CA2438965A1 - Bioactive nanocomposites and methods for their use - Google Patents
Bioactive nanocomposites and methods for their use Download PDFInfo
- Publication number
- CA2438965A1 CA2438965A1 CA002438965A CA2438965A CA2438965A1 CA 2438965 A1 CA2438965 A1 CA 2438965A1 CA 002438965 A CA002438965 A CA 002438965A CA 2438965 A CA2438965 A CA 2438965A CA 2438965 A1 CA2438965 A1 CA 2438965A1
- Authority
- CA
- Canada
- Prior art keywords
- composition
- ceramic
- polymer
- poly
- lactide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000000034 method Methods 0.000 title claims abstract description 41
- 230000000975 bioactive effect Effects 0.000 title claims abstract description 14
- 239000002114 nanocomposite Substances 0.000 title description 13
- 239000000203 mixture Substances 0.000 claims abstract description 97
- 239000000919 ceramic Substances 0.000 claims abstract description 78
- 210000000988 bone and bone Anatomy 0.000 claims abstract description 36
- 239000007943 implant Substances 0.000 claims abstract description 34
- 239000002245 particle Substances 0.000 claims abstract description 29
- 239000002639 bone cement Substances 0.000 claims abstract description 14
- 229920000249 biocompatible polymer Polymers 0.000 claims abstract description 12
- 230000007547 defect Effects 0.000 claims abstract description 10
- 239000008240 homogeneous mixture Substances 0.000 claims abstract description 8
- 230000000399 orthopedic effect Effects 0.000 claims abstract description 8
- 230000000087 stabilizing effect Effects 0.000 claims abstract description 6
- 229920000642 polymer Polymers 0.000 claims description 68
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims description 44
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 44
- -1 polyethylene Polymers 0.000 claims description 25
- 239000001506 calcium phosphate Substances 0.000 claims description 14
- 239000002904 solvent Substances 0.000 claims description 14
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 12
- 229910052791 calcium Inorganic materials 0.000 claims description 12
- 239000011575 calcium Substances 0.000 claims description 12
- 239000004696 Poly ether ether ketone Substances 0.000 claims description 11
- 235000011010 calcium phosphates Nutrition 0.000 claims description 11
- 229920002530 polyetherether ketone Polymers 0.000 claims description 11
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 11
- 229910000389 calcium phosphate Inorganic materials 0.000 claims description 10
- 239000011159 matrix material Substances 0.000 claims description 8
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims description 7
- 239000004926 polymethyl methacrylate Substances 0.000 claims description 7
- JJTUDXZGHPGLLC-IMJSIDKUSA-N 4511-42-6 Chemical compound C[C@@H]1OC(=O)[C@H](C)OC1=O JJTUDXZGHPGLLC-IMJSIDKUSA-N 0.000 claims description 6
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Polymers OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims description 4
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims description 4
- 229920001244 Poly(D,L-lactide) Polymers 0.000 claims description 4
- 239000004698 Polyethylene Substances 0.000 claims description 4
- 229920000954 Polyglycolide Polymers 0.000 claims description 4
- 229920001432 poly(L-lactide) Polymers 0.000 claims description 4
- 229920000218 poly(hydroxyvalerate) Polymers 0.000 claims description 4
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims description 4
- 239000004417 polycarbonate Substances 0.000 claims description 4
- 229920000515 polycarbonate Polymers 0.000 claims description 4
- 229920000573 polyethylene Polymers 0.000 claims description 4
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims description 4
- 239000005313 bioactive glass Substances 0.000 claims description 3
- 238000012545 processing Methods 0.000 claims description 3
- 229910000391 tricalcium phosphate Inorganic materials 0.000 claims description 3
- 229940078499 tricalcium phosphate Drugs 0.000 claims description 3
- 230000003014 reinforcing effect Effects 0.000 claims description 2
- 230000004927 fusion Effects 0.000 abstract description 22
- 230000001737 promoting effect Effects 0.000 abstract description 7
- 125000006850 spacer group Chemical group 0.000 abstract description 5
- 238000002156 mixing Methods 0.000 description 12
- 239000002131 composite material Substances 0.000 description 10
- 239000003102 growth factor Substances 0.000 description 10
- 239000000463 material Substances 0.000 description 8
- 239000002831 pharmacologic agent Substances 0.000 description 8
- 229920006209 poly(L-lactide-co-D,L-lactide) Polymers 0.000 description 8
- 102000007350 Bone Morphogenetic Proteins Human genes 0.000 description 7
- 108010007726 Bone Morphogenetic Proteins Proteins 0.000 description 7
- 229940112869 bone morphogenetic protein Drugs 0.000 description 7
- 239000002105 nanoparticle Substances 0.000 description 7
- 239000003795 chemical substances by application Substances 0.000 description 6
- 230000008901 benefit Effects 0.000 description 5
- 238000001125 extrusion Methods 0.000 description 5
- 238000001746 injection moulding Methods 0.000 description 5
- 229910052751 metal Inorganic materials 0.000 description 5
- 239000002184 metal Substances 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 208000002193 Pain Diseases 0.000 description 4
- 230000009286 beneficial effect Effects 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 239000008188 pellet Substances 0.000 description 4
- 238000001356 surgical procedure Methods 0.000 description 4
- 206010016654 Fibrosis Diseases 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 230000004761 fibrosis Effects 0.000 description 3
- 239000008187 granular material Substances 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 238000003754 machining Methods 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 229920001059 synthetic polymer Polymers 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 208000028389 Nerve injury Diseases 0.000 description 2
- 102100033337 PDZ and LIM domain protein 7 Human genes 0.000 description 2
- 101710121660 PDZ and LIM domain protein 7 Proteins 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- 229910052586 apatite Inorganic materials 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 2
- 230000036760 body temperature Effects 0.000 description 2
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 2
- 238000004891 communication Methods 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 230000009969 flowable effect Effects 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 238000011065 in-situ storage Methods 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 239000000155 melt Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000000178 monomer Substances 0.000 description 2
- 230000008764 nerve damage Effects 0.000 description 2
- 230000002138 osteoinductive effect Effects 0.000 description 2
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- 235000021317 phosphate Nutrition 0.000 description 2
- 238000009832 plasma treatment Methods 0.000 description 2
- 238000006116 polymerization reaction Methods 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 238000011282 treatment Methods 0.000 description 2
- 102100028728 Bone morphogenetic protein 1 Human genes 0.000 description 1
- 108090000654 Bone morphogenetic protein 1 Proteins 0.000 description 1
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 102000016942 Elastin Human genes 0.000 description 1
- 108010014258 Elastin Proteins 0.000 description 1
- 102000018233 Fibroblast Growth Factor Human genes 0.000 description 1
- 108050007372 Fibroblast Growth Factor Proteins 0.000 description 1
- 208000004044 Hypesthesia Diseases 0.000 description 1
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical group COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 1
- 208000010428 Muscle Weakness Diseases 0.000 description 1
- 206010028372 Muscular weakness Diseases 0.000 description 1
- 208000001132 Osteoporosis Diseases 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- 229920002732 Polyanhydride Polymers 0.000 description 1
- 229920001710 Polyorthoester Polymers 0.000 description 1
- 102000013275 Somatomedins Human genes 0.000 description 1
- 102000009618 Transforming Growth Factors Human genes 0.000 description 1
- 108010009583 Transforming Growth Factors Proteins 0.000 description 1
- 241001447056 Uristes Species 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000000735 allogeneic effect Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 229940035676 analgesics Drugs 0.000 description 1
- 238000000137 annealing Methods 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940124599 anti-inflammatory drug Drugs 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 238000011882 arthroplasty Methods 0.000 description 1
- 230000000712 assembly Effects 0.000 description 1
- 238000000429 assembly Methods 0.000 description 1
- 230000008512 biological response Effects 0.000 description 1
- 230000002051 biphasic effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000006664 bond formation reaction Methods 0.000 description 1
- 210000002805 bone matrix Anatomy 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 235000011089 carbon dioxide Nutrition 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000004568 cement Substances 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 238000000748 compression moulding Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 239000007857 degradation product Substances 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 229920002549 elastin Polymers 0.000 description 1
- 238000002594 fluoroscopy Methods 0.000 description 1
- 238000005242 forging Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 208000034783 hypoesthesia Diseases 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000000921 morphogenic effect Effects 0.000 description 1
- 231100000862 numbness Toxicity 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 238000007747 plating Methods 0.000 description 1
- 229920000117 poly(dioxanone) Polymers 0.000 description 1
- 239000002745 poly(ortho ester) Substances 0.000 description 1
- 229920002627 poly(phosphazenes) Polymers 0.000 description 1
- 229920001610 polycaprolactone Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 238000012805 post-processing Methods 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 239000011877 solvent mixture Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 210000000278 spinal cord Anatomy 0.000 description 1
- 210000001032 spinal nerve Anatomy 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 238000004381 surface treatment Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- GBNXLQPMFAUCOI-UHFFFAOYSA-H tetracalcium;oxygen(2-);diphosphate Chemical compound [O-2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GBNXLQPMFAUCOI-UHFFFAOYSA-H 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 238000007669 thermal treatment Methods 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
- 229920001187 thermosetting polymer Polymers 0.000 description 1
- 239000004416 thermosoftening plastic Substances 0.000 description 1
- 238000001721 transfer moulding Methods 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 238000003828 vacuum filtration Methods 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000001238 wet grinding Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/0047—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L24/0073—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix
- A61L24/0084—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix containing fillers of phosphorus-containing inorganic compounds, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16C—SHAFTS; FLEXIBLE SHAFTS; ELEMENTS OR CRANKSHAFT MECHANISMS; ROTARY BODIES OTHER THAN GEARING ELEMENTS; BEARINGS
- F16C2240/00—Specified values or numerical ranges of parameters; Relations between them
- F16C2240/40—Linear dimensions, e.g. length, radius, thickness, gap
- F16C2240/60—Thickness, e.g. thickness of coatings
- F16C2240/64—Thickness, e.g. thickness of coatings in the nanometer range
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Materials Engineering (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Inorganic Chemistry (AREA)
- Composite Materials (AREA)
- Surgery (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Surgical Instruments (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/790,741 | 2001-02-22 | ||
| US09/790,741 US20020115742A1 (en) | 2001-02-22 | 2001-02-22 | Bioactive nanocomposites and methods for their use |
| PCT/US2002/004333 WO2002068009A2 (en) | 2001-02-22 | 2002-02-14 | Bioactive nanocomposites and methods for their use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2438965A1 true CA2438965A1 (en) | 2002-09-06 |
Family
ID=25151629
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002438965A Abandoned CA2438965A1 (en) | 2001-02-22 | 2002-02-14 | Bioactive nanocomposites and methods for their use |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20020115742A1 (enExample) |
| EP (1) | EP1368073B1 (enExample) |
| JP (2) | JP2004521685A (enExample) |
| AT (1) | ATE535266T1 (enExample) |
| CA (1) | CA2438965A1 (enExample) |
| ES (1) | ES2375270T3 (enExample) |
| WO (1) | WO2002068009A2 (enExample) |
Families Citing this family (141)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2523814C (en) | 1997-02-11 | 2007-02-06 | Gary Karlin Michelson | Segmentable skeletal plating system |
| US6949251B2 (en) * | 2001-03-02 | 2005-09-27 | Stryker Corporation | Porous β-tricalcium phosphate granules for regeneration of bone tissue |
| KR100383433B1 (ko) * | 2001-06-29 | 2003-05-12 | 주식회사 씨엠리서치 | 고강도 뼈 고정용 생분해성 유기 고분자/무기 복합 소재의제조 방법 및 그에 의해 제조된 생분해성 유기고분자/무기 복합 소재 |
| US7744651B2 (en) | 2002-09-18 | 2010-06-29 | Warsaw Orthopedic, Inc | Compositions and methods for treating intervertebral discs with collagen-based materials |
| US20040054414A1 (en) | 2002-09-18 | 2004-03-18 | Trieu Hai H. | Collagen-based materials and methods for augmenting intervertebral discs |
| JP2006515765A (ja) | 2002-11-15 | 2006-06-08 | エスディージーアイ・ホールディングス・インコーポレーテッド | 滑膜性関節を治療するためのコラーゲンベース材料および方法 |
| US20040186471A1 (en) * | 2002-12-07 | 2004-09-23 | Sdgi Holdings, Inc. | Method and apparatus for intervertebral disc expansion |
| US20050251267A1 (en) * | 2004-05-04 | 2005-11-10 | John Winterbottom | Cell permeable structural implant |
| DE10258773A1 (de) * | 2002-12-16 | 2004-07-08 | SDGI Holding, Inc., Wilmington | Knochenersatzmaterial |
| DE10301669A1 (de) * | 2003-01-17 | 2004-07-29 | Gesellschaft zur Förderung von Medizin-, Bio- und Umwelttechnologien e.V. | Bioaktive keramische Kompositmaterialien und Verfahren zu deren Herstellung |
| EP1671662A4 (en) * | 2003-08-27 | 2010-12-15 | Makoto Ogiso | STRUCTURAL BODY OF BIOCOMPATIBLE MATERIAL IMPREGNATED WITH FINE-BONE DUST AND MANUFACTURING METHOD THEREFOR |
| WO2007014192A2 (en) | 2005-07-25 | 2007-02-01 | Smith & Nephew, Inc. | Systems and methods for using polyaxial plates |
| US8105367B2 (en) | 2003-09-29 | 2012-01-31 | Smith & Nephew, Inc. | Bone plate and bone plate assemblies including polyaxial fasteners |
| US7422713B2 (en) * | 2003-10-14 | 2008-09-09 | Hewlett-Packard Development Company, L.P. | Hybrid organic-inorganic composition for solid freeform fabrication |
| US7455805B2 (en) * | 2003-10-28 | 2008-11-25 | Hewlett-Packard Development Company, L.P. | Resin-modified inorganic phosphate cement for solid freeform fabrication |
| DE102004022505A1 (de) * | 2003-12-12 | 2005-08-18 | Centrum für Prototypenbau GmbH | Industriell hergestelltes Implantat und Herstellungsverfahren hierfür sowie Knochenersatzwerkstoff zur Verwendung für ein solches Implantat und zu dessen Herstellung |
| US20100191292A1 (en) * | 2004-02-17 | 2010-07-29 | Demeo Joseph | Oriented polymer implantable device and process for making same |
| US7758896B2 (en) * | 2004-04-16 | 2010-07-20 | University Of Massachusetts | Porous calcium phosphate networks for synthetic bone material |
| JP2007537007A (ja) | 2004-05-12 | 2007-12-20 | マサチューセッツ インスティテュート オブ テクノロジー | 溶剤蒸気膜形成を含んだ立体印刷法等の製法 |
| JP2006093631A (ja) * | 2004-09-27 | 2006-04-06 | Matsushita Electric Ind Co Ltd | 半導体集積回路の製造方法および半導体集積回路の製造装置 |
| US7250550B2 (en) | 2004-10-22 | 2007-07-31 | Wright Medical Technology, Inc. | Synthetic bone substitute material |
| CA2583911A1 (en) * | 2004-10-28 | 2006-05-11 | Microchips, Inc. | Orthopedic and dental implant devices providing controlled drug delivery |
| BG802Y1 (bg) * | 2004-12-09 | 2006-05-31 | Стефан СТАНЧЕВ | Имплантат за обездвижване на прешленни структури |
| CA2535938C (en) * | 2005-02-10 | 2014-11-25 | Cordis Corporation | Biodegradable medical devices with enhanced mechanical strength and pharmacological functions |
| US20060224082A1 (en) * | 2005-04-05 | 2006-10-05 | Vetter James W | Methods and devices for removing tissue from a patient and placing a marker in the patient |
| US9119901B2 (en) * | 2005-04-28 | 2015-09-01 | Warsaw Orthopedic, Inc. | Surface treatments for promoting selective tissue attachment to medical impants |
| US8414907B2 (en) * | 2005-04-28 | 2013-04-09 | Warsaw Orthopedic, Inc. | Coatings on medical implants to guide soft tissue healing |
| DE102005022176B4 (de) * | 2005-05-09 | 2009-06-25 | Martin-Luther-Universität Halle-Wittenberg | Verfahren zur Herstellung von bioresorbierbaren Verbundmaterialien und seine Verwendung als Implantatmaterial sowie bioresorbiebaren Verbundmaterialien |
| US8814567B2 (en) | 2005-05-26 | 2014-08-26 | Zimmer Dental, Inc. | Dental implant prosthetic device with improved osseointegration and esthetic features |
| WO2007001624A2 (en) * | 2005-06-28 | 2007-01-04 | Microchips, Inc. | Medical and dental implant devices for controlled drug delivery |
| JP4907908B2 (ja) * | 2005-06-29 | 2012-04-04 | ルネサスエレクトロニクス株式会社 | 駆動回路及び表示装置 |
| US9101654B2 (en) * | 2005-07-12 | 2015-08-11 | University Of South Carolina | Bioresorbable composite for repairing skeletal tissue |
| US8382807B2 (en) | 2005-07-25 | 2013-02-26 | Smith & Nephew, Inc. | Systems and methods for using polyaxial plates |
| EP1928346B1 (en) | 2005-08-30 | 2016-05-04 | Zimmer Dental, Inc. | Dental implant with improved osseointegration features |
| US8562346B2 (en) | 2005-08-30 | 2013-10-22 | Zimmer Dental, Inc. | Dental implant for a jaw with reduced bone volume and improved osseointegration features |
| US9763788B2 (en) | 2005-09-09 | 2017-09-19 | Board Of Trustees Of The University Of Arkansas | Bone regeneration using biodegradable polymeric nanocomposite materials and applications of the same |
| WO2007030616A2 (en) | 2005-09-09 | 2007-03-15 | Wright Medical Technology, Inc. | Composite bone graft substitute cement and articles produced therefrom |
| US8936805B2 (en) | 2005-09-09 | 2015-01-20 | Board Of Trustees Of The University Of Arkansas | Bone regeneration using biodegradable polymeric nanocomposite materials and applications of the same |
| US8025903B2 (en) | 2005-09-09 | 2011-09-27 | Wright Medical Technology, Inc. | Composite bone graft substitute cement and articles produced therefrom |
| US8518123B2 (en) * | 2005-09-09 | 2013-08-27 | Board Of Trustees Of The University Of Arkansas | System and method for tissue generation and bone regeneration |
| CA2629600C (en) * | 2005-11-14 | 2011-11-01 | Biomet 3I, Inc. | Deposition of discrete nanoparticles on an implant surface |
| US20070154514A1 (en) * | 2005-12-30 | 2007-07-05 | Demakas John J | Therapeutic Structures |
| US20100040668A1 (en) * | 2006-01-12 | 2010-02-18 | Rutgers, The State University Of New Jersey | Biomimetic Hydroxyapatite Composite Materials and Methods for the Preparation Thereof |
| US8287914B2 (en) | 2006-01-12 | 2012-10-16 | Rutgers, The State University Of New Jersey | Biomimetic hydroxyapatite synthesis |
| EP1976460A4 (en) | 2006-01-19 | 2012-06-20 | Warsaw Orthopedic Inc | INJECTABLE AND FORMABLE BONE REPLACEMENT MATERIALS |
| US20070213718A1 (en) * | 2006-02-14 | 2007-09-13 | Sdgi Holdings, Inc. | Treatment of the vertebral column |
| US20070213717A1 (en) * | 2006-02-14 | 2007-09-13 | Sdgi Holdings, Inc. | Biological fusion in the vertebral column |
| US7520888B2 (en) | 2006-02-14 | 2009-04-21 | Warsaw Orthopedic, Inc. | Treatment of the vertebral column |
| US20070227547A1 (en) * | 2006-02-14 | 2007-10-04 | Sdgi Holdings, Inc. | Treatment of the vertebral column |
| US8016859B2 (en) | 2006-02-17 | 2011-09-13 | Medtronic, Inc. | Dynamic treatment system and method of use |
| EP1996114A4 (en) * | 2006-03-06 | 2011-08-31 | Nano Orthopedics Llc | BIO-MATERIAL COMPOSED OF PLGA / HYDROXYAPATITE AND METHOD OF MANUFACTURE |
| GB0608345D0 (en) * | 2006-04-27 | 2006-06-07 | Univ Warwick | Implant |
| US20080004703A1 (en) * | 2006-06-30 | 2008-01-03 | Warsaw Orthopedic, Inc. | Method of treating a patient using a collagen material |
| US20080004431A1 (en) * | 2006-06-30 | 2008-01-03 | Warsaw Orthopedic Inc | Method of manufacturing an injectable collagen material |
| US8399619B2 (en) | 2006-06-30 | 2013-03-19 | Warsaw Orthopedic, Inc. | Injectable collagen material |
| US8118779B2 (en) | 2006-06-30 | 2012-02-21 | Warsaw Orthopedic, Inc. | Collagen delivery device |
| US20100015068A1 (en) * | 2006-07-06 | 2010-01-21 | Massachusetts Institute Of Technology | Methods and Compositions For Altering Biological Surfaces |
| EP1891984A1 (en) * | 2006-08-24 | 2008-02-27 | Graftys | Macroporous and highly resorbable apatitic calcium-phosphate cement |
| AU2007300509C1 (en) * | 2006-09-25 | 2014-03-06 | Orthovita, Inc. | Bioactive load-bearing composites |
| EP2068952A2 (en) * | 2006-10-05 | 2009-06-17 | CAM Aesthetics B.V. i.o. | Hydroxyapatite tissue filler and its preparation and use |
| US7972648B2 (en) * | 2006-10-24 | 2011-07-05 | Biomet 3I, Llc | Deposition of discrete nanoparticles on a nanostructured surface of an implant |
| FR2912739B1 (fr) * | 2007-02-15 | 2012-10-12 | Noraker | Procede de preparation d'un materiau composite, materiau obtenu et applications |
| US11179243B2 (en) * | 2007-02-28 | 2021-11-23 | Happe Spine Llc | Implantable devices |
| US20080206297A1 (en) * | 2007-02-28 | 2008-08-28 | Roeder Ryan K | Porous composite biomaterials and related methods |
| US20080311172A1 (en) * | 2007-04-25 | 2008-12-18 | Schapira Jay N | Programmed-release, nanostructured biological construct |
| GB0713351D0 (en) * | 2007-07-10 | 2007-08-22 | Smith & Nephew | Nanoparticulate fillers |
| US20090061389A1 (en) * | 2007-08-30 | 2009-03-05 | Matthew Lomicka | Dental implant prosthetic device with improved osseointegration and shape for resisting rotation |
| WO2009034087A2 (en) * | 2007-09-11 | 2009-03-19 | Solvay Advanced Polymers, L.L.C. | New prosthetic devices |
| US20090131867A1 (en) | 2007-11-16 | 2009-05-21 | Liu Y King | Steerable vertebroplasty system with cavity creation element |
| US20090131886A1 (en) | 2007-11-16 | 2009-05-21 | Liu Y King | Steerable vertebroplasty system |
| US20090131950A1 (en) * | 2007-11-16 | 2009-05-21 | Liu Y King | Vertebroplasty method with enhanced control |
| US9510885B2 (en) | 2007-11-16 | 2016-12-06 | Osseon Llc | Steerable and curvable cavity creation system |
| WO2009073209A1 (en) * | 2007-12-06 | 2009-06-11 | Osseon Therapeutics, Inc. | Vertebroplasty implant with enhanced interfacial shear strength |
| WO2009097218A1 (en) | 2008-01-28 | 2009-08-06 | Biomet 3I, Llc | Implant surface with increased hydrophilicity |
| JP5232483B2 (ja) * | 2008-01-30 | 2013-07-10 | 日本特殊陶業株式会社 | 生体インプラント |
| US8685432B2 (en) * | 2008-03-25 | 2014-04-01 | University Of Utah Research Foundation | Controlled release tissue graft combination biomaterials |
| US8470040B2 (en) * | 2008-04-02 | 2013-06-25 | Pioneer Surgical Technology, Inc. | Intervertebral implant devices for supporting vertebrae and devices and methods for insertion thereof |
| EP2127689A1 (en) * | 2008-05-27 | 2009-12-02 | RevisiOs B.V. i.o. | Novel homogenous osteoinductive nanocomposites |
| US8899982B2 (en) | 2008-07-02 | 2014-12-02 | Zimmer Dental, Inc. | Implant with structure for securing a porous portion |
| US9095396B2 (en) | 2008-07-02 | 2015-08-04 | Zimmer Dental, Inc. | Porous implant with non-porous threads |
| US8231387B2 (en) | 2008-07-02 | 2012-07-31 | Zimmer, Inc. | Porous implant with non-porous threads |
| US8562348B2 (en) * | 2008-07-02 | 2013-10-22 | Zimmer Dental, Inc. | Modular implant with secured porous portion |
| JP5155058B2 (ja) * | 2008-08-05 | 2013-02-27 | 日本特殊陶業株式会社 | 骨充填材 |
| US20100114314A1 (en) | 2008-11-06 | 2010-05-06 | Matthew Lomicka | Expandable bone implant |
| US7940600B2 (en) * | 2008-12-02 | 2011-05-10 | Seagate Technology Llc | Non-volatile memory with stray magnetic field compensation |
| US20100168798A1 (en) * | 2008-12-30 | 2010-07-01 | Clineff Theodore D | Bioactive composites of polymer and glass and method for making same |
| US8609127B2 (en) | 2009-04-03 | 2013-12-17 | Warsaw Orthopedic, Inc. | Medical implant with bioactive material and method of making the medical implant |
| US20100298832A1 (en) | 2009-05-20 | 2010-11-25 | Osseon Therapeutics, Inc. | Steerable curvable vertebroplasty drill |
| DE102009026622A1 (de) * | 2009-05-29 | 2010-12-02 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Formkörper mit eingebetteten Kopplungspartikeln für Biomoleküle |
| US9707058B2 (en) | 2009-07-10 | 2017-07-18 | Zimmer Dental, Inc. | Patient-specific implants with improved osseointegration |
| US9399086B2 (en) | 2009-07-24 | 2016-07-26 | Warsaw Orthopedic, Inc | Implantable medical devices |
| DE102009043550A1 (de) | 2009-09-30 | 2011-05-19 | Aap Biomaterials Gmbh | Knochenzement und Verfahren zu dessen Herstellung |
| US8602782B2 (en) | 2009-11-24 | 2013-12-10 | Zimmer Dental, Inc. | Porous implant device with improved core |
| BRPI0906274A8 (pt) * | 2009-12-22 | 2018-04-03 | Einco Biomaterial Ltda Me | Processo de produção, compósitos, sistema e dispositivos médico-veterinários bio-ativos, biointegráveis, condutores, indutores teciduais para fixação, reparo, reconstrução, remodelação, plastias intra, supra teciduais e/ou totais, permanentes, biológica e fisiologicamente biocompatíveis |
| US8641418B2 (en) * | 2010-03-29 | 2014-02-04 | Biomet 3I, Llc | Titanium nano-scale etching on an implant surface |
| WO2011137377A1 (en) | 2010-04-29 | 2011-11-03 | Dfine, Inc. | System for use in treatment of vertebral fractures |
| US9265857B2 (en) | 2010-05-11 | 2016-02-23 | Howmedica Osteonics Corp. | Organophosphorous, multivalent metal compounds, and polymer adhesive interpenetrating network compositions and methods |
| CN101899193A (zh) * | 2010-07-09 | 2010-12-01 | 华东理工大学 | 含有氟磷灰石的聚醚醚酮复合材料及制备方法和应用 |
| WO2012004637A1 (en) | 2010-07-09 | 2012-01-12 | Indian Institute Of Technology Kanpur | Hydroxyapatite poly(etheretherketone) nanocomposities and method of manufacturing same |
| CN101879332A (zh) * | 2010-07-13 | 2010-11-10 | 北京大学 | 含有氟磷灰石和二氧化钛的聚醚醚酮复合材料及制备方法 |
| KR101324170B1 (ko) * | 2010-09-16 | 2013-11-05 | 한국과학기술연구원 | 표면 개질된 금속 입자 및 생분해성 고분자를 포함하는 생체 이식물, 이의 염증 억제용으로서의 용도 및 그 제조 방법 |
| US8551525B2 (en) | 2010-12-23 | 2013-10-08 | Biostructures, Llc | Bone graft materials and methods |
| GB2488111A (en) | 2011-02-14 | 2012-08-22 | Invibio Ltd | Components incorporating bioactive material |
| WO2012158527A2 (en) | 2011-05-13 | 2012-11-22 | Howmedica Osteonics | Organophosphorous & multivalent metal compound compositions & methods |
| JP2014522673A (ja) | 2011-06-15 | 2014-09-08 | スミス アンド ネフュー インコーポレーテッド | 角度が可変とされたロッキング用のインプラント |
| US8668723B2 (en) | 2011-07-19 | 2014-03-11 | Neurostructures, Inc. | Anterior cervical plate |
| EP2792712B1 (en) * | 2011-12-15 | 2016-07-20 | Tokuyama Dental Corporation | Organic/inorganic composite, manufacturing method therefor, dental material, and bone substitute material |
| WO2013142118A1 (en) | 2012-03-20 | 2013-09-26 | Biomet 3I, Llc | Surface treatment for an implant surface |
| WO2013154704A1 (en) | 2012-04-12 | 2013-10-17 | Howard University | Polylactide and apatite compositions and methods of making the same |
| TW201919579A (zh) | 2012-11-09 | 2019-06-01 | 霍華德大學 | 用於牙齒琺瑯質保護之嵌段共聚物 |
| US9889235B2 (en) | 2013-02-05 | 2018-02-13 | University Of Utah Research Foundation | Implantable devices for bone or joint defects |
| CN108095860A (zh) * | 2013-03-13 | 2018-06-01 | 瑞特医疗技术公司 | 矫正植入件增强部、系统、以及方法 |
| US9949839B2 (en) | 2013-03-13 | 2018-04-24 | Wright Medical Technology, Inc. | Revision implant augments, systems, and methods |
| WO2015062357A1 (zh) * | 2013-10-30 | 2015-05-07 | 中山大学 | 一种可注射复合型骨水泥及其制备方法和应用 |
| TWI651103B (zh) | 2013-12-13 | 2019-02-21 | 萊特醫技股份有限公司 | 多相骨移植替代材料 |
| US9629664B2 (en) | 2014-01-20 | 2017-04-25 | Neurostructures, Inc. | Anterior cervical plate |
| US9486250B2 (en) | 2014-02-20 | 2016-11-08 | Mastros Innovations, LLC. | Lateral plate |
| EP3116555B1 (en) * | 2014-03-14 | 2021-08-25 | Ecole Polytechnique Fédérale de Lausanne (EPFL) | Active agent-particle combination supporting bone regeneration |
| WO2016082941A1 (en) * | 2014-11-27 | 2016-06-02 | Carl Zeiss Smt Gmbh | Lithography apparatus comprising a plurality of individually controllable write heads |
| US10993750B2 (en) | 2015-09-18 | 2021-05-04 | Smith & Nephew, Inc. | Bone plate |
| US10136998B2 (en) | 2016-08-30 | 2018-11-27 | Wright Medical Technology, Inc. | Revision total ankle implants |
| US20200040149A1 (en) * | 2016-10-06 | 2020-02-06 | Foundation For Research And Business, Seoul National University Of Science And Technology | Polymer-ceramic hybrid film having mechanical properties and elasticity, and method for manufacturing same |
| CN109862834B (zh) | 2016-10-27 | 2022-05-24 | Dfine有限公司 | 具有接合剂递送通道的可弯曲的骨凿 |
| CA3041114A1 (en) | 2016-11-28 | 2018-05-31 | Dfine, Inc. | Tumor ablation devices and related methods |
| WO2018107036A1 (en) | 2016-12-09 | 2018-06-14 | Dfine, Inc. | Medical devices for treating hard tissues and related methods |
| EP3565486B1 (en) | 2017-01-06 | 2021-11-10 | Dfine, Inc. | Osteotome with a distal portion for simultaneous advancement and articulation |
| US10980641B2 (en) | 2017-05-04 | 2021-04-20 | Neurostructures, Inc. | Interbody spacer |
| US10512547B2 (en) | 2017-05-04 | 2019-12-24 | Neurostructures, Inc. | Interbody spacer |
| CN107412852A (zh) * | 2017-07-26 | 2017-12-01 | 山东冠龙医疗用品有限公司 | 骨水泥组合物及其套组 |
| EP3678602A4 (en) | 2017-09-08 | 2021-10-06 | Pioneer Surgical Technology, Inc. | DISC IMPLANTS, INSTRUMENTS AND PROCEDURES |
| USD907771S1 (en) | 2017-10-09 | 2021-01-12 | Pioneer Surgical Technology, Inc. | Intervertebral implant |
| CN110339395B (zh) * | 2018-04-03 | 2021-09-21 | 暨南大学 | 一种pmma基的水合骨水泥及其制备方法与应用 |
| US11076892B2 (en) | 2018-08-03 | 2021-08-03 | Neurostructures, Inc. | Anterior cervical plate |
| US11071629B2 (en) | 2018-10-13 | 2021-07-27 | Neurostructures Inc. | Interbody spacer |
| CN109316627A (zh) * | 2018-10-26 | 2019-02-12 | 中国医学科学院北京协和医院 | 一种新型人工骨材料及其制备方法和应用 |
| WO2020097334A1 (en) | 2018-11-08 | 2020-05-14 | Dfine, Inc. | Ablation systems with parameter-based modulation and related devices and methods |
| CN109908400A (zh) * | 2019-04-28 | 2019-06-21 | 上海尚融生物科技有限公司 | 一种抗生素骨水泥椎间融合器的材料与制作方法 |
| EP4031040B1 (en) | 2019-09-18 | 2025-04-09 | Merit Medical Systems, Inc. | Osteotome with inflatable portion and multiwire articulation |
| US11382761B2 (en) | 2020-04-11 | 2022-07-12 | Neurostructures, Inc. | Expandable interbody spacer |
| US11304817B2 (en) | 2020-06-05 | 2022-04-19 | Neurostructures, Inc. | Expandable interbody spacer |
| US11717419B2 (en) | 2020-12-10 | 2023-08-08 | Neurostructures, Inc. | Expandable interbody spacer |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2501683C3 (de) * | 1975-01-17 | 1979-11-29 | Ernst Leitz Wetzlar Gmbh, 6300 Wetzlar | Polymeres Verbundmaterial für prothetische Zwecke und Verfahren zu seiner Herstellung |
| AT352867B (de) * | 1976-05-12 | 1979-10-10 | Battelle Institut E V | Knochenersatz-knochenverbund-oder prothesen- verankerungswerkstoff und verfahren zu seiner herstellung |
| EP0030583B1 (de) * | 1979-12-18 | 1984-06-13 | Oscobal Ag | Knochenersatzmaterial und Verfahren zur Herstellung eines Knochenersatzmaterials |
| DE3135113A1 (de) * | 1981-09-04 | 1983-03-24 | Bayer Ag, 5090 Leverkusen | Photopolymerisierbare massen, deren verwendung fuer zahnaerztliche zwecke, sowie verfahren zur herstellung von zahnersatzteilen, zahnfuellungen und ueberzuegen |
| US5217492A (en) * | 1982-09-29 | 1993-06-08 | Bio-Metric Systems, Inc. | Biomolecule attachment to hydrophobic surfaces |
| US5002582A (en) * | 1982-09-29 | 1991-03-26 | Bio-Metric Systems, Inc. | Preparation of polymeric surfaces via covalently attaching polymers |
| DE3479402D1 (en) * | 1984-06-12 | 1989-09-21 | Oscobal Ag | Method of producing a bone replacement material |
| US5001169A (en) * | 1984-10-24 | 1991-03-19 | Collagen Corporation | Inductive collagen-based bone repair preparations |
| US4888366A (en) * | 1984-10-24 | 1989-12-19 | Collagen Corporation | Inductive collagen-based bone repair preparations |
| US4636526A (en) * | 1985-02-19 | 1987-01-13 | The Dow Chemical Company | Composites of unsintered calcium phosphates and synthetic biodegradable polymers useful as hard tissue prosthetics |
| US5273964A (en) * | 1985-03-20 | 1993-12-28 | Lemons J E | Inorganic and organic composition for treatment of bone lesions |
| US5246457A (en) * | 1985-03-28 | 1993-09-21 | Collagen Corporation | Xenogeneic collagen/mineral preparations in bone repair |
| US4776890A (en) * | 1985-12-18 | 1988-10-11 | Collagen Corporation | Preparation of collagen hydroxyapatite matrix for bone repair |
| US4743229A (en) * | 1986-09-29 | 1988-05-10 | Collagen Corporation | Collagen/mineral mixing device and method |
| US4865602A (en) * | 1986-11-06 | 1989-09-12 | Collagen Corporation | Gamma irradiation of collagen/mineral mixtures |
| WO1993013030A1 (fr) * | 1988-01-30 | 1993-07-08 | Ryo Enomoto | Ceramiques composites a phosphate de calcium, renforcees par des fibres, et procede de fabrication |
| US5204319A (en) * | 1988-01-30 | 1993-04-20 | Ibiden Co., Ltd. | Fiber reinforced ceramics of calcium phosphate series compounds |
| US5015247A (en) * | 1988-06-13 | 1991-05-14 | Michelson Gary K | Threaded spinal implant |
| DE4120325A1 (de) * | 1991-06-20 | 1992-12-24 | Merck Patent Gmbh | Implantatwerkstoff |
| US5320844A (en) * | 1992-03-12 | 1994-06-14 | Liu Sung Tsuen | Composite materials for hard tissue replacement |
| JPH06105900A (ja) * | 1992-09-22 | 1994-04-19 | Mitsubishi Materials Corp | 生体活性セラミックス被覆インプラント |
| US5364399A (en) * | 1993-02-05 | 1994-11-15 | Danek Medical, Inc. | Anterior cervical plating system |
| US5380298A (en) * | 1993-04-07 | 1995-01-10 | The United States Of America As Represented By The Secretary Of The Navy | Medical device with infection preventing feature |
| US5721049A (en) * | 1993-11-15 | 1998-02-24 | Trustees Of The University Of Pennsylvania | Composite materials using bone bioactive glass and ceramic fibers |
| US5468544A (en) * | 1993-11-15 | 1995-11-21 | The Trustees Of The University Of Pennsylvania | Composite materials using bone bioactive glass and ceramic fibers |
| AU3795395A (en) * | 1994-11-30 | 1996-06-06 | Ethicon Inc. | Hard tissue bone cements and substitutes |
| US5782919A (en) * | 1995-03-27 | 1998-07-21 | Sdgi Holdings, Inc. | Interbody fusion device and method for restoration of normal spinal anatomy |
| US6027742A (en) * | 1995-05-19 | 2000-02-22 | Etex Corporation | Bioresorbable ceramic composites |
| CA2172917A1 (en) | 1995-06-07 | 1996-12-08 | Hugh R. Mcmullin | Moldable collagen compositions for hard tissue repair and augmentation |
| US5776193A (en) * | 1995-10-16 | 1998-07-07 | Orquest, Inc. | Bone grafting matrix |
| US5728753A (en) * | 1995-11-09 | 1998-03-17 | University Of London | Bioactive composite material for repair of hard and soft tissues |
| US5817328A (en) * | 1996-01-17 | 1998-10-06 | Cambridge Scientific, Inc. | Material for buffered resorbable internal fixation devices and method for making same |
| US5964807A (en) * | 1996-08-08 | 1999-10-12 | Trustees Of The University Of Pennsylvania | Compositions and methods for intervertebral disc reformation |
| US5858318A (en) * | 1996-11-27 | 1999-01-12 | Luo; Ping | Methods of synthesizing hydroxyapatite powders and bulk materials |
| US5914356A (en) * | 1996-12-06 | 1999-06-22 | Orthovita, Inc. | Bioactive load bearing bone bonding compositions |
| US5977204A (en) * | 1997-04-11 | 1999-11-02 | Osteobiologics, Inc. | Biodegradable implant material comprising bioactive ceramic |
| ZA983955B (en) * | 1997-05-15 | 2001-08-13 | Sdgi Holdings Inc | Anterior cervical plating system. |
| US6033438A (en) * | 1997-06-03 | 2000-03-07 | Sdgi Holdings, Inc. | Open intervertebral spacer |
| US5972368A (en) * | 1997-06-11 | 1999-10-26 | Sdgi Holdings, Inc. | Bone graft composites and spacers |
| JPH11164879A (ja) * | 1997-12-08 | 1999-06-22 | Nippon Electric Glass Co Ltd | 生体活性セメント組成物 |
| US6139585A (en) * | 1998-03-11 | 2000-10-31 | Depuy Orthopaedics, Inc. | Bioactive ceramic coating and method |
| US6165486A (en) * | 1998-11-19 | 2000-12-26 | Carnegie Mellon University | Biocompatible compositions and methods of using same |
| CA2366377A1 (en) * | 1999-03-31 | 2000-10-05 | Brigham And Women's Hospital, Inc. | Nanocomposite surgical materials and method of producing them |
| JP3817966B2 (ja) * | 1999-04-28 | 2006-09-06 | グンゼ株式会社 | 高剪断強度を有する医療材料及び製造方法 |
| US6270347B1 (en) * | 1999-06-10 | 2001-08-07 | Rensselaer Polytechnic Institute | Nanostructured ceramics and composite materials for orthopaedic-dental implants |
| DE19930335A1 (de) * | 1999-07-02 | 2001-01-18 | Henkel Kgaa | Kompositmaterialien aus Calciumverbindungen und Proteinkomponenten |
| AU2001231264A1 (en) * | 2000-01-31 | 2001-08-07 | Advanced Research And Technology Institute, Inc. | Composite biomaterial including anisometric calcium phosphate reinforcement particles and related methods |
| WO2002022117A1 (en) * | 2000-09-12 | 2002-03-21 | Zakrytoe Aktsionernoe Obschestvo 'ostim' | Preparation for treating diseases of bone tissues |
-
2001
- 2001-02-22 US US09/790,741 patent/US20020115742A1/en not_active Abandoned
-
2002
- 2002-02-14 WO PCT/US2002/004333 patent/WO2002068009A2/en not_active Ceased
- 2002-02-14 AT AT02704421T patent/ATE535266T1/de active
- 2002-02-14 EP EP02704421A patent/EP1368073B1/en not_active Expired - Lifetime
- 2002-02-14 CA CA002438965A patent/CA2438965A1/en not_active Abandoned
- 2002-02-14 ES ES02704421T patent/ES2375270T3/es not_active Expired - Lifetime
- 2002-02-14 JP JP2002567372A patent/JP2004521685A/ja active Pending
-
2003
- 2003-07-30 US US10/630,092 patent/US7230039B2/en not_active Expired - Lifetime
-
2010
- 2010-04-28 JP JP2010103834A patent/JP2010246934A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ATE535266T1 (de) | 2011-12-15 |
| WO2002068009A3 (en) | 2003-03-06 |
| WO2002068009A2 (en) | 2002-09-06 |
| ES2375270T3 (es) | 2012-02-28 |
| EP1368073B1 (en) | 2011-11-30 |
| US20040024081A1 (en) | 2004-02-05 |
| JP2010246934A (ja) | 2010-11-04 |
| US7230039B2 (en) | 2007-06-12 |
| EP1368073A2 (en) | 2003-12-10 |
| US20020115742A1 (en) | 2002-08-22 |
| JP2004521685A (ja) | 2004-07-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |