DK1399568T3 - Fremgangsmåde til fremstilling af rekombinant trypsin - Google Patents

Fremgangsmåde til fremstilling af rekombinant trypsin

Info

Publication number
DK1399568T3
DK1399568T3 DK02716713T DK02716713T DK1399568T3 DK 1399568 T3 DK1399568 T3 DK 1399568T3 DK 02716713 T DK02716713 T DK 02716713T DK 02716713 T DK02716713 T DK 02716713T DK 1399568 T3 DK1399568 T3 DK 1399568T3
Authority
DK
Denmark
Prior art keywords
trypsin
producing recombinant
recombinant trypsin
trypsinogen
autolysis
Prior art date
Application number
DK02716713T
Other languages
Danish (da)
English (en)
Inventor
Stephan Glaser
Frank Geipel
Johann-Peter Thalhofer
Rainer Mueller
Bernhard Rexer
Claus Schneider
Michael Ratka
Stephanie Ronning
Hellmut Eckstein
Claudia Giessel
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8176376&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1399568(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of DK1399568T3 publication Critical patent/DK1399568T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6427—Chymotrypsins (3.4.21.1; 3.4.21.2); Trypsin (3.4.21.4)

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
DK02716713T 2001-02-01 2002-02-01 Fremgangsmåde til fremstilling af rekombinant trypsin DK1399568T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP01102342 2001-02-01

Publications (1)

Publication Number Publication Date
DK1399568T3 true DK1399568T3 (da) 2006-03-27

Family

ID=8176376

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02716713T DK1399568T3 (da) 2001-02-01 2002-02-01 Fremgangsmåde til fremstilling af rekombinant trypsin

Country Status (10)

Country Link
US (2) US7276605B2 (https=)
EP (1) EP1399568B1 (https=)
JP (1) JP4159878B2 (https=)
CN (1) CN1545553B (https=)
AT (1) ATE310092T1 (https=)
CA (1) CA2437342C (https=)
CZ (1) CZ303658B6 (https=)
DE (1) DE50204952D1 (https=)
DK (1) DK1399568T3 (https=)
WO (1) WO2002061064A2 (https=)

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AU2006291780B2 (en) * 2005-09-14 2011-12-08 F. Hoffmann-La Roche Ag Cleavage of precursors of insulins by a variant of trypsin
CA2746470A1 (en) * 2009-01-06 2010-07-15 Raymond-David Pridmore Processing of macronutrients
CN101967469B (zh) * 2009-07-28 2012-11-14 上海雅心生物技术有限公司 一种高稳定性的重组胰蛋白酶的生产及应用
US8975041B2 (en) 2009-09-10 2015-03-10 Biocon Limited Fusion proteins and method of expression thereof
WO2012104099A1 (en) 2011-02-04 2012-08-09 Glucometrix Ag Process for the production of recombinant trypsin
CN103805584B (zh) * 2012-11-12 2016-08-24 宜昌东阳光长江药业股份有限公司 一种重组胰蛋白酶纯化方法
CN103405756B (zh) * 2013-07-10 2014-12-24 浙江众益制药股份有限公司 药物组合物复方消化酶胶囊(ii)及其制备方法
EP3797780B1 (en) 2014-04-17 2022-09-14 Biogen MA Inc. Compositions and methods for modulation of smn2 splicing in a subject
CN104046605A (zh) * 2014-05-29 2014-09-17 中国科学院广州能源研究所 一种嗜温耐乙醇β-葡萄糖苷酶及其编码基因和应用
US10436802B2 (en) 2014-09-12 2019-10-08 Biogen Ma Inc. Methods for treating spinal muscular atrophy
JP6686361B2 (ja) * 2014-11-26 2020-04-22 東ソー株式会社 細胞回収のための標本作製方法
WO2016164896A2 (en) 2015-04-10 2016-10-13 Ionis Pharmaceuticals, Inc. Modulation of smn expression
US11198867B2 (en) 2016-06-16 2021-12-14 Ionis Pharmaceuticals, Inc. Combinations for the modulation of SMN expression
CN106350497B (zh) * 2016-11-24 2019-07-16 天津大学 一种胰蛋白酶及其制备方法与应用
CN110511916B (zh) * 2019-08-06 2021-06-01 杭州浦泰生物科技有限公司 一种重组胰蛋白酶的生产工艺
CN120505310A (zh) 2020-02-28 2025-08-19 Ionis制药公司 用于调节smn2的化合物和方法
CN115216463B (zh) * 2022-06-15 2023-08-15 武汉瀚海新酶生物科技有限公司 具有稳定性的重组胰蛋白酶及其制备方法和应用
WO2024110426A1 (en) 2022-11-23 2024-05-30 F. Hoffmann-La Roche Ag Method for increasing recombinant protein expression

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Also Published As

Publication number Publication date
CA2437342A1 (en) 2002-08-08
CA2437342C (en) 2013-08-06
CZ303658B6 (cs) 2013-02-06
US7276605B2 (en) 2007-10-02
CN1545553B (zh) 2011-09-21
JP4159878B2 (ja) 2008-10-01
CZ20032337A3 (cs) 2004-04-14
ATE310092T1 (de) 2005-12-15
US20040203095A1 (en) 2004-10-14
EP1399568A2 (de) 2004-03-24
CN1545553A (zh) 2004-11-10
US7666629B2 (en) 2010-02-23
WO2002061064A3 (de) 2003-12-24
EP1399568B1 (de) 2005-11-16
DE50204952D1 (de) 2005-12-22
WO2002061064A2 (de) 2002-08-08
JP2004520049A (ja) 2004-07-08
US20080064084A1 (en) 2008-03-13

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