JP2004523546A5 - - Google Patents
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- JP2004523546A5 JP2004523546A5 JP2002564505A JP2002564505A JP2004523546A5 JP 2004523546 A5 JP2004523546 A5 JP 2004523546A5 JP 2002564505 A JP2002564505 A JP 2002564505A JP 2002564505 A JP2002564505 A JP 2002564505A JP 2004523546 A5 JP2004523546 A5 JP 2004523546A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- dioxo
- ylmethyl
- methoxy
- carboxylic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 150000001875 compounds Chemical class 0.000 claims 77
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 67
- 125000004430 oxygen atom Chemical group O* 0.000 claims 53
- 229910052739 hydrogen Inorganic materials 0.000 claims 48
- -1 2,1,3-benzothiadiazolyl Chemical group 0.000 claims 47
- 239000001257 hydrogen Substances 0.000 claims 47
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 41
- 229910052717 sulfur Inorganic materials 0.000 claims 40
- 229910052757 nitrogen Inorganic materials 0.000 claims 32
- 125000003118 aryl group Chemical group 0.000 claims 28
- 229910052736 halogen Inorganic materials 0.000 claims 27
- 150000002367 halogens Chemical class 0.000 claims 27
- 229910052760 oxygen Inorganic materials 0.000 claims 25
- 125000004434 sulfur atom Chemical group 0.000 claims 23
- 150000002430 hydrocarbons Chemical group 0.000 claims 21
- 238000000034 method Methods 0.000 claims 17
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 16
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 15
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 15
- 150000003839 salts Chemical class 0.000 claims 15
- 150000001204 N-oxides Chemical class 0.000 claims 14
- 125000000217 alkyl group Chemical group 0.000 claims 14
- 125000000623 heterocyclic group Chemical group 0.000 claims 14
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 14
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 13
- 239000002253 acid Substances 0.000 claims 11
- 125000004432 carbon atom Chemical group C* 0.000 claims 11
- 125000000753 cycloalkyl group Chemical group 0.000 claims 11
- 150000002829 nitrogen Chemical group 0.000 claims 11
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 11
- 125000005871 1,3-benzodioxolyl group Chemical group 0.000 claims 10
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Substances CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 10
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 10
- 125000004093 cyano group Chemical group *C#N 0.000 claims 10
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 10
- 239000001301 oxygen Chemical group 0.000 claims 10
- 125000004076 pyridyl group Chemical group 0.000 claims 10
- 150000003254 radicals Chemical class 0.000 claims 10
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims 9
- 125000005842 heteroatom Chemical group 0.000 claims 9
- WMFOQBRAJBCJND-UHFFFAOYSA-M Lithium hydroxide Chemical compound [Li+].[OH-] WMFOQBRAJBCJND-UHFFFAOYSA-M 0.000 claims 8
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 8
- 125000004601 benzofurazanyl group Chemical group N1=C2C(=NO1)C(=CC=C2)* 0.000 claims 8
- 125000002541 furyl group Chemical group 0.000 claims 8
- 125000001072 heteroaryl group Chemical group 0.000 claims 8
- 125000002883 imidazolyl group Chemical group 0.000 claims 8
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 8
- 239000011593 sulfur Chemical group 0.000 claims 8
- 125000001544 thienyl group Chemical group 0.000 claims 8
- UIKAZNIHBZKRPC-UHFFFAOYSA-N 4-[[6-[(4-methoxyphenyl)methylcarbamoyl]-1-methyl-2,4-dioxoquinazolin-3-yl]methyl]benzoic acid Chemical compound C1=CC(OC)=CC=C1CNC(=O)C1=CC=C(N(C)C(=O)N(CC=2C=CC(=CC=2)C(O)=O)C2=O)C2=C1 UIKAZNIHBZKRPC-UHFFFAOYSA-N 0.000 claims 7
- 239000005711 Benzoic acid Substances 0.000 claims 7
- FPQVGDGSRVMNMR-JCTPKUEWSA-N [[(z)-(1-cyano-2-ethoxy-2-oxoethylidene)amino]oxy-(dimethylamino)methylidene]-dimethylazanium;tetrafluoroborate Chemical compound F[B-](F)(F)F.CCOC(=O)C(\C#N)=N/OC(N(C)C)=[N+](C)C FPQVGDGSRVMNMR-JCTPKUEWSA-N 0.000 claims 7
- 239000012190 activator Substances 0.000 claims 7
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 6
- 229960000583 acetic acid Drugs 0.000 claims 6
- 125000000928 benzodioxinyl group Chemical group O1C(=COC2=C1C=CC=C2)* 0.000 claims 6
- 125000004618 benzofuryl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 6
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 6
- 125000001041 indolyl group Chemical group 0.000 claims 6
- 238000002360 preparation method Methods 0.000 claims 6
- 125000003342 alkenyl group Chemical group 0.000 claims 5
- IDPURXSQCKYKIJ-UHFFFAOYSA-N 1-(4-methoxyphenyl)methanamine Chemical compound COC1=CC=C(CN)C=C1 IDPURXSQCKYKIJ-UHFFFAOYSA-N 0.000 claims 4
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 4
- 125000000304 alkynyl group Chemical group 0.000 claims 4
- 150000001408 amides Chemical class 0.000 claims 4
- 125000005605 benzo group Chemical group 0.000 claims 4
- 150000002148 esters Chemical class 0.000 claims 4
- 125000001624 naphthyl group Chemical group 0.000 claims 4
- ONDPHDOFVYQSGI-UHFFFAOYSA-N zinc nitrate Chemical compound [Zn+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O ONDPHDOFVYQSGI-UHFFFAOYSA-N 0.000 claims 4
- RTWDCTBZYBUYAK-UHFFFAOYSA-N 3-benzyl-1-methyl-2,4-dioxoquinazoline-6-carboxylic acid Chemical compound O=C1N(C)C2=CC=C(C(O)=O)C=C2C(=O)N1CC1=CC=CC=C1 RTWDCTBZYBUYAK-UHFFFAOYSA-N 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- XDJZRCOZZFZKGP-UHFFFAOYSA-N n-[(4-methoxyphenyl)methyl]-1-methyl-3-[[4-(methylsulfamoyl)phenyl]methyl]-2,4-dioxoquinazoline-6-carboxamide Chemical compound C1=CC(S(=O)(=O)NC)=CC=C1CN1C(=O)C2=CC(C(=O)NCC=3C=CC(OC)=CC=3)=CC=C2N(C)C1=O XDJZRCOZZFZKGP-UHFFFAOYSA-N 0.000 claims 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 2
- ZILSBZLQGRBMOR-UHFFFAOYSA-N 1,3-benzodioxol-5-ylmethanamine Chemical compound NCC1=CC=C2OCOC2=C1 ZILSBZLQGRBMOR-UHFFFAOYSA-N 0.000 claims 2
- BWPRWCSTBFYGLT-UHFFFAOYSA-N 1,3-benzodioxol-5-ylmethyl 3-benzyl-1-methyl-2,4-dioxoquinazoline-6-carboxylate Chemical compound O=C1N(C)C2=CC=C(C(=O)OCC=3C=C4OCOC4=CC=3)C=C2C(=O)N1CC1=CC=CC=C1 BWPRWCSTBFYGLT-UHFFFAOYSA-N 0.000 claims 2
- HJMGNZAVOCBDAL-UHFFFAOYSA-N 1-[4-[[6-[(4-methoxyphenyl)methylcarbamoyl]-1-methyl-2,4-dioxoquinazolin-3-yl]methyl]phenyl]cyclopropane-1-carboxylic acid Chemical compound C1=CC(OC)=CC=C1CNC(=O)C1=CC=C(N(C)C(=O)N(CC=2C=CC(=CC=2)C2(CC2)C(O)=O)C2=O)C2=C1 HJMGNZAVOCBDAL-UHFFFAOYSA-N 0.000 claims 2
- NOVBKOBBAJJCSW-UHFFFAOYSA-N 2-fluoro-4-[[6-[(4-methoxyphenyl)methylcarbamoyl]-1-methyl-2,4-dioxoquinazolin-3-yl]methyl]benzoic acid Chemical compound C1=CC(OC)=CC=C1CNC(=O)C1=CC=C(N(C)C(=O)N(CC=2C=C(F)C(C(O)=O)=CC=2)C2=O)C2=C1 NOVBKOBBAJJCSW-UHFFFAOYSA-N 0.000 claims 2
- TVUJJDYQUHTFSL-UHFFFAOYSA-N 2-hydroxy-4-[[6-[(4-methoxyphenyl)methylcarbamoyl]-1-methyl-2,4-dioxoquinazolin-3-yl]methyl]benzoic acid Chemical compound C1=CC(OC)=CC=C1CNC(=O)C1=CC=C(N(C)C(=O)N(CC=2C=C(O)C(C(O)=O)=CC=2)C2=O)C2=C1 TVUJJDYQUHTFSL-UHFFFAOYSA-N 0.000 claims 2
- BIXCXFICAILKMG-UHFFFAOYSA-N 3-[(3,4-difluorophenyl)methyl]-1-methyl-2,4-dioxo-n-(pyridin-3-ylmethyl)quinazoline-6-carboxamide Chemical compound O=C1N(C)C2=CC=C(C(=O)NCC=3C=NC=CC=3)C=C2C(=O)N1CC1=CC=C(F)C(F)=C1 BIXCXFICAILKMG-UHFFFAOYSA-N 0.000 claims 2
- DANLCJUCLTZJHP-UHFFFAOYSA-N 3-[(3,4-difluorophenyl)methyl]-n-[(4-methoxyphenyl)methyl]-1-methyl-2,4-dioxoquinazoline-6-carboxamide Chemical compound C1=CC(OC)=CC=C1CNC(=O)C1=CC=C(N(C)C(=O)N(CC=2C=C(F)C(F)=CC=2)C2=O)C2=C1 DANLCJUCLTZJHP-UHFFFAOYSA-N 0.000 claims 2
- QDOIJCKFBQQXDC-UHFFFAOYSA-N 3-[(3-fluorophenyl)methyl]-1-methyl-2,4-dioxo-n-(pyridin-4-ylmethyl)quinazoline-6-carboxamide Chemical compound O=C1N(C)C2=CC=C(C(=O)NCC=3C=CN=CC=3)C=C2C(=O)N1CC1=CC=CC(F)=C1 QDOIJCKFBQQXDC-UHFFFAOYSA-N 0.000 claims 2
- UDKYTSSHCNBMLD-UHFFFAOYSA-N 3-[(3-fluorophenyl)methyl]-n-[(3-methoxyphenyl)methyl]-1-methyl-2,4-dioxoquinazoline-6-carboxamide Chemical compound COC1=CC=CC(CNC(=O)C=2C=C3C(=O)N(CC=4C=C(F)C=CC=4)C(=O)N(C)C3=CC=2)=C1 UDKYTSSHCNBMLD-UHFFFAOYSA-N 0.000 claims 2
- QAXTXYVAZKPVGS-UHFFFAOYSA-N 3-[(3-fluorophenyl)methyl]-n-[(4-methoxyphenyl)methyl]-1-methyl-2,4-dioxoquinazoline-6-carboxamide Chemical compound C1=CC(OC)=CC=C1CNC(=O)C1=CC=C(N(C)C(=O)N(CC=2C=C(F)C=CC=2)C2=O)C2=C1 QAXTXYVAZKPVGS-UHFFFAOYSA-N 0.000 claims 2
- LMDPQQZZOBOYOO-UHFFFAOYSA-N 3-[(4-acetamidophenyl)methyl]-n-[(4-methoxyphenyl)methyl]-1-methyl-2,4-dioxoquinazoline-6-carboxamide Chemical compound C1=CC(OC)=CC=C1CNC(=O)C1=CC=C(N(C)C(=O)N(CC=2C=CC(NC(C)=O)=CC=2)C2=O)C2=C1 LMDPQQZZOBOYOO-UHFFFAOYSA-N 0.000 claims 2
- YXOAZJDQWORJDL-UHFFFAOYSA-N 3-[(4-aminophenyl)methyl]-n-[(4-methoxyphenyl)methyl]-1-methyl-2,4-dioxoquinazoline-6-carboxamide Chemical compound C1=CC(OC)=CC=C1CNC(=O)C1=CC=C(N(C)C(=O)N(CC=2C=CC(N)=CC=2)C2=O)C2=C1 YXOAZJDQWORJDL-UHFFFAOYSA-N 0.000 claims 2
- RBSZNGZWLIVRMJ-UHFFFAOYSA-N 3-[(4-bromophenyl)methyl]-n-[(2-methoxypyridin-4-yl)methyl]-1-methyl-2,4-dioxoquinazoline-6-carboxamide Chemical compound C1=NC(OC)=CC(CNC(=O)C=2C=C3C(=O)N(CC=4C=CC(Br)=CC=4)C(=O)N(C)C3=CC=2)=C1 RBSZNGZWLIVRMJ-UHFFFAOYSA-N 0.000 claims 2
- XZWZZIDYMGUHPU-UHFFFAOYSA-N 3-[(4-chlorophenyl)methyl]-n-[(3-methoxyphenyl)methyl]-1-methyl-2,4-dioxoquinazoline-6-carboxamide Chemical compound COC1=CC=CC(CNC(=O)C=2C=C3C(=O)N(CC=4C=CC(Cl)=CC=4)C(=O)N(C)C3=CC=2)=C1 XZWZZIDYMGUHPU-UHFFFAOYSA-N 0.000 claims 2
- UHMHFRZRKXLOKN-UHFFFAOYSA-N 3-[(4-cyanophenyl)methyl]-n-[(4-methoxyphenyl)methyl]-1-methyl-2,4-dioxoquinazoline-6-carboxamide Chemical compound C1=CC(OC)=CC=C1CNC(=O)C1=CC=C(N(C)C(=O)N(CC=2C=CC(=CC=2)C#N)C2=O)C2=C1 UHMHFRZRKXLOKN-UHFFFAOYSA-N 0.000 claims 2
- PQHQROVVUPAICX-UHFFFAOYSA-N 3-[(4-fluorophenyl)methyl]-1-methyl-2,4-dioxo-n-(pyridin-4-ylmethyl)quinazoline-6-carboxamide Chemical compound O=C1N(C)C2=CC=C(C(=O)NCC=3C=CN=CC=3)C=C2C(=O)N1CC1=CC=C(F)C=C1 PQHQROVVUPAICX-UHFFFAOYSA-N 0.000 claims 2
- MYSGCPGBUCOWLB-UHFFFAOYSA-N 3-[(4-fluorophenyl)methyl]-n-[(3-methoxyphenyl)methyl]-1-methyl-2,4-dioxoquinazoline-6-carboxamide Chemical compound COC1=CC=CC(CNC(=O)C=2C=C3C(=O)N(CC=4C=CC(F)=CC=4)C(=O)N(C)C3=CC=2)=C1 MYSGCPGBUCOWLB-UHFFFAOYSA-N 0.000 claims 2
- MHNKIWAAGICYBL-UHFFFAOYSA-N 3-[(4-fluorophenyl)methyl]-n-[(4-methoxyphenyl)methyl]-1-methyl-2,4-dioxoquinazoline-6-carboxamide Chemical compound C1=CC(OC)=CC=C1CNC(=O)C1=CC=C(N(C)C(=O)N(CC=2C=CC(F)=CC=2)C2=O)C2=C1 MHNKIWAAGICYBL-UHFFFAOYSA-N 0.000 claims 2
- WAHUQWWKOHQZPQ-UHFFFAOYSA-N 3-[(4-methoxyphenyl)methyl]-1-methyl-2,4-dioxo-n-(pyridin-4-ylmethyl)quinazoline-6-carboxamide Chemical compound C1=CC(OC)=CC=C1CN1C(=O)C2=CC(C(=O)NCC=3C=CN=CC=3)=CC=C2N(C)C1=O WAHUQWWKOHQZPQ-UHFFFAOYSA-N 0.000 claims 2
- LWOFFGNQTSVPAZ-UHFFFAOYSA-N 3-[[4-(dimethylcarbamoyl)phenyl]methyl]-n-[(4-methoxyphenyl)methyl]-1-methyl-2,4-dioxoquinazoline-6-carboxamide Chemical compound C1=CC(OC)=CC=C1CNC(=O)C1=CC=C(N(C)C(=O)N(CC=2C=CC(=CC=2)C(=O)N(C)C)C2=O)C2=C1 LWOFFGNQTSVPAZ-UHFFFAOYSA-N 0.000 claims 2
- ADXKXKZONBGARM-UHFFFAOYSA-N 3-[[4-(dimethylsulfamoyl)phenyl]methyl]-n-[(4-methoxyphenyl)methyl]-1-methyl-2,4-dioxoquinazoline-6-carboxamide Chemical compound C1=CC(OC)=CC=C1CNC(=O)C1=CC=C(N(C)C(=O)N(CC=2C=CC(=CC=2)S(=O)(=O)N(C)C)C2=O)C2=C1 ADXKXKZONBGARM-UHFFFAOYSA-N 0.000 claims 2
- IDRUMHZMIGERQP-UHFFFAOYSA-N 3-benzyl-n-[(4-methoxyphenyl)methyl]-2,4-dioxo-1h-quinazoline-6-carboxamide Chemical compound C1=CC(OC)=CC=C1CNC(=O)C1=CC=C(NC(=O)N(CC=2C=CC=CC=2)C2=O)C2=C1 IDRUMHZMIGERQP-UHFFFAOYSA-N 0.000 claims 2
- HROXCYNRYJKFOE-UHFFFAOYSA-N 4-[[1-ethyl-6-[(4-methoxyphenyl)methylcarbamoyl]-2,4-dioxoquinazolin-3-yl]methyl]benzoic acid Chemical compound O=C1N(CC)C2=CC=C(C(=O)NCC=3C=CC(OC)=CC=3)C=C2C(=O)N1CC1=CC=C(C(O)=O)C=C1 HROXCYNRYJKFOE-UHFFFAOYSA-N 0.000 claims 2
- BFQZPNWOQOYTNB-UHFFFAOYSA-N 4-[[1-methyl-2,4-dioxo-6-(pyridin-4-ylmethylcarbamoyl)quinazolin-3-yl]methyl]benzoic acid Chemical compound O=C1N(C)C2=CC=C(C(=O)NCC=3C=CN=CC=3)C=C2C(=O)N1CC1=CC=C(C(O)=O)C=C1 BFQZPNWOQOYTNB-UHFFFAOYSA-N 0.000 claims 2
- FKKIJKXREOJWED-UHFFFAOYSA-N 4-[[1-methyl-6-[(4-methylsulfanylphenyl)methylcarbamoyl]-2,4-dioxoquinazolin-3-yl]methyl]benzoic acid Chemical compound C1=CC(SC)=CC=C1CNC(=O)C1=CC=C(N(C)C(=O)N(CC=2C=CC(=CC=2)C(O)=O)C2=O)C2=C1 FKKIJKXREOJWED-UHFFFAOYSA-N 0.000 claims 2
- GHQSGKMBAWBNEX-UHFFFAOYSA-N 4-[[6-(1,3-benzodioxol-5-ylmethylcarbamoyl)-1-methyl-2,4-dioxoquinazolin-3-yl]methyl]benzoic acid Chemical compound O=C1N(C)C2=CC=C(C(=O)NCC=3C=C4OCOC4=CC=3)C=C2C(=O)N1CC1=CC=C(C(O)=O)C=C1 GHQSGKMBAWBNEX-UHFFFAOYSA-N 0.000 claims 2
- XDTGZUADOQNHPD-UHFFFAOYSA-N 4-[[6-(2,1,3-benzoxadiazol-5-ylmethylcarbamoyl)-1-methyl-2,4-dioxoquinazolin-3-yl]methyl]benzoic acid Chemical compound O=C1N(C)C2=CC=C(C(=O)NCC3=CC4=NON=C4C=C3)C=C2C(=O)N1CC1=CC=C(C(O)=O)C=C1 XDTGZUADOQNHPD-UHFFFAOYSA-N 0.000 claims 2
- IANWYYAFXBVPBB-UHFFFAOYSA-N 4-[[6-[(3-methoxyphenyl)methylcarbamoyl]-1-methyl-2,4-dioxopyrido[3,4-d]pyrimidin-3-yl]methyl]benzoic acid Chemical compound COC1=CC=CC(CNC(=O)C=2N=CC3=C(C(N(CC=4C=CC(=CC=4)C(O)=O)C(=O)N3C)=O)C=2)=C1 IANWYYAFXBVPBB-UHFFFAOYSA-N 0.000 claims 2
- GALQOPPFKVTHHX-UHFFFAOYSA-N 4-[[6-[(4-fluorophenyl)methylcarbamoyl]-1-methyl-2,4-dioxoquinazolin-3-yl]methyl]benzoic acid Chemical compound O=C1N(C)C2=CC=C(C(=O)NCC=3C=CC(F)=CC=3)C=C2C(=O)N1CC1=CC=C(C(O)=O)C=C1 GALQOPPFKVTHHX-UHFFFAOYSA-N 0.000 claims 2
- IRFKUHPCEUQYND-UHFFFAOYSA-N 4-[[6-[(4-methoxyphenyl)methylcarbamoyl]-1-methyl-2,4-dioxopyrido[2,3-d]pyrimidin-3-yl]methyl]benzoic acid Chemical compound C1=CC(OC)=CC=C1CNC(=O)C1=CN=C(N(C)C(=O)N(CC=2C=CC(=CC=2)C(O)=O)C2=O)C2=C1 IRFKUHPCEUQYND-UHFFFAOYSA-N 0.000 claims 2
- RRXWVBJYYYJEOV-UHFFFAOYSA-N 4-[[6-[(4-methoxyphenyl)methylcarbamoyl]-1-methyl-2,4-dioxopyrido[3,4-d]pyrimidin-3-yl]methyl]benzoic acid Chemical compound C1=CC(OC)=CC=C1CNC(=O)C1=CC(C(N(CC=2C=CC(=CC=2)C(O)=O)C(=O)N2C)=O)=C2C=N1 RRXWVBJYYYJEOV-UHFFFAOYSA-N 0.000 claims 2
- KDNPIUHXVOCSFH-UHFFFAOYSA-N 4-[[6-[(4-methoxyphenyl)methylcarbamoyl]-1-methyl-2,4-dioxoquinazolin-3-yl]methyl]-2-methylbenzoic acid Chemical compound C1=CC(OC)=CC=C1CNC(=O)C1=CC=C(N(C)C(=O)N(CC=2C=C(C)C(C(O)=O)=CC=2)C2=O)C2=C1 KDNPIUHXVOCSFH-UHFFFAOYSA-N 0.000 claims 2
- BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 claims 2
- LQZMLBORDGWNPD-UHFFFAOYSA-N N-iodosuccinimide Chemical compound IN1C(=O)CCC1=O LQZMLBORDGWNPD-UHFFFAOYSA-N 0.000 claims 2
- SPEUIVXLLWOEMJ-UHFFFAOYSA-N acetaldehyde dimethyl acetal Natural products COC(C)OC SPEUIVXLLWOEMJ-UHFFFAOYSA-N 0.000 claims 2
- 206010064930 age-related macular degeneration Diseases 0.000 claims 2
- 229910052799 carbon Chemical group 0.000 claims 2
- 150000001721 carbon Chemical group 0.000 claims 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 2
- MVPPADPHJFYWMZ-UHFFFAOYSA-N chlorobenzene Chemical compound ClC1=CC=CC=C1 MVPPADPHJFYWMZ-UHFFFAOYSA-N 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- DEDLCWVUFNMRCZ-UHFFFAOYSA-N ethyl 2-fluoro-4-[[6-[(4-methoxyphenyl)methylcarbamoyl]-1-methyl-2,4-dioxoquinazolin-3-yl]methyl]benzoate Chemical compound C1=C(F)C(C(=O)OCC)=CC=C1CN1C(=O)C2=CC(C(=O)NCC=3C=CC(OC)=CC=3)=CC=C2N(C)C1=O DEDLCWVUFNMRCZ-UHFFFAOYSA-N 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 208000002780 macular degeneration Diseases 0.000 claims 2
- NBFZGDKLPSNUNW-UHFFFAOYSA-N methyl 4-[[1-methyl-2,4-dioxo-6-(pyridin-4-ylmethylcarbamoyl)quinazolin-3-yl]methyl]benzoate Chemical compound C1=CC(C(=O)OC)=CC=C1CN1C(=O)C2=CC(C(=O)NCC=3C=CN=CC=3)=CC=C2N(C)C1=O NBFZGDKLPSNUNW-UHFFFAOYSA-N 0.000 claims 2
- LEMUGRKFWBDGID-UHFFFAOYSA-N methyl 4-[[6-[(3-methoxyphenyl)methylcarbamoyl]-1-methyl-2,4-dioxoquinazolin-3-yl]methyl]benzoate Chemical compound C1=CC(C(=O)OC)=CC=C1CN1C(=O)C2=CC(C(=O)NCC=3C=C(OC)C=CC=3)=CC=C2N(C)C1=O LEMUGRKFWBDGID-UHFFFAOYSA-N 0.000 claims 2
- IYFTZKZDBHQERK-UHFFFAOYSA-N methyl 4-[[6-[(4-fluorophenyl)methylcarbamoyl]-1-methyl-2,4-dioxoquinazolin-3-yl]methyl]benzoate Chemical compound C1=CC(C(=O)OC)=CC=C1CN1C(=O)C2=CC(C(=O)NCC=3C=CC(F)=CC=3)=CC=C2N(C)C1=O IYFTZKZDBHQERK-UHFFFAOYSA-N 0.000 claims 2
- HLTSJJUYHQREGW-UHFFFAOYSA-N methyl 4-[[6-[(4-methoxyphenyl)methylcarbamoyl]-1-methyl-2,4-dioxopyrido[3,4-d]pyrimidin-3-yl]methyl]benzoate Chemical compound C1=CC(C(=O)OC)=CC=C1CN1C(=O)C2=CC(C(=O)NCC=3C=CC(OC)=CC=3)=NC=C2N(C)C1=O HLTSJJUYHQREGW-UHFFFAOYSA-N 0.000 claims 2
- HCQBQWQVNIECRB-UHFFFAOYSA-N methyl 4-[[6-[(4-methoxyphenyl)methylcarbamoyl]-1-methyl-2,4-dioxoquinazolin-3-yl]methyl]-2-methylbenzoate Chemical compound C1=C(C)C(C(=O)OC)=CC=C1CN1C(=O)C2=CC(C(=O)NCC=3C=CC(OC)=CC=3)=CC=C2N(C)C1=O HCQBQWQVNIECRB-UHFFFAOYSA-N 0.000 claims 2
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 2
- OSEITAJRDPRJNG-UHFFFAOYSA-N n,3-bis(1,3-benzodioxol-5-ylmethyl)-2,4-dioxo-1h-quinazoline-6-carboxamide Chemical compound C1=C2OCOC2=CC(CN2C(=O)NC3=CC=C(C=C3C2=O)C(NCC=2C=C3OCOC3=CC=2)=O)=C1 OSEITAJRDPRJNG-UHFFFAOYSA-N 0.000 claims 2
- CXTYZSSOMNTKNZ-UHFFFAOYSA-N n,3-bis[(4-methoxyphenyl)methyl]-1-methyl-2,4-dioxoquinazoline-6-carboxamide Chemical compound C1=CC(OC)=CC=C1CNC(=O)C1=CC=C(N(C)C(=O)N(CC=2C=CC(OC)=CC=2)C2=O)C2=C1 CXTYZSSOMNTKNZ-UHFFFAOYSA-N 0.000 claims 2
- LRSIORLZFKZVOE-UHFFFAOYSA-N n-(1,3-benzodioxol-5-ylmethyl)-2,4-dioxo-3-(thiophen-2-ylmethyl)-1h-quinazoline-6-carboxamide Chemical compound C=1C=C2OCOC2=CC=1CNC(=O)C(C=C1C2=O)=CC=C1NC(=O)N2CC1=CC=CS1 LRSIORLZFKZVOE-UHFFFAOYSA-N 0.000 claims 2
- MBDLLPPZHNHZCL-UHFFFAOYSA-N n-(1,3-benzodioxol-5-ylmethyl)-3-[(4-chlorophenyl)methyl]-2,4-dioxo-1h-quinazoline-6-carboxamide Chemical compound C1=CC(Cl)=CC=C1CN1C(=O)C2=CC(C(=O)NCC=3C=C4OCOC4=CC=3)=CC=C2NC1=O MBDLLPPZHNHZCL-UHFFFAOYSA-N 0.000 claims 2
- OGIOFSPBUNCVQL-UHFFFAOYSA-N n-(1,3-benzodioxol-5-ylmethyl)-3-benzyl-1-methyl-2,4-dioxopyrido[3,4-d]pyrimidine-6-carboxamide Chemical compound O=C1N(C)C2=CN=C(C(=O)NCC=3C=C4OCOC4=CC=3)C=C2C(=O)N1CC1=CC=CC=C1 OGIOFSPBUNCVQL-UHFFFAOYSA-N 0.000 claims 2
- XHMUYKNWOKYJSD-UHFFFAOYSA-N n-(1,3-benzodioxol-5-ylmethyl)-3-benzyl-1-methyl-2,4-dioxoquinazoline-6-carboxamide Chemical compound O=C1N(C)C2=CC=C(C(=O)NCC=3C=C4OCOC4=CC=3)C=C2C(=O)N1CC1=CC=CC=C1 XHMUYKNWOKYJSD-UHFFFAOYSA-N 0.000 claims 2
- UKAYJIRWQJUFJM-UHFFFAOYSA-N n-[(4-methoxyphenyl)methyl]-1-methyl-2,4-dioxo-3-[(4-sulfamoylphenyl)methyl]quinazoline-6-carboxamide Chemical compound C1=CC(OC)=CC=C1CNC(=O)C1=CC=C(N(C)C(=O)N(CC=2C=CC(=CC=2)S(N)(=O)=O)C2=O)C2=C1 UKAYJIRWQJUFJM-UHFFFAOYSA-N 0.000 claims 2
- XYMOXMHPCZQPMU-UHFFFAOYSA-N n-[(4-methoxyphenyl)methyl]-1-methyl-3-[(4-nitrophenyl)methyl]-2,4-dioxoquinazoline-6-carboxamide Chemical compound C1=CC(OC)=CC=C1CNC(=O)C1=CC=C(N(C)C(=O)N(CC=2C=CC(=CC=2)[N+]([O-])=O)C2=O)C2=C1 XYMOXMHPCZQPMU-UHFFFAOYSA-N 0.000 claims 2
- OVACKGJTSPTGTJ-UHFFFAOYSA-N n-[(4-methoxyphenyl)methyl]-1-methyl-3-[[4-(2-methyltetrazol-5-yl)phenyl]methyl]-2,4-dioxoquinazoline-6-carboxamide Chemical compound C1=CC(OC)=CC=C1CNC(=O)C1=CC=C(N(C)C(=O)N(CC=2C=CC(=CC=2)C2=NN(C)N=N2)C2=O)C2=C1 OVACKGJTSPTGTJ-UHFFFAOYSA-N 0.000 claims 2
- RSYIBKXNDYAFEL-UHFFFAOYSA-N n-[(4-methoxyphenyl)methyl]-1-methyl-3-[[4-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl]methyl]-2,4-dioxoquinazoline-6-carboxamide Chemical compound C1=CC(OC)=CC=C1CNC(=O)C1=CC=C(N(C)C(=O)N(CC=2C=CC(=CC=2)C=2ON=C(C)N=2)C2=O)C2=C1 RSYIBKXNDYAFEL-UHFFFAOYSA-N 0.000 claims 2
- VARPADYZPUCKDI-UHFFFAOYSA-N n-[(4-methoxyphenyl)methyl]-1-methyl-3-[[4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]methyl]-2,4-dioxoquinazoline-6-carboxamide Chemical compound C1=CC(OC)=CC=C1CNC(=O)C1=CC=C(N(C)C(=O)N(CC=2C=CC(=CC=2)C=2N=C(C)ON=2)C2=O)C2=C1 VARPADYZPUCKDI-UHFFFAOYSA-N 0.000 claims 2
- JLZQYWHTRPRTLV-UHFFFAOYSA-N n-[(4-methoxyphenyl)methyl]-1-methyl-3-[[4-(methylcarbamoyl)phenyl]methyl]-2,4-dioxoquinazoline-6-carboxamide Chemical compound C1=CC(C(=O)NC)=CC=C1CN1C(=O)C2=CC(C(=O)NCC=3C=CC(OC)=CC=3)=CC=C2N(C)C1=O JLZQYWHTRPRTLV-UHFFFAOYSA-N 0.000 claims 2
- 125000004043 oxo group Chemical group O=* 0.000 claims 2
- LXNAVEXFUKBNMK-UHFFFAOYSA-N palladium(II) acetate Substances [Pd].CC(O)=O.CC(O)=O LXNAVEXFUKBNMK-UHFFFAOYSA-N 0.000 claims 2
- YJVFFLUZDVXJQI-UHFFFAOYSA-L palladium(ii) acetate Chemical compound [Pd+2].CC([O-])=O.CC([O-])=O YJVFFLUZDVXJQI-UHFFFAOYSA-L 0.000 claims 2
- TXQWFIVRZNOPCK-UHFFFAOYSA-N pyridin-4-ylmethanamine Chemical compound NCC1=CC=NC=C1 TXQWFIVRZNOPCK-UHFFFAOYSA-N 0.000 claims 2
- AOTJPJKTPAATCK-UHFFFAOYSA-N pyridin-4-ylmethyl 3-benzyl-1-methyl-2,4-dioxoquinazoline-6-carboxylate Chemical compound O=C1N(C)C2=CC=C(C(=O)OCC=3C=CN=CC=3)C=C2C(=O)N1CC1=CC=CC=C1 AOTJPJKTPAATCK-UHFFFAOYSA-N 0.000 claims 2
- SQFNUNIRVOWSPI-UHFFFAOYSA-N pyridin-4-ylmethyl 3-benzyl-2,4-dioxo-1h-quinazoline-6-carboxylate Chemical compound C=1C=C2NC(=O)N(CC=3C=CC=CC=3)C(=O)C2=CC=1C(=O)OCC1=CC=NC=C1 SQFNUNIRVOWSPI-UHFFFAOYSA-N 0.000 claims 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 2
- 238000010992 reflux Methods 0.000 claims 2
- JPJALAQPGMAKDF-UHFFFAOYSA-N selenium dioxide Chemical compound O=[Se]=O JPJALAQPGMAKDF-UHFFFAOYSA-N 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 150000003463 sulfur Chemical group 0.000 claims 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 2
- HQSDPWFGZSQCKQ-UHFFFAOYSA-N (2-amino-3-methylbutanoyl)oxymethyl 4-[[6-[(4-methoxyphenyl)methylcarbamoyl]-1-methyl-2,4-dioxoquinazolin-3-yl]methyl]benzoate;hydrochloride Chemical compound Cl.C1=CC(OC)=CC=C1CNC(=O)C1=CC=C(N(C)C(=O)N(CC=2C=CC(=CC=2)C(=O)OCOC(=O)C(N)C(C)C)C2=O)C2=C1 HQSDPWFGZSQCKQ-UHFFFAOYSA-N 0.000 claims 1
- UQAHBOKPZNLKRF-UHFFFAOYSA-N (2-methoxypyridin-4-yl)methanamine Chemical compound COC1=CC(CN)=CC=N1 UQAHBOKPZNLKRF-UHFFFAOYSA-N 0.000 claims 1
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 1
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- DIIIISSCIXVANO-UHFFFAOYSA-N 1,2-Dimethylhydrazine Chemical compound CNNC DIIIISSCIXVANO-UHFFFAOYSA-N 0.000 claims 1
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- TXXNKVRSKUSXEV-UHFFFAOYSA-N 1-ethyl-3-[(3-fluorophenyl)methyl]-2,4-dioxo-n-(pyridin-4-ylmethyl)quinazoline-6-carboxamide Chemical compound O=C1N(CC)C2=CC=C(C(=O)NCC=3C=CN=CC=3)C=C2C(=O)N1CC1=CC=CC(F)=C1 TXXNKVRSKUSXEV-UHFFFAOYSA-N 0.000 claims 1
- AFYASAWYQWZWKM-UHFFFAOYSA-N 2-(dimethylamino)butan-2-yl 4-[[6-[(4-methoxyphenyl)methylcarbamoyl]-1-methyl-2,4-dioxoquinazolin-3-yl]methyl]benzoate Chemical compound C1=CC(C(=O)OC(C)(CC)N(C)C)=CC=C1CN1C(=O)C2=CC(C(=O)NCC=3C=CC(OC)=CC=3)=CC=C2N(C)C1=O AFYASAWYQWZWKM-UHFFFAOYSA-N 0.000 claims 1
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- YRMSHADTQHNGNO-UHFFFAOYSA-N 2-(dimethylamino)ethyl 4-[[6-[(4-methoxyphenyl)methylcarbamoyl]-1-methyl-2,4-dioxoquinazolin-3-yl]methyl]-2-methylbenzoate Chemical compound C1=CC(OC)=CC=C1CNC(=O)C1=CC=C(N(C)C(=O)N(CC=2C=C(C)C(C(=O)OCCN(C)C)=CC=2)C2=O)C2=C1 YRMSHADTQHNGNO-UHFFFAOYSA-N 0.000 claims 1
- UYHGHPZUDWAIEC-UHFFFAOYSA-N 2-[4-[[(3-benzyl-1-methyl-2,4-dioxoquinazoline-6-carbonyl)amino]methyl]phenoxy]acetic acid Chemical compound O=C1N(C)C2=CC=C(C(=O)NCC=3C=CC(OCC(O)=O)=CC=3)C=C2C(=O)N1CC1=CC=CC=C1 UYHGHPZUDWAIEC-UHFFFAOYSA-N 0.000 claims 1
- SYUDNCKOGMKWKJ-UHFFFAOYSA-N 2-[4-[[1-methyl-2,4-dioxo-6-(pyridin-4-ylmethylcarbamoyl)quinazolin-3-yl]methyl]phenyl]acetic acid Chemical compound O=C1N(C)C2=CC=C(C(=O)NCC=3C=CN=CC=3)C=C2C(=O)N1CC1=CC=C(CC(O)=O)C=C1 SYUDNCKOGMKWKJ-UHFFFAOYSA-N 0.000 claims 1
- FLKWDTPIWAYMBJ-UHFFFAOYSA-N 2-[4-[[6-[(4-methoxyphenyl)methylcarbamoyl]-1-methyl-2,4-dioxoquinazolin-3-yl]methyl]phenyl]acetic acid Chemical compound C1=CC(OC)=CC=C1CNC(=O)C1=CC=C(N(C)C(=O)N(CC=2C=CC(CC(O)=O)=CC=2)C2=O)C2=C1 FLKWDTPIWAYMBJ-UHFFFAOYSA-N 0.000 claims 1
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- KTKCULQPWKXXPK-UHFFFAOYSA-N 3-(cyclohexylmethyl)-n-[(4-methoxyphenyl)methyl]-1-methyl-2,4-dioxoquinazoline-6-carboxamide Chemical compound C1=CC(OC)=CC=C1CNC(=O)C1=CC=C(N(C)C(=O)N(CC2CCCCC2)C2=O)C2=C1 KTKCULQPWKXXPK-UHFFFAOYSA-N 0.000 claims 1
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- HRLDEBDIIPILFW-UHFFFAOYSA-N 3-[(3-chloro-4-fluorophenyl)methyl]-n-[(4-methoxyphenyl)methyl]-1-methyl-2,4-dioxoquinazoline-6-carboxamide Chemical compound C1=CC(OC)=CC=C1CNC(=O)C1=CC=C(N(C)C(=O)N(CC=2C=C(Cl)C(F)=CC=2)C2=O)C2=C1 HRLDEBDIIPILFW-UHFFFAOYSA-N 0.000 claims 1
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- UCPJQWQSVDTQJX-UHFFFAOYSA-N benzyl 1-benzyl-2,4-dioxo-3-(pyridin-4-ylmethyl)quinazoline-6-carboxylate Chemical compound C=1C=C2N(CC=3C=CC=CC=3)C(=O)N(CC=3C=CN=CC=3)C(=O)C2=CC=1C(=O)OCC1=CC=CC=C1 UCPJQWQSVDTQJX-UHFFFAOYSA-N 0.000 claims 1
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- SYAQNCVNGHMVCN-UHFFFAOYSA-N benzyl 3-benzyl-2,4-dioxo-1h-pyrido[2,3-d]pyrimidine-6-carboxylate Chemical compound C=1N=C2NC(=O)N(CC=3C=CC=CC=3)C(=O)C2=CC=1C(=O)OCC1=CC=CC=C1 SYAQNCVNGHMVCN-UHFFFAOYSA-N 0.000 claims 1
- OZNWNODUKWRKHE-UHFFFAOYSA-N benzyl 3-benzyl-2,4-dioxo-1h-quinazoline-6-carboxylate Chemical compound C=1C=C2NC(=O)N(CC=3C=CC=CC=3)C(=O)C2=CC=1C(=O)OCC1=CC=CC=C1 OZNWNODUKWRKHE-UHFFFAOYSA-N 0.000 claims 1
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- OYMZALQJGNWTHO-UHFFFAOYSA-N chloromethyl 4-[[6-[(4-methoxyphenyl)methylcarbamoyl]-1-methyl-2,4-dioxoquinazolin-3-yl]methyl]benzoate Chemical compound C1=CC(OC)=CC=C1CNC(=O)C1=CC=C(N(C)C(=O)N(CC=2C=CC(=CC=2)C(=O)OCCl)C2=O)C2=C1 OYMZALQJGNWTHO-UHFFFAOYSA-N 0.000 claims 1
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- WKYYVCNGGGFTDI-UHFFFAOYSA-N ethyl 4-[6-[(4-methoxyphenyl)methylcarbamoyl]-1-methyl-2,4-dioxoquinazolin-3-yl]butanoate Chemical compound C1=C2C(=O)N(CCCC(=O)OCC)C(=O)N(C)C2=CC=C1C(=O)NCC1=CC=C(OC)C=C1 WKYYVCNGGGFTDI-UHFFFAOYSA-N 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- DYMYIYFXUNBCNK-SNAWJCMRSA-N methyl (e)-4-[6-[(4-methoxyphenyl)methylcarbamoyl]-1-methyl-2,4-dioxoquinazolin-3-yl]but-2-enoate Chemical compound C1=C2C(=O)N(C/C=C/C(=O)OC)C(=O)N(C)C2=CC=C1C(=O)NCC1=CC=C(OC)C=C1 DYMYIYFXUNBCNK-SNAWJCMRSA-N 0.000 claims 1
- JZAAHHIQGCUEJT-UHFFFAOYSA-N methyl 2-[4-[[6-[(4-methoxyphenyl)methylcarbamoyl]-1-methyl-2,4-dioxoquinazolin-3-yl]methyl]phenyl]acetate Chemical compound C1=CC(CC(=O)OC)=CC=C1CN1C(=O)C2=CC(C(=O)NCC=3C=CC(OC)=CC=3)=CC=C2N(C)C1=O JZAAHHIQGCUEJT-UHFFFAOYSA-N 0.000 claims 1
- WXEADQXEDXIXNN-UHFFFAOYSA-N methyl 2-[4-[[6-[(4-methoxyphenyl)methylcarbamoyl]-1-methyl-2,4-dioxoquinazolin-3-yl]methyl]phenyl]benzoate Chemical compound COC(=O)C1=CC=CC=C1C(C=C1)=CC=C1CN1C(=O)C2=CC(C(=O)NCC=3C=CC(OC)=CC=3)=CC=C2N(C)C1=O WXEADQXEDXIXNN-UHFFFAOYSA-N 0.000 claims 1
- PZBNCPLDCWMEBH-UHFFFAOYSA-N methyl 2-chloro-4-[[6-[(4-methoxyphenyl)methylcarbamoyl]-1-methyl-2,4-dioxoquinazolin-3-yl]methyl]benzoate Chemical compound C1=C(Cl)C(C(=O)OC)=CC=C1CN1C(=O)C2=CC(C(=O)NCC=3C=CC(OC)=CC=3)=CC=C2N(C)C1=O PZBNCPLDCWMEBH-UHFFFAOYSA-N 0.000 claims 1
- MRMRIWSHVRACLI-UHFFFAOYSA-N methyl 2-hydroxy-4-[[6-[(4-methoxyphenyl)methylcarbamoyl]-1-methyl-2,4-dioxoquinazolin-3-yl]methyl]benzoate Chemical compound C1=C(O)C(C(=O)OC)=CC=C1CN1C(=O)C2=CC(C(=O)NCC=3C=CC(OC)=CC=3)=CC=C2N(C)C1=O MRMRIWSHVRACLI-UHFFFAOYSA-N 0.000 claims 1
- TYAUAOBJCFQZSI-UHFFFAOYSA-N methyl 2-methoxy-4-[[6-[(4-methoxyphenyl)methylcarbamoyl]-1-methyl-2,4-dioxoquinazolin-3-yl]methyl]benzoate Chemical compound C1=C(OC)C(C(=O)OC)=CC=C1CN1C(=O)C2=CC(C(=O)NCC=3C=CC(OC)=CC=3)=CC=C2N(C)C1=O TYAUAOBJCFQZSI-UHFFFAOYSA-N 0.000 claims 1
- JTESWPPRUDCPGG-UHFFFAOYSA-N methyl 3-[6-[(4-methoxyphenyl)methylcarbamoyl]-1-methyl-2,4-dioxoquinazolin-3-yl]propanoate Chemical compound C1=C2C(=O)N(CCC(=O)OC)C(=O)N(C)C2=CC=C1C(=O)NCC1=CC=C(OC)C=C1 JTESWPPRUDCPGG-UHFFFAOYSA-N 0.000 claims 1
- CVUOECXHMFHDBC-UHFFFAOYSA-N methyl 3-[[6-[(4-methoxyphenyl)methylcarbamoyl]-1-methyl-2,4-dioxoquinazolin-3-yl]methyl]benzoate Chemical compound COC(=O)C1=CC=CC(CN2C(C3=CC(=CC=C3N(C)C2=O)C(=O)NCC=2C=CC(OC)=CC=2)=O)=C1 CVUOECXHMFHDBC-UHFFFAOYSA-N 0.000 claims 1
- CJLJKCMBXBVAPR-UHFFFAOYSA-N methyl 4-[[1-ethyl-6-[(4-methoxyphenyl)methylcarbamoyl]-2,4-dioxoquinazolin-3-yl]methyl]benzoate Chemical compound O=C1N(CC)C2=CC=C(C(=O)NCC=3C=CC(OC)=CC=3)C=C2C(=O)N1CC1=CC=C(C(=O)OC)C=C1 CJLJKCMBXBVAPR-UHFFFAOYSA-N 0.000 claims 1
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| US26866101P | 2001-02-14 | 2001-02-14 | |
| PCT/EP2002/001979 WO2002064572A1 (en) | 2001-02-14 | 2002-02-11 | Quinazolines as mmp-13 inhibitors |
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| JP2004523546A JP2004523546A (ja) | 2004-08-05 |
| JP2004523546A5 true JP2004523546A5 (https=) | 2005-12-22 |
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| EP (1) | EP1368324A1 (https=) |
| JP (1) | JP2004523546A (https=) |
| KR (1) | KR20030074827A (https=) |
| CN (1) | CN1537105A (https=) |
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2002
- 2002-02-08 PA PA20028539401A patent/PA8539401A1/es unknown
- 2002-02-11 EP EP02722137A patent/EP1368324A1/en not_active Withdrawn
- 2002-02-11 PL PL02367396A patent/PL367396A1/xx not_active Application Discontinuation
- 2002-02-11 KR KR10-2003-7010659A patent/KR20030074827A/ko not_active Ceased
- 2002-02-11 WO PCT/EP2002/001979 patent/WO2002064572A1/en not_active Ceased
- 2002-02-11 JP JP2002564505A patent/JP2004523546A/ja not_active Abandoned
- 2002-02-11 AP APAP/P/2003/002841A patent/AP2003002841A0/en unknown
- 2002-02-11 OA OA1200300200A patent/OA12550A/en unknown
- 2002-02-11 CZ CZ20032142A patent/CZ20032142A3/cs unknown
- 2002-02-11 EA EA200300792A patent/EA200300792A1/ru unknown
- 2002-02-11 SK SK1001-2003A patent/SK10012003A3/sk unknown
- 2002-02-11 BR BR0207268-8A patent/BR0207268A/pt not_active IP Right Cessation
- 2002-02-11 IL IL15710902A patent/IL157109A0/xx unknown
- 2002-02-11 CA CA002437122A patent/CA2437122A1/en not_active Abandoned
- 2002-02-11 CN CNA028050142A patent/CN1537105A/zh active Pending
- 2002-02-11 EE EEP200300384A patent/EE200300384A/xx unknown
- 2002-02-11 HU HU0303164A patent/HUP0303164A2/hu unknown
- 2002-02-11 MX MXPA03007248A patent/MXPA03007248A/es unknown
- 2002-02-13 US US10/075,954 patent/US20020193377A1/en not_active Abandoned
- 2002-02-13 PE PE2002000118A patent/PE20021005A1/es not_active Application Discontinuation
- 2002-02-13 AR ARP020100470A patent/AR032676A1/es not_active Application Discontinuation
- 2002-02-13 UY UY27173A patent/UY27173A1/es not_active Application Discontinuation
- 2002-02-13 SV SV2002000876A patent/SV2003000876A/es not_active Application Discontinuation
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2003
- 2003-07-08 TN TNPCT/EP2002/001979A patent/TNSN03045A1/en unknown
- 2003-07-24 IS IS6886A patent/IS6886A/is unknown
- 2003-08-04 ZA ZA2003/06008A patent/ZA200306008B/en unknown
- 2003-08-12 MA MA27274A patent/MA26994A1/fr unknown
- 2003-08-13 NO NO20033593A patent/NO20033593L/no not_active Application Discontinuation
- 2003-08-13 EC EC2003004730A patent/ECSP034730A/es unknown
- 2003-08-13 BG BG108091A patent/BG108091A/xx unknown
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