JP2004529194A5 - - Google Patents
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- Publication number
- JP2004529194A5 JP2004529194A5 JP2003500044A JP2003500044A JP2004529194A5 JP 2004529194 A5 JP2004529194 A5 JP 2004529194A5 JP 2003500044 A JP2003500044 A JP 2003500044A JP 2003500044 A JP2003500044 A JP 2003500044A JP 2004529194 A5 JP2004529194 A5 JP 2004529194A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- phenyl
- ncoo
- coo
- alkylene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 65
- -1 R8 is H Chemical group 0.000 claims 12
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 11
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 9
- 125000003118 aryl group Chemical group 0.000 claims 6
- 125000001624 naphthyl group Chemical group 0.000 claims 5
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 4
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 3
- 125000001041 indolyl group Chemical group 0.000 claims 3
- 125000002757 morpholinyl group Chemical group 0.000 claims 3
- 125000003386 piperidinyl group Chemical group 0.000 claims 3
- 125000004076 pyridyl group Chemical group 0.000 claims 3
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 3
- 125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 claims 3
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 2
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 2
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10125567A DE10125567B4 (de) | 2001-05-25 | 2001-05-25 | Carbonamid substituierte Phenylharnstoffderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| DE10207369A DE10207369A1 (de) | 2002-02-21 | 2002-02-21 | Carbonamid substituierte Phenylharnstoffderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| PCT/EP2002/005205 WO2002096864A1 (de) | 2001-05-25 | 2002-05-11 | Carbonsäureamid substituierte phenylharnstoffderivate, verfahren zu ihrer herstellung als arzneimittel |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004529194A JP2004529194A (ja) | 2004-09-24 |
| JP2004529194A5 true JP2004529194A5 (https=) | 2005-12-22 |
| JP4167592B2 JP4167592B2 (ja) | 2008-10-15 |
Family
ID=26009397
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003500044A Expired - Fee Related JP4167592B2 (ja) | 2001-05-25 | 2002-05-11 | カルボキサミド置換フェニル尿素誘導体、及び医薬としてのそれらの製造方法 |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US6812250B2 (https=) |
| EP (1) | EP1404650B1 (https=) |
| JP (1) | JP4167592B2 (https=) |
| KR (1) | KR20040003007A (https=) |
| CN (1) | CN1218936C (https=) |
| AR (1) | AR036029A1 (https=) |
| AT (1) | ATE386017T1 (https=) |
| AU (1) | AU2002344151B2 (https=) |
| BG (1) | BG108318A (https=) |
| BR (1) | BR0210008A (https=) |
| CA (1) | CA2448023A1 (https=) |
| CZ (1) | CZ20033200A3 (https=) |
| DE (1) | DE50211685D1 (https=) |
| EE (1) | EE200300581A (https=) |
| HR (1) | HRP20030971A2 (https=) |
| HU (1) | HUP0400052A3 (https=) |
| IL (1) | IL159031A0 (https=) |
| MX (1) | MXPA03009840A (https=) |
| NO (1) | NO20035220D0 (https=) |
| NZ (1) | NZ529697A (https=) |
| PE (1) | PE20021091A1 (https=) |
| PL (1) | PL363871A1 (https=) |
| RU (1) | RU2291858C2 (https=) |
| SK (1) | SK14442003A3 (https=) |
| WO (1) | WO2002096864A1 (https=) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0205175D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
| GB0205165D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
| GB0205162D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
| GB0205176D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
| GB0205166D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
| GB0205170D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
| DE10215907A1 (de) * | 2002-04-11 | 2003-11-06 | Aventis Pharma Gmbh | Acyl-4-carboxyphenyl-harnstoffderivate, Verfahren zu deren Herstellung und deren Verwendung |
| US7223796B2 (en) | 2002-04-11 | 2007-05-29 | Sanofi-Aventis Deutschland Gmbh | Acyl-4-carboxyphenylurea derivatives, processes for preparing them and their use |
| DE10215908B4 (de) * | 2002-04-11 | 2005-08-18 | Aventis Pharma Deutschland Gmbh | Acyl-3-carboxyphenyl-harnstoffderivate und deren Verwendung als Arzneimittel |
| US7262220B2 (en) * | 2002-07-11 | 2007-08-28 | Sanofi-Aventis Deutschland Gmbh | Urea- and urethane-substituted acylureas, process for their preparation and their use |
| BR0312593A (pt) * | 2002-07-11 | 2005-04-12 | Aventis Pharma Gmbh | Aciluréias substituìdas por uréia e uretano, processo para a sua produção e sua aplicação |
| RS20050019A (sr) | 2002-07-12 | 2007-09-21 | Sanofi - Aventis Pharma Deutschland Gmbh., | Heterociklično supstituisani benzoilkarbamidi,postupak za njihovu proizvodnju i njihova primena kao leka |
| DE10302452B4 (de) * | 2003-01-23 | 2005-02-24 | Aventis Pharma Deutschland Gmbh | Carbonylamino-substituierte Acyl-phenyl-harnstoffderivate, Verfahren zu deren Herstellung und deren Verwendung |
| DE10306502B4 (de) * | 2003-02-17 | 2005-03-17 | Aventis Pharma Deutschland Gmbh | Substituierte 3-(Benzoylureido)-thiophenderivate und sie enthaltende Arzneimittel |
| US7148246B2 (en) | 2003-02-27 | 2006-12-12 | Sanofi-Aventis Deutschland Gmbh | Cycloalkyl derivatives having bioisosteric carboxylic acid groups, processes for their preparation and their use as pharmaceuticals |
| DE10308351A1 (de) | 2003-02-27 | 2004-11-25 | Aventis Pharma Deutschland Gmbh | 1,3-substituierte Cycloalkylderivate mit sauren, meist heterocyclischen Gruppen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| DE10308352A1 (de) | 2003-02-27 | 2004-09-09 | Aventis Pharma Deutschland Gmbh | Arylcycloalkylderivate mit verzweigten Seitenketten, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel |
| DE10308353A1 (de) | 2003-02-27 | 2004-12-02 | Aventis Pharma Deutschland Gmbh | Diarylcycloalkylderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| US7173151B2 (en) | 2003-02-27 | 2007-02-06 | Sanofi-Aventisdeutschand Gmbh | Cycloalkyl-substituted alkanoic acid derivatives, processes for their preparation and their use as pharmaceuticals |
| DE10308355A1 (de) | 2003-02-27 | 2004-12-23 | Aventis Pharma Deutschland Gmbh | Aryl-cycloalkyl substituierte Alkansäurederivate, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel |
| DE10309929B4 (de) * | 2003-03-07 | 2006-02-23 | Sanofi-Aventis Deutschland Gmbh | Substituierte Benzoylureidopyridyl-piperidin- und -pyrrolidin-carbonsäurederivate, Verfahren zu deren Herstellung und deren Verwendung |
| US7501440B2 (en) | 2003-03-07 | 2009-03-10 | Sanofi-Aventis Deutschland Gmbh | Substituted benzoylureidopyridylpiperidine-and-pyrrolidinecarboxylic acid derivatives, processes for preparing them and their use |
| DE10335092B3 (de) | 2003-08-01 | 2005-02-03 | Aventis Pharma Deutschland Gmbh | Substituierte Benzoylureido-o-benzoylamide, Verfahren zu deren Herstellung und deren Verwendung |
| AU2004266228A1 (en) * | 2003-08-13 | 2005-03-03 | Amgen, Inc. | Melanin concentrating hormone receptor antagonists |
| US7241787B2 (en) | 2004-01-25 | 2007-07-10 | Sanofi-Aventis Deutschland Gmbh | Substituted N-cycloexylimidazolinones, process for their preparation and their use as medicaments |
| EP1586573B1 (en) | 2004-04-01 | 2007-02-07 | Sanofi-Aventis Deutschland GmbH | Oxadiazolones, processes for their preparation and their use as pharmaceuticals |
| US7795448B2 (en) | 2004-05-06 | 2010-09-14 | Cytokinetics, Incorporated | Imidazoyl-benzamide anti-cancer agents |
| US7504413B2 (en) | 2004-05-06 | 2009-03-17 | Cytokinetics, Inc. | N-(4-(imidazo[1,2A]pyridin-YL)phenethyl)benzamide inhibitors of the mitotic kinesin CENP-E for treating certain cellular proliferation diseases |
| US7618981B2 (en) | 2004-05-06 | 2009-11-17 | Cytokinetics, Inc. | Imidazopyridinyl-benzamide anti-cancer agents |
| EP1884513A4 (en) * | 2005-05-23 | 2010-04-28 | Japan Tobacco Inc | PYRAZOLE COMPOUND AND THERAPEUTIC AGENT FOR DIABETES COMPRISING THE SAME |
| DE102005026762A1 (de) | 2005-06-09 | 2006-12-21 | Sanofi-Aventis Deutschland Gmbh | Azolopyridin-2-on-derivate als Inhibitoren von Lipasen und Phospholipasen |
| PE20110235A1 (es) | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden linagliptina y metmorfina |
| US20080045289A1 (en) * | 2006-08-10 | 2008-02-21 | Wayne Odom | System and device for conducting a game of chance |
| US8375455B2 (en) | 2006-08-10 | 2013-02-12 | Wayne Odom | System, method, and device for storing and delivering data |
| EP2096111A1 (en) * | 2006-11-20 | 2009-09-02 | Japan Tobacco Inc. | Pyrazoles and use thereof as drugs |
| US8634162B2 (en) * | 2007-03-08 | 2014-01-21 | HGST Netherlands B.V. | Perpendicular write head having a stepped flare structure and method of manufacture thereof |
| DE102007012284A1 (de) | 2007-03-16 | 2008-09-18 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel |
| CL2008000979A1 (es) * | 2007-04-11 | 2008-10-17 | Sumitomo Chemical Co | Proceso para producir un compuesto derivado de 2-piridin-2-il-2h-pirazol-3-fenilamida; compuestos intermediarios; el compuesto en si; composicion plaguicida que contiene a dicho compuesto; uso de dicho compuesto como plaguicida; y metodo para control |
| DE102007035334A1 (de) | 2007-07-27 | 2009-01-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel |
| DE102007035333A1 (de) | 2007-07-27 | 2009-01-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel |
| DE102007042154A1 (de) | 2007-09-05 | 2009-03-12 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Arylsulfonylaminomethyphosphonsäure-Derivate, deren Herstellung und deren Verwendung als Arzneimittel |
| FR2930552B1 (fr) * | 2008-04-24 | 2012-10-12 | Centre Nat Rech Scient | N-acylthiourees et n-acylurees inhibiteurs de la voie de signalisation des proteines hedgehog |
| US8844054B2 (en) | 2012-04-06 | 2014-09-23 | Wayne Odom | System, method, and device for communicating and storing and delivering data |
| US8448236B1 (en) | 2012-12-07 | 2013-05-21 | Wayne Odom | System, method, and device for storing and delivering data |
| US9378339B2 (en) | 2012-04-06 | 2016-06-28 | Wayne Odom | System, method, and device for delivering communications and storing and delivering data |
| US8572720B1 (en) | 2013-05-20 | 2013-10-29 | Wayne Odom | System, method, and device for communicating and storing and delivering data |
| US9043934B2 (en) | 2012-04-06 | 2015-05-26 | Wayne Odom | System, method, and device for delivering communications and storing and delivering data |
| US8677510B2 (en) | 2012-04-06 | 2014-03-18 | Wayne Odom | System, method, and device for communicating and storing and delivering data |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA793186B (en) | 1978-07-06 | 1981-02-25 | Duphar Int Res | New urea and thiourea compounds, method of preparing the new compounds, as well as insecticidal compositions on the basis of these compounds |
| DE3478573D1 (en) | 1983-09-01 | 1989-07-13 | Duphar Int Res | Benzoyl urea derivatives having anti-tumor activity |
| ATE40111T1 (de) | 1984-07-05 | 1989-02-15 | Duphar Int Res | Benzoylharnstoffverbindungen sowie solche enthaltende insektizide und akarizide zusammensetzungen. |
| TW255880B (https=) * | 1992-09-09 | 1995-09-01 | Hoechst Ag | |
| AU727775B2 (en) | 1996-01-17 | 2000-12-21 | Novo Nordisk A/S | Fused 1,2,4-thiadiazine and fused 1,4-thiazine derivatives, their preparation and use |
| IL128332A0 (en) | 1996-08-30 | 2000-01-31 | Novo Nordisk As | GLP-1 derivatives |
| IL127296A (en) | 1996-12-31 | 2003-01-12 | Reddy Research Foundation | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them |
| PL338013A1 (en) | 1997-07-16 | 2000-09-25 | Novo Nordisk As | Derivatives of condensed 1,2,4-thiadiazine, their production and application |
| TWI234557B (en) * | 1999-05-26 | 2005-06-21 | Telik Inc | Novel naphthalene ureas as glucose uptake enhancers |
| TR200401029T4 (tr) * | 2000-06-09 | 2004-06-21 | Aventis Pharma Deutschland Gmbh | Asilfenil-üre türevleri, imalat yöntemleri ve ilaç maddesi olarak kullanımları |
-
2002
- 2002-05-03 PE PE2002000376A patent/PE20021091A1/es not_active Application Discontinuation
- 2002-05-11 BR BR0210008-8A patent/BR0210008A/pt not_active IP Right Cessation
- 2002-05-11 KR KR10-2003-7015334A patent/KR20040003007A/ko not_active Ceased
- 2002-05-11 SK SK1444-2003A patent/SK14442003A3/sk unknown
- 2002-05-11 HR HR20030971A patent/HRP20030971A2/xx not_active Application Discontinuation
- 2002-05-11 CZ CZ20033200A patent/CZ20033200A3/cs unknown
- 2002-05-11 CA CA002448023A patent/CA2448023A1/en not_active Abandoned
- 2002-05-11 MX MXPA03009840A patent/MXPA03009840A/es active IP Right Grant
- 2002-05-11 CN CNB028105974A patent/CN1218936C/zh not_active Expired - Fee Related
- 2002-05-11 AU AU2002344151A patent/AU2002344151B2/en not_active Ceased
- 2002-05-11 EE EEP200300581A patent/EE200300581A/xx unknown
- 2002-05-11 EP EP02774016A patent/EP1404650B1/de not_active Expired - Lifetime
- 2002-05-11 JP JP2003500044A patent/JP4167592B2/ja not_active Expired - Fee Related
- 2002-05-11 PL PL02363871A patent/PL363871A1/xx not_active Application Discontinuation
- 2002-05-11 AT AT02774016T patent/ATE386017T1/de not_active IP Right Cessation
- 2002-05-11 HU HU0400052A patent/HUP0400052A3/hu unknown
- 2002-05-11 NZ NZ529697A patent/NZ529697A/en unknown
- 2002-05-11 WO PCT/EP2002/005205 patent/WO2002096864A1/de not_active Ceased
- 2002-05-11 DE DE50211685T patent/DE50211685D1/de not_active Expired - Lifetime
- 2002-05-11 RU RU2003137222/04A patent/RU2291858C2/ru not_active IP Right Cessation
- 2002-05-11 IL IL15903102A patent/IL159031A0/xx unknown
- 2002-05-23 AR ARP020101919A patent/AR036029A1/es unknown
- 2002-05-24 US US10/153,597 patent/US6812250B2/en not_active Expired - Lifetime
-
2003
- 2003-11-05 BG BG108318A patent/BG108318A/xx unknown
- 2003-11-24 NO NO20035220A patent/NO20035220D0/no not_active Application Discontinuation
-
2004
- 2004-11-01 US US10/978,674 patent/US20050143456A1/en not_active Abandoned
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