JP2011506619A - ナノ粒子フィラー - Google Patents
ナノ粒子フィラー Download PDFInfo
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- JP2011506619A JP2011506619A JP2010516192A JP2010516192A JP2011506619A JP 2011506619 A JP2011506619 A JP 2011506619A JP 2010516192 A JP2010516192 A JP 2010516192A JP 2010516192 A JP2010516192 A JP 2010516192A JP 2011506619 A JP2011506619 A JP 2011506619A
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F2/00—Processes of polymerisation
- C08F2/44—Polymerisation in the presence of compounding ingredients, e.g. plasticisers, dyestuffs, fillers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/446—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/12—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L31/125—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L31/127—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix containing fillers of phosphorus-containing inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/12—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L31/125—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L31/128—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix containing other specific inorganic fillers not covered by A61L31/126 or A61L31/127
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/148—Materials at least partially resorbable by the body
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/18—Oxygen-containing compounds, e.g. metal carbonyls
- C08K3/24—Acids; Salts thereof
- C08K3/26—Carbonates; Bicarbonates
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/32—Phosphorus-containing compounds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
- C08L67/04—Polyesters derived from hydroxycarboxylic acids, e.g. lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/18—Oxygen-containing compounds, e.g. metal carbonyls
- C08K3/24—Acids; Salts thereof
- C08K3/26—Carbonates; Bicarbonates
- C08K2003/265—Calcium, strontium or barium carbonate
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Composite Materials (AREA)
- Materials Engineering (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Nanotechnology (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- General Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Physics & Mathematics (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Materials For Medical Uses (AREA)
- Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
- Biological Depolymerization Polymers (AREA)
Abstract
Description
本出願は、参照によりその全内容が本明細書に組み込まれる、2007年7月10日出願の英国特許仮出願0713351.5号明細書のPCT国際出願である。
ポリグリコリド
ポリラクチド
グリコリドとラクチドのコポリマー
ポリカプロラクトン
グリコリド/トリメチレンカーボネートコポリマー
ポリ-DL-乳酸(PDLLA)
ポリ-D-乳酸(PDLA)
ラクチド/テトラメチルグリコリドコポリマー
ラクチド/トリメチレンカーボネートコポリマー
ラクチド/d-バレロラクトンコポリマー
ラクチド/e-カプロラクトンコポリマー
PLA/ポリエチレンオキシドコポリマー
ポリデプシペプチド
非対称3,6-置換ポリ-1,4-ジオキサン-2,5-ジオン
ポリ-b-ヒドロキシブチレート
PHB/b-ヒドロキシバレレートコポリマー
ポリ-b-ヒドロキシプロピオネート
ポリ-p-ジオキサノン
ポリ-d-バレロラクトン
メチルメタクリレート-N-ビニルピロリドンコポリマー
ポリエステルアミド
シュウ酸のポリエステル
ポリジヒドロピラン
ポリアルキル-2-シアノクリレート
ポリウレタン(PU)
ポリビニルアルコール(PVA)
ポリペプチド
ポリ-b-リンゴ酸(PMLA)
ポリ-b-アルカン酸ポリカーボネート
a)第1のポリマーをナノ粒子剤と重合させて組合せを形成するステップと、
b)a)において生成された組合せを第2のポリマーとブレンドするステップとを含み、第2のポリマーは第1のポリマーより高い分子量を有する。
最小量の希HClで溶解することにより作製した。得られた溶液を容量フラスコ内で1000mlに希釈した。密封容器内でプルプル酸アンモニウム(1.0g)を200gのショ糖と完全に混合し、後に指示薬として0.2gの量で使用した。カルシウムイオン濃度が未知である既知体積の溶液の一定量を容量フラスコ内に入れ、1mlのNH2OH・HCl、1mlのNaOH(80g l-1)及びプルプル酸アンモニウムを添加し、色がピンクから紫に変化するまでEDTAで滴定した。EDTAの体積を記録し、カルシウム濃度を決定した。また、乾燥試料の分子量の変化を、GPCを使用して確定した。
Claims (15)
- 生体吸収性ポリマー内に組み込んで、前記生体吸収性ポリマーの酸性分解生成物を中和するための中和剤を含むナノ粒子の使用。
- 中和剤が、炭酸塩、重炭酸塩、またはリン酸塩からなる群から選択される、酸性分解生成物を中和することができる塩である、請求項1に記載の使用。
- 中和剤が、遊離カルシウムイオンの源である、請求項1または2に記載のナノ粒子の使用。
- 中和剤が、炭酸カルシウムまたはリン酸カルシウムである、請求項1から3のいずれか一項に記載の使用。
- リン酸カルシウムが、アパタイトである、請求項4に記載の使用。
- アパタイトが、ヒドロキシアパタイトである、請求項5に記載の使用。
- ポリマー内の中和剤の濃度が、約5〜20wt%である、請求項1から6のいずれか一項に記載の使用。
- 濃度が、約7〜15wt%である、請求項6または7に記載の使用。
- ナノ粒子の直径が、100nm未満である、請求項1から8のいずれか一項に記載の使用。
- 第1のポリマーと、第2のポリマーとを含むポリマー複合材であって、第1のポリマーは第2のポリマーより低い分子量を有し、中和剤のナノ粒子が少なくとも第1のポリマー全体に分布している、ポリマー複合材。
- 第1のポリマー及び第2のポリマーの両方が、PDLLAまたはそのコポリマーであり、第1のポリマーは、炭酸カルシウムのナノ粒子を含む、請求項10に記載のポリマー複合材。
- 全体に分布したナノ粒子中和剤を含む第1のポリマーと、第2のポリマーとを含む複合材を製造する方法であって、
a)第1のポリマーをナノ粒子剤と重合させて組合せを形成するステップと、
b)a)において生成された組合せを第2のポリマーとブレンドして複合材を形成するステップとを含み、第2のポリマーは第1のポリマーより高い分子量を有する方法。 - 第1のポリマーがPDLLAまたはそのコポリマーであり、ナノ粒子剤が炭酸カルシウムである、請求項12に記載の方法。
- ポリマー材料と、ポリマー材料全体に分布したナノ粒子中和剤とを含む複合材であって、ポリマー材料がPDLLAまたはそのコポリマーからなる、複合材。
- ポリマー材料と、ポリマー材料全体に分布したナノ粒子中和剤とを含む複合材であって、ポリマー材料がPLLA以外の任意のポリマー材料である、複合材。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0713351.5 | 2007-07-10 | ||
GBGB0713351.5A GB0713351D0 (en) | 2007-07-10 | 2007-07-10 | Nanoparticulate fillers |
PCT/US2008/069391 WO2009009520A2 (en) | 2007-07-10 | 2008-07-08 | Nanoparticulate fillers |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2011506619A true JP2011506619A (ja) | 2011-03-03 |
JP5753687B2 JP5753687B2 (ja) | 2015-07-22 |
Family
ID=38461314
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010516192A Expired - Fee Related JP5753687B2 (ja) | 2007-07-10 | 2008-07-08 | ナノ粒子フィラー |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP2170983A2 (ja) |
JP (1) | JP5753687B2 (ja) |
AU (1) | AU2008275226B2 (ja) |
GB (1) | GB0713351D0 (ja) |
WO (1) | WO2009009520A2 (ja) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014184939A1 (ja) * | 2013-05-16 | 2014-11-20 | 株式会社ソフセラ | 生分解性材料 |
JP2018012845A (ja) * | 2017-10-12 | 2018-01-25 | 株式会社ソフセラ | 生分解性材料 |
JPWO2018056019A1 (ja) * | 2016-09-21 | 2019-07-04 | グンゼ株式会社 | 徐放性薬剤の製造方法及び徐放性薬剤 |
JP2019534236A (ja) * | 2016-08-02 | 2019-11-28 | ビー.ブラウン、サージカル、ソシエダッド、アノニマB.Braun Surgical, S.A. | 永久分極ハイドロキシアパタイト、その製造方法および使用 |
JP2021511405A (ja) * | 2018-01-17 | 2021-05-06 | ザ・セカント・グループ・エルエルシー | pHを調節する生分解性ポリマーおよびポリ(グリセロールセバシン酸)で増強された細胞培養培地 |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CZ309811B6 (cs) * | 2021-03-26 | 2023-11-01 | Vysoká Škola Báňská-Technická Univerzita Ostrava | Degradabilní polymerní kompozitní materiál, zejména s antimikrobiálními účinky |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH06313096A (ja) * | 1993-04-28 | 1994-11-08 | Toyo Ink Mfg Co Ltd | ポリエステル樹脂高濃度着色物およびそれを用いたポリエステル繊維用着色組成物 |
JP2004521685A (ja) * | 2001-02-22 | 2004-07-22 | エスディージーアイ・ホールディングス・インコーポレーテッド | 生物活性名ナノ組成物及びその使用方法 |
JP2005334654A (ja) * | 2004-05-28 | 2005-12-08 | Cordis Corp | 包封された緩衝剤を含む医用インプラント |
JP2006249184A (ja) * | 2005-03-09 | 2006-09-21 | Osaka Univ | 無機微粒子含有重合性組成物及びその製造方法、並びに、無機微粒子含有重合体組成物 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070282434A1 (en) * | 2006-05-30 | 2007-12-06 | Yunbing Wang | Copolymer-bioceramic composite implantable medical devices |
-
2007
- 2007-07-10 GB GBGB0713351.5A patent/GB0713351D0/en not_active Ceased
-
2008
- 2008-07-08 AU AU2008275226A patent/AU2008275226B2/en not_active Ceased
- 2008-07-08 WO PCT/US2008/069391 patent/WO2009009520A2/en active Application Filing
- 2008-07-08 JP JP2010516192A patent/JP5753687B2/ja not_active Expired - Fee Related
- 2008-07-08 EP EP08781477A patent/EP2170983A2/en not_active Withdrawn
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH06313096A (ja) * | 1993-04-28 | 1994-11-08 | Toyo Ink Mfg Co Ltd | ポリエステル樹脂高濃度着色物およびそれを用いたポリエステル繊維用着色組成物 |
JP2004521685A (ja) * | 2001-02-22 | 2004-07-22 | エスディージーアイ・ホールディングス・インコーポレーテッド | 生物活性名ナノ組成物及びその使用方法 |
JP2005334654A (ja) * | 2004-05-28 | 2005-12-08 | Cordis Corp | 包封された緩衝剤を含む医用インプラント |
JP2006249184A (ja) * | 2005-03-09 | 2006-09-21 | Osaka Univ | 無機微粒子含有重合性組成物及びその製造方法、並びに、無機微粒子含有重合体組成物 |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014184939A1 (ja) * | 2013-05-16 | 2014-11-20 | 株式会社ソフセラ | 生分解性材料 |
CN105264014A (zh) * | 2013-05-16 | 2016-01-20 | 株式会社索夫塞拉 | 生物降解性材料 |
EP2998358A4 (en) * | 2013-05-16 | 2017-02-08 | SofSera Corporation | Biodegradable material |
JPWO2014184939A1 (ja) * | 2013-05-16 | 2017-02-23 | 株式会社ソフセラ | 生分解性材料 |
JP2019534236A (ja) * | 2016-08-02 | 2019-11-28 | ビー.ブラウン、サージカル、ソシエダッド、アノニマB.Braun Surgical, S.A. | 永久分極ハイドロキシアパタイト、その製造方法および使用 |
JP7023955B2 (ja) | 2016-08-02 | 2022-02-22 | ビー.ブラウン、サージカル、ソシエダッド、アノニマ | 永久分極ハイドロキシアパタイト、その製造方法および使用 |
JPWO2018056019A1 (ja) * | 2016-09-21 | 2019-07-04 | グンゼ株式会社 | 徐放性薬剤の製造方法及び徐放性薬剤 |
JP2018012845A (ja) * | 2017-10-12 | 2018-01-25 | 株式会社ソフセラ | 生分解性材料 |
JP2021511405A (ja) * | 2018-01-17 | 2021-05-06 | ザ・セカント・グループ・エルエルシー | pHを調節する生分解性ポリマーおよびポリ(グリセロールセバシン酸)で増強された細胞培養培地 |
JP7345478B2 (ja) | 2018-01-17 | 2023-09-15 | ザ・セカント・グループ・エルエルシー | pHを調節する生分解性ポリマーおよびポリ(グリセロールセバシン酸)で増強された細胞培養培地 |
Also Published As
Publication number | Publication date |
---|---|
JP5753687B2 (ja) | 2015-07-22 |
WO2009009520A2 (en) | 2009-01-15 |
AU2008275226A1 (en) | 2009-01-15 |
EP2170983A2 (en) | 2010-04-07 |
GB0713351D0 (en) | 2007-08-22 |
WO2009009520A3 (en) | 2009-06-25 |
AU2008275226B2 (en) | 2014-08-21 |
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