahren zur anwendung |
| WO1998032858A2 (en) | 1997-01-23 | 1998-07-30 | Schering Corporation | Mammalian chemokines; receptors; reagents; uses |
| EP0878542A3 (en) * | 1997-04-22 | 2000-04-19 | Smithkline Beecham Corporation | cDNA clone HMTMF81 that encodes a novel human 7-transmembrane receptor |
| EP1019502A2 (en) * | 1997-08-06 | 2000-07-19 | Regeneron Pharmaceuticals, Inc. | Human orphan receptor ntr-1 |
| US6329159B1 (en) * | 1999-03-11 | 2001-12-11 | Millennium Pharmaceuticals, Inc. | Anti-GPR-9-6 antibodies and methods of identifying agents which modulate GPR-9-6 function |
| YU78601A (sh) * | 1999-05-05 | 2005-07-19 | Aventis Pharma Deutschland Gmbh. | 1-(p-tienilbenzil)-imidazoli kao agonisti angiotenzin-(1-7)- receptora, postupak za njihovu proizvodnju, njihova primena i farmaceutski preparati koji ih sadrže |
| AU3247201A (en) * | 2000-01-07 | 2001-07-16 | Stichting Klinische Farmacologie | Gene therapy to promote angiogenesis and/or the treatment of heart failure |
| EP1562940B1 (en) | 2002-11-18 | 2007-05-30 | ChemoCentryx Inc | Aryl sulfonamides |
-
1999
- 1999-03-11 US US09/266,464 patent/US6329159B1/en not_active Expired - Lifetime
-
2000
- 2000-03-10 US US09/522,752 patent/US6936248B1/en not_active Expired - Lifetime
- 2000-03-10 JP JP2000604070A patent/JP5112578B2/ja not_active Expired - Lifetime
- 2000-03-10 AU AU35226/00A patent/AU771603B2/en not_active Expired
- 2000-03-10 AT AT00913864T patent/ATE517123T1/de not_active IP Right Cessation
- 2000-03-10 WO PCT/US2000/006240 patent/WO2000053635A1/en not_active Ceased
- 2000-03-10 CA CA2365230A patent/CA2365230C/en not_active Expired - Lifetime
- 2000-03-10 EP EP00913864.5A patent/EP1157043B2/en not_active Expired - Lifetime
-
2001
- 2001-09-13 US US09/952,385 patent/US6689570B2/en not_active Expired - Lifetime
- 2001-09-28 US US09/966,755 patent/US6884574B2/en not_active Expired - Lifetime
- 2001-10-23 US US10/000,759 patent/US7485301B2/en not_active Expired - Lifetime
-
2005
- 2005-04-19 US US11/109,349 patent/US7381412B2/en not_active Expired - Lifetime
-
2011
- 2011-08-17 JP JP2011178577A patent/JP5933204B2/ja not_active Expired - Lifetime
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