CA2431767A1 - Substituted pyrrolidines as ccr-3 receptor antagonists - Google Patents

Substituted pyrrolidines as ccr-3 receptor antagonists Download PDF

Info

Publication number
CA2431767A1
CA2431767A1 CA002431767A CA2431767A CA2431767A1 CA 2431767 A1 CA2431767 A1 CA 2431767A1 CA 002431767 A CA002431767 A CA 002431767A CA 2431767 A CA2431767 A CA 2431767A CA 2431767 A1 CA2431767 A1 CA 2431767A1
Authority
CA
Canada
Prior art keywords
alkyl
compound
formula
hydrogen
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002431767A
Other languages
English (en)
French (fr)
Inventor
Denis John Kertesz
Michael Garret Roepel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2431767A1 publication Critical patent/CA2431767A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA002431767A 2000-12-19 2001-12-13 Substituted pyrrolidines as ccr-3 receptor antagonists Abandoned CA2431767A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25658500P 2000-12-19 2000-12-19
US60/256,585 2000-12-19
PCT/EP2001/014670 WO2002050064A1 (en) 2000-12-19 2001-12-13 Substituted pyrrolidines as ccr-3 receptor antagonists

Publications (1)

Publication Number Publication Date
CA2431767A1 true CA2431767A1 (en) 2002-06-27

Family

ID=22972794

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002431767A Abandoned CA2431767A1 (en) 2000-12-19 2001-12-13 Substituted pyrrolidines as ccr-3 receptor antagonists

Country Status (15)

Country Link
US (2) US6552028B2 (enExample)
EP (1) EP1358181B1 (enExample)
JP (1) JP2004519443A (enExample)
KR (1) KR20030061455A (enExample)
CN (1) CN1239498C (enExample)
AR (1) AR035519A1 (enExample)
AT (1) ATE374198T1 (enExample)
AU (1) AU2002216107A1 (enExample)
BR (1) BR0116352A (enExample)
CA (1) CA2431767A1 (enExample)
DE (1) DE60130684T2 (enExample)
ES (1) ES2292530T3 (enExample)
MX (1) MXPA03005581A (enExample)
WO (1) WO2002050064A1 (enExample)
ZA (1) ZA200304530B (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1871222A (zh) * 2003-10-24 2006-11-29 霍夫曼-拉罗奇有限公司 Ccr3受体拮抗剂

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2143143A1 (en) * 1994-03-08 1995-09-09 Toshihiko Tanaka 3-phenylpyrrolidine derivatives
IL125658A0 (en) * 1997-08-18 1999-04-11 Hoffmann La Roche Ccr-3 receptor antagonists
KR20010081034A (ko) * 1998-11-20 2001-08-25 프리돌린 클라우스너, 롤란드 비. 보레르 피페리딘 씨씨알-3 수용체 길항제
JP3593037B2 (ja) 1998-11-20 2004-11-24 エフ．ホフマン−ラ ロシュ アーゲー ピロリジン誘導体ｃｃｒ−３受容体アンタゴニスト
CA2347909A1 (en) 1998-12-18 2000-06-22 Joseph B. Santella, Iii N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
ATE302005T1 (de) 1998-12-18 2005-09-15 Bristol Myers Squibb Pharma Co N-ureidoalkylpiperidine als modulatoren der aktivität der chemokinrezeptoren
AU2057200A (en) 1998-12-18 2000-07-03 Du Pont Pharmaceuticals Company N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
AU2056700A (en) 1998-12-18 2000-07-03 Du Pont Pharmaceuticals Company 2-substituted-4-nitrogen heterocycles as modulators of chemokine receptor activity
CA2347912A1 (en) 1998-12-18 2000-06-22 Soo S. Ko Heterocyclic piperidines as modulators of chemokine receptor activity
EP1156807A4 (en) 1998-12-18 2002-04-03 Du Pont Pharm Co N-UREIDOALKYL-PIPERIDINES FOR USE AS MODULATORS OF THE ACTIVITY OF CHIMIOKIN RECEPTORS
AU3126700A (en) 1998-12-18 2000-07-03 Du Pont Pharmaceuticals Company N-ureidoalkyl-piperidines as modulators of chemokine receptor activity

Also Published As

Publication number Publication date
BR0116352A (pt) 2003-12-02
ES2292530T3 (es) 2008-03-16
US6552028B2 (en) 2003-04-22
MXPA03005581A (es) 2003-10-06
ZA200304530B (en) 2004-09-10
AR035519A1 (es) 2004-06-02
ATE374198T1 (de) 2007-10-15
US20020198255A1 (en) 2002-12-26
CN1481379A (zh) 2004-03-10
EP1358181B1 (en) 2007-09-26
DE60130684D1 (de) 2007-11-08
WO2002050064A1 (en) 2002-06-27
KR20030061455A (ko) 2003-07-18
JP2004519443A (ja) 2004-07-02
EP1358181A1 (en) 2003-11-05
DE60130684T2 (de) 2008-08-14
US20030199532A1 (en) 2003-10-23
CN1239498C (zh) 2006-02-01
AU2002216107A1 (en) 2002-07-01

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued