JP2016511823A5 - - Google Patents
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- Publication number
- JP2016511823A5 JP2016511823A5 JP2015553864A JP2015553864A JP2016511823A5 JP 2016511823 A5 JP2016511823 A5 JP 2016511823A5 JP 2015553864 A JP2015553864 A JP 2015553864A JP 2015553864 A JP2015553864 A JP 2015553864A JP 2016511823 A5 JP2016511823 A5 JP 2016511823A5
- Authority
- JP
- Japan
- Prior art keywords
- kininogen
- intact
- value
- cut
- pkal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108010077861 Kininogens Proteins 0.000 claims 50
- 102000010631 Kininogens Human genes 0.000 claims 50
- 238000000034 method Methods 0.000 claims 19
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 13
- 208000035475 disorder Diseases 0.000 claims 11
- 230000001404 mediated effect Effects 0.000 claims 11
- 238000001514 detection method Methods 0.000 claims 7
- 239000003795 chemical substances by application Substances 0.000 claims 6
- 208000024891 symptom Diseases 0.000 claims 5
- 108010058188 Low-Molecular-Weight Kininogen Proteins 0.000 claims 3
- 239000003112 inhibitor Substances 0.000 claims 3
- 230000008961 swelling Effects 0.000 claims 3
- 206010019860 Hereditary angioedema Diseases 0.000 claims 2
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 claims 2
- 206010030113 Oedema Diseases 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 230000003993 interaction Effects 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 208000024780 Urticaria Diseases 0.000 claims 1
- 230000001387 anti-histamine Effects 0.000 claims 1
- 239000000739 antihistaminic agent Substances 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000003246 corticosteroid Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229960001340 histamine Drugs 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000002093 peripheral effect Effects 0.000 claims 1
- 230000000306 recurrent effect Effects 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 238000001262 western blot Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361754607P | 2013-01-20 | 2013-01-20 | |
| US61/754,607 | 2013-01-20 | ||
| PCT/US2014/012107 WO2014113712A1 (en) | 2013-01-20 | 2014-01-17 | Evaluation and treatment of bradykinin-mediated disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018221155A Division JP6772237B2 (ja) | 2013-01-20 | 2018-11-27 | ブラジキニン媒介障害の評価および治療 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016511823A JP2016511823A (ja) | 2016-04-21 |
| JP2016511823A5 true JP2016511823A5 (enExample) | 2017-02-23 |
| JP6444315B2 JP6444315B2 (ja) | 2018-12-26 |
Family
ID=51210106
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015553864A Active JP6444315B2 (ja) | 2013-01-20 | 2014-01-17 | ブラジキニン媒介障害の評価および治療 |
| JP2018221155A Active JP6772237B2 (ja) | 2013-01-20 | 2018-11-27 | ブラジキニン媒介障害の評価および治療 |
| JP2020164435A Pending JP2021008483A (ja) | 2013-01-20 | 2020-09-30 | ブラジキニン媒介障害の評価および治療 |
| JP2022029441A Active JP7496380B2 (ja) | 2013-01-20 | 2022-02-28 | ブラジキニン媒介障害の評価および治療 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018221155A Active JP6772237B2 (ja) | 2013-01-20 | 2018-11-27 | ブラジキニン媒介障害の評価および治療 |
| JP2020164435A Pending JP2021008483A (ja) | 2013-01-20 | 2020-09-30 | ブラジキニン媒介障害の評価および治療 |
| JP2022029441A Active JP7496380B2 (ja) | 2013-01-20 | 2022-02-28 | ブラジキニン媒介障害の評価および治療 |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US11156612B2 (enExample) |
| EP (3) | EP3456744B1 (enExample) |
| JP (4) | JP6444315B2 (enExample) |
| KR (3) | KR102381478B1 (enExample) |
| CN (2) | CN111044725B (enExample) |
| AU (4) | AU2014207420B2 (enExample) |
| CA (2) | CA3209608A1 (enExample) |
| CY (1) | CY1122164T1 (enExample) |
| DK (1) | DK2948479T3 (enExample) |
| ES (1) | ES2692408T3 (enExample) |
| HR (1) | HRP20181734T1 (enExample) |
| HU (1) | HUE041332T2 (enExample) |
| IL (2) | IL273688B2 (enExample) |
| LT (1) | LT2948479T (enExample) |
| PL (1) | PL2948479T3 (enExample) |
| PT (1) | PT2948479T (enExample) |
| RS (1) | RS57890B1 (enExample) |
| SI (1) | SI2948479T1 (enExample) |
| SM (1) | SMT201800563T1 (enExample) |
| TR (1) | TR201815856T4 (enExample) |
| WO (1) | WO2014113712A1 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2905545T3 (es) | 2010-01-06 | 2022-04-11 | Takeda Pharmaceuticals Co | Proteínas de unión a calicreína plasmática |
| IL269565B2 (en) | 2011-01-06 | 2024-06-01 | Dyax Corp | Plasma kallikrein binding proteins |
| CN111044725B (zh) | 2013-01-20 | 2024-03-29 | 武田药品工业株式会社 | 缓激肽介导的病症的评估和治疗 |
| EP2970502A4 (en) | 2013-03-15 | 2016-11-30 | Dyax Corp | ANTI-PLASMA KALLIKREIN ANTIBODY |
| TWI636047B (zh) | 2013-08-14 | 2018-09-21 | 英商卡爾維斯塔製藥有限公司 | 雜環衍生物 |
| PT3060908T (pt) | 2013-10-21 | 2021-05-27 | Dyax Corp | Diagnóstico e tratamento de doenças autoimunes |
| KR20250066486A (ko) | 2013-10-21 | 2025-05-13 | 다케다 파머수티컬 컴패니 리미티드 | 혈장 칼리크레인 시스템 바이오마커를 결정하기 위한 검정법 |
| KR102424183B1 (ko) | 2014-01-21 | 2022-07-26 | 다케다 파머수티컬 컴패니 리미티드 | 혈장 칼리크레인 결합 단백질 및 유전성 혈관부종을 치료하는 데 있어서의 이의 용도 |
| EP3122782A4 (en) | 2014-03-27 | 2017-09-13 | Dyax Corp. | Compositions and methods for treatment of diabetic macular edema |
| GB201421083D0 (en) | 2014-11-27 | 2015-01-14 | Kalvista Pharmaceuticals Ltd | Enzyme inhibitors |
| US20180298110A1 (en) * | 2015-03-30 | 2018-10-18 | Dyax Corp. | Plasma kallikrein inhibitors and uses thereof for preventing hereditary angioedema attack |
| JP6903648B2 (ja) * | 2015-10-19 | 2021-07-14 | ダイアックス コーポレーション | 切断高分子量キニノーゲンを検出するイムノアッセイ |
| CN116077648A (zh) * | 2015-12-11 | 2023-05-09 | 武田药品工业株式会社 | 血浆激肽释放酶抑制剂及其治疗遗传性血管性水肿发作的用途 |
| EP3390439B1 (en) * | 2015-12-15 | 2025-03-12 | Takeda Pharmaceutical Company Limited | Peptide quantitation assay for differentiating full-length high molecular weight kininogen (hmwk) and cleaved hmwk |
| HRP20201131T1 (hr) | 2016-05-31 | 2020-10-30 | Kalvista Pharmaceuticals Limited | Derivati pirazola kao inhibitori kalikreina plazme |
| GB201609607D0 (en) | 2016-06-01 | 2016-07-13 | Kalvista Pharmaceuticals Ltd | Polymorphs of N-(3-Fluoro-4-methoxypyridin-2-yl)methyl)-3-(methoxymethyl)-1-({4-((2-oxopy ridin-1-yl)methyl)phenyl}methyl)pyrazole-4-carboxamide and salts |
| EP3513196A1 (en) * | 2016-09-16 | 2019-07-24 | Dyax Corp. | Protein biomarkers for diseases associated with the contact activation system |
| MX2019002918A (es) * | 2016-09-16 | 2019-07-18 | Dyax Corp | Biomarcadores de metabolitos para enfermedades asociadas con el sistema de activacion por contacto. |
| GB201719881D0 (en) | 2017-11-29 | 2018-01-10 | Kalvista Pharmaceuticals Ltd | Solid forms of plasma kallikrein inhibitor and salts thereof |
| DK3716952T3 (da) | 2017-11-29 | 2022-03-14 | Kalvista Pharmaceuticals Ltd | Doseringsformer omfattende en plasmakallikrein-inhibitor |
| WO2019165308A1 (en) * | 2018-02-22 | 2019-08-29 | The Regents Of The University Of California | Threshold-stimulated plasma kallikrein activity as a biomarker for diagnosis of bradykinin-mediated angioedema |
| WO2021028645A1 (en) | 2019-08-09 | 2021-02-18 | Kalvista Pharmaceuticals Limited | Plasma kallikrein inhibitors |
| JP2023521667A (ja) * | 2020-04-04 | 2023-05-25 | 武田薬品工業株式会社 | 血漿カリクレイン阻害剤及び急性呼吸窮迫症候群を処置するためのその使用 |
| CN113777331A (zh) * | 2020-06-09 | 2021-12-10 | 张曼 | 尿液激肽原-1及其多肽片段在烧伤中的应用 |
| EP4548103A2 (en) * | 2022-06-30 | 2025-05-07 | Takeda Pharmaceutical Company Limited | Protein biomarkers for lanadelumab treatment |
Family Cites Families (53)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CA1312564C (en) | 1985-07-12 | 1993-01-12 | Robert W. Colman | Monoclonal antibodies to human plasma prekallikrein and methods of preparing and using same |
| US5047323A (en) | 1986-01-22 | 1991-09-10 | Temple University Of The Commonwealth System Of Higher Education | Method for detecting human kininogen using monoclonal antibodies thereto |
| US4908431A (en) * | 1986-01-22 | 1990-03-13 | Temple University-Of The Commonwealth System Of Higher Education | Monoclonal antibodies to human kininogen and methods of preparing same |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5260203A (en) | 1986-09-02 | 1993-11-09 | Enzon, Inc. | Single polypeptide chain binding molecules |
| US4881175A (en) | 1986-09-02 | 1989-11-14 | Genex Corporation | Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides |
| KR960009766B1 (ko) | 1986-09-10 | 1996-07-24 | 니혼 소오끼 세이야꾸 가부시기가이샤 | 생리 활성물질 측정법 |
| US4882272A (en) | 1986-10-01 | 1989-11-21 | Temple University - Of The Commonwealth System Of Higher Education | High molecular weight kininogen assay |
| US5025796A (en) | 1988-12-01 | 1991-06-25 | The United States Of America As Represented By The Department Of Health And Human Services | Apparatus and methods for determining in vivo response to thermal stimulation in in an unrestrained subject |
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| WO1993003748A1 (en) * | 1991-08-13 | 1993-03-04 | Temple University - Of The Commonwealth System Of Higher Education | Modulation of blood pressure and inhibition of platelet activation with kininogen fragment |
| EP0739355B1 (en) | 1994-01-11 | 2004-09-08 | Dyax Corporation | Kallikrein-inhibiting "kunitz domain" proteins and analogues thereof |
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| JP4346798B2 (ja) | 1999-08-19 | 2009-10-21 | 協和メデックス株式会社 | Ｈｃｖコア抗原の検出または定量方法およびそれに用いる検出または定量試薬。 |
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| US7235530B2 (en) * | 2004-09-27 | 2007-06-26 | Dyax Corporation | Kallikrein inhibitors and anti-thrombolytic agents and uses thereof |
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| EP2369930A4 (en) | 2008-12-02 | 2012-10-03 | Joslin Diabetes Ct | METHOD OF REDUCING BLOOD PRESSURE USING PLASMATIC KALLICREIN INHIBITORS |
| AU2013205086A1 (en) * | 2009-01-06 | 2013-05-16 | Dyax Corp. | Treatment of mucositis with kallikrein inhibitors |
| FR2942233B1 (fr) | 2009-02-19 | 2015-03-13 | Lfb Biotechnologies | Moyens pour la purification d'une proteine du plasma sanguin, et procedes pour sa mise en oeuvre |
| CN102762203A (zh) | 2009-12-18 | 2012-10-31 | 艾克提弗赛特制药股份有限公司 | 血浆激肽释放酶抑制剂的前药 |
| US9206123B2 (en) | 2009-12-18 | 2015-12-08 | Activesite Pharmaceuticals, Inc. | Prodrugs of inhibitors of plasma kallikrein |
| ES2905545T3 (es) * | 2010-01-06 | 2022-04-11 | Takeda Pharmaceuticals Co | Proteínas de unión a calicreína plasmática |
| EP2593121A2 (en) | 2010-07-13 | 2013-05-22 | University Of Rochester | THE cAMP/PKA/HDAC5 PATHWAY AND USES THEREOF |
| AU2011336345B2 (en) | 2010-12-02 | 2016-07-07 | Becton, Dickinson And Company | Blood collection devices containing blood stabilization agent |
| IL269565B2 (en) | 2011-01-06 | 2024-06-01 | Dyax Corp | Plasma kallikrein binding proteins |
| AU2012267546B2 (en) | 2011-06-10 | 2015-12-24 | Ionis Pharmaceuticals, Inc. | Methods for modulating kallikrein (KLKB1) expression |
| US9187749B2 (en) | 2011-06-10 | 2015-11-17 | Isis Pharmaceuticals, Inc. | Methods for modulating factor 12 expression |
| CN111044725B (zh) | 2013-01-20 | 2024-03-29 | 武田药品工业株式会社 | 缓激肽介导的病症的评估和治疗 |
| US20140220552A1 (en) | 2013-02-01 | 2014-08-07 | Becton, Dickinson And Company | Blood collection devices containing contact pathway inhibition additives |
| PT3060908T (pt) | 2013-10-21 | 2021-05-27 | Dyax Corp | Diagnóstico e tratamento de doenças autoimunes |
| KR20250066486A (ko) | 2013-10-21 | 2025-05-13 | 다케다 파머수티컬 컴패니 리미티드 | 혈장 칼리크레인 시스템 바이오마커를 결정하기 위한 검정법 |
| KR102424183B1 (ko) | 2014-01-21 | 2022-07-26 | 다케다 파머수티컬 컴패니 리미티드 | 혈장 칼리크레인 결합 단백질 및 유전성 혈관부종을 치료하는 데 있어서의 이의 용도 |
| JP6903648B2 (ja) | 2015-10-19 | 2021-07-14 | ダイアックス コーポレーション | 切断高分子量キニノーゲンを検出するイムノアッセイ |
-
2014
- 2014-01-17 CN CN201911415224.8A patent/CN111044725B/zh active Active
- 2014-01-17 KR KR1020217000831A patent/KR102381478B1/ko active Active
- 2014-01-17 PT PT14740444T patent/PT2948479T/pt unknown
- 2014-01-17 WO PCT/US2014/012107 patent/WO2014113712A1/en not_active Ceased
- 2014-01-17 KR KR1020157022389A patent/KR102203880B1/ko active Active
- 2014-01-17 JP JP2015553864A patent/JP6444315B2/ja active Active
- 2014-01-17 SM SM20180563T patent/SMT201800563T1/it unknown
- 2014-01-17 RS RS20181235A patent/RS57890B1/sr unknown
- 2014-01-17 PL PL14740444T patent/PL2948479T3/pl unknown
- 2014-01-17 US US14/761,690 patent/US11156612B2/en active Active
- 2014-01-17 ES ES14740444.6T patent/ES2692408T3/es active Active
- 2014-01-17 SI SI201430933T patent/SI2948479T1/sl unknown
- 2014-01-17 CA CA3209608A patent/CA3209608A1/en active Pending
- 2014-01-17 DK DK14740444.6T patent/DK2948479T3/en active
- 2014-01-17 EP EP18186356.4A patent/EP3456744B1/en active Active
- 2014-01-17 IL IL273688A patent/IL273688B2/en unknown
- 2014-01-17 EP EP23164279.4A patent/EP4234583A3/en active Pending
- 2014-01-17 KR KR1020227010217A patent/KR102523810B1/ko active Active
- 2014-01-17 AU AU2014207420A patent/AU2014207420B2/en active Active
- 2014-01-17 TR TR2018/15856T patent/TR201815856T4/tr unknown
- 2014-01-17 LT LTEP14740444.6T patent/LT2948479T/lt unknown
- 2014-01-17 HR HRP20181734TT patent/HRP20181734T1/hr unknown
- 2014-01-17 HU HUE14740444A patent/HUE041332T2/hu unknown
- 2014-01-17 EP EP14740444.6A patent/EP2948479B1/en active Active
- 2014-01-17 CN CN201480005158.6A patent/CN105073778B/zh active Active
- 2014-01-17 CA CA2897336A patent/CA2897336C/en active Active
-
2015
- 2015-06-15 IL IL239428A patent/IL239428B/en active IP Right Grant
-
2018
- 2018-11-01 CY CY20181101140T patent/CY1122164T1/el unknown
- 2018-11-07 AU AU2018260845A patent/AU2018260845B2/en active Active
- 2018-11-27 JP JP2018221155A patent/JP6772237B2/ja active Active
-
2020
- 2020-09-30 JP JP2020164435A patent/JP2021008483A/ja active Pending
- 2020-11-25 AU AU2020277178A patent/AU2020277178B2/en active Active
-
2021
- 2021-10-01 US US17/491,813 patent/US20220170936A1/en active Pending
-
2022
- 2022-02-28 JP JP2022029441A patent/JP7496380B2/ja active Active
-
2024
- 2024-08-09 AU AU2024205664A patent/AU2024205664A1/en active Pending
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