JP2004525174A5 - - Google Patents
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- Publication number
- JP2004525174A5 JP2004525174A5 JP2002579437A JP2002579437A JP2004525174A5 JP 2004525174 A5 JP2004525174 A5 JP 2004525174A5 JP 2002579437 A JP2002579437 A JP 2002579437A JP 2002579437 A JP2002579437 A JP 2002579437A JP 2004525174 A5 JP2004525174 A5 JP 2004525174A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- compound
- formula
- nhc
- nhr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 17
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 8
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 7
- 101100079984 Caenorhabditis elegans nhr-9 gene Proteins 0.000 claims 7
- 125000001072 heteroaryl group Chemical group 0.000 claims 7
- 150000003839 salts Chemical group 0.000 claims 5
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 4
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 4
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 3
- 125000006577 C1-C6 hydroxyalkyl group Chemical group 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 claims 2
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000003983 fluorenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3CC12)* 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000006574 non-aromatic ring group Chemical group 0.000 claims 2
- 230000009435 amidation Effects 0.000 claims 1
- 238000007112 amidation reaction Methods 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- -1 heteroaryl N-oxide Chemical class 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 238000006268 reductive amination reaction Methods 0.000 claims 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0108876.4A GB0108876D0 (en) | 2001-04-09 | 2001-04-09 | Organic Compounds |
| PCT/EP2002/003871 WO2002081449A1 (en) | 2001-04-09 | 2002-04-08 | Bipiperidinyl-derivatives and their use as chemokine receptors inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004525174A JP2004525174A (ja) | 2004-08-19 |
| JP2004525174A5 true JP2004525174A5 (https=) | 2005-06-09 |
| JP4366079B2 JP4366079B2 (ja) | 2009-11-18 |
Family
ID=9912541
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002579437A Expired - Fee Related JP4366079B2 (ja) | 2001-04-09 | 2002-04-08 | ビピペリジニル誘導体およびケモカインレセプターインヒビターとしてのそれらの使用 |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US20040142920A1 (https=) |
| EP (1) | EP1379504B1 (https=) |
| JP (1) | JP4366079B2 (https=) |
| KR (1) | KR100616039B1 (https=) |
| CN (1) | CN100469767C (https=) |
| AR (1) | AR035815A1 (https=) |
| AT (1) | ATE446950T1 (https=) |
| AU (1) | AU2002302511B2 (https=) |
| BR (1) | BR0208741A (https=) |
| CA (1) | CA2439241C (https=) |
| CZ (1) | CZ20032723A3 (https=) |
| DE (1) | DE60234167D1 (https=) |
| EC (1) | ECSP034765A (https=) |
| ES (1) | ES2335393T3 (https=) |
| GB (1) | GB0108876D0 (https=) |
| HU (1) | HUP0303724A3 (https=) |
| IL (1) | IL157428A0 (https=) |
| MX (1) | MXPA03009220A (https=) |
| NO (1) | NO20034324D0 (https=) |
| NZ (1) | NZ528712A (https=) |
| PE (1) | PE20021004A1 (https=) |
| PL (1) | PL363011A1 (https=) |
| PT (1) | PT1379504E (https=) |
| RU (1) | RU2296751C2 (https=) |
| SK (1) | SK12422003A3 (https=) |
| WO (1) | WO2002081449A1 (https=) |
| ZA (1) | ZA200306432B (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE319703T1 (de) | 2001-07-02 | 2006-03-15 | Piperidinverbindungen, die sich als modulatoren der chemokinrezeptoraktivität eignen | |
| GB0120461D0 (en) | 2001-08-22 | 2001-10-17 | Astrazeneca Ab | Novel compounds |
| AR036366A1 (es) * | 2001-08-29 | 2004-09-01 | Schering Corp | Derivados de piperidina utiles como antagonistas de ccr5, composiciones farmaceuticas, el uso de dichos derivados para la fabricación de un medicamento y un kit |
| GB0122503D0 (en) | 2001-09-18 | 2001-11-07 | Astrazeneca Ab | Chemical compounds |
| SE0200843D0 (sv) | 2002-03-19 | 2002-03-19 | Astrazeneca Ab | Chemical compounds |
| SE0200844D0 (sv) | 2002-03-19 | 2002-03-19 | Astrazeneca Ab | Chemical compounds |
| SE0202838D0 (sv) * | 2002-09-24 | 2002-09-24 | Astrazeneca Ab | Chemical compounds |
| DE60307308T2 (de) * | 2002-10-04 | 2006-12-28 | Ucb S.A. | 4-aminopiperidin-derivate, verfahren zur herstellung und ihre verwendung als arzneimittel |
| GB0223223D0 (en) * | 2002-10-07 | 2002-11-13 | Novartis Ag | Organic compounds |
| AU2003300911A1 (en) * | 2002-12-13 | 2004-07-09 | Smithkline Beecham Corporation | Heterocyclic compounds as ccr5 antagonists |
| SE0300957D0 (sv) | 2003-04-01 | 2003-04-01 | Astrazeneca Ab | Chemical compounds |
| US20070043079A1 (en) * | 2003-04-18 | 2007-02-22 | Hiromu Habashita | Heterocyclic compound containing nitrogen atom and use thereof |
| FR2854158B1 (fr) | 2003-04-25 | 2006-11-17 | Sanofi Synthelabo | Derives de 2-acylamino-4-phenylethiazole, leur preparation et leur application en therapeutique |
| RU2006100190A (ru) * | 2003-06-13 | 2006-08-10 | Шеринг Акциенгезельшафт (De) | Производные хинолиламида в качестве антагонистов ccr-5 |
| KR20060100409A (ko) * | 2003-11-03 | 2006-09-20 | 쉐링 코포레이션 | 케모킨 수용체 억제제로서 유용한 비피페리디닐 유도체 |
| US7498346B2 (en) * | 2003-12-11 | 2009-03-03 | Genzyme Corporation | Chemokine receptor binding compounds |
| US7479496B2 (en) | 2004-02-19 | 2009-01-20 | Bristol-Myers Squibb Company | Substituted spiro azabicyclics as modulators of chemokine receptor activity |
| US7288563B2 (en) | 2004-02-19 | 2007-10-30 | Bristol-Myers Squibb Company | Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity |
| US7230022B2 (en) | 2004-02-19 | 2007-06-12 | Bristol-Myers Squibb Company | Substituted fused bicyclic amines as modulators of chemokine receptor activity |
| US7381738B2 (en) | 2004-02-19 | 2008-06-03 | Bristol-Myers Squibb Company | Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity |
| CA2595574A1 (en) * | 2005-01-20 | 2006-07-27 | Pfizer Limited. | Chemical compounds |
| JP2009501793A (ja) | 2005-07-21 | 2009-01-22 | アストラゼネカ・アクチエボラーグ | 新規ピペリジン誘導体 |
| WO2008030853A2 (en) * | 2006-09-06 | 2008-03-13 | Incyte Corporation | Combination therapy for human immunodeficiency virus infection |
| EP2088860A4 (en) * | 2006-12-06 | 2010-12-22 | Genzyme Corp | COMPOUNDS FOR BINDING TO A CHEMOKINE RECEPTOR |
| AU2010232729A1 (en) | 2009-03-31 | 2011-10-20 | Arqule, Inc. | Substituted indolo-pyridinone compounds |
| AU2012225232B2 (en) | 2011-03-09 | 2016-05-12 | Richard G. Pestell | Prostate cancer cell lines, gene signatures and uses thereof |
| JP6518585B2 (ja) | 2012-05-14 | 2019-05-22 | リチャード ジー． ペステル | がんの治療のためのｃｃｒ５の修飾薬の使用 |
| EP3083610A1 (de) | 2013-12-19 | 2016-10-26 | Bayer Pharma Aktiengesellschaft | Substituierte bipiperidinyl-derivate als adrenrezeptor alpha 2c antagonisten |
| KR20160098424A (ko) | 2013-12-19 | 2016-08-18 | 바이엘 파마 악티엔게젤샤프트 | 치환된 피페리디닐-테트라히드로퀴놀린 |
| CR20160276A (es) | 2013-12-19 | 2016-10-20 | Bayer Pharma AG | "piperidiniltetrahidroquinolinas sustituidas y su uso como antagonistas de los adenoreceptores alpha-2c" |
| US20160318866A1 (en) | 2013-12-19 | 2016-11-03 | Bayer Pharma Aktiengesellschaft | Substituted bipiperidinyl derivatives |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2676054B1 (fr) * | 1991-05-03 | 1993-09-03 | Sanofi Elf | Nouveaux composes n-alkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant. |
| TW531537B (en) * | 1995-12-27 | 2003-05-11 | Janssen Pharmaceutica Nv | 1-(1,2-disubstituted piperidinyl)-4-substituted piperidine derivatives |
| US5952349A (en) * | 1996-07-10 | 1999-09-14 | Schering Corporation | Muscarinic antagonists for treating memory loss |
| SK285631B6 (sk) * | 1996-09-10 | 2007-05-03 | Dr. Karl Thomae Gmbh | Modifikované aminokyseliny, farmaceutický prostriedok s ich obsahom a ich použitie |
| DE19637043A1 (de) * | 1996-09-12 | 1998-03-19 | Boehringer Mannheim Gmbh | Neue Aminoalkoholderivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel und Reagenzien |
| DE19643331A1 (de) * | 1996-10-21 | 1998-04-23 | Thomae Gmbh Dr K | 1-(4-Piperidinyl)-piperidinylene, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| KR100439357B1 (ko) * | 1999-05-04 | 2004-07-07 | 쉐링 코포레이션 | Ｃｃｒ５ 길항제로서 유용한 피페리딘 유도체 |
| US6391865B1 (en) * | 1999-05-04 | 2002-05-21 | Schering Corporation | Piperazine derivatives useful as CCR5 antagonists |
| EP1192133B1 (en) * | 1999-06-11 | 2006-11-02 | Merck & Co., Inc. | N-cyclopentyl modulators of chemokine receptor activity |
| WO2001098268A2 (en) * | 2000-06-21 | 2001-12-27 | Bristol-Myers Squibb Pharma Company | Piperidine amides as modulators of chemokine receptor activity |
| CA2422013A1 (en) * | 2000-09-14 | 2002-03-21 | Schering Corporation | Substituted urea neuropeptide y y5 receptor antagonists |
| AR036366A1 (es) * | 2001-08-29 | 2004-09-01 | Schering Corp | Derivados de piperidina utiles como antagonistas de ccr5, composiciones farmaceuticas, el uso de dichos derivados para la fabricación de un medicamento y un kit |
| GB0223223D0 (en) * | 2002-10-07 | 2002-11-13 | Novartis Ag | Organic compounds |
-
2001
- 2001-04-09 GB GBGB0108876.4A patent/GB0108876D0/en not_active Ceased
-
2002
- 2002-04-05 AR ARP020101270A patent/AR035815A1/es not_active Application Discontinuation
- 2002-04-08 AU AU2002302511A patent/AU2002302511B2/en not_active Ceased
- 2002-04-08 WO PCT/EP2002/003871 patent/WO2002081449A1/en not_active Ceased
- 2002-04-08 PT PT02730122T patent/PT1379504E/pt unknown
- 2002-04-08 AT AT02730122T patent/ATE446950T1/de not_active IP Right Cessation
- 2002-04-08 KR KR1020037013161A patent/KR100616039B1/ko not_active Expired - Fee Related
- 2002-04-08 NZ NZ528712A patent/NZ528712A/en unknown
- 2002-04-08 IL IL15742802A patent/IL157428A0/xx unknown
- 2002-04-08 JP JP2002579437A patent/JP4366079B2/ja not_active Expired - Fee Related
- 2002-04-08 HU HU0303724A patent/HUP0303724A3/hu unknown
- 2002-04-08 US US10/472,653 patent/US20040142920A1/en not_active Abandoned
- 2002-04-08 CZ CZ20032723A patent/CZ20032723A3/cs unknown
- 2002-04-08 PL PL02363011A patent/PL363011A1/xx not_active Application Discontinuation
- 2002-04-08 PE PE2002000282A patent/PE20021004A1/es not_active Application Discontinuation
- 2002-04-08 EP EP02730122A patent/EP1379504B1/en not_active Expired - Lifetime
- 2002-04-08 ES ES02730122T patent/ES2335393T3/es not_active Expired - Lifetime
- 2002-04-08 SK SK1242-2003A patent/SK12422003A3/sk not_active Application Discontinuation
- 2002-04-08 BR BR0208741-3A patent/BR0208741A/pt not_active IP Right Cessation
- 2002-04-08 MX MXPA03009220A patent/MXPA03009220A/es active IP Right Grant
- 2002-04-08 CA CA2439241A patent/CA2439241C/en not_active Expired - Fee Related
- 2002-04-08 DE DE60234167T patent/DE60234167D1/de not_active Expired - Lifetime
- 2002-04-08 RU RU2003130642/04A patent/RU2296751C2/ru not_active IP Right Cessation
- 2002-04-08 CN CNB028079507A patent/CN100469767C/zh not_active Expired - Fee Related
-
2003
- 2003-08-19 ZA ZA200306432A patent/ZA200306432B/en unknown
- 2003-09-11 EC EC2003004765A patent/ECSP034765A/es unknown
- 2003-09-26 NO NO20034324A patent/NO20034324D0/no not_active Application Discontinuation
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