JP2004519443A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2004519443A5 JP2004519443A5 JP2002551560A JP2002551560A JP2004519443A5 JP 2004519443 A5 JP2004519443 A5 JP 2004519443A5 JP 2002551560 A JP2002551560 A JP 2002551560A JP 2002551560 A JP2002551560 A JP 2002551560A JP 2004519443 A5 JP2004519443 A5 JP 2004519443A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- alkyl
- formula
- hydrogen
- alk
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 43
- 229910052739 hydrogen Inorganic materials 0.000 claims 23
- 239000001257 hydrogen Substances 0.000 claims 23
- 150000002431 hydrogen Chemical class 0.000 claims 14
- 125000003118 aryl group Chemical group 0.000 claims 13
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 9
- 125000002252 acyl group Chemical group 0.000 claims 9
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 125000004432 carbon atom Chemical group C* 0.000 claims 7
- 125000004404 heteroalkyl group Chemical group 0.000 claims 6
- 125000002947 alkylene group Chemical group 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 5
- GVNVAWHJIKLAGL-UHFFFAOYSA-N 2-(cyclohexen-1-yl)cyclohexan-1-one Chemical compound O=C1CCCCC1C1=CCCCC1 GVNVAWHJIKLAGL-UHFFFAOYSA-N 0.000 claims 4
- -1 C 1 -C 6 alkyl Chemical group 0.000 claims 4
- 101100167062 Caenorhabditis elegans chch-3 gene Proteins 0.000 claims 4
- 101150065749 Churc1 gene Proteins 0.000 claims 4
- 102100038239 Protein Churchill Human genes 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 125000006239 protecting group Chemical group 0.000 claims 4
- 125000000246 pyrimidin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=C1[H] 0.000 claims 4
- 125000005843 halogen group Chemical group 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 125000003762 3,4-dimethoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1* 0.000 claims 2
- 102000004499 CCR3 Receptors Human genes 0.000 claims 2
- 108010017316 CCR3 Receptors Proteins 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 230000008878 coupling Effects 0.000 claims 2
- 238000010168 coupling process Methods 0.000 claims 2
- 238000005859 coupling reaction Methods 0.000 claims 2
- 150000004820 halides Chemical class 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 2
- 239000002464 receptor antagonist Substances 0.000 claims 2
- 229940044551 receptor antagonist Drugs 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 2
- 150000003461 sulfonyl halides Chemical class 0.000 claims 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 2
- 125000004189 3,4-dichlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(Cl)C([H])=C1* 0.000 claims 1
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 claims 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims 1
- 239000005977 Ethylene Substances 0.000 claims 1
- ZIHQUWYJSTVYAT-UHFFFAOYSA-N [NH-][N+]([O-])=O Chemical compound [NH-][N+]([O-])=O ZIHQUWYJSTVYAT-UHFFFAOYSA-N 0.000 claims 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 125000006296 sulfonyl amino group Chemical group [H]N(*)S(*)(=O)=O 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25658500P | 2000-12-19 | 2000-12-19 | |
| PCT/EP2001/014670 WO2002050064A1 (en) | 2000-12-19 | 2001-12-13 | Substituted pyrrolidines as ccr-3 receptor antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004519443A JP2004519443A (ja) | 2004-07-02 |
| JP2004519443A5 true JP2004519443A5 (enExample) | 2005-12-22 |
Family
ID=22972794
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002551560A Pending JP2004519443A (ja) | 2000-12-19 | 2001-12-13 | Ｃｃｒ−３受容体拮抗薬としての置換ピロリジン |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US6552028B2 (enExample) |
| EP (1) | EP1358181B1 (enExample) |
| JP (1) | JP2004519443A (enExample) |
| KR (1) | KR20030061455A (enExample) |
| CN (1) | CN1239498C (enExample) |
| AR (1) | AR035519A1 (enExample) |
| AT (1) | ATE374198T1 (enExample) |
| AU (1) | AU2002216107A1 (enExample) |
| BR (1) | BR0116352A (enExample) |
| CA (1) | CA2431767A1 (enExample) |
| DE (1) | DE60130684T2 (enExample) |
| ES (1) | ES2292530T3 (enExample) |
| MX (1) | MXPA03005581A (enExample) |
| WO (1) | WO2002050064A1 (enExample) |
| ZA (1) | ZA200304530B (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1871222A (zh) * | 2003-10-24 | 2006-11-29 | 霍夫曼-拉罗奇有限公司 | Ccr3受体拮抗剂 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2143143A1 (en) * | 1994-03-08 | 1995-09-09 | Toshihiko Tanaka | 3-phenylpyrrolidine derivatives |
| IL125658A0 (en) * | 1997-08-18 | 1999-04-11 | Hoffmann La Roche | Ccr-3 receptor antagonists |
| KR20010081034A (ko) * | 1998-11-20 | 2001-08-25 | 프리돌린 클라우스너, 롤란드 비. 보레르 | 피페리딘 씨씨알-3 수용체 길항제 |
| JP3593037B2 (ja) | 1998-11-20 | 2004-11-24 | エフ．ホフマン−ラ ロシュ アーゲー | ピロリジン誘導体ｃｃｒ−３受容体アンタゴニスト |
| CA2347909A1 (en) | 1998-12-18 | 2000-06-22 | Joseph B. Santella, Iii | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
| ATE302005T1 (de) | 1998-12-18 | 2005-09-15 | Bristol Myers Squibb Pharma Co | N-ureidoalkylpiperidine als modulatoren der aktivität der chemokinrezeptoren |
| AU2057200A (en) | 1998-12-18 | 2000-07-03 | Du Pont Pharmaceuticals Company | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
| AU2056700A (en) | 1998-12-18 | 2000-07-03 | Du Pont Pharmaceuticals Company | 2-substituted-4-nitrogen heterocycles as modulators of chemokine receptor activity |
| CA2347912A1 (en) | 1998-12-18 | 2000-06-22 | Soo S. Ko | Heterocyclic piperidines as modulators of chemokine receptor activity |
| EP1156807A4 (en) | 1998-12-18 | 2002-04-03 | Du Pont Pharm Co | N-UREIDOALKYL-PIPERIDINES FOR USE AS MODULATORS OF THE ACTIVITY OF CHIMIOKIN RECEPTORS |
| AU3126700A (en) | 1998-12-18 | 2000-07-03 | Du Pont Pharmaceuticals Company | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
-
2001
- 2001-12-13 ES ES01271370T patent/ES2292530T3/es not_active Expired - Lifetime
- 2001-12-13 CN CNB018208789A patent/CN1239498C/zh not_active Expired - Fee Related
- 2001-12-13 KR KR10-2003-7008134A patent/KR20030061455A/ko not_active Ceased
- 2001-12-13 EP EP01271370A patent/EP1358181B1/en not_active Expired - Lifetime
- 2001-12-13 JP JP2002551560A patent/JP2004519443A/ja active Pending
- 2001-12-13 MX MXPA03005581A patent/MXPA03005581A/es active IP Right Grant
- 2001-12-13 WO PCT/EP2001/014670 patent/WO2002050064A1/en not_active Ceased
- 2001-12-13 CA CA002431767A patent/CA2431767A1/en not_active Abandoned
- 2001-12-13 AU AU2002216107A patent/AU2002216107A1/en not_active Abandoned
- 2001-12-13 AT AT01271370T patent/ATE374198T1/de not_active IP Right Cessation
- 2001-12-13 BR BR0116352-3A patent/BR0116352A/pt not_active IP Right Cessation
- 2001-12-13 DE DE60130684T patent/DE60130684T2/de not_active Expired - Fee Related
- 2001-12-17 AR ARP010105833A patent/AR035519A1/es not_active Application Discontinuation
- 2001-12-19 US US10/034,034 patent/US6552028B2/en not_active Expired - Fee Related
-
2003
- 2003-02-18 US US10/368,097 patent/US20030199532A1/en not_active Abandoned
- 2003-06-10 ZA ZA200304530A patent/ZA200304530B/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN111848616B (zh) | 吡啶酮衍生物及其用于制备抗流感病毒药物的用途 | |
| CN110041327B (zh) | 吡啶酮衍生物、其组合物及作为抗流感病毒药物的应用 | |
| JP2005511532A5 (enExample) | ||
| JP2001510154A5 (enExample) | ||
| KR20050047552A (ko) | 베타-2 작용제로서의 인돌 유도체 | |
| JP2009512659A5 (enExample) | ||
| BR112013010738B1 (pt) | Composto de alquilsulfinil tiazolida | |
| JP2010540593A5 (enExample) | ||
| PT96255B (pt) | Processo para a preparacao de novos derivados da 1-naftil-piperazina | |
| JP2004532240A (ja) | ５−ｈｔ６受容体アンタゴニストとしてのベンゾ［ｄ］アゼピン誘導体 | |
| WO2008117229A4 (en) | Muscarinic receptor antagonists | |
| MX2014012992A (es) | Derivado de quinazolindiona. | |
| CN102924443B (zh) | 含有杂环的5-羟基吲哚类衍生物及其用途 | |
| WO2011002103A2 (en) | A cycloalkane derivative | |
| JP2007503432A5 (enExample) | ||
| JP2006519812A (ja) | フェニルスルホン誘導体およびｃｎｓ障害の治療におけるその使用 | |
| JP2007532628A5 (enExample) | ||
| CN111303147B (zh) | 吡啶酮衍生物、其组合物及作为抗流感病毒药物的应用 | |
| JP2006511498A5 (enExample) | ||
| JPH11506772A (ja) | 抗ウイルス化合物 | |
| JP2010535751A5 (enExample) | ||
| RU2007125659A (ru) | Фенилпиперазиновые производные с сочетанием свойств неполного агонизма к рецепторам дофамина-d2 и ингибирования повторного поглощения серотонина | |
| JP5460614B2 (ja) | アゼチジン誘導体、それらの調製、およびそれらの治療における適用 | |
| CN113582969B (zh) | 一种酰基硫脲类化合物在制备抗肠道病毒药物中的应用 | |
| CN110590660B (zh) | 一种喹啉甲酰胺类化合物及其制备方法与抗肠道病毒71型的应用 |