JP2004523558A - 縮合環式スクシンイミド化合物およびその類似体、核内ホルモン受容体機能のモジュレーター - Google Patents
縮合環式スクシンイミド化合物およびその類似体、核内ホルモン受容体機能のモジュレーター Download PDFInfo
- Publication number
- JP2004523558A JP2004523558A JP2002567306A JP2002567306A JP2004523558A JP 2004523558 A JP2004523558 A JP 2004523558A JP 2002567306 A JP2002567306 A JP 2002567306A JP 2002567306 A JP2002567306 A JP 2002567306A JP 2004523558 A JP2004523558 A JP 2004523558A
- Authority
- JP
- Japan
- Prior art keywords
- isoindole
- dione
- tetrahydro
- substituted
- hexahydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 0 *[C@@](C1CCCC2C1)([C@@]2(*)C(O1)=O)C1=O Chemical compound *[C@@](C1CCCC2C1)([C@@]2(*)C(O1)=O)C1=O 0.000 description 2
- CNSLDIYIVUKXCO-DBINIWSISA-N CC(C)=C(C(CC1)[C@@H]2C(N3c4cc(Cl)cc(Cl)c4)=O)C1C2C3=O Chemical compound CC(C)=C(C(CC1)[C@@H]2C(N3c4cc(Cl)cc(Cl)c4)=O)C1C2C3=O CNSLDIYIVUKXCO-DBINIWSISA-N 0.000 description 1
- KTHBOBLAFWUOCS-PDPWUNHUSA-N O=C([C@H](C1CC2CC1)[C@H]2C1=O)N1C(c1c2cccc1)=CS2(=O)=O Chemical compound O=C([C@H](C1CC2CC1)[C@H]2C1=O)N1C(c1c2cccc1)=CS2(=O)=O KTHBOBLAFWUOCS-PDPWUNHUSA-N 0.000 description 1
- LXTVHSVKCKTUCO-GCFXKKPUSA-N O=C(c1ccccc1)Nc(cc(c(Cl)c1)Cl)c1N(C([C@@H]1C2C3CC1CC3)=O)C2=O Chemical compound O=C(c1ccccc1)Nc(cc(c(Cl)c1)Cl)c1N(C([C@@H]1C2C3CC1CC3)=O)C2=O LXTVHSVKCKTUCO-GCFXKKPUSA-N 0.000 description 1
- NIBJOAFGPOGRLK-VUYMNGMJSA-N OC(C[C@](C1CC2CC1)(C2C(O1)=O)C1=O)=O Chemical compound OC(C[C@](C1CC2CC1)(C2C(O1)=O)C1=O)=O NIBJOAFGPOGRLK-VUYMNGMJSA-N 0.000 description 1
- FVOPGJHWZNSVSQ-TXTTUAKNSA-N OC([C@H](C(CC12)C[C@H]1c1ccccc1)[C@H]2C(O)=O)=O Chemical compound OC([C@H](C(CC12)C[C@H]1c1ccccc1)[C@H]2C(O)=O)=O FVOPGJHWZNSVSQ-TXTTUAKNSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US27167201P | 2001-02-27 | 2001-02-27 | |
PCT/US2002/005302 WO2002067939A1 (en) | 2001-02-27 | 2002-02-20 | Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2004523558A true JP2004523558A (ja) | 2004-08-05 |
Family
ID=23036570
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2002567306A Withdrawn JP2004523558A (ja) | 2001-02-27 | 2002-02-20 | 縮合環式スクシンイミド化合物およびその類似体、核内ホルモン受容体機能のモジュレーター |
Country Status (6)
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008526888A (ja) * | 2005-01-10 | 2008-07-24 | アカディア ファーマシューティカルズ インコーポレイテッド | 選択的アンドロゲン受容体モジュレータとしてのアミノフェニル誘導体 |
JP2014522859A (ja) * | 2011-07-21 | 2014-09-08 | シュエンジュウ・ファーマ・カンパニー・リミテッド | 複素環置換ピリミジン化合物 |
Families Citing this family (56)
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US20040077605A1 (en) * | 2001-06-20 | 2004-04-22 | Salvati Mark E. | Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function |
US7001911B2 (en) * | 2000-06-28 | 2006-02-21 | Bristol-Myers Squibb Company | Fused cyclic modulators of nuclear hormone receptor function |
EP1854798A3 (en) * | 2000-09-19 | 2007-11-28 | Bristol-Myers Squibb Company | Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function |
SI1454903T1 (sl) * | 2001-12-11 | 2010-12-31 | Kyowa Hakko Kirin Co Ltd | Tiadiazolinski derivati za zdravljenje raka |
JP4434740B2 (ja) * | 2001-12-19 | 2010-03-17 | ブリストル−マイヤーズ スクイブ カンパニー | 核ホルモン受容体機能の調節剤である、縮合ヘテロ環化合物およびその類似体 |
AU2002950217A0 (en) | 2002-07-16 | 2002-09-12 | Prana Biotechnology Limited | 8- Hydroxy Quinoline Derivatives |
JP4676881B2 (ja) * | 2003-04-18 | 2011-04-27 | 協和発酵キリン株式会社 | M期キネシン阻害剤 |
US20070276017A1 (en) * | 2003-06-10 | 2007-11-29 | Chikara Murakata | Thiadiazoline Derivative |
US8530509B2 (en) | 2003-06-20 | 2013-09-10 | Siga Technologies, Inc. | Compounds, compositions and methods for treatment and prevention of orthopoxvirus infections and associated diseases |
AU2004249250C1 (en) * | 2003-06-20 | 2012-04-12 | Siga Technologies, Inc. | Compounds, compositions and methods for treatment and prevention of orthopoxvirus infections and associated diseases |
US7737168B2 (en) | 2003-06-20 | 2010-06-15 | Siga Technologies, Inc. | Compounds, compositions, and methods for treatment and prevention of orthopoxvirus infections and associated diseases |
JPWO2005035512A1 (ja) * | 2003-10-10 | 2006-12-21 | 協和醗酵工業株式会社 | チアジアゾリン誘導体 |
US8383637B2 (en) * | 2004-08-06 | 2013-02-26 | Jansssen Pharmaceutica N.V. | 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE) |
US8436006B2 (en) * | 2004-08-06 | 2013-05-07 | Jansssen Pharmaceutica N.V. | 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE) |
US8426429B2 (en) * | 2004-08-06 | 2013-04-23 | Jansssen Pharmaceutica N.V. | 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE) |
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WO2006137490A1 (ja) * | 2005-06-24 | 2006-12-28 | Kyowa Hakko Kogyo Co., Ltd. | 再狭窄治療剤 |
WO2007092854A2 (en) * | 2006-02-06 | 2007-08-16 | Janssen Pharmaceutica N.V. | 2-AMINO-QUINOLINE DERIVATIVES USEFUL AS INHIBITORS OF β-SECRETASE (BACE) |
WO2007092839A2 (en) * | 2006-02-06 | 2007-08-16 | Janssen Pharmaceutica N.V. | Macrocycle derivatives useful as inhibitors of beta-secretase (bace) |
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MX348481B (es) | 2007-04-23 | 2017-06-15 | Siga Tech Inc | Productos quimicos, composiciones y metodos para tratamiento y prevencion de infecciones de virus orthopox y enfermedades asociadas. |
US8466171B2 (en) * | 2007-11-01 | 2013-06-18 | Bristol-Myers Squibb Company | Fused heterocyclic compounds useful as modulators of nuclear hormone receptor function |
NZ586831A (en) * | 2008-01-28 | 2012-02-24 | Janssen Pharmaceutica Nv | 6-substituted-thio-2-amino-quinoline derivatives useful as inhibitors of beta-secretase (bace) |
NZ586830A (en) * | 2008-01-29 | 2012-02-24 | Janssen Pharmaceutica Nv | 2-amino-quinoline derivatives useful as inhibitors of beta-secretase (bace) |
DE102008022221A1 (de) * | 2008-05-06 | 2009-11-12 | Universität des Saarlandes | Inhibitoren der humanen Aldosteronsynthase CYP11B2 |
WO2009155001A2 (en) | 2008-05-27 | 2009-12-23 | The Board Of Regents Of The University Of Texas System | Wnt protein signalling inhibitors |
JPWO2011007819A1 (ja) | 2009-07-17 | 2012-12-27 | 塩野義製薬株式会社 | ラクタムまたはベンゼンスルホンアミド化合物を含有する医薬 |
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US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
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US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
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US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
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US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
CN103193696B (zh) * | 2013-04-18 | 2015-11-11 | 北京大学 | 降冰片烯基酰亚胺体系甲壳型聚合物单体及其聚合物 |
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CN106349160B (zh) * | 2016-08-05 | 2019-07-26 | 浙江工业大学 | 一种8-氨基喹啉衍生物及其制备与应用 |
CN107954992A (zh) * | 2017-12-15 | 2018-04-24 | 田元强 | 吡咯二酮衍生物及其在小菜蛾和桃蚜防治中的应用 |
CN110183456A (zh) * | 2019-07-11 | 2019-08-30 | 河南师范大学 | 一种2-芳基吲唑琥珀酰亚胺螺环化合物的合成方法 |
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-
2002
- 2002-02-14 US US10/075,870 patent/US20040087548A1/en not_active Abandoned
- 2002-02-20 JP JP2002567306A patent/JP2004523558A/ja not_active Withdrawn
- 2002-02-20 HU HU0304055A patent/HUP0304055A2/hu unknown
- 2002-02-20 WO PCT/US2002/005302 patent/WO2002067939A1/en active Application Filing
- 2002-02-20 EP EP02719057A patent/EP1379249A4/en not_active Withdrawn
- 2002-02-20 CA CA002439265A patent/CA2439265A1/en not_active Abandoned
-
2005
- 2005-12-19 US US11/311,731 patent/US7655688B2/en active Active
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2008526888A (ja) * | 2005-01-10 | 2008-07-24 | アカディア ファーマシューティカルズ インコーポレイテッド | 選択的アンドロゲン受容体モジュレータとしてのアミノフェニル誘導体 |
JP2014522859A (ja) * | 2011-07-21 | 2014-09-08 | シュエンジュウ・ファーマ・カンパニー・リミテッド | 複素環置換ピリミジン化合物 |
Also Published As
Publication number | Publication date |
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CA2439265A1 (en) | 2002-09-06 |
US7655688B2 (en) | 2010-02-02 |
US20040087548A1 (en) | 2004-05-06 |
EP1379249A4 (en) | 2008-01-09 |
US20060111424A1 (en) | 2006-05-25 |
WO2002067939A1 (en) | 2002-09-06 |
EP1379249A1 (en) | 2004-01-14 |
HUP0304055A2 (hu) | 2004-04-28 |
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