GB1039020A - Process for the preparation of 5-nitrofurfuraldehyde diacetate - Google Patents

Process for the preparation of 5-nitrofurfuraldehyde diacetate

Info

Publication number
GB1039020A
GB1039020A GB3840364A GB3840364A GB1039020A GB 1039020 A GB1039020 A GB 1039020A GB 3840364 A GB3840364 A GB 3840364A GB 3840364 A GB3840364 A GB 3840364A GB 1039020 A GB1039020 A GB 1039020A
Authority
GB
United Kingdom
Prior art keywords
nitrofurfuraldehyde
diacetate
acetic anhydride
furfuraldehyde
prepared
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3840364A
Inventor
John Cameron Turner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biorex Laboratories Ltd
Original Assignee
Biorex Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biorex Laboratories Ltd filed Critical Biorex Laboratories Ltd
Priority to GB3840364A priority Critical patent/GB1039020A/en
Publication of GB1039020A publication Critical patent/GB1039020A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/70—Nitro radicals
    • C07D307/71—Nitro radicals attached in position 5

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

5-Nitrofurfuraldehyde diacetate is prepared by the nitration of furfuraldehyde with phosphoric acid and an alkali metal nitrate in the presence of acetic anhydride. In a preferred process a mixture of furfuraldehyde, acetic anhydride and sodium nitrate is added to a mixture of approximately 100% phosphoric acid and acetic anhydride to effect nitration at a temperature of 30 DEG to 50 DEG C. N - (5 - Nitro - 2 - furfurylidene) - 1 - amino-hydantoin, i.e. nitrofurantoin, may be prepared by reacting 5-nitrofurfuraldehyde diacetate with the reaction product obtained by the reaction of potassium cyanate with ethyl hydrazino-acetic acid ester hydrochloride.
GB3840364A 1964-09-21 1964-09-21 Process for the preparation of 5-nitrofurfuraldehyde diacetate Expired GB1039020A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB3840364A GB1039020A (en) 1964-09-21 1964-09-21 Process for the preparation of 5-nitrofurfuraldehyde diacetate

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3840364A GB1039020A (en) 1964-09-21 1964-09-21 Process for the preparation of 5-nitrofurfuraldehyde diacetate

Publications (1)

Publication Number Publication Date
GB1039020A true GB1039020A (en) 1966-08-17

Family

ID=10403240

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3840364A Expired GB1039020A (en) 1964-09-21 1964-09-21 Process for the preparation of 5-nitrofurfuraldehyde diacetate

Country Status (1)

Country Link
GB (1) GB1039020A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7655689B2 (en) 2000-06-28 2010-02-02 Bristol-Myers Squibb Company Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
US7655688B2 (en) 2001-02-27 2010-02-02 Bristol-Myers Squibb Company Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
CN108069944A (en) * 2016-11-17 2018-05-25 湖南尔康制药股份有限公司 A kind of improvement of the method for synthesizing and refining of furantoin

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7655689B2 (en) 2000-06-28 2010-02-02 Bristol-Myers Squibb Company Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
US7655688B2 (en) 2001-02-27 2010-02-02 Bristol-Myers Squibb Company Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
CN108069944A (en) * 2016-11-17 2018-05-25 湖南尔康制药股份有限公司 A kind of improvement of the method for synthesizing and refining of furantoin
CN108069944B (en) * 2016-11-17 2020-07-07 湖南尔康制药股份有限公司 Preparation method of nitrofurantoin

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