JP2004521685A - 生物活性名ナノ組成物及びその使用方法 - Google Patents
生物活性名ナノ組成物及びその使用方法 Download PDFInfo
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- JP2004521685A JP2004521685A JP2002567372A JP2002567372A JP2004521685A JP 2004521685 A JP2004521685 A JP 2004521685A JP 2002567372 A JP2002567372 A JP 2002567372A JP 2002567372 A JP2002567372 A JP 2002567372A JP 2004521685 A JP2004521685 A JP 2004521685A
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- composition
- polymer
- ceramic
- poly
- lactide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000000203 mixture Substances 0.000 title claims abstract description 99
- 238000000034 method Methods 0.000 title claims abstract description 38
- 239000000919 ceramic Substances 0.000 claims abstract description 71
- 210000000988 bone and bone Anatomy 0.000 claims abstract description 40
- 239000007943 implant Substances 0.000 claims abstract description 32
- 239000002245 particle Substances 0.000 claims abstract description 29
- 239000002639 bone cement Substances 0.000 claims abstract description 14
- 230000000975 bioactive effect Effects 0.000 claims abstract description 12
- 229920000249 biocompatible polymer Polymers 0.000 claims abstract description 12
- 230000007547 defect Effects 0.000 claims abstract description 10
- 239000008240 homogeneous mixture Substances 0.000 claims abstract description 8
- 230000000399 orthopedic effect Effects 0.000 claims abstract description 7
- 229920000642 polymer Polymers 0.000 claims description 71
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims description 44
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 44
- 239000002904 solvent Substances 0.000 claims description 15
- 239000001506 calcium phosphate Substances 0.000 claims description 13
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 13
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 12
- 229910052791 calcium Inorganic materials 0.000 claims description 12
- 239000011575 calcium Substances 0.000 claims description 12
- 235000011010 calcium phosphates Nutrition 0.000 claims description 11
- 229910000389 calcium phosphate Inorganic materials 0.000 claims description 10
- 239000011159 matrix material Substances 0.000 claims description 8
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims description 7
- 239000004926 polymethyl methacrylate Substances 0.000 claims description 7
- JJTUDXZGHPGLLC-IMJSIDKUSA-N 4511-42-6 Chemical compound C[C@@H]1OC(=O)[C@H](C)OC1=O JJTUDXZGHPGLLC-IMJSIDKUSA-N 0.000 claims description 5
- 239000004696 Poly ether ether ketone Substances 0.000 claims description 5
- 229920002530 polyetherether ketone Polymers 0.000 claims description 5
- -1 polyethylene Polymers 0.000 claims description 5
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Polymers OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims description 4
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims description 4
- 229920001244 Poly(D,L-lactide) Polymers 0.000 claims description 4
- 239000004698 Polyethylene Substances 0.000 claims description 4
- 229920000954 Polyglycolide Polymers 0.000 claims description 4
- 229920000331 Polyhydroxybutyrate Polymers 0.000 claims description 4
- 229920001432 poly(L-lactide) Polymers 0.000 claims description 4
- 239000005015 poly(hydroxybutyrate) Substances 0.000 claims description 4
- 229920000218 poly(hydroxyvalerate) Polymers 0.000 claims description 4
- 239000004417 polycarbonate Substances 0.000 claims description 4
- 229920000515 polycarbonate Polymers 0.000 claims description 4
- 229920000573 polyethylene Polymers 0.000 claims description 4
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims description 4
- 239000005313 bioactive glass Substances 0.000 claims description 3
- 238000012545 processing Methods 0.000 claims description 2
- 230000003014 reinforcing effect Effects 0.000 claims description 2
- 229910000391 tricalcium phosphate Inorganic materials 0.000 claims description 2
- 235000019731 tricalcium phosphate Nutrition 0.000 claims description 2
- 229940078499 tricalcium phosphate Drugs 0.000 claims description 2
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims 3
- JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical compound CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 claims 1
- 230000004927 fusion Effects 0.000 abstract description 21
- 230000001737 promoting effect Effects 0.000 abstract description 6
- 125000006850 spacer group Chemical group 0.000 abstract description 5
- 230000000087 stabilizing effect Effects 0.000 abstract description 5
- 239000003102 growth factor Substances 0.000 description 11
- 238000002156 mixing Methods 0.000 description 11
- 239000002114 nanocomposite Substances 0.000 description 11
- 239000002131 composite material Substances 0.000 description 9
- 239000002831 pharmacologic agent Substances 0.000 description 8
- 229920006209 poly(L-lactide-co-D,L-lactide) Polymers 0.000 description 8
- 239000000463 material Substances 0.000 description 7
- 239000002105 nanoparticle Substances 0.000 description 7
- 102000007350 Bone Morphogenetic Proteins Human genes 0.000 description 6
- 108010007726 Bone Morphogenetic Proteins Proteins 0.000 description 6
- 229940112869 bone morphogenetic protein Drugs 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 6
- 229920001643 poly(ether ketone) Polymers 0.000 description 6
- 230000008901 benefit Effects 0.000 description 5
- 238000001125 extrusion Methods 0.000 description 5
- 238000001746 injection moulding Methods 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 208000002193 Pain Diseases 0.000 description 4
- 230000009286 beneficial effect Effects 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 239000008188 pellet Substances 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 239000008187 granular material Substances 0.000 description 3
- 238000003754 machining Methods 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 238000001356 surgical procedure Methods 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 208000028389 Nerve injury Diseases 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 230000033115 angiogenesis Effects 0.000 description 2
- 238000011882 arthroplasty Methods 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 2
- 230000036760 body temperature Effects 0.000 description 2
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- 230000009969 flowable effect Effects 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 238000011065 in-situ storage Methods 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 239000000155 melt Substances 0.000 description 2
- 239000000178 monomer Substances 0.000 description 2
- 230000000921 morphogenic effect Effects 0.000 description 2
- 230000008764 nerve damage Effects 0.000 description 2
- 230000002138 osteoinductive effect Effects 0.000 description 2
- 238000006116 polymerization reaction Methods 0.000 description 2
- 238000003672 processing method Methods 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 210000000278 spinal cord Anatomy 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 229920001059 synthetic polymer Polymers 0.000 description 2
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
- 102100028728 Bone morphogenetic protein 1 Human genes 0.000 description 1
- 108090000654 Bone morphogenetic protein 1 Proteins 0.000 description 1
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 102000016942 Elastin Human genes 0.000 description 1
- 108010014258 Elastin Proteins 0.000 description 1
- 102000018233 Fibroblast Growth Factor Human genes 0.000 description 1
- 108050007372 Fibroblast Growth Factor Proteins 0.000 description 1
- 208000004044 Hypesthesia Diseases 0.000 description 1
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 description 1
- 208000003618 Intervertebral Disc Displacement Diseases 0.000 description 1
- 208000034693 Laceration Diseases 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical group COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 1
- 208000010428 Muscle Weakness Diseases 0.000 description 1
- 206010028372 Muscular weakness Diseases 0.000 description 1
- 229920002292 Nylon 6 Polymers 0.000 description 1
- 208000001132 Osteoporosis Diseases 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- 229920002732 Polyanhydride Polymers 0.000 description 1
- 102000013275 Somatomedins Human genes 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000000735 allogeneic effect Effects 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 229940035676 analgesics Drugs 0.000 description 1
- 238000000137 annealing Methods 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 229910052586 apatite Inorganic materials 0.000 description 1
- 230000000712 assembly Effects 0.000 description 1
- 238000000429 assembly Methods 0.000 description 1
- 238000006065 biodegradation reaction Methods 0.000 description 1
- 230000002051 biphasic effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000002805 bone matrix Anatomy 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 235000011089 carbon dioxide Nutrition 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- 239000004568 cement Substances 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000000748 compression moulding Methods 0.000 description 1
- 239000002872 contrast media Substances 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 239000007857 degradation product Substances 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 229920002549 elastin Polymers 0.000 description 1
- 238000002594 fluoroscopy Methods 0.000 description 1
- 238000005242 forging Methods 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000000833 heterodimer Substances 0.000 description 1
- 208000034783 hypoesthesia Diseases 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000011859 microparticle Substances 0.000 description 1
- 231100000862 numbness Toxicity 0.000 description 1
- 150000002905 orthoesters Chemical class 0.000 description 1
- 238000007500 overflow downdraw method Methods 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 238000009832 plasma treatment Methods 0.000 description 1
- 238000007747 plating Methods 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 229920002627 poly(phosphazenes) Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 238000012805 post-processing Methods 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 230000004043 responsiveness Effects 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 239000011877 solvent mixture Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 210000001032 spinal nerve Anatomy 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 238000004381 surface treatment Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- GBNXLQPMFAUCOI-UHFFFAOYSA-H tetracalcium;oxygen(2-);diphosphate Chemical compound [O-2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GBNXLQPMFAUCOI-UHFFFAOYSA-H 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
- 229920001187 thermosetting polymer Polymers 0.000 description 1
- 239000004634 thermosetting polymer Substances 0.000 description 1
- 239000004416 thermosoftening plastic Substances 0.000 description 1
- 238000001721 transfer moulding Methods 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 238000003828 vacuum filtration Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/0047—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L24/0073—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix
- A61L24/0084—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix containing fillers of phosphorus-containing inorganic compounds, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16C—SHAFTS; FLEXIBLE SHAFTS; ELEMENTS OR CRANKSHAFT MECHANISMS; ROTARY BODIES OTHER THAN GEARING ELEMENTS; BEARINGS
- F16C2240/00—Specified values or numerical ranges of parameters; Relations between them
- F16C2240/40—Linear dimensions, e.g. length, radius, thickness, gap
- F16C2240/60—Thickness, e.g. thickness of coatings
- F16C2240/64—Thickness, e.g. thickness of coatings in the nanometer range
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Materials Engineering (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Inorganic Chemistry (AREA)
- Composite Materials (AREA)
- Surgery (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Surgical Instruments (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/790,741 US20020115742A1 (en) | 2001-02-22 | 2001-02-22 | Bioactive nanocomposites and methods for their use |
| PCT/US2002/004333 WO2002068009A2 (en) | 2001-02-22 | 2002-02-14 | Bioactive nanocomposites and methods for their use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010103834A Division JP2010246934A (ja) | 2001-02-22 | 2010-04-28 | 生物活性なナノ組成物及びその使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004521685A true JP2004521685A (ja) | 2004-07-22 |
| JP2004521685A5 JP2004521685A5 (enExample) | 2009-01-22 |
Family
ID=25151629
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002567372A Pending JP2004521685A (ja) | 2001-02-22 | 2002-02-14 | 生物活性名ナノ組成物及びその使用方法 |
| JP2010103834A Pending JP2010246934A (ja) | 2001-02-22 | 2010-04-28 | 生物活性なナノ組成物及びその使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010103834A Pending JP2010246934A (ja) | 2001-02-22 | 2010-04-28 | 生物活性なナノ組成物及びその使用方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20020115742A1 (enExample) |
| EP (1) | EP1368073B1 (enExample) |
| JP (2) | JP2004521685A (enExample) |
| AT (1) | ATE535266T1 (enExample) |
| CA (1) | CA2438965A1 (enExample) |
| ES (1) | ES2375270T3 (enExample) |
| WO (1) | WO2002068009A2 (enExample) |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005119302A (ja) * | 2003-10-14 | 2005-05-12 | Hewlett-Packard Development Co Lp | 立体造形のための混成有機−無機組成物 |
| JP2005132112A (ja) * | 2003-10-28 | 2005-05-26 | Hewlett-Packard Development Co Lp | 固体自由造形用の樹脂変性無機リン酸セメント |
| JP2006223860A (ja) * | 2005-02-10 | 2006-08-31 | Cordis Corp | 機械的強度および薬理機能を強化した生分解性医療用具 |
| JP2009178281A (ja) * | 2008-01-30 | 2009-08-13 | Ngk Spark Plug Co Ltd | 生体インプラント |
| JP2010501235A (ja) * | 2006-08-24 | 2010-01-21 | グラフティ | 有マクロ孔性および高い吸収性を有するアパタイト型リン酸カルシウムセメント |
| JP2010504158A (ja) * | 2006-09-25 | 2010-02-12 | ビタ スペシャル パーパス コーポレイション | 生理活性負荷支持複合体 |
| JP2010035827A (ja) * | 2008-08-05 | 2010-02-18 | Ngk Spark Plug Co Ltd | 骨充填材 |
| JP2011506619A (ja) * | 2007-07-10 | 2011-03-03 | スミス アンド ネフュー インコーポレーテッド | ナノ粒子フィラー |
| WO2013088921A1 (ja) * | 2011-12-15 | 2013-06-20 | 株式会社トクヤマデンタル | 有機無機複合材、その製造方法、歯科用材料および骨代替材料 |
| JP2015521951A (ja) * | 2014-03-25 | 2015-08-03 | ライト メディカル テクノロジー インコーポレイテッドＷｒｉｇｈｔ Ｍｅｄｉｃａｌ Ｔｅｃｈｎｏｌｏｇｙ， Ｉｎｃ． | 矯正インプラント補強物、システム、および方法 |
| US9662821B2 (en) | 2008-12-30 | 2017-05-30 | Orthovita, Inc. | Bioactive composites of polymer and glass and method for making same |
| US9949839B2 (en) | 2013-03-13 | 2018-04-24 | Wright Medical Technology, Inc. | Revision implant augments, systems, and methods |
| US10136998B2 (en) | 2016-08-30 | 2018-11-27 | Wright Medical Technology, Inc. | Revision total ankle implants |
Families Citing this family (128)
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| JP2005119302A (ja) * | 2003-10-14 | 2005-05-12 | Hewlett-Packard Development Co Lp | 立体造形のための混成有機−無機組成物 |
| JP2005132112A (ja) * | 2003-10-28 | 2005-05-26 | Hewlett-Packard Development Co Lp | 固体自由造形用の樹脂変性無機リン酸セメント |
| JP2006223860A (ja) * | 2005-02-10 | 2006-08-31 | Cordis Corp | 機械的強度および薬理機能を強化した生分解性医療用具 |
| JP2010501235A (ja) * | 2006-08-24 | 2010-01-21 | グラフティ | 有マクロ孔性および高い吸収性を有するアパタイト型リン酸カルシウムセメント |
| US9381275B2 (en) | 2006-09-25 | 2016-07-05 | Orthovita, Inc. | Bioactive load-bearing composites |
| JP2010504158A (ja) * | 2006-09-25 | 2010-02-12 | ビタ スペシャル パーパス コーポレイション | 生理活性負荷支持複合体 |
| US8597675B2 (en) | 2006-09-25 | 2013-12-03 | Orthovita, Inc. | Bioactive load-bearing composites |
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| US10195308B2 (en) | 2006-09-25 | 2019-02-05 | Orthovita, Inc. | Bioactive load-bearing composites |
| JP2011506619A (ja) * | 2007-07-10 | 2011-03-03 | スミス アンド ネフュー インコーポレーテッド | ナノ粒子フィラー |
| JP2009178281A (ja) * | 2008-01-30 | 2009-08-13 | Ngk Spark Plug Co Ltd | 生体インプラント |
| JP2010035827A (ja) * | 2008-08-05 | 2010-02-18 | Ngk Spark Plug Co Ltd | 骨充填材 |
| US9662821B2 (en) | 2008-12-30 | 2017-05-30 | Orthovita, Inc. | Bioactive composites of polymer and glass and method for making same |
| US10307511B2 (en) | 2008-12-30 | 2019-06-04 | Orthovita, Inc. | Bioactive composites of polymer and glass and method for making same |
| WO2013088921A1 (ja) * | 2011-12-15 | 2013-06-20 | 株式会社トクヤマデンタル | 有機無機複合材、その製造方法、歯科用材料および骨代替材料 |
| US9512280B2 (en) | 2011-12-15 | 2016-12-06 | Tokuyama Dental Corporation | Organic/inorganic composite, manufacturing method therefor, dental material, and bone substitute material |
| US9949839B2 (en) | 2013-03-13 | 2018-04-24 | Wright Medical Technology, Inc. | Revision implant augments, systems, and methods |
| JP2015521951A (ja) * | 2014-03-25 | 2015-08-03 | ライト メディカル テクノロジー インコーポレイテッドＷｒｉｇｈｔ Ｍｅｄｉｃａｌ Ｔｅｃｈｎｏｌｏｇｙ， Ｉｎｃ． | 矯正インプラント補強物、システム、および方法 |
| US10136998B2 (en) | 2016-08-30 | 2018-11-27 | Wright Medical Technology, Inc. | Revision total ankle implants |
Also Published As
| Publication number | Publication date |
|---|---|
| ATE535266T1 (de) | 2011-12-15 |
| WO2002068009A3 (en) | 2003-03-06 |
| WO2002068009A2 (en) | 2002-09-06 |
| ES2375270T3 (es) | 2012-02-28 |
| EP1368073B1 (en) | 2011-11-30 |
| US20040024081A1 (en) | 2004-02-05 |
| JP2010246934A (ja) | 2010-11-04 |
| US7230039B2 (en) | 2007-06-12 |
| CA2438965A1 (en) | 2002-09-06 |
| EP1368073A2 (en) | 2003-12-10 |
| US20020115742A1 (en) | 2002-08-22 |
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