GB716337A - Manufacture of pantetheine - Google Patents

Manufacture of pantetheine

Info

Publication number
GB716337A
GB716337A GB3003851A GB3003851A GB716337A GB 716337 A GB716337 A GB 716337A GB 3003851 A GB3003851 A GB 3003851A GB 3003851 A GB3003851 A GB 3003851A GB 716337 A GB716337 A GB 716337A
Authority
GB
United Kingdom
Prior art keywords
alanine
aralkylthioethylamine
carboaralkoxy
alanyl
carbo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3003851A
Inventor
James Baddiley
Eric Malcolm Thain
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Research Development Corp UK
Original Assignee
National Research Development Corp UK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National Research Development Corp UK filed Critical National Research Development Corp UK
Priority to GB3003851A priority Critical patent/GB716337A/en
Publication of GB716337A publication Critical patent/GB716337A/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00Carboxylic acid amides
    • C07C233/01Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Pantetheine is obtained by reacting a mixed anhydride of carbo-aralkoxy-b -alanine or an alkyl ester of carbo-aralkoxy-b -alanine with an aralkylthioethylamine, e.g. 2-benzylthioethylamine in the presence of an inert solvent to produce N - (carbo - aralkoxy - b - alanyl) - 2 - aralkylthioethylamine, removing the aralkyl and carbo-aralkoxy groups from the N-(carboaralkoxy - b - alanyl) - 2 - aralkylthioethylamine by hydrogenolysis and reacting the resulting amino-thiol, N-b -alanyl-2-mercaptoethylamine, with pantolactone to produce pantetheine. The aralkylthioethylamine is reacted with the mixed anhydride of carboaralkoxy-b -alanine in the temperature range 0 DEG to 20 DEG C. and with the alkyl ester of carboaralkoxy-b -alanine in the temperature range 50 DEG to 150 DEG C. As mixed anhydride of carboaralkoxy-b -alanine there may be used an azide, chloride of sulphuric anhydride. The hydrogenolysis may be effected with alkali metal, e.g. sodium and liquid ammonia. The N-b -alanyl-2-mercaptoethylamine is reacted with pantolactone at approximately 100 DEG C.
GB3003851A 1951-12-21 1951-12-21 Manufacture of pantetheine Expired GB716337A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB3003851A GB716337A (en) 1951-12-21 1951-12-21 Manufacture of pantetheine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3003851A GB716337A (en) 1951-12-21 1951-12-21 Manufacture of pantetheine

Publications (1)

Publication Number Publication Date
GB716337A true GB716337A (en) 1954-10-06

Family

ID=10301271

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3003851A Expired GB716337A (en) 1951-12-21 1951-12-21 Manufacture of pantetheine

Country Status (1)

Country Link
GB (1) GB716337A (en)

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