ES2375270T3 - Nanocompuestos bioactivos y métodos para su uso. - Google Patents
Nanocompuestos bioactivos y métodos para su uso. Download PDFInfo
- Publication number
- ES2375270T3 ES2375270T3 ES02704421T ES02704421T ES2375270T3 ES 2375270 T3 ES2375270 T3 ES 2375270T3 ES 02704421 T ES02704421 T ES 02704421T ES 02704421 T ES02704421 T ES 02704421T ES 2375270 T3 ES2375270 T3 ES 2375270T3
- Authority
- ES
- Spain
- Prior art keywords
- ceramic material
- polymer
- composition
- bone
- calcium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title claims abstract description 37
- 230000000975 bioactive effect Effects 0.000 title claims abstract description 13
- 239000000203 mixture Substances 0.000 claims abstract description 84
- 210000000988 bone and bone Anatomy 0.000 claims abstract description 36
- 239000007943 implant Substances 0.000 claims abstract description 34
- 239000002245 particle Substances 0.000 claims abstract description 32
- 239000000919 ceramic Substances 0.000 claims abstract description 25
- 239000002639 bone cement Substances 0.000 claims abstract description 16
- 229920000249 biocompatible polymer Polymers 0.000 claims abstract description 14
- 230000000399 orthopedic effect Effects 0.000 claims abstract description 11
- 230000007547 defect Effects 0.000 claims abstract description 10
- 239000008240 homogeneous mixture Substances 0.000 claims abstract description 8
- 230000000087 stabilizing effect Effects 0.000 claims abstract description 6
- 229920000642 polymer Polymers 0.000 claims description 65
- 229910010293 ceramic material Inorganic materials 0.000 claims description 56
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims description 49
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical group [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 49
- 239000003102 growth factor Substances 0.000 claims description 24
- 239000001506 calcium phosphate Substances 0.000 claims description 18
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 18
- 239000011236 particulate material Substances 0.000 claims description 16
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 15
- 229910052791 calcium Inorganic materials 0.000 claims description 15
- 239000011575 calcium Substances 0.000 claims description 15
- 239000002904 solvent Substances 0.000 claims description 14
- 235000011010 calcium phosphates Nutrition 0.000 claims description 13
- 229910000389 calcium phosphate Inorganic materials 0.000 claims description 12
- 239000000463 material Substances 0.000 claims description 12
- 102000007350 Bone Morphogenetic Proteins Human genes 0.000 claims description 10
- 108010007726 Bone Morphogenetic Proteins Proteins 0.000 claims description 10
- 229940112869 bone morphogenetic protein Drugs 0.000 claims description 10
- 239000004696 Poly ether ether ketone Substances 0.000 claims description 9
- 239000011159 matrix material Substances 0.000 claims description 9
- 229920002530 polyetherether ketone Polymers 0.000 claims description 9
- 102100033337 PDZ and LIM domain protein 7 Human genes 0.000 claims description 5
- 101710121660 PDZ and LIM domain protein 7 Proteins 0.000 claims description 5
- 230000009466 transformation Effects 0.000 claims description 5
- 229910000391 tricalcium phosphate Inorganic materials 0.000 claims description 5
- 235000019731 tricalcium phosphate Nutrition 0.000 claims description 5
- 229940078499 tricalcium phosphate Drugs 0.000 claims description 5
- 102000018233 Fibroblast Growth Factor Human genes 0.000 claims description 4
- 108050007372 Fibroblast Growth Factor Proteins 0.000 claims description 4
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims description 4
- 102000013275 Somatomedins Human genes 0.000 claims description 4
- 229910019142 PO4 Inorganic materials 0.000 claims description 3
- 239000005313 bioactive glass Substances 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 3
- 239000010452 phosphate Substances 0.000 claims description 3
- -1 polyethylene Polymers 0.000 claims description 3
- 229920000193 polymethacrylate Polymers 0.000 claims description 3
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Polymers OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims description 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims description 2
- 229920001244 Poly(D,L-lactide) Polymers 0.000 claims description 2
- 239000004698 Polyethylene Substances 0.000 claims description 2
- 229920000954 Polyglycolide Polymers 0.000 claims description 2
- 229920000331 Polyhydroxybutyrate Polymers 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 229920001432 poly(L-lactide) Polymers 0.000 claims description 2
- 239000005015 poly(hydroxybutyrate) Substances 0.000 claims description 2
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- 229920000573 polyethylene Polymers 0.000 claims description 2
- 230000003014 reinforcing effect Effects 0.000 claims description 2
- GBNXLQPMFAUCOI-UHFFFAOYSA-H tetracalcium;oxygen(2-);diphosphate Chemical compound [O-2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GBNXLQPMFAUCOI-UHFFFAOYSA-H 0.000 claims description 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims description 2
- 229920000218 poly(hydroxyvalerate) Polymers 0.000 claims 1
- 230000004927 fusion Effects 0.000 abstract description 22
- 230000001737 promoting effect Effects 0.000 abstract description 6
- 125000006850 spacer group Chemical group 0.000 abstract description 5
- 239000002114 nanocomposite Substances 0.000 description 10
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- 230000008901 benefit Effects 0.000 description 5
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- 238000001746 injection moulding Methods 0.000 description 5
- 229910052751 metal Inorganic materials 0.000 description 5
- 239000002184 metal Substances 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- JJTUDXZGHPGLLC-IMJSIDKUSA-N 4511-42-6 Chemical compound C[C@@H]1OC(=O)[C@H](C)OC1=O JJTUDXZGHPGLLC-IMJSIDKUSA-N 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 208000002193 Pain Diseases 0.000 description 4
- 229910052586 apatite Inorganic materials 0.000 description 4
- 230000009286 beneficial effect Effects 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 239000008188 pellet Substances 0.000 description 4
- 238000011282 treatment Methods 0.000 description 4
- 206010016654 Fibrosis Diseases 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 239000006185 dispersion Substances 0.000 description 3
- 230000004761 fibrosis Effects 0.000 description 3
- 239000008187 granular material Substances 0.000 description 3
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- 210000000278 spinal cord Anatomy 0.000 description 3
- 238000001356 surgical procedure Methods 0.000 description 3
- 229920001059 synthetic polymer Polymers 0.000 description 3
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 2
- 230000036760 body temperature Effects 0.000 description 2
- 230000008468 bone growth Effects 0.000 description 2
- 159000000007 calcium salts Chemical class 0.000 description 2
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 2
- 238000004891 communication Methods 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
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- 238000011065 in-situ storage Methods 0.000 description 2
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- 239000000155 melt Substances 0.000 description 2
- 239000000178 monomer Substances 0.000 description 2
- 230000002138 osteoinductive effect Effects 0.000 description 2
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 2
- 235000021317 phosphate Nutrition 0.000 description 2
- 238000009832 plasma treatment Methods 0.000 description 2
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 2
- 238000006116 polymerization reaction Methods 0.000 description 2
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- 239000000725 suspension Substances 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 102100028728 Bone morphogenetic protein 1 Human genes 0.000 description 1
- 108090000654 Bone morphogenetic protein 1 Proteins 0.000 description 1
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 102000016942 Elastin Human genes 0.000 description 1
- 108010014258 Elastin Proteins 0.000 description 1
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- 241000124008 Mammalia Species 0.000 description 1
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical group COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 1
- 101710167839 Morphogenetic protein Proteins 0.000 description 1
- 208000010428 Muscle Weakness Diseases 0.000 description 1
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- 239000000316 bone substitute Substances 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
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- 238000005266 casting Methods 0.000 description 1
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- 208000034783 hypoesthesia Diseases 0.000 description 1
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- 229920002994 synthetic fiber Polymers 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
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- 238000012800 visualization Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000001238 wet grinding Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/0047—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L24/0073—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix
- A61L24/0084—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix containing fillers of phosphorus-containing inorganic compounds, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16C—SHAFTS; FLEXIBLE SHAFTS; ELEMENTS OR CRANKSHAFT MECHANISMS; ROTARY BODIES OTHER THAN GEARING ELEMENTS; BEARINGS
- F16C2240/00—Specified values or numerical ranges of parameters; Relations between them
- F16C2240/40—Linear dimensions, e.g. length, radius, thickness, gap
- F16C2240/60—Thickness, e.g. thickness of coatings
- F16C2240/64—Thickness, e.g. thickness of coatings in the nanometer range
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Materials Engineering (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Inorganic Chemistry (AREA)
- Composite Materials (AREA)
- Surgery (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
- Surgical Instruments (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/790,741 US20020115742A1 (en) | 2001-02-22 | 2001-02-22 | Bioactive nanocomposites and methods for their use |
| US790741 | 2001-02-22 | ||
| PCT/US2002/004333 WO2002068009A2 (en) | 2001-02-22 | 2002-02-14 | Bioactive nanocomposites and methods for their use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2375270T3 true ES2375270T3 (es) | 2012-02-28 |
Family
ID=25151629
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES02704421T Expired - Lifetime ES2375270T3 (es) | 2001-02-22 | 2002-02-14 | Nanocompuestos bioactivos y métodos para su uso. |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20020115742A1 (enExample) |
| EP (1) | EP1368073B1 (enExample) |
| JP (2) | JP2004521685A (enExample) |
| AT (1) | ATE535266T1 (enExample) |
| CA (1) | CA2438965A1 (enExample) |
| ES (1) | ES2375270T3 (enExample) |
| WO (1) | WO2002068009A2 (enExample) |
Families Citing this family (141)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4467647B2 (ja) | 1997-02-11 | 2010-05-26 | ウォーソー・オーソペディック・インコーポレーテッド | 骨プレーティングシステム |
| US6949251B2 (en) * | 2001-03-02 | 2005-09-27 | Stryker Corporation | Porous β-tricalcium phosphate granules for regeneration of bone tissue |
| KR100383433B1 (ko) * | 2001-06-29 | 2003-05-12 | 주식회사 씨엠리서치 | 고강도 뼈 고정용 생분해성 유기 고분자/무기 복합 소재의제조 방법 및 그에 의해 제조된 생분해성 유기고분자/무기 복합 소재 |
| US7744651B2 (en) | 2002-09-18 | 2010-06-29 | Warsaw Orthopedic, Inc | Compositions and methods for treating intervertebral discs with collagen-based materials |
| US20040054414A1 (en) | 2002-09-18 | 2004-03-18 | Trieu Hai H. | Collagen-based materials and methods for augmenting intervertebral discs |
| CN100394989C (zh) | 2002-11-15 | 2008-06-18 | 华沙整形外科股份有限公司 | 包含微粒状基于胶原材料的组合物的制药应用和包含所述组合物的滑膜关节 |
| US20040186471A1 (en) * | 2002-12-07 | 2004-09-23 | Sdgi Holdings, Inc. | Method and apparatus for intervertebral disc expansion |
| US20050251267A1 (en) * | 2004-05-04 | 2005-11-10 | John Winterbottom | Cell permeable structural implant |
| DE10258773A1 (de) * | 2002-12-16 | 2004-07-08 | SDGI Holding, Inc., Wilmington | Knochenersatzmaterial |
| DE10301669A1 (de) * | 2003-01-17 | 2004-07-29 | Gesellschaft zur Förderung von Medizin-, Bio- und Umwelttechnologien e.V. | Bioaktive keramische Kompositmaterialien und Verfahren zu deren Herstellung |
| AU2003261747A1 (en) * | 2003-08-27 | 2005-03-29 | Makoto Ogiso | Structural body constituted of biocompatible material impregnated with fine bone dust and process for producing the same |
| US8105367B2 (en) | 2003-09-29 | 2012-01-31 | Smith & Nephew, Inc. | Bone plate and bone plate assemblies including polyaxial fasteners |
| US7422713B2 (en) * | 2003-10-14 | 2008-09-09 | Hewlett-Packard Development Company, L.P. | Hybrid organic-inorganic composition for solid freeform fabrication |
| US7455805B2 (en) * | 2003-10-28 | 2008-11-25 | Hewlett-Packard Development Company, L.P. | Resin-modified inorganic phosphate cement for solid freeform fabrication |
| DE102004022505A1 (de) * | 2003-12-12 | 2005-08-18 | Centrum für Prototypenbau GmbH | Industriell hergestelltes Implantat und Herstellungsverfahren hierfür sowie Knochenersatzwerkstoff zur Verwendung für ein solches Implantat und zu dessen Herstellung |
| US20100191292A1 (en) * | 2004-02-17 | 2010-07-29 | Demeo Joseph | Oriented polymer implantable device and process for making same |
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| JP3817966B2 (ja) * | 1999-04-28 | 2006-09-06 | グンゼ株式会社 | 高剪断強度を有する医療材料及び製造方法 |
| US6270347B1 (en) * | 1999-06-10 | 2001-08-07 | Rensselaer Polytechnic Institute | Nanostructured ceramics and composite materials for orthopaedic-dental implants |
| DE19930335A1 (de) * | 1999-07-02 | 2001-01-18 | Henkel Kgaa | Kompositmaterialien aus Calciumverbindungen und Proteinkomponenten |
| WO2001054746A2 (en) * | 2000-01-31 | 2001-08-02 | Advanced Research And Technology Institute, Inc. | Composite biomaterial including anisometric calcium phosphate reinforcement particles |
| WO2002022117A1 (en) * | 2000-09-12 | 2002-03-21 | Zakrytoe Aktsionernoe Obschestvo 'ostim' | Preparation for treating diseases of bone tissues |
-
2001
- 2001-02-22 US US09/790,741 patent/US20020115742A1/en not_active Abandoned
-
2002
- 2002-02-14 CA CA002438965A patent/CA2438965A1/en not_active Abandoned
- 2002-02-14 WO PCT/US2002/004333 patent/WO2002068009A2/en not_active Ceased
- 2002-02-14 AT AT02704421T patent/ATE535266T1/de active
- 2002-02-14 JP JP2002567372A patent/JP2004521685A/ja active Pending
- 2002-02-14 EP EP02704421A patent/EP1368073B1/en not_active Expired - Lifetime
- 2002-02-14 ES ES02704421T patent/ES2375270T3/es not_active Expired - Lifetime
-
2003
- 2003-07-30 US US10/630,092 patent/US7230039B2/en not_active Expired - Lifetime
-
2010
- 2010-04-28 JP JP2010103834A patent/JP2010246934A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US7230039B2 (en) | 2007-06-12 |
| US20020115742A1 (en) | 2002-08-22 |
| CA2438965A1 (en) | 2002-09-06 |
| EP1368073B1 (en) | 2011-11-30 |
| WO2002068009A3 (en) | 2003-03-06 |
| US20040024081A1 (en) | 2004-02-05 |
| JP2004521685A (ja) | 2004-07-22 |
| EP1368073A2 (en) | 2003-12-10 |
| WO2002068009A2 (en) | 2002-09-06 |
| JP2010246934A (ja) | 2010-11-04 |
| ATE535266T1 (de) | 2011-12-15 |
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