JP2004521111A - 局所麻酔薬および使用法 - Google Patents

局所麻酔薬および使用法 Download PDF

Info

Publication number
JP2004521111A
JP2004521111A JP2002559004A JP2002559004A JP2004521111A JP 2004521111 A JP2004521111 A JP 2004521111A JP 2002559004 A JP2002559004 A JP 2002559004A JP 2002559004 A JP2002559004 A JP 2002559004A JP 2004521111 A JP2004521111 A JP 2004521111A
Authority
JP
Japan
Prior art keywords
administration
hours
formulation
local
bupivacaine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2002559004A
Other languages
English (en)
Japanese (ja)
Other versions
JP2004521111A5 (cg-RX-API-DMAC7.html
Inventor
チェイシン，マーク
バスカーク，グレン ヴァン
マスキーウィッツ，リチャード
ケトカー，アモル
バートン，ケビン
シャメーム，モハメド
ランドー，クレイグ
コールズ，セリア
スワントン，ルース
ラクーチュア，ピーター
Original Assignee
ユーロ−セルティーク，エス．エイ．
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ユーロ−セルティーク，エス．エイ． filed Critical ユーロ−セルティーク，エス．エイ．
Publication of JP2004521111A publication Critical patent/JP2004521111A/ja
Publication of JP2004521111A5 publication Critical patent/JP2004521111A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Anesthesiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2002559004A 2001-01-25 2002-01-25 局所麻酔薬および使用法 Pending JP2004521111A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26418601P 2001-01-25 2001-01-25
PCT/US2002/002461 WO2002058670A1 (en) 2001-01-25 2002-01-25 Local anesthetic, and method of use

Publications (2)

Publication Number Publication Date
JP2004521111A true JP2004521111A (ja) 2004-07-15
JP2004521111A5 JP2004521111A5 (cg-RX-API-DMAC7.html) 2005-10-27

Family

ID=23004954

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002559004A Pending JP2004521111A (ja) 2001-01-25 2002-01-25 局所麻酔薬および使用法

Country Status (4)

Country Link
US (1) US20030152637A1 (cg-RX-API-DMAC7.html)
EP (1) EP1363602A4 (cg-RX-API-DMAC7.html)
JP (1) JP2004521111A (cg-RX-API-DMAC7.html)
WO (1) WO2002058670A1 (cg-RX-API-DMAC7.html)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007081061A1 (ja) * 2006-01-16 2007-07-19 Japan Science And Technology Agency 神経因性疼痛治療剤
JP2008543876A (ja) 2005-06-17 2008-12-04 ウイスコンシン アラムニ リサーチ ファンデーション 癌の化学療法および放射線療法の際に細胞を保護するための局所的血管収縮剤および方法
JP2010530435A (ja) * 2007-06-19 2010-09-09 ウォーソー・オーソペディック・インコーポレーテッド 局所的に投与される低用量のコルチコステロイド
JP2011503213A (ja) * 2007-11-19 2011-01-27 カプスレイテッド システムズ インコーポレイテッド マイクロ粒子を使用する局所麻酔薬の持続放出および手術適用方法
JP2011508791A (ja) * 2008-04-18 2011-03-17 ウォーソー・オーソペディック・インコーポレーテッド 生物分解性ポリマー担体中のフルオシノロン製剤
JP2011518164A (ja) * 2008-04-18 2011-06-23 ウォーソー・オーソペディック・インコーポレーテッド 生分解性材料中のデキサメタゾン配合物
JP2011518187A (ja) * 2008-04-18 2011-06-23 メドトロニック，インコーポレイテッド 局所麻酔薬を含む術後疼痛を処置する方法および組成物
JP4865792B2 (ja) * 2005-07-12 2012-02-01 赴朝 李 局所麻酔薬の効果増強・時間延長剤
JP2019514976A (ja) * 2016-05-05 2019-06-06 リクイディア・テクノロジーズ・インコーポレーテッド 負荷と放出が正確に制御された術後疼痛用粒子

Families Citing this family (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5409699A (en) 1999-07-05 2001-01-22 Idea Ag A method for the improvement of transport across adaptable semi-permeable barriers
KR20040058101A (ko) 2001-11-14 2004-07-03 알자 코포레이션 카테터 주입가능한 데포 조성물 및 그의 용도
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
EP1539101B1 (en) 2002-07-31 2009-01-07 ALZA Corporation Injectable multimodal polymer depot compositions and uses thereof
EP1526835B1 (en) 2002-07-31 2008-04-23 ALZA Corporation Injectable depot compositions and uses thereof
US7473432B2 (en) 2002-10-11 2009-01-06 Idea Ag NSAID formulations, based on highly adaptable aggregates, for improved transport through barriers and topical drug delivery
FR2846557B1 (fr) * 2002-10-30 2007-06-08 Statice Sante Structure implantable pour la liberation prolongee et controlee d'un principe actif
KR20050088288A (ko) 2002-11-06 2005-09-05 알자 코포레이션 제어식 방출 데포 제형
EP2959893A1 (en) 2002-12-13 2015-12-30 DURECT Corporation Oral drug delivery system comprising high viscosity liquid carrier materials
US7431849B1 (en) * 2004-03-05 2008-10-07 Specialty Earth Sciences Llc Encapsulated reactant and process
US10335757B2 (en) * 2004-03-05 2019-07-02 Specialty Earth Sciences Process for making environmental reactant(s)
SI1809329T1 (sl) * 2004-09-17 2012-05-31 Durect Corp Lokalni anestetični sestavek ki vsebuje SAIB spodaljšanim sproščanjem
AU2012201226B2 (en) * 2004-09-17 2014-08-14 Durect Corporation Sustained local anesthetic composition containing preferably a sugar ester such as SAIB
EA014852B1 (ru) * 2004-09-17 2011-02-28 Дьюрект Корпорейшн Система контролируемой доставки
BRPI0516912A2 (pt) * 2004-11-24 2009-06-23 Algorx Pharmaceuticals Inc formulação a base do capsaicinoide em gel e usos da mesma
US20070027105A1 (en) 2005-07-26 2007-02-01 Alza Corporation Peroxide removal from drug delivery vehicle
US20080069855A1 (en) * 2006-08-21 2008-03-20 Bonutti Peter M Method of inhibiting the formation of adhesions and scar tissue and reducing blood loss
US8337883B2 (en) 2006-11-03 2012-12-25 Durect Corporation Transdermal delivery systems
US8470360B2 (en) * 2008-04-18 2013-06-25 Warsaw Orthopedic, Inc. Drug depots having different release profiles for reducing, preventing or treating pain and inflammation
AU2008335809A1 (en) 2007-12-06 2009-06-18 Durect Corporation Methods useful for the treatment of pain, arthritic conditions, or inflammation associated with a chronic condition
CA2710515A1 (en) * 2007-12-28 2009-07-09 Khashayar Kevin Neshat Controlled release local anesthetic for post dental surgery and method of use
AU2014277860A1 (en) * 2008-01-22 2015-01-22 Board Of Regents, The University Of Texas System Volatile anesthetic compositions and methods of use
US20110159078A1 (en) * 2008-01-22 2011-06-30 Vapogenix, Inc Volatile Anesthetic Compositions and Methods of Use
DK2244737T3 (da) 2008-01-22 2019-07-08 Univ Texas Flygtige anæstetiske sammensætninger omfattende ekstraktionsopløsningsmidler til regional anæstesi og/eller smertelindring
US20090263456A1 (en) * 2008-04-18 2009-10-22 Warsaw Orthopedic, Inc. Methods and Compositions for Reducing Preventing and Treating Adhesives
US20090264478A1 (en) * 2008-04-18 2009-10-22 Warsaw Orthopedic, Inc. Sulfasalazine formulations in a biodegradable polymer carrier
WO2010019953A1 (en) 2008-08-15 2010-02-18 Arcion Therapeutics, Inc. High concentration local anesthetic formulations for treating non-neuropathic pain
CN101352422B (zh) * 2008-09-17 2011-04-20 厦门朝阳生物工程有限公司 河豚毒素冻干粉针制剂及其制备方法
US20100260844A1 (en) 2008-11-03 2010-10-14 Scicinski Jan J Oral pharmaceutical dosage forms
US20100130958A1 (en) * 2008-11-26 2010-05-27 David Kang Device and Methods for Subcutaneous Delivery of High Viscosity Fluids
US20100143437A1 (en) * 2008-12-09 2010-06-10 Morris Edward J Implantable analgesic
US8870876B2 (en) 2009-02-13 2014-10-28 Tarsus Medical Inc. Methods and devices for treating hallux valgus
EP2451944A4 (en) 2009-07-10 2012-11-28 Harvard College PERMANENTLY CHARGED SODIUM AND CALCIUM CHANNEL BLOCKERS AS ANTI-INFLAMMATORY AGENTS
US8277459B2 (en) 2009-09-25 2012-10-02 Tarsus Medical Inc. Methods and devices for treating a structural bone and joint deformity
US20110117175A1 (en) * 2009-11-18 2011-05-19 Rosenbaum Richard J Sweet analgesic for use in medical procedures or treatments
US8652141B2 (en) 2010-01-21 2014-02-18 Tarsus Medical Inc. Methods and devices for treating hallux valgus
WO2011116304A1 (en) * 2010-03-19 2011-09-22 Halozyme, Inc. Gas-pressured medication delivery device
US8696719B2 (en) 2010-06-03 2014-04-15 Tarsus Medical Inc. Methods and devices for treating hallux valgus
BR112012031928B1 (pt) * 2010-06-30 2021-08-31 Troikaa Pharmaceuticals Ltd Composições farmacêuticas as quais incluem paracetamol e processo para preparação do mesmo
CN103619886B (zh) 2011-06-29 2016-09-14 柯惠Lp公司 氧化纤维素的溶解
US8965516B2 (en) * 2012-03-08 2015-02-24 Spr Therapeutics, Llc System and method for treatment of pain related to limb joint replacement surgery
US20150111918A1 (en) 2012-03-08 2015-04-23 Medtronic Ardian Luxembourg S.a.r.l Immune system neuromodulation and associated systems and methods
US9271937B2 (en) 2012-05-31 2016-03-01 Covidien Lp Oxidized cellulose microspheres
US9499636B2 (en) 2012-06-28 2016-11-22 Covidien Lp Dissolution of oxidized cellulose and particle preparation by cross-linking with multivalent cations
US10391074B2 (en) 2012-12-07 2019-08-27 Sambria Pharmaceuticals, Llc Topical preparation for pain relief
US10265283B2 (en) 2012-12-07 2019-04-23 Sambria Pharmaceuticals, Llc Topical composition and delivery system and its use
KR102370470B1 (ko) * 2013-03-15 2022-03-04 헤론 테라퓨틱스 인코포레이티드 폴리오르토에스테르 및 비프로톤성 용매의 조성물
US10413566B2 (en) 2013-03-15 2019-09-17 Covidien Lp Thixotropic oxidized cellulose solutions and medical applications thereof
DK2968225T3 (da) * 2013-03-15 2019-05-27 Childrens Medical Ct Corp Neosaxitoxinkombinationsformuleringer til forlænget lokalanæstesi
CA2905131A1 (en) 2013-03-15 2014-09-18 Durect Corporation Compositions with a rheological modifier to reduce dissolution variability
CN105517536B (zh) 2013-03-21 2019-08-16 优普顺药物公司美国分部 可注射的持续释放组合物及其用于治疗关节炎症及相关疼痛的方法
US9205105B2 (en) * 2013-05-22 2015-12-08 John Ascencion Campa, Iii Indication and technique for the use of cross-linked hyaluronic acid in the management of pain
US20160303242A1 (en) 2013-12-09 2016-10-20 Durect Corporation Pharmaceutically Active Agent Complexes, Polymer Complexes, and Compositions and Methods Involving the Same
SG10201902407PA (en) * 2014-09-19 2019-04-29 Eupraxia Pharmaceuticals Inc Injectable microparticles for hyper-localized release of therapeutic agents
US10449152B2 (en) * 2014-09-26 2019-10-22 Covidien Lp Drug loaded microspheres for post-operative chronic pain
JP2017536187A (ja) 2014-12-03 2017-12-07 メタベンション インコーポレイテッド 神経または他の組織を調節するためのシステムおよび方法
GB201505527D0 (en) 2015-03-31 2015-05-13 Jmedtech Pte Ltd Composition
US9855317B2 (en) 2015-04-27 2018-01-02 Reflex Medical, Inc. Systems and methods for sympathetic cardiopulmonary neuromodulation
JP6833811B2 (ja) 2015-08-03 2021-02-24 プレジデント アンド フェローズ オブ ハーバード カレッジ 荷電イオンチャネル遮断薬及び使用方法
BR112018008415A2 (en) 2015-10-27 2018-10-30 Eupraxia Pharmaceuticals Inc. sustained release formulations of local anesthetics
US20170143740A1 (en) * 2015-11-24 2017-05-25 Ramon Cabreja Anesthetic formulation
WO2017139487A1 (en) * 2016-02-09 2017-08-17 Northwind Medical, Inc. Methods, agents, and devices for local neuromodulation of autonomic nerves
US11154547B2 (en) 2016-06-29 2021-10-26 Tulavi Therapeutics, Inc. Treatment of sepsis and related inflammatory conditions by local neuromodulation of the autonomic nervous system
AU2017292791B2 (en) 2016-07-06 2023-05-25 Orient Pharma Co., Ltd. Oral dosage form with drug composition, barrier layer and drug layer
US10647045B1 (en) 2016-11-03 2020-05-12 Specialty Earth Sciences, Llc Shaped or sized encapsulated reactant and method of making
EP3570833A4 (en) 2017-01-20 2020-08-05 Warsaw Orthopedic, Inc. ANESTHETIC COMPOSITIONS AND PROCEDURES USING IMIDAZOLINE COMPOUNDS
CN106844975B (zh) * 2017-01-26 2019-07-19 中国石油大学(北京) 一种确定注气井注入中早期co2等效波及半径的方法及装置
CN111432807A (zh) 2017-10-06 2020-07-17 铸造疗法股份有限公司 用于控制释放治疗剂的可植入贮库
CN111655303A (zh) 2018-01-08 2020-09-11 铸造疗法股份有限公司 经由治疗剂的控制递送用于治疗腔内癌症的装置、系统和方法
CN112367980A (zh) 2018-05-12 2021-02-12 铸造疗法股份有限公司 用于控制释放治疗剂的可植入贮库
US20210315587A1 (en) 2018-07-02 2021-10-14 Tulavi Therapeutics, Inc. Methods and devices for in situ formed nerve cap with rapid release
CN117599244A (zh) 2018-07-02 2024-02-27 图拉维治疗股份有限公司 原位形成神经帽的方法和装置
WO2020047013A1 (en) 2018-08-28 2020-03-05 Foundry Therapeutics, Inc. Polymer implants
IL263336B (en) * 2018-11-28 2019-10-31 Pomp Gil Compounds for the treatment of symphysiolysis
CN113924094A (zh) 2019-03-11 2022-01-11 诺西恩医疗公司 酯取代的离子通道阻滞剂及其使用方法
US10828287B2 (en) 2019-03-11 2020-11-10 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
EP3937929A4 (en) 2019-03-11 2022-12-28 Nocion Therapeutics, Inc. CHARGED ION CHANNEL BLOCKERS AND METHODS OF USE
WO2020185881A1 (en) 2019-03-11 2020-09-17 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
US10780083B1 (en) 2019-03-11 2020-09-22 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
BR112022008575A2 (pt) 2019-11-06 2022-08-09 Nocion Therapeutics Inc Bloqueadores de canal iônico carregado e métodos para uso
EP4054586A4 (en) 2019-11-06 2023-11-22 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
BR112022013784A2 (pt) 2020-01-13 2022-10-11 Durect Corp Sistemas de distribuição de fármacos de liberação prolongada com impurezas reduzidas e métodos relacionados
KR20230022830A (ko) 2020-03-11 2023-02-16 녹시온 테라퓨틱스 인코포레이티드 하전된 이온 채널 차단제 및 사용 방법
US12162851B2 (en) 2020-03-11 2024-12-10 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
CA3180971A1 (en) * 2020-04-22 2021-10-28 Scienture, Inc. Long-acting bupivacaine microsphere formulations
US12490952B2 (en) 2020-07-16 2025-12-09 National Guard Health Affairs Combined sub-iliopsoas and subpectineal blocks—for hip surgery
JP6886551B1 (ja) * 2020-11-06 2021-06-16 医療法人祥和会 歯科用の局所麻酔液
JP2024503402A (ja) 2021-01-12 2024-01-25 デュレクト コーポレーション 徐放性薬物送達システム及び関連の方法
US11918565B1 (en) * 2022-11-03 2024-03-05 Pacira Pharmaceuticals, Inc. Treatment of post-operative pain via sciatic nerve block with sustained-release liposomal anesthetic compositions
US12226610B2 (en) 2022-11-03 2025-02-18 Pacira Pharmaceuticals, Inc. Treatment of pain associated with total knee arthroplasty with sustained-release liposomal anesthetic compositions

Family Cites Families (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2835628A (en) * 1957-04-01 1958-05-20 Jacob A Saffir Means for treating teeth
US3185625A (en) * 1961-11-08 1965-05-25 Brown Ethan Allan Injectionable substances
US3337400A (en) * 1965-10-08 1967-08-22 Joel P Smith Aqueous post-surgical injection by infiltration with a local anesthetic, a substantially water-insoluble, local anti-inflammatory gluco corticoid, and an antibiotic
US3507952A (en) * 1968-12-20 1970-04-21 Smithkline Corp Sustained release bolus for animal husbandry
US3887699A (en) * 1969-03-24 1975-06-03 Seymour Yolles Biodegradable polymeric article for dispensing drugs
US3755558A (en) * 1971-02-23 1973-08-28 Du Pont Polylactide drug mixtures for topical application atelet aggregation
US3736646A (en) * 1971-10-18 1973-06-05 American Cyanamid Co Method of attaching surgical needles to multifilament polyglycolic acid absorbable sutures
JPS528795B2 (cg-RX-API-DMAC7.html) * 1971-12-30 1977-03-11
US4001388A (en) * 1973-06-14 1977-01-04 Alza Corporation Ophthalmological bioerodible drug dispensing formulation
US3976071A (en) * 1974-01-07 1976-08-24 Dynatech Corporation Methods of improving control of release rates and products useful in same
US4039653A (en) * 1974-01-23 1977-08-02 Defoney, Brenman, Mayes & Baron Long-acting articles for oral delivery and process
US4093709A (en) * 1975-01-28 1978-06-06 Alza Corporation Drug delivery devices manufactured from poly(orthoesters) and poly(orthocarbonates)
US4089800A (en) * 1975-04-04 1978-05-16 Ppg Industries, Inc. Method of preparing microcapsules
US3972995A (en) * 1975-04-14 1976-08-03 American Home Products Corporation Dosage form
US4076798A (en) * 1975-05-29 1978-02-28 American Cyanamid Company High molecular weight polyester resin, the method of making the same and the use thereof as a pharmaceutical composition
US4144317A (en) * 1975-05-30 1979-03-13 Alza Corporation Device consisting of copolymer having acetoxy groups for delivering drugs
US4011312A (en) * 1975-06-25 1977-03-08 American Home Products Corporation Prolonged release drug form for the treatment of bovine mastitis
US3972999A (en) * 1975-06-25 1976-08-03 American Home Products Corporation (Del.) Griseofulvin dosage forms
US4034758A (en) * 1975-09-08 1977-07-12 Alza Corporation Osmotic therapeutic system for administering medicament
US4070347A (en) * 1976-08-16 1978-01-24 Alza Corporation Poly(orthoester) co- and homopolymers and poly(orthocarbonate) co- and homopolymers having carbonyloxy functionality
US4164560A (en) * 1977-01-05 1979-08-14 Folkman Moses J Systems for the controlled release of macromolecules
US4166800A (en) * 1977-08-25 1979-09-04 Sandoz, Inc. Processes for preparation of microspheres
US4166107A (en) * 1978-07-25 1979-08-28 The United States Of America As Represented By The Secretary Of Agriculture Sustained release bolus formulations containing insect growth regulators for control of livestock pests
US4276880A (en) * 1978-09-14 1981-07-07 Oscar Malmin Cannula and process
US4331728A (en) * 1978-10-11 1982-05-25 Alza Corporation Laminate made of a cellulose acetate layer and an elastomeric material layer
US4756907A (en) * 1978-10-17 1988-07-12 Stolle Research & Development Corp. Active/passive immunization of the internal female reproductive organs
US4585651A (en) * 1978-10-17 1986-04-29 Stolle Research & Development Corporation Active/passive immunization of the internal female reproductive organs
GB2042888B (en) * 1979-03-05 1983-09-28 Teijin Ltd Preparation for administration to the mucosa of the oral or nasal cavity
US4384975A (en) * 1980-06-13 1983-05-24 Sandoz, Inc. Process for preparation of microspheres
US4321038A (en) * 1980-07-18 1982-03-23 Van R Dental Products, Inc. Braided gingival retraction cord
US4389330A (en) * 1980-10-06 1983-06-21 Stolle Research And Development Corporation Microencapsulation process
IE52535B1 (en) * 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
US4369172A (en) * 1981-12-18 1983-01-18 Forest Laboratories Inc. Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose
US4434153A (en) * 1982-03-22 1984-02-28 Alza Corporation Drug delivery system comprising a reservoir containing a plurality of tiny pills
US4530840A (en) * 1982-07-29 1985-07-23 The Stolle Research And Development Corporation Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents
US4568535A (en) * 1982-08-06 1986-02-04 Loesche Walter J Composition for periodontal administration
FR2537980B1 (fr) * 1982-12-17 1986-12-19 Sandoz Sa Derives d'acides hydroxycarboxyliques oligomeres, leur preparation et leur utilisation
US4906474A (en) * 1983-03-22 1990-03-06 Massachusetts Institute Of Technology Bioerodible polyanhydrides for controlled drug delivery
US4757128A (en) * 1986-08-01 1988-07-12 Massachusetts Institute Of Technology High molecular weight polyanhydride and preparation thereof
US4597960A (en) * 1983-04-19 1986-07-01 Cohen Edgar C Microencapsulated astringent hemostatic agents and methods of use
JPS59222406A (ja) * 1983-06-01 1984-12-14 Teijin Ltd 歯周疾患治療用製剤及びその製造法
US4725442A (en) * 1983-06-17 1988-02-16 Haynes Duncan H Microdroplets of water-insoluble drugs and injectable formulations containing same
US4685883A (en) * 1983-09-12 1987-08-11 Jernberg Gary R Local delivery of chemotherapeutic agents for the treatment of periodontal disease
US4892736A (en) * 1983-10-07 1990-01-09 The Forsyth Dental Infirmary For Children Intra-pocket drug delivery devices for treatment of periodontal diseases
JPS60100516A (ja) * 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
US6217911B1 (en) * 1995-05-22 2001-04-17 The United States Of America As Represented By The Secretary Of The Army sustained release non-steroidal, anti-inflammatory and lidocaine PLGA microspheres
US4891225A (en) * 1984-05-21 1990-01-02 Massachusetts Institute Of Technology Bioerodible polyanhydrides for controlled drug delivery
US4650665A (en) * 1985-02-08 1987-03-17 Ethicon, Inc. Controlled release of pharmacologically active agents from an absorbable biologically compatible putty-like composition
US4568536A (en) * 1985-02-08 1986-02-04 Ethicon, Inc. Controlled release of pharmacologically active agents from an absorbable biologically compatible putty-like composition
US4735945A (en) * 1986-03-13 1988-04-05 Vipont Laboratories, Inc. Method for inhibiting bone resorption and collagenase release
JPS62223112A (ja) * 1986-03-25 1987-10-01 Rooto Seiyaku Kk 歯周病治療剤
US4919939A (en) * 1986-04-29 1990-04-24 Pharmetrix Corporation Periodontal disease treatment system
US4861627A (en) * 1987-05-01 1989-08-29 Massachusetts Institute Of Technology Preparation of multiwall polymeric microcapsules
US5000886A (en) * 1987-05-26 1991-03-19 American Cyanamid Company Silicone-hardened pharmaceutical microcapsules and process of making the same
US5225441A (en) * 1987-06-18 1993-07-06 Block Drug Company, Inc. Treatment of periodontal disease
US5013553A (en) * 1987-06-30 1991-05-07 Vipont Pharmaceutical, Inc. Drug delivery devices
US5019379A (en) * 1987-07-31 1991-05-28 Massachusetts Institute Of Technology Unsaturated polyanhydrides
JP2670680B2 (ja) * 1988-02-24 1997-10-29 株式会社ビーエムジー 生理活性物質含有ポリ乳酸系微小球およびその製造法
LU87410A1 (fr) * 1988-12-20 1990-07-10 Cird Composition cosmetique ou pharmaceutique contenant des microspheres de polymeres ou de corps gras chargees d'au moins un produit actif
US5236355A (en) * 1988-12-22 1993-08-17 American Cyanamid Company Apparatus for the treatment of periodontal disease
US5032384A (en) * 1989-01-27 1991-07-16 Block Drug Company, Inc. Compositions and method for the treatment of disease
US5194581A (en) * 1989-03-09 1993-03-16 Leong Kam W Biodegradable poly(phosphoesters)
US5122367A (en) * 1989-03-31 1992-06-16 Massachusetts Institute Of Technology Polyanhydride bioerodible controlled release implants for administration of stabilized growth hormone
US5007790A (en) * 1989-04-11 1991-04-16 Depomed Systems, Inc. Sustained-release oral drug dosage form
US5019400A (en) * 1989-05-01 1991-05-28 Enzytech, Inc. Very low temperature casting of controlled release microspheres
DE69024953T3 (de) * 1989-05-04 2005-01-27 Southern Research Institute, Birmingham Einkapselungsverfahren
DE3916020C2 (de) * 1989-05-17 1994-06-01 Burkhard Dr Wichert Retardierende Mikropartikel aus bioabbaubaren Polyestern; Verfahren zu deren Herstellung unter Verzicht auf toxische Lösungsmittel und diese Mikropartikel enthaltende pharmazentische Zubereitungen
US5227165A (en) * 1989-11-13 1993-07-13 Nova Pharmaceutical Corporation Liposphere delivery systems for local anesthetics
US5188837A (en) * 1989-11-13 1993-02-23 Nova Pharmaceutical Corporation Lipsopheres for controlled delivery of substances
US5198220A (en) * 1989-11-17 1993-03-30 The Procter & Gamble Company Sustained release compositions for treating periodontal disease
US5084267A (en) * 1989-11-17 1992-01-28 The Procter & Gamble Company Sustained release compositions for treating periodontal disease
US5288496A (en) * 1990-05-15 1994-02-22 Stolle Research & Development Corporation Growth promoters for animals
US5114718A (en) * 1990-09-20 1992-05-19 The Procter & Gamble Company Sustained release compositions for treating periodontol disease
US5222529A (en) * 1990-12-21 1993-06-29 American Cyanamid Company Filling apparatus
PT99989A (pt) * 1991-01-09 1994-05-31 Alza Corp Dispositivos biodegradaveis e composicoes para libertacao difusivel de agentes
US5176907A (en) * 1991-08-13 1993-01-05 The Johns Hopkins University School Of Medicine Biocompatible and biodegradable poly (phosphoester-urethanes)
WO1993019739A1 (en) * 1992-03-30 1993-10-14 Alza Corporation Viscous suspensions of controlled-release drug particles
US5700485A (en) * 1992-09-10 1997-12-23 Children's Medical Center Corporation Prolonged nerve blockade by the combination of local anesthetic and glucocorticoid
US5922340A (en) * 1992-09-10 1999-07-13 Children's Medical Center Corporation High load formulations and methods for providing prolonged local anesthesia
CA2144407C (en) * 1992-09-10 2000-05-30 Charles B. Berde Biodegradable polymer matrices for sustained delivery of local anesthetic agents
US5330452A (en) * 1993-06-01 1994-07-19 Zook Gerald P Topical medicating device
EP1649850A1 (en) * 1993-11-19 2006-04-26 Alkermes Controlled Therapeutics Inc. II Preparation of biodegradable microparticles containing a biologically active agent
US5650173A (en) * 1993-11-19 1997-07-22 Alkermes Controlled Therapeutics Inc. Ii Preparation of biodegradable microparticles containing a biologically active agent
US6051576A (en) * 1994-01-28 2000-04-18 University Of Kentucky Research Foundation Means to achieve sustained release of synergistic drugs by conjugation
US5492901A (en) * 1994-08-16 1996-02-20 Fabunan; Ruben G. Cobranin-F injection envenomation antidote
KR100245395B1 (ko) * 1995-06-09 2000-03-02 그린 마틴, 브라이언 쥐 테슬리 장기간의 국소 마취를 제공하는 제형 및 그 방법
US5747060A (en) * 1996-03-26 1998-05-05 Euro-Celtique, S.A. Prolonged local anesthesia with colchicine
AU733867B2 (en) * 1996-06-24 2001-05-31 Euro-Celtique S.A. Methods for providing safe local anesthesia
US6046187A (en) * 1996-09-16 2000-04-04 Children's Medical Center Corporation Formulations and methods for providing prolonged local anesthesia
IL129951A0 (en) * 1997-07-02 2000-02-29 Euro Celtique Sa Prolonged anesthesia in joints and body spaces
TW577758B (en) * 1997-10-27 2004-03-01 Ssp Co Ltd Intra-articular preparation for the treatment of arthropathy
GB9819272D0 (en) * 1998-09-03 1998-10-28 Andaris Ltd Microparticles
US6103255A (en) * 1999-04-16 2000-08-15 Rutgers, The State University Porous polymer scaffolds for tissue engineering

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008543876A (ja) 2005-06-17 2008-12-04 ウイスコンシン アラムニ リサーチ ファンデーション 癌の化学療法および放射線療法の際に細胞を保護するための局所的血管収縮剤および方法
US11197836B2 (en) 2005-06-17 2021-12-14 Wisconsin Alumni Research Foundation Topical vasoconstrictor preparations and methods for protecting cells during cancer chemotherapy and radiotherapy
JP4865792B2 (ja) * 2005-07-12 2012-02-01 赴朝 李 局所麻酔薬の効果増強・時間延長剤
WO2007081061A1 (ja) * 2006-01-16 2007-07-19 Japan Science And Technology Agency 神経因性疼痛治療剤
JP2010530435A (ja) * 2007-06-19 2010-09-09 ウォーソー・オーソペディック・インコーポレーテッド 局所的に投与される低用量のコルチコステロイド
JP2011503213A (ja) * 2007-11-19 2011-01-27 カプスレイテッド システムズ インコーポレイテッド マイクロ粒子を使用する局所麻酔薬の持続放出および手術適用方法
JP2011508791A (ja) * 2008-04-18 2011-03-17 ウォーソー・オーソペディック・インコーポレーテッド 生物分解性ポリマー担体中のフルオシノロン製剤
JP2011518164A (ja) * 2008-04-18 2011-06-23 ウォーソー・オーソペディック・インコーポレーテッド 生分解性材料中のデキサメタゾン配合物
JP2011518187A (ja) * 2008-04-18 2011-06-23 メドトロニック，インコーポレイテッド 局所麻酔薬を含む術後疼痛を処置する方法および組成物
JP2019514976A (ja) * 2016-05-05 2019-06-06 リクイディア・テクノロジーズ・インコーポレーテッド 負荷と放出が正確に制御された術後疼痛用粒子

Also Published As

Publication number Publication date
EP1363602A1 (en) 2003-11-26
WO2002058670A1 (en) 2002-08-01
EP1363602A4 (en) 2006-01-11
US20030152637A1 (en) 2003-08-14

Similar Documents

Publication Publication Date Title
JP2004521111A (ja) 局所麻酔薬および使用法
CA2271750C (en) Prolonged anesthesia in joints and body spaces
EP2767292B1 (en) Sustained Local Anesthetic Composition Containing SAIB
US6426339B1 (en) Formulations and methods for providing prolonged local anesthesia
US8956642B2 (en) Bupivacaine formulation in a polyorthoester carrier
DK3085363T3 (en) PHARMACEUTICAL ADMINISTRATION TO PROVIDE LOCAL ANALYSIS, LOCAL ANESTHESIA OR NERVOUS BLOCKS
US8940315B2 (en) Benzodiazepine formulation in a polyorthoester carrier
JP2001515492A (ja) カプサイシンまたはカプサイシンアナログを含有する組成物および局所麻酔
US8034368B2 (en) Drug delivery device for providing local analgesia, local anesthesia or nerve blockage
CN101854922A (zh) 用于减轻、预防或治疗疼痛和炎症的具有不同释放曲线的长效制剂
BR112014000159A2 (pt) composição oral, e, uso de uma composição oral
JP2011518787A (ja) 痙直及び振戦のような術後作用をクロニジンで治療する方法
BR112019017724A2 (pt) Sistemas depot de glatiramer para tratar formas progressivas de esclerose múltipla
US5945435A (en) Levobupivacaine and its use
JP2001500504A (ja) 痛覚消失をもたらす方法
Barr et al. Post surgical pain management with poly (ortho esters)
Rasmussen et al. Controlled, clinical trial assessing saphenous, tibial and common peroneal nerve blocks for the control of perioperative pain following femoro-tibial joint surgery in the nonchondrodystrophoid dog
CN116669717A (zh) 长效原位成型/胶凝组合物
AU775685B2 (en) Prolonged anesthesia in joints and body spaces
CN100398093C (zh) 皮下给药系统、其制备方法及其治疗胆碱能缺乏障碍的用途
JP2004525096A (ja) チエニルシクロヘキシルアミン誘導体の新規な医療用途
CN104487051B (zh) 用于脊椎施用的可注射过饱和对乙酰氨基酚溶液
Khandagale et al. A REVIEW ON LOCAL ANESTHETIC SUSTAINED-RELEASE PAIN MANAGEMENT
Gao et al. Bupivacaine Multivesicular Liposomes/Meloxicam Nanocrystals in a Thermosensitive Gel Adapted to the
HK1230090B (en) A drug delivery device for providing local analgesia, local anesthesia or nerve blockade

Legal Events

Date Code Title Description
A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20071218

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20080520