AR035519A1 - Derivados de pirrolidina 2,4-substituidos, antagonistas del receptor ccr-3 - Google Patents
Derivados de pirrolidina 2,4-substituidos, antagonistas del receptor ccr-3Info
- Publication number
- AR035519A1 AR035519A1 ARP010105833A ARP010105833A AR035519A1 AR 035519 A1 AR035519 A1 AR 035519A1 AR P010105833 A ARP010105833 A AR P010105833A AR P010105833 A ARP010105833 A AR P010105833A AR 035519 A1 AR035519 A1 AR 035519A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- hydrogen
- group
- heteroalkyl
- aryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Los compuestos son útiles como antagonistas del receptor CCR-3 y por lo tanto, pueden utilizarse en el tratamiento de enfermedades tratables a través de la administración de antagonista del receptor CCR-3. Reivindicación 1: Un compuesto de fórmula (1) en la cual: R1 es hidrógeno, alquilo C1-6, acilo, heteroalquilo, -CONR3R4 (donde R3 y R4 son independientemente hidrógeno o alquilo C1-6), COOR5 (donde R5 es hidrógeno, alquilo C1-6 o heteroalquilo) o -SO2R6 donde R6 es alquilo C1-6; alk1 es una cadena de alquileno C1-6; X es -NHCO- o -CONH-; Y es una cadena de alquileno C1-3 o una cadena de alquileno C2-3, donde uno de los átomos de carbono se reemplaza por un heteroátomo seleccionado entre el grupo que comprende -O-, -NRb- [donde Rb es hidrógeno, alquilo C1-6, acilo, -CONR7R8 (donde R7 y R8 son independientemente hidrógeno o alquilo C1-6), -COOR9 (donde R9 es hidrógeno, alquilo C1-6 o heteroalquilo), arilo o arilalquilo C1-6)] y -S(O)n- donde n es un entero que oscila entre 0 y 2; Ar1 es un grupo heteroarilo o grupo fenilo, donde el grupo heteroarilo o fenilo está sustituido, además del grupo Ar2, por un sustituyente seleccionado entre el grupo que comprende hidrógeno, halo, alquilo C1-6, alcoxi C1-6, nitro, amido, aminosulfonilo y sulfonilamino; Ar2 es arilo; alk2 es una cadena de alquileno C1-6, donde uno de los átomos de carbono está opcionalmente reemplazado por -CO-, -NRc [donde Rc es hidrógeno, alquilo C1-6, acilo, -CONR10R11 (donde R10 y R11 son independientemente hidrógeno o alquilo C1-6), COOR12 (donde R12 es hidrógeno, alquilo C1-6 o heteroalquilo), arilo o arilalquilo C1-6)] o -S(O)n1- donde n1 es un entero que oscila entre 0 y 2; Ar3 es cicloalquilo C3-7, arilo o heteroarilo; o una sal farmacéuticamente aceptable del mismo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25658500P | 2000-12-19 | 2000-12-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR035519A1 true AR035519A1 (es) | 2004-06-02 |
Family
ID=22972794
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP010105833A AR035519A1 (es) | 2000-12-19 | 2001-12-17 | Derivados de pirrolidina 2,4-substituidos, antagonistas del receptor ccr-3 |
Country Status (15)
Country | Link |
---|---|
US (2) | US6552028B2 (es) |
EP (1) | EP1358181B1 (es) |
JP (1) | JP2004519443A (es) |
KR (1) | KR20030061455A (es) |
CN (1) | CN1239498C (es) |
AR (1) | AR035519A1 (es) |
AT (1) | ATE374198T1 (es) |
AU (1) | AU2002216107A1 (es) |
BR (1) | BR0116352A (es) |
CA (1) | CA2431767A1 (es) |
DE (1) | DE60130684T2 (es) |
ES (1) | ES2292530T3 (es) |
MX (1) | MXPA03005581A (es) |
WO (1) | WO2002050064A1 (es) |
ZA (1) | ZA200304530B (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2004283842A1 (en) * | 2003-10-24 | 2005-05-06 | F. Hoffmann-La Roche Ag | CCR3 receptor antagonists |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2143143A1 (en) * | 1994-03-08 | 1995-09-09 | Toshihiko Tanaka | 3-phenylpyrrolidine derivatives |
IL125658A0 (en) * | 1997-08-18 | 1999-04-11 | Hoffmann La Roche | Ccr-3 receptor antagonists |
TR200101397T2 (tr) * | 1998-11-20 | 2001-11-21 | F.Hoffmann-La Roche Ag | Piperidin CCR-3 reseptörü antagonistleri |
AU763960B2 (en) | 1998-11-20 | 2003-08-07 | F. Hoffmann-La Roche Ag | Pyrrolidine derivatives-CCR-3 receptor antagonists |
EP1158980B1 (en) | 1998-12-18 | 2005-08-24 | Bristol-Myers Squibb Pharma Company | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
AU2056800A (en) | 1998-12-18 | 2000-07-03 | Du Pont Pharmaceuticals Company | Heterocyclic piperidines as modulators of chemokine receptor activity |
IL142768A0 (en) | 1998-12-18 | 2002-03-10 | Du Pont Pharm Co | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
AU2056700A (en) | 1998-12-18 | 2000-07-03 | Du Pont Pharmaceuticals Company | 2-substituted-4-nitrogen heterocycles as modulators of chemokine receptor activity |
EP1140087A4 (en) | 1998-12-18 | 2002-04-03 | Du Pont Pharm Co | N-UREIDOALKYL-PIPERIDINES FOR USE AS MODULATORS OF THE ACTIVITY OF CHIMIOKIN RECEPTORS |
AU2482100A (en) | 1998-12-18 | 2000-07-03 | Du Pont Pharmaceuticals Company | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
EP1140086A4 (en) | 1998-12-18 | 2002-04-03 | Du Pont Pharm Co | N-UREIDOALKYL-PIPERIDINES FOR USE AS MODULATORS OF THE ACTIVITY OF CHIMIOKIN RECEPTORS |
-
2001
- 2001-12-13 KR KR10-2003-7008134A patent/KR20030061455A/ko not_active Application Discontinuation
- 2001-12-13 AT AT01271370T patent/ATE374198T1/de not_active IP Right Cessation
- 2001-12-13 EP EP01271370A patent/EP1358181B1/en not_active Expired - Lifetime
- 2001-12-13 ES ES01271370T patent/ES2292530T3/es not_active Expired - Lifetime
- 2001-12-13 AU AU2002216107A patent/AU2002216107A1/en not_active Abandoned
- 2001-12-13 CA CA002431767A patent/CA2431767A1/en not_active Abandoned
- 2001-12-13 CN CNB018208789A patent/CN1239498C/zh not_active Expired - Fee Related
- 2001-12-13 DE DE60130684T patent/DE60130684T2/de not_active Expired - Fee Related
- 2001-12-13 JP JP2002551560A patent/JP2004519443A/ja active Pending
- 2001-12-13 BR BR0116352-3A patent/BR0116352A/pt not_active IP Right Cessation
- 2001-12-13 MX MXPA03005581A patent/MXPA03005581A/es active IP Right Grant
- 2001-12-13 WO PCT/EP2001/014670 patent/WO2002050064A1/en active IP Right Grant
- 2001-12-17 AR ARP010105833A patent/AR035519A1/es not_active Application Discontinuation
- 2001-12-19 US US10/034,034 patent/US6552028B2/en not_active Expired - Fee Related
-
2003
- 2003-02-18 US US10/368,097 patent/US20030199532A1/en not_active Abandoned
- 2003-06-10 ZA ZA200304530A patent/ZA200304530B/en unknown
Also Published As
Publication number | Publication date |
---|---|
KR20030061455A (ko) | 2003-07-18 |
US20030199532A1 (en) | 2003-10-23 |
WO2002050064A1 (en) | 2002-06-27 |
CN1481379A (zh) | 2004-03-10 |
ZA200304530B (en) | 2004-09-10 |
CN1239498C (zh) | 2006-02-01 |
DE60130684T2 (de) | 2008-08-14 |
JP2004519443A (ja) | 2004-07-02 |
US20020198255A1 (en) | 2002-12-26 |
EP1358181B1 (en) | 2007-09-26 |
US6552028B2 (en) | 2003-04-22 |
ATE374198T1 (de) | 2007-10-15 |
ES2292530T3 (es) | 2008-03-16 |
CA2431767A1 (en) | 2002-06-27 |
AU2002216107A1 (en) | 2002-07-01 |
EP1358181A1 (en) | 2003-11-05 |
DE60130684D1 (de) | 2007-11-08 |
BR0116352A (pt) | 2003-12-02 |
MXPA03005581A (es) | 2003-10-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC | Refusal | ||
FA | Abandonment or withdrawal |