AR033979A1 - Metodo para preparar un polipeptido il-18 fisiologicamente activo - Google Patents
Metodo para preparar un polipeptido il-18 fisiologicamente activoInfo
- Publication number
- AR033979A1 AR033979A1 ARP010102818A ARP010102818A AR033979A1 AR 033979 A1 AR033979 A1 AR 033979A1 AR P010102818 A ARP010102818 A AR P010102818A AR P010102818 A ARP010102818 A AR P010102818A AR 033979 A1 AR033979 A1 AR 033979A1
- Authority
- AR
- Argentina
- Prior art keywords
- polypeptide
- active polypeptide
- physiologically active
- preparing
- precursor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Un método para producir un polipéptido fisiológicamente activo, que comprende poner en contacto un polipéptido precursor con una enzima activante, o co-expresar el polipéptido con una proteasa activante. Un método para producir un polipéptido activo a partir de un polipéptido precursor de ese polipéptido, que tiene un segmento de activación de proteasa que comprende la secuencia de aminoácidos XEYD, donde X se selecciona de un grupo de aminoácidos formado por W, L, F, Y, I, V, D ó E; e Y se selecciona de un grupo de aminoácidos formado por H, I, A, T, S, P ó E, que comprende: (i) poner en contacto caspasa 4 con el polipéptido precursor y (ii) purificar el polipéptido activo.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21183200P | 2000-06-15 | 2000-06-15 | |
| US22412800P | 2000-08-10 | 2000-08-10 | |
| US26492301P | 2001-01-20 | 2001-01-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR033979A1 true AR033979A1 (es) | 2004-01-21 |
Family
ID=27395664
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010102818A AR033979A1 (es) | 2000-06-15 | 2001-06-13 | Metodo para preparar un polipeptido il-18 fisiologicamente activo |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US7186528B2 (es) |
| EP (1) | EP1292697B1 (es) |
| JP (1) | JP5121109B2 (es) |
| KR (1) | KR20030022144A (es) |
| CN (1) | CN100390281C (es) |
| AR (1) | AR033979A1 (es) |
| AT (1) | ATE437234T1 (es) |
| AU (2) | AU2001280442B2 (es) |
| BR (1) | BR0111692A (es) |
| CA (1) | CA2412730C (es) |
| CZ (1) | CZ20024085A3 (es) |
| DE (1) | DE60139316D1 (es) |
| DK (1) | DK1292697T3 (es) |
| ES (1) | ES2329875T3 (es) |
| HK (1) | HK1055138A1 (es) |
| HU (1) | HUP0501002A3 (es) |
| IL (2) | IL153422A0 (es) |
| MX (1) | MXPA02012292A (es) |
| MY (1) | MY136526A (es) |
| NO (1) | NO330682B1 (es) |
| NZ (1) | NZ522845A (es) |
| PL (2) | PL366134A1 (es) |
| PT (1) | PT1292697E (es) |
| SI (1) | SI1292697T1 (es) |
| WO (1) | WO2001098455A2 (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2338515A3 (en) * | 2000-02-10 | 2011-11-16 | Abbott Laboratories | Antibodies that bind human interleukin-18 and methods of making and using |
| ATE459647T1 (de) | 2003-04-15 | 2010-03-15 | Glaxosmithkline Llc | Humane il-18 substitutionsmutanten und deren konjugate |
| AU2004266213A1 (en) * | 2003-08-15 | 2005-03-03 | University Of Florida | Identification of porphyromonas gingivalis virulence polynucleotides for diagnosis, treatment, and monitoring of periodontal diseases |
| US7968684B2 (en) * | 2003-11-12 | 2011-06-28 | Abbott Laboratories | IL-18 binding proteins |
| JP2007512008A (ja) * | 2003-11-24 | 2007-05-17 | ノボ ノルディスク アクティーゼルスカブ | 融合タンパク質及び該タンパク質の切断方法 |
| PL1793859T3 (pl) * | 2004-08-20 | 2009-08-31 | Smithkline Beecham Corp | Leczenie zapalenia śluzówki jamy ustnej i jelit przez podawanie ludzkiej IL-18 |
| WO2008033499A2 (en) | 2006-09-14 | 2008-03-20 | The Trustees Of The University Of Pennsylvania | Modulation of regulatory t cells by human il-18 |
| PE20090190A1 (es) * | 2007-03-23 | 2009-03-22 | Smithkline Beecham Corp | Combinacion de anticuerpos anti-cd20 y polipeptidos de il-18 |
| KR101940430B1 (ko) | 2014-08-07 | 2019-01-18 | 가꼬우호우징 효고 이카다이가쿠 | Il-18과 분자 표적 항체를 병용하는 암 치료약 |
| JP2019023165A (ja) * | 2015-12-11 | 2019-02-14 | 国立大学法人京都大学 | インターロイキン−１８活性阻害剤 |
| KR20200080749A (ko) * | 2018-12-27 | 2020-07-07 | 주식회사 폴루스 | N-말단의 메티오닌이 절단된 목적 단백질 발현용 유전자 발현 카세트 및 이를 이용하여 n-말단의 메티오닌이 절단된 목적 단백질을 생산하는 방법 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5985863A (en) * | 1996-09-12 | 1999-11-16 | Vertex Pharmaceuticals, Inc. | Compositions and methods for decreasing IGIF and IFN-γ production by administering an ICE inhibitor |
| US6204261B1 (en) * | 1995-12-20 | 2001-03-20 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β Converting enzyme inhibitors |
| US5192324A (en) | 1982-02-18 | 1993-03-09 | Howmedica Inc. | Bone prosthesis with porous coating |
| ATE247708T1 (de) * | 1986-10-02 | 2003-09-15 | Massachusetts Inst Technology | Verfahren zur regulierung der metabolischen stabilität von proteinen |
| US5212058A (en) | 1990-05-09 | 1993-05-18 | Massachusetts Institute Of Technology | Nucleic acid encoding ubiquitin-specific proteases |
| DK0531404T3 (da) | 1990-05-09 | 1995-09-18 | Massachusetts Inst Technology | Ubiquitin-specifik protease |
| US5914254A (en) | 1993-08-02 | 1999-06-22 | Celtrix Pharmaceuticals, Inc. | Expression of fusion polypeptides transported out of the cytoplasm without leader sequences |
| US6110701A (en) | 1994-04-08 | 2000-08-29 | Merck Frosst Canada & Co. | DNA encoding precursor of interleukin-1β converting enzyme--related cysteine proteinase II (ICErel -II) |
| US5552536A (en) | 1994-04-08 | 1996-09-03 | Merck Frosst Canada, Inc. | DNA encoding precursor of interleukin-1 beta converting enzyme - related cysteine proteinase III (ice rel-III) |
| EP0692536B1 (en) | 1994-07-14 | 2000-11-22 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | IFN-Y production inducing protein and monoclonal antibody of the same |
| JP2724987B2 (ja) | 1994-11-15 | 1998-03-09 | 株式会社林原生物化学研究所 | インターフェロン−γの産生を誘導するポリペプチド |
| TW464656B (en) | 1994-11-15 | 2001-11-21 | Hayashibara Biochem Lab | Interferon-gamma production inducing polypeptide monoclonal antibody, and agent for interferon-gamma susceptive disease |
| US6074050A (en) | 1997-12-03 | 2000-06-13 | Hewlett-Packard Company | Method and apparatus for venting an ink container |
| AU1341797A (en) | 1995-12-29 | 1997-07-28 | Incyte Pharmaceuticals, Inc. | Nucleic acids encoding interferon gamma inducing factor-2 |
| JPH1080270A (ja) * | 1996-07-19 | 1998-03-31 | Hayashibara Biochem Lab Inc | ポリペプチドをプロセッシングする酵素 |
| TW515843B (en) * | 1996-07-25 | 2003-01-01 | Hayashibara Biochem Lab | Process for producing an active polypeptide inducing interferon-γ production |
| JP4010606B2 (ja) * | 1996-07-25 | 2007-11-21 | 株式会社林原生物化学研究所 | ポリペプチドの製造方法 |
| US6054487A (en) | 1997-03-18 | 2000-04-25 | Basf Aktiengesellschaft | Methods and compositions for modulating responsiveness to corticosteroids |
| KR20010034305A (ko) * | 1998-01-23 | 2001-04-25 | 한센 핀 베네드 | 효모에서 원하는 폴리펩티드를 만드는 방법 |
-
2001
- 2001-06-11 MX MXPA02012292A patent/MXPA02012292A/es active IP Right Grant
- 2001-06-11 NZ NZ522845A patent/NZ522845A/en not_active IP Right Cessation
- 2001-06-11 PL PL01366134A patent/PL366134A1/xx not_active Application Discontinuation
- 2001-06-11 HU HU0501002A patent/HUP0501002A3/hu unknown
- 2001-06-11 AU AU2001280442A patent/AU2001280442B2/en not_active Ceased
- 2001-06-11 US US10/311,491 patent/US7186528B2/en not_active Expired - Lifetime
- 2001-06-11 DE DE60139316T patent/DE60139316D1/de not_active Expired - Lifetime
- 2001-06-11 PL PL387774A patent/PL208592B1/pl not_active IP Right Cessation
- 2001-06-11 DK DK01958830T patent/DK1292697T3/da active
- 2001-06-11 PT PT01958830T patent/PT1292697E/pt unknown
- 2001-06-11 JP JP2002504604A patent/JP5121109B2/ja not_active Expired - Lifetime
- 2001-06-11 ES ES01958830T patent/ES2329875T3/es not_active Expired - Lifetime
- 2001-06-11 IL IL15342201A patent/IL153422A0/xx active IP Right Grant
- 2001-06-11 SI SI200130942T patent/SI1292697T1/sl unknown
- 2001-06-11 EP EP01958830A patent/EP1292697B1/en not_active Expired - Lifetime
- 2001-06-11 AT AT01958830T patent/ATE437234T1/de active
- 2001-06-11 WO PCT/US2001/018804 patent/WO2001098455A2/en active IP Right Grant
- 2001-06-11 BR BR0111692-4A patent/BR0111692A/pt not_active Withdrawn
- 2001-06-11 AU AU8044201A patent/AU8044201A/xx active Pending
- 2001-06-11 KR KR1020027016834A patent/KR20030022144A/ko not_active Application Discontinuation
- 2001-06-11 CZ CZ20024085A patent/CZ20024085A3/cs unknown
- 2001-06-11 CN CNB018112781A patent/CN100390281C/zh not_active Expired - Fee Related
- 2001-06-11 CA CA2412730A patent/CA2412730C/en not_active Expired - Lifetime
- 2001-06-13 AR ARP010102818A patent/AR033979A1/es active IP Right Grant
- 2001-06-14 MY MYPI20012804A patent/MY136526A/en unknown
-
2002
- 2002-12-12 IL IL153422A patent/IL153422A/en not_active IP Right Cessation
- 2002-12-13 NO NO20026002A patent/NO330682B1/no not_active IP Right Cessation
-
2003
- 2003-08-20 HK HK03105972.8A patent/HK1055138A1/xx not_active IP Right Cessation
-
2006
- 2006-04-11 US US11/402,187 patent/US7442526B2/en not_active Expired - Lifetime
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |