JP2004520049A5 - - Google Patents

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Publication number
JP2004520049A5
JP2004520049A5 JP2002561621A JP2002561621A JP2004520049A5 JP 2004520049 A5 JP2004520049 A5 JP 2004520049A5 JP 2002561621 A JP2002561621 A JP 2002561621A JP 2002561621 A JP2002561621 A JP 2002561621A JP 2004520049 A5 JP2004520049 A5 JP 2004520049A5
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JP
Japan
Prior art keywords
propeptide sequence
recombinant
nucleic acid
trypsinogen
host cell
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Application number
JP2002561621A
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English (en)
Japanese (ja)
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JP4159878B2 (ja
JP2004520049A (ja
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Priority claimed from PCT/EP2002/001072 external-priority patent/WO2002061064A2/de
Publication of JP2004520049A publication Critical patent/JP2004520049A/ja
Publication of JP2004520049A5 publication Critical patent/JP2004520049A5/ja
Application granted granted Critical
Publication of JP4159878B2 publication Critical patent/JP4159878B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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JP2002561621A 2001-02-01 2002-02-01 組換えトリプシンの製造方法 Expired - Lifetime JP4159878B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01102342 2001-02-01
PCT/EP2002/001072 WO2002061064A2 (de) 2001-02-01 2002-02-01 Verfahren zur herstellung von rekombinantem trypsin

Publications (3)

Publication Number Publication Date
JP2004520049A JP2004520049A (ja) 2004-07-08
JP2004520049A5 true JP2004520049A5 (https=) 2005-07-07
JP4159878B2 JP4159878B2 (ja) 2008-10-01

Family

ID=8176376

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002561621A Expired - Lifetime JP4159878B2 (ja) 2001-02-01 2002-02-01 組換えトリプシンの製造方法

Country Status (10)

Country Link
US (2) US7276605B2 (https=)
EP (1) EP1399568B1 (https=)
JP (1) JP4159878B2 (https=)
CN (1) CN1545553B (https=)
AT (1) ATE310092T1 (https=)
CA (1) CA2437342C (https=)
CZ (1) CZ303658B6 (https=)
DE (1) DE50204952D1 (https=)
DK (1) DK1399568T3 (https=)
WO (1) WO2002061064A2 (https=)

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AU2006291780B2 (en) * 2005-09-14 2011-12-08 F. Hoffmann-La Roche Ag Cleavage of precursors of insulins by a variant of trypsin
CA2746470A1 (en) * 2009-01-06 2010-07-15 Raymond-David Pridmore Processing of macronutrients
CN101967469B (zh) * 2009-07-28 2012-11-14 上海雅心生物技术有限公司 一种高稳定性的重组胰蛋白酶的生产及应用
US8975041B2 (en) 2009-09-10 2015-03-10 Biocon Limited Fusion proteins and method of expression thereof
WO2012104099A1 (en) 2011-02-04 2012-08-09 Glucometrix Ag Process for the production of recombinant trypsin
CN103805584B (zh) * 2012-11-12 2016-08-24 宜昌东阳光长江药业股份有限公司 一种重组胰蛋白酶纯化方法
CN103405756B (zh) * 2013-07-10 2014-12-24 浙江众益制药股份有限公司 药物组合物复方消化酶胶囊(ii)及其制备方法
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CN104046605A (zh) * 2014-05-29 2014-09-17 中国科学院广州能源研究所 一种嗜温耐乙醇β-葡萄糖苷酶及其编码基因和应用
US10436802B2 (en) 2014-09-12 2019-10-08 Biogen Ma Inc. Methods for treating spinal muscular atrophy
JP6686361B2 (ja) * 2014-11-26 2020-04-22 東ソー株式会社 細胞回収のための標本作製方法
WO2016164896A2 (en) 2015-04-10 2016-10-13 Ionis Pharmaceuticals, Inc. Modulation of smn expression
US11198867B2 (en) 2016-06-16 2021-12-14 Ionis Pharmaceuticals, Inc. Combinations for the modulation of SMN expression
CN106350497B (zh) * 2016-11-24 2019-07-16 天津大学 一种胰蛋白酶及其制备方法与应用
CN110511916B (zh) * 2019-08-06 2021-06-01 杭州浦泰生物科技有限公司 一种重组胰蛋白酶的生产工艺
CN120505310A (zh) 2020-02-28 2025-08-19 Ionis制药公司 用于调节smn2的化合物和方法
CN115216463B (zh) * 2022-06-15 2023-08-15 武汉瀚海新酶生物科技有限公司 具有稳定性的重组胰蛋白酶及其制备方法和应用
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