GB1011849A - The manufacture of 3-amino-isoxazole compounds - Google Patents

The manufacture of 3-amino-isoxazole compounds

Info

Publication number
GB1011849A
GB1011849A GB31317/64A GB3131764A GB1011849A GB 1011849 A GB1011849 A GB 1011849A GB 31317/64 A GB31317/64 A GB 31317/64A GB 3131764 A GB3131764 A GB 3131764A GB 1011849 A GB1011849 A GB 1011849A
Authority
GB
United Kingdom
Prior art keywords
amino
isoxazole compounds
formula
manufacture
hydroxylamine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB31317/64A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH970663A external-priority patent/CH421963A/en
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of GB1011849A publication Critical patent/GB1011849A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/04—Preparatory processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J10/00—Chemical processes in general for reacting liquid with gaseous media other than in the presence of solid particles, or apparatus specially adapted therefor
    • B01J10/02—Chemical processes in general for reacting liquid with gaseous media other than in the presence of solid particles, or apparatus specially adapted therefor of the thin-film type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/18—Stationary reactors having moving elements inside
    • B01J19/20—Stationary reactors having moving elements inside in the form of helices, e.g. screw reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/24—Stationary reactors without moving elements inside
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04C—APPARATUS USING FREE VORTEX FLOW, e.g. CYCLONES
    • B04C5/00—Apparatus in which the axial direction of the vortex is reversed
    • B04C5/08—Vortex chamber constructions
    • B04C5/081—Shapes or dimensions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/14—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/14—Nitrogen atoms
    • C07D261/16—Benzene-sulfonamido isoxazoles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00051—Controlling the temperature
    • B01J2219/00074—Controlling the temperature by indirect heating or cooling employing heat exchange fluids
    • B01J2219/00076—Controlling the temperature by indirect heating or cooling employing heat exchange fluids with heat exchange elements inside the reactor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00051—Controlling the temperature
    • B01J2219/00074—Controlling the temperature by indirect heating or cooling employing heat exchange fluids
    • B01J2219/00087—Controlling the temperature by indirect heating or cooling employing heat exchange fluids with heat exchange elements outside the reactor
    • B01J2219/00094—Jackets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00162—Controlling or regulating processes controlling the pressure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00168—Controlling or regulating processes controlling the viscosity

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Physics & Mathematics (AREA)
  • Geometry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Polyamides (AREA)
  • Polymerisation Methods In General (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)

Abstract

3-Amino isoxazole compounds of the general formula <FORM:1011849/C2/1> in which R1 and R2 are alkyl, aralkyl or aryl groups, these substituents being optional, are prepared by reacting an a ,b -dihalo-carboxylic acid nitrile of the formula <FORM:1011849/C2/2> or an a ,b -unsaturated-a -halo-carboxylic acid of formula <FORM:1011849/C2/3> in alkaline medium with hydroxylamine or an N-acyl-hydroxylamine. The term "acyl" is defined as including both "oyl" and "amoyl" groups. The 3-amino isoxazole compounds may be further reacted, without isolation, with a benzenesulphonyl halide to produce the corresponding 3 - sulphanilamido - isoxazole. Specifications 1,011,850 and 981,469 are referred to.
GB31317/64A 1962-08-24 1964-08-04 The manufacture of 3-amino-isoxazole compounds Expired GB1011849A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21932462A 1962-08-24 1962-08-24
CH970663A CH421963A (en) 1963-08-06 1963-08-06 Process for the preparation of aminoisoxazoles

Publications (1)

Publication Number Publication Date
GB1011849A true GB1011849A (en) 1965-12-01

Family

ID=25705221

Family Applications (3)

Application Number Title Priority Date Filing Date
GB1050453D Active GB1050453A (en) 1962-08-24
GB31317/64A Expired GB1011849A (en) 1962-08-24 1964-08-04 The manufacture of 3-amino-isoxazole compounds
GB31318/64A Expired GB1011850A (en) 1962-08-24 1964-08-04 Sulphonamides and a process for the manufacture thereof

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB1050453D Active GB1050453A (en) 1962-08-24

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB31318/64A Expired GB1011850A (en) 1962-08-24 1964-08-04 Sulphonamides and a process for the manufacture thereof

Country Status (12)

Country Link
BE (3) BE651386A (en)
BR (2) BR6461412D0 (en)
CH (1) CH443229A (en)
DE (3) DE1520327A1 (en)
DK (1) DK113321B (en)
FR (2) FR1410207A (en)
GB (3) GB1011849A (en)
LU (1) LU44311A1 (en)
NL (4) NL144279B (en)
NO (1) NO115360B (en)
OA (1) OA00939A (en)
SE (3) SE321092B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4442260A (en) * 1983-03-14 1984-04-10 E. I. Du Pont De Nemours & Company Preparation of salt solution useful for making nylon
IL80260A0 (en) * 1986-10-09 1987-01-30 Bromine Compounds Ltd Process for the manufacture of 3-amino-5-methylisoxazole
GB2390314A (en) * 2002-07-02 2004-01-07 Protensive Ltd Reactor with rotating spiral member, and heat transfer member
DE10331952A1 (en) * 2003-07-15 2005-02-10 Degussa Ag Apparatus and process for discontinuous polycondensation
CN104829586B (en) * 2015-04-13 2018-06-15 泰兴市沃特尔化工有限公司 A kind of method and its cracker prepared by glycolide

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1059459B (en) * 1956-09-04 1959-06-18 Shionogi & Co Process for the preparation of the therapeutically useful 3-sulfanilamido-5-methylisoxazole

Also Published As

Publication number Publication date
LU44311A1 (en) 1964-02-22
GB1050453A (en)
BR6461412D0 (en) 1973-07-17
NL297048A (en)
FR1410207A (en) 1965-09-10
GB1011850A (en) 1965-12-01
SE300986B (en) 1968-05-20
OA00939A (en) 1968-03-22
NO115360B (en) 1968-09-23
DK113321B (en) 1969-03-10
FR3957M (en) 1966-02-28
NL6408919A (en) 1965-02-08
DE1520327A1 (en) 1969-05-22
BE636533A (en)
SE320368B (en) 1970-02-09
BE651387A (en) 1965-02-04
NL6408283A (en) 1965-02-08
DE1280873B (en) 1968-10-24
SE321092B (en) 1970-02-23
DE1445902A1 (en) 1968-12-19
BE651386A (en) 1965-02-04
CH443229A (en) 1967-09-15
NL144279B (en) 1974-12-16
NL132128C (en)
BR6461413D0 (en) 1973-08-09

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