CN100469767C - 联哌啶衍生物及其作为趋化因子受体抑制剂的用途 - Google Patents

联哌啶衍生物及其作为趋化因子受体抑制剂的用途 Download PDF

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CN100469767C
CN100469767C CNB028079507A CN02807950A CN100469767C CN 100469767 C CN100469767 C CN 100469767C CN B028079507 A CNB028079507 A CN B028079507A CN 02807950 A CN02807950 A CN 02807950A CN 100469767 C CN100469767 C CN 100469767C
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formula
phenyl
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CN1501915A (zh
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R·阿尔贝特
C·布伦斯
F·农宁格
M·施特赖夫
G·托马
H-G·策尔韦斯
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Novartis AG
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
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    • C07D211/96—Sulfur atom
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CNB028079507A 2001-04-09 2002-04-08 联哌啶衍生物及其作为趋化因子受体抑制剂的用途 Expired - Fee Related CN100469767C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0108876.4A GB0108876D0 (en) 2001-04-09 2001-04-09 Organic Compounds
GB0108876.4 2001-04-09

Publications (2)

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CN1501915A CN1501915A (zh) 2004-06-02
CN100469767C true CN100469767C (zh) 2009-03-18

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US (1) US20040142920A1 (https=)
EP (1) EP1379504B1 (https=)
JP (1) JP4366079B2 (https=)
KR (1) KR100616039B1 (https=)
CN (1) CN100469767C (https=)
AR (1) AR035815A1 (https=)
AT (1) ATE446950T1 (https=)
AU (1) AU2002302511B2 (https=)
BR (1) BR0208741A (https=)
CA (1) CA2439241C (https=)
CZ (1) CZ20032723A3 (https=)
DE (1) DE60234167D1 (https=)
EC (1) ECSP034765A (https=)
ES (1) ES2335393T3 (https=)
GB (1) GB0108876D0 (https=)
HU (1) HUP0303724A3 (https=)
IL (1) IL157428A0 (https=)
MX (1) MXPA03009220A (https=)
NO (1) NO20034324D0 (https=)
NZ (1) NZ528712A (https=)
PE (1) PE20021004A1 (https=)
PL (1) PL363011A1 (https=)
PT (1) PT1379504E (https=)
RU (1) RU2296751C2 (https=)
SK (1) SK12422003A3 (https=)
WO (1) WO2002081449A1 (https=)
ZA (1) ZA200306432B (https=)

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CN1898231B (zh) 2003-11-03 2010-10-27 先灵公司 用作趋化因子受体抑制剂的双六氢吡啶衍生物
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US7479496B2 (en) 2004-02-19 2009-01-20 Bristol-Myers Squibb Company Substituted spiro azabicyclics as modulators of chemokine receptor activity
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CA2756870A1 (en) 2009-03-31 2010-10-07 Arqule, Inc. Substituted indolo-pyridinone compounds
BR112013023050A8 (pt) 2011-03-09 2018-09-25 G Pestell Richard antagonista de ccr5, método para determinar se um indivíduo humano tendo câncer de próstata está sofrendo de ou sob o risco de desenvolver metástase, para identificar um antagonista de ccr5, método para determinar se um indivíduo humano tendo câncer de próstata está sofrendo de ou sob o risco de desenvolver metástase, para identificar um composto candidato, para produzir in vitro células epiteliais primárias, para diagnosticar câncer de próstata, para selecionar um tratamento para um indivíduo tendo um câncer/tumor de próstata, linhagem de célula, e, modelo animal
AU2013262977A1 (en) 2012-05-14 2015-01-22 Prostagene, Llc Using modulators of CCR5 for treating cancer
WO2015091420A1 (de) 2013-12-19 2015-06-25 Bayer Pharma Aktiengesellschaft Substituierte bipiperidinyl-derivate als adrenrezeptor alpha 2c antagonisten
CN106029648A (zh) 2013-12-19 2016-10-12 拜耳制药股份公司 作为肾上腺素能受体α2C拮抗剂的取代的联哌啶基衍生物
AP2016009276A0 (en) 2013-12-19 2016-06-30 Bayer Pharma AG Substituted piperidinyl-tetrahydroquinolines and their use as alpha-2c adrenoreceptor antagonists
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DE19643331A1 (de) * 1996-10-21 1998-04-23 Thomae Gmbh Dr K 1-(4-Piperidinyl)-piperidinylene, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung

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