JP2004527585A - 脂質−ポリマー結合体 - Google Patents

脂質−ポリマー結合体 Download PDF

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Publication number
JP2004527585A
JP2004527585A JP2003502069A JP2003502069A JP2004527585A JP 2004527585 A JP2004527585 A JP 2004527585A JP 2003502069 A JP2003502069 A JP 2003502069A JP 2003502069 A JP2003502069 A JP 2003502069A JP 2004527585 A JP2004527585 A JP 2004527585A
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JP
Japan
Prior art keywords
polymer
poly
lipid
conjugate
amino acid
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Pending
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JP2003502069A
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English (en)
Japanese (ja)
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JP2004527585A5 (enExample
Inventor
ジョスベルト マールテン メッツェラー
ウィルヘルムス エヴェラルドゥス ヘンニンク
ヴリンゲル トム デ
ベール レオナルドゥス ウィルヘルムス テオドルス デ
クリスティエン オウソレン
ゲリット ストルム
ペテル ブルイン
Original Assignee
ヤマノウチ ユーロープ ベスローテン フェンノートシャップ
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Application filed by ヤマノウチ ユーロープ ベスローテン フェンノートシャップ filed Critical ヤマノウチ ユーロープ ベスローテン フェンノートシャップ
Publication of JP2004527585A publication Critical patent/JP2004527585A/ja
Publication of JP2004527585A5 publication Critical patent/JP2004527585A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
    • C08G69/10—Alpha-amino-carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Polyamides (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Cosmetics (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2003502069A 2001-06-01 2002-06-03 脂質−ポリマー結合体 Pending JP2004527585A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01202107 2001-06-01
PCT/EP2002/006432 WO2002098951A2 (en) 2001-06-01 2002-06-03 Lipid-polymer-conjugates

Publications (2)

Publication Number Publication Date
JP2004527585A true JP2004527585A (ja) 2004-09-09
JP2004527585A5 JP2004527585A5 (enExample) 2006-01-05

Family

ID=8180408

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2003502069A Pending JP2004527585A (ja) 2001-06-01 2002-06-03 脂質−ポリマー結合体
JP2003502070A Pending JP2004527586A (ja) 2001-06-01 2002-06-03 脂質−ポリマー結合体組成物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2003502070A Pending JP2004527586A (ja) 2001-06-01 2002-06-03 脂質−ポリマー結合体組成物

Country Status (20)

Country Link
US (3) US20040254352A1 (enExample)
EP (2) EP1392756B1 (enExample)
JP (2) JP2004527585A (enExample)
KR (2) KR100874847B1 (enExample)
CN (2) CN1271116C (enExample)
AT (2) ATE416214T1 (enExample)
BR (2) BR0209695A (enExample)
CA (2) CA2448856A1 (enExample)
CZ (2) CZ20033480A3 (enExample)
DE (2) DE60230137D1 (enExample)
EE (2) EE200300598A (enExample)
ES (2) ES2282439T3 (enExample)
HR (2) HRP20030975A2 (enExample)
HU (2) HUP0400171A2 (enExample)
MX (2) MXPA03011050A (enExample)
NO (2) NO20035263D0 (enExample)
PL (2) PL367479A1 (enExample)
SK (2) SK15972003A3 (enExample)
WO (2) WO2002098951A2 (enExample)
ZA (2) ZA200308937B (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007129746A1 (ja) * 2006-05-09 2007-11-15 Osaka University コレステロールアミン導入ポリ－γ－グルタミン酸誘導体
JP2008024816A (ja) * 2006-07-20 2008-02-07 Shimadzu Corp 新規な両親媒性物質、それを用いた薬剤搬送システム及び分子イメージングシステム
JP2008120887A (ja) * 2006-11-09 2008-05-29 Univ Kansai 柔軟性生分解性ポリマー
JP2013530128A (ja) * 2010-04-13 2013-07-25 株式会社アモーレパシフィック 経皮吸収用高分子‐リポソームナノ複合体組成物及びその製造方法
WO2019172362A1 (ja) * 2018-03-07 2019-09-12 公益財団法人川崎市産業振興財団 刺激応答性ポリマー

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE416214T1 (de) * 2001-06-01 2008-12-15 Astellas Pharma Europ B V Zusammensetzungen enthaltend lipid-polymer konjugate
FR2840614B1 (fr) 2002-06-07 2004-08-27 Flamel Tech Sa Polyaminoacides fonctionnalises par de l'alpha-tocopherol et leurs applications notamment therapeutiques
EP1393720A1 (en) * 2002-08-27 2004-03-03 Universiteit Utrecht Vesicle-encapsulated corticosteroids for treatment of cancer
SG113442A1 (en) * 2002-11-29 2005-08-29 Agency Science Tech & Res Improved temperature sensitive micelles
FR2855521B1 (fr) 2003-05-28 2005-08-05 Flamel Tech Sa Polyaminoacides fonctionnalises par au moins un groupement h ydrophobe et leurs applications notamment therapeutiques.
EP1481683A1 (en) * 2003-05-30 2004-12-01 Yamanouchi Pharmaceutical Co. Ltd. P-selectin targeting ligand and compositions thereof
SE527505C2 (sv) * 2003-06-10 2006-03-28 Anna Imberg Komposita material och partiklar
FR2860516B1 (fr) * 2003-10-03 2006-01-13 Flamel Tech Sa Homopolyaminoacides telecheliques fonctionnalises par des groupements hydrophobes et leurs applications notamment therapeutiques
ITRM20070327A1 (it) * 2007-06-11 2008-12-12 Univ Palermo Vettori colloidali a struttura poliamminoacidica per il rilascio orale di peptidi e proteine e relativo metodo di produzione.
US20090285882A1 (en) * 2008-04-22 2009-11-19 Jochen Weiss Stabilized Liposome Compositions and Related Methods of Use
ES2385995B2 (es) * 2011-01-10 2013-05-21 Universidade De Santiago De Compostela Nanocápsulas con cubierta polimérica
US9993427B2 (en) * 2013-03-14 2018-06-12 Biorest Ltd. Liposome formulation and manufacture
WO2023282296A1 (ja) * 2021-07-07 2023-01-12 日油株式会社 ｐＨ応答性脂質誘導体
WO2024232832A1 (en) * 2023-05-11 2024-11-14 Agency For Science, Technology And Research A compound for preparing lipid nanoparticles encapsulating an agent, nanoparticle composition comprising said compound and related methods thereof
WO2025021942A1 (en) 2023-07-27 2025-01-30 Bracco Suisse Sa Ultrasound responsive vesicles containing lipid-polyamino acid conjugates
WO2025031991A1 (en) * 2023-08-04 2025-02-13 Polypeptide Therapeutic Solutions, S.L. Stealth-stabilized sulfur-containing lipo/polyamino acids
WO2025080209A1 (en) * 2023-10-10 2025-04-17 Agency For Science, Technology And Research A compound for preparing lipid nanoparticles encapsulating an agent, nanoparticle composition comprising said compound and related methods thereof
WO2025090023A1 (en) * 2023-10-24 2025-05-01 Agency For Science, Technology And Research A compound for preparing lipid nanoparticles encapsulating an agent, nanoparticle composition comprising said compound, and related methods thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08507523A (ja) * 1993-03-03 1996-08-13 シキュース ファーマシューティカルズ，インコーポレイテッド 脂質−ポリマー結合体およびリポソーム

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0657722B2 (ja) * 1986-05-27 1994-08-03 三菱化成株式会社 水溶性ポリマ−組成物
US5149794A (en) * 1990-11-01 1992-09-22 State Of Oregon Covalent lipid-drug conjugates for drug targeting
US6333021B1 (en) * 1994-11-22 2001-12-25 Bracco Research S.A. Microcapsules, method of making and their use
US5972379A (en) * 1995-02-14 1999-10-26 Sequus Pharmaceuticals, Inc. Liposome composition and method for administering a quinolone
US6197332B1 (en) * 1997-08-13 2001-03-06 Chiron Corporation Lipid-conjugated polyamide compounds and related compositions and methods thereof
GB9811059D0 (en) * 1998-05-23 1998-07-22 Univ Strathclyde Polyamino acid vesicles
ATE416214T1 (de) * 2001-06-01 2008-12-15 Astellas Pharma Europ B V Zusammensetzungen enthaltend lipid-polymer konjugate

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08507523A (ja) * 1993-03-03 1996-08-13 シキュース ファーマシューティカルズ，インコーポレイテッド 脂質−ポリマー結合体およびリポソーム

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JPN6009015207, Ｆ． Ｒｙｐａｃｅｋ ｅｔ ａｌ．, Ｍａｃｒｏｍｏｌｅｃｕｌａｒ Ｓｙｍｐｏｓｉａ, 1997, Ｖｏｌ． １２３, ｐ． ９−２４ *

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007129746A1 (ja) * 2006-05-09 2007-11-15 Osaka University コレステロールアミン導入ポリ－γ－グルタミン酸誘導体
JP5331967B2 (ja) * 2006-05-09 2013-10-30 国立大学法人大阪大学 コレステロールアミン導入ポリ−γ−グルタミン酸誘導体
JP2008024816A (ja) * 2006-07-20 2008-02-07 Shimadzu Corp 新規な両親媒性物質、それを用いた薬剤搬送システム及び分子イメージングシステム
US8945526B2 (en) 2006-07-20 2015-02-03 Shimadzu Corporation Amphiphilic substance, and drug delivery system and molecular imaging system using the same
JP2008120887A (ja) * 2006-11-09 2008-05-29 Univ Kansai 柔軟性生分解性ポリマー
JP2013530128A (ja) * 2010-04-13 2013-07-25 株式会社アモーレパシフィック 経皮吸収用高分子‐リポソームナノ複合体組成物及びその製造方法
US9572769B2 (en) 2010-04-13 2017-02-21 Amorepacific Corporation Polymer-liposome nanocomposite composition for percutaneous absorption, and method for preparing same
WO2019172362A1 (ja) * 2018-03-07 2019-09-12 公益財団法人川崎市産業振興財団 刺激応答性ポリマー
JPWO2019172362A1 (ja) * 2018-03-07 2021-03-11 公益財団法人川崎市産業振興財団 刺激応答性ポリマー

Also Published As

Publication number Publication date
US20040241222A1 (en) 2004-12-02
EE200300596A (et) 2004-02-16
ES2318027T3 (es) 2009-05-01
HUP0400171A2 (en) 2007-02-28
WO2002098951A3 (en) 2003-02-20
US20100145018A1 (en) 2010-06-10
HUP0400174A2 (en) 2007-02-28
PL367479A1 (en) 2005-02-21
EP1392756B1 (en) 2007-02-14
CN1308375C (zh) 2007-04-04
KR20040027512A (ko) 2004-04-01
CN1271116C (zh) 2006-08-23
DE60218154T2 (de) 2007-10-31
MXPA03011049A (es) 2004-06-25
ES2282439T3 (es) 2007-10-16
ZA200308937B (en) 2004-11-17
WO2002098951A2 (en) 2002-12-12
CZ20033480A3 (cs) 2004-07-14
CN1602326A (zh) 2005-03-30
EP1392755A1 (en) 2004-03-03
CA2448858A1 (en) 2002-12-12
DE60230137D1 (de) 2009-01-15
HRP20030976A2 (en) 2005-08-31
NO20035263D0 (no) 2003-11-27
SK15982003A3 (sk) 2004-06-08
ATE416214T1 (de) 2008-12-15
PL369455A1 (en) 2005-04-18
CZ20033479A3 (cs) 2004-07-14
ATE353927T1 (de) 2007-03-15
DE60218154D1 (de) 2007-03-29
KR100894852B1 (ko) 2009-04-24
JP2004527586A (ja) 2004-09-09
NO20035264D0 (no) 2003-11-27
BR0209695A (pt) 2005-01-11
MXPA03011050A (es) 2004-06-25
KR100874847B1 (ko) 2008-12-19
HRP20030975A2 (en) 2005-08-31
KR20040027513A (ko) 2004-04-01
EP1392756A2 (en) 2004-03-03
US20040254352A1 (en) 2004-12-16
BR0209699A (pt) 2005-02-01
EP1392755B1 (en) 2008-12-03
CN1520435A (zh) 2004-08-11
CA2448856A1 (en) 2002-12-12
EE200300598A (et) 2004-02-16
SK15972003A3 (sk) 2004-06-08
ZA200308938B (en) 2004-11-17
WO2002098952A1 (en) 2002-12-12

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