JP2004512814A5 - - Google Patents
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- JP2004512814A5 JP2004512814A5 JP2001543143A JP2001543143A JP2004512814A5 JP 2004512814 A5 JP2004512814 A5 JP 2004512814A5 JP 2001543143 A JP2001543143 A JP 2001543143A JP 2001543143 A JP2001543143 A JP 2001543143A JP 2004512814 A5 JP2004512814 A5 JP 2004512814A5
- Authority
- JP
- Japan
- Prior art keywords
- epitope
- hla
- hpv
- amino acid
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001413 amino acids Chemical group 0.000 description 7
- 108090000765 processed proteins & peptides Proteins 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 102000004169 proteins and genes Human genes 0.000 description 5
- 102000004196 processed proteins & peptides Human genes 0.000 description 3
- QNAYBMKLOCPYGJ-UWTATZPHSA-N D-alanine Chemical compound C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 description 2
- QNAYBMKLOCPYGJ-UHFFFAOYSA-N D-alpha-Ala Natural products CC([NH3+])C([O-])=O QNAYBMKLOCPYGJ-UHFFFAOYSA-N 0.000 description 2
- 102000006354 HLA-DR Antigens Human genes 0.000 description 2
- 108010058597 HLA-DR Antigens Proteins 0.000 description 2
- 210000004698 lymphocyte Anatomy 0.000 description 2
- BVAUMRCGVHUWOZ-ZETCQYMHSA-N (2s)-2-(cyclohexylazaniumyl)propanoate Chemical compound OC(=O)[C@H](C)NC1CCCCC1 BVAUMRCGVHUWOZ-ZETCQYMHSA-N 0.000 description 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
- 108700028369 Alleles Proteins 0.000 description 1
- 108010035452 HLA-A1 Antigen Proteins 0.000 description 1
- 108010074032 HLA-A2 Antigen Proteins 0.000 description 1
- 102000025850 HLA-A2 Antigen Human genes 0.000 description 1
- 101800000324 Immunoglobulin A1 protease translocator Proteins 0.000 description 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- 241000223960 Plasmodium falciparum Species 0.000 description 1
- 101710132597 Protein E5 Proteins 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 108010055044 Tetanus Toxin Proteins 0.000 description 1
- 229960003767 alanine Drugs 0.000 description 1
- 229940024606 amino acid Drugs 0.000 description 1
- 125000000539 amino acid group Chemical group 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 210000002443 helper t lymphocyte Anatomy 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 210000003046 sporozoite Anatomy 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 229940118376 tetanus toxin Drugs 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17270599P | 1999-12-10 | 1999-12-10 | |
| US09/641,528 US7026443B1 (en) | 1999-12-10 | 2000-08-15 | Inducing cellular immune responses to human Papillomavirus using peptide and nucleic acid compositions |
| PCT/US2000/033549 WO2001041799A1 (en) | 1999-12-10 | 2000-12-11 | Inducing cellular immune responses to human papillomavirus using peptide and nucleic acid compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004512814A JP2004512814A (ja) | 2004-04-30 |
| JP2004512814A5 true JP2004512814A5 (https=) | 2005-01-20 |
Family
ID=26868370
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001543143A Pending JP2004512814A (ja) | 1999-12-10 | 2000-12-11 | ペプチドおよび核酸組成物を使用する、ヒトパピローマウイルスに対する細胞性免疫応答の誘導 |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US7026443B1 (https=) |
| EP (1) | EP1246644A4 (https=) |
| JP (1) | JP2004512814A (https=) |
| AU (3) | AU2258201A (https=) |
| CA (1) | CA2393960C (https=) |
| MX (1) | MXPA02005639A (https=) |
| WO (1) | WO2001041799A1 (https=) |
Families Citing this family (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL105554A (en) * | 1992-05-05 | 1999-08-17 | Univ Leiden | Peptides of human papillomavirus for use in preparations elicit a human T cell response |
| US20050100928A1 (en) * | 1999-09-16 | 2005-05-12 | Zycos Inc., A Delaware Corporation | Nucleic acids encoding polyepitope polypeptides |
| EP1911461B1 (en) | 2000-10-19 | 2011-12-07 | Epimmune Inc. | HLA class I and II binding peptides and their uses |
| US20060222656A1 (en) * | 2005-04-01 | 2006-10-05 | University Of Maryland, Baltimore | MAGE-A3/HPV 16 peptide vaccines for head and neck cancer |
| AU2002322009A1 (en) * | 2001-05-18 | 2002-12-03 | Mayo Foundation For Medical Education And Research | Chimeric antigen-specific t cell-activating polypeptides |
| US8067535B2 (en) * | 2003-01-24 | 2011-11-29 | The University Of Massachusetts | Identification of gene sequences and proteins involved in vaccinia virus dominant T cell epitopes |
| US7217526B2 (en) * | 2003-01-24 | 2007-05-15 | University Of Massachusetts Medical School | Identification of gene sequences and proteins involved in vaccinia virus dominant T cell epitopes |
| EP1661999A4 (en) * | 2003-08-01 | 2006-11-02 | Inst Basic Med Sciences Pla | PROCESS FOR PREPARING AN EPITOPE CHIMERIC GENE VACCINE |
| MY140664A (en) | 2003-09-29 | 2010-01-15 | Merck Sharp & Dohme | Optimized expression of hpv 45 l1 in yeast |
| MY139500A (en) * | 2003-11-12 | 2009-10-30 | Merck Sharp & Dohme | Optimized expression of hpv 58 l1 in yeast |
| AU2005222776A1 (en) * | 2003-12-31 | 2005-09-29 | Genimmune N.V. | Inducing cellular immune responses to human papillomavirus using peptide and nucleic acid compositions |
| EP2650346A1 (en) | 2004-04-28 | 2013-10-16 | Headwaters Heavy Oil, LLC | Ebullated bed hydroprocessing method for treating heavy hydrocarbons |
| US10941353B2 (en) | 2004-04-28 | 2021-03-09 | Hydrocarbon Technology & Innovation, Llc | Methods and mixing systems for introducing catalyst precursor into heavy oil feedstock |
| EP1753845B1 (en) * | 2004-04-28 | 2018-01-03 | Headwaters Heavy Oil, LLC | Fixed bed hydroprocessing methods and systems and methods for upgrading an existing fixed bed system |
| US8252893B2 (en) * | 2005-01-31 | 2012-08-28 | Board Of Trustees Of The University Of Arkansas | CD8 T cell epitopes in HPV 16 E6 and E7 proteins and uses thereof |
| AU2006236905B2 (en) * | 2005-04-15 | 2010-06-03 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods and compositions for producing an enhanced immune response to a human papillomavirus immunogen |
| CA2523032A1 (en) | 2005-10-07 | 2007-04-07 | Immunovaccine Technologies Inc. | Vaccines for cancer therapy |
| US20070218080A1 (en) * | 2006-03-14 | 2007-09-20 | Mackay Memorial Hospital | Peptide antigen of human papillomavirus type 16 and application thereof |
| AU2007278831B2 (en) * | 2006-07-28 | 2013-03-21 | The Trustees Of The University Of Pennsylvania | Improved vaccines and methods for using the same |
| US20090123488A1 (en) * | 2006-08-14 | 2009-05-14 | Thymon, Llc | Compositions and methods for the treatment and prophylaxis of Alzheimer's disease |
| EP2167137B1 (en) * | 2007-05-31 | 2013-10-16 | GENimmune N.V. | Hpv polyepitope constructs and uses thereof |
| WO2009021063A2 (en) * | 2007-08-06 | 2009-02-12 | The Regents Of The University Of California | Composition and method of use for hcv immunization |
| CA2700808C (en) | 2007-09-27 | 2017-11-14 | Immunovaccine Technologies Inc. | Use of liposomes in a carrier comprising a continuous hydrophobic phase for delivery of polynucleotides in vivo |
| US8652482B2 (en) * | 2007-10-03 | 2014-02-18 | The Board Of Trustees Of The University Of Arkansas | HPV E6 protein T cell epitopes and uses thereof |
| US8722851B2 (en) * | 2007-11-02 | 2014-05-13 | Pain Therapeutics, Inc. | Analgesia with minimal tolerance and dependence by a mu opioid receptor agonist that also binds filamin A |
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| KR20090103571A (ko) * | 2008-03-28 | 2009-10-01 | 바이오코아 주식회사 | 면역성 펩타이드 및 그 펩타이드를 포함하는 ｈｐｖ 관련질환 예방 또는 치료용 조성물 |
| US9096681B2 (en) | 2008-06-02 | 2015-08-04 | Dana-Farber Cancer Institute, Inc. | XBP1, CD138, and CS1 peptides |
| ES2524699T3 (es) | 2008-06-05 | 2014-12-11 | Immunovaccine Technologies Inc. | Composiciones que comprenden liposomas, un antígeno, un polinucleótido y un vehículo que comprende una fase continua de una sustancia hidrófoba |
| TW201000119A (en) * | 2008-06-10 | 2010-01-01 | Oncotherapy Science Inc | MYBL2 epitope peptides and vaccines containing the same |
| TWI526219B (zh) | 2008-06-19 | 2016-03-21 | 腫瘤療法 科學股份有限公司 | Ｃｄｃａ１抗原決定位胜肽及含此胜肽的疫苗 |
| EP2344191A4 (en) * | 2008-09-02 | 2013-02-13 | Antigen Express Inc | HUMAN PAPILLOMAVIRUS / LI-KEY HYBRIDS AND METHODS OF USE |
| EP2391635B1 (en) | 2009-01-28 | 2017-04-26 | Epimmune Inc. | Pan-dr binding polypeptides and uses thereof |
| ES2712892T3 (es) * | 2010-02-16 | 2019-05-16 | Oesterreichische Akademie Der Wss | Anticuerpos anti-E7 del HPV |
| US20120045413A1 (en) * | 2010-04-09 | 2012-02-23 | Mayumi Nakagawa | Human papilloma virus peptide-specific T-cell response for treatment of warts |
| TWI507413B (zh) * | 2010-11-15 | 2015-11-11 | Nat Health Research Institutes | 脂質化多抗原表位疫苗 |
| US8663964B2 (en) * | 2011-07-20 | 2014-03-04 | Tamir Biotechnology, Inc. | Methods of treating human papillomavirus |
| US9790440B2 (en) | 2011-09-23 | 2017-10-17 | Headwaters Technology Innovation Group, Inc. | Methods for increasing catalyst concentration in heavy oil and/or coal resid hydrocracker |
| ES2402286B1 (es) * | 2011-09-29 | 2014-03-04 | Universidad De Valladolid | Péptido inmunogénico del gluten y sus aplicaciones. |
| JP6240077B2 (ja) | 2011-10-06 | 2017-11-29 | イムノバクシーン・テクノロジーズ・インコーポレイテッドＩｍｍｕｎｏｖａｃｃｉｎｅ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｉｎｃ． | Ｔｌｒ２を活性化するか、またはその活性を増加させるアジュバントを含むリポソーム組成物およびその使用 |
| US8715681B2 (en) * | 2012-02-02 | 2014-05-06 | Hengsun Pharmaceutical Technology Co. Ltd. | Minimal motifs of linear B-cell epitopes in L1 protein from human papillomavirus type 58 and their applications |
| EP2870171B1 (en) * | 2012-07-05 | 2017-06-28 | Gwangju Institute of Science and Technology | Decoy peptides inhibiting protein phosphatase 1-mediated dephosphorylation of phospholamban |
| WO2014010229A1 (en) | 2012-07-10 | 2014-01-16 | Oncotherapy Science, Inc. | Cdca1 epitope peptides for th1 cells and vaccines containing the same |
| US9644157B2 (en) | 2012-07-30 | 2017-05-09 | Headwaters Heavy Oil, Llc | Methods and systems for upgrading heavy oil using catalytic hydrocracking and thermal coking |
| CA2888803A1 (en) | 2012-11-05 | 2014-05-08 | Jooeun Bae | Xbp1, cd138, and cs1 peptides, pharmaceutical compositions that include the peptides, and methods of using such peptides and compositions |
| CN106632617B (zh) * | 2013-02-22 | 2020-07-03 | 艾托金生物医药（苏州）有限公司 | 用于检测抗人乳头瘤病毒抗体的抗原及相关免疫检测试剂盒 |
| CN110592133A (zh) * | 2013-05-17 | 2019-12-20 | 北京安百胜生物科技有限公司 | 用汉逊酵母表达系统产生hpv31 l1蛋白的方法 |
| KR101523503B1 (ko) * | 2013-09-17 | 2015-05-29 | 강원대학교산학협력단 | 아디포넥틴으로부터 유래한 펩타이드 및 이를 포함하는 조성물 |
| EP2883550A1 (en) | 2013-12-12 | 2015-06-17 | Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts | Novel promiscuous HPV16-derived T helper epitopes for immunotherapy |
| US9919034B2 (en) | 2014-03-28 | 2018-03-20 | Tamir Biotechnology, Inc. | Methods of treating and prophylactically protecting mammalian patients infected by viruses classified in Baltimore group V |
| KR101680567B1 (ko) | 2014-07-09 | 2016-11-29 | 연세대학교 산학협력단 | 인유두종바이러스 펩타이드의 자궁경부암 진단 및 치료 용도 |
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| WO2016138350A1 (en) * | 2015-02-26 | 2016-09-01 | The Board Of Trustees Of The University Of Arkansas | Recall antigen for promoting t-helper type 1 response |
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| EP3307238B1 (en) | 2015-06-15 | 2025-12-31 | Orgenesis Inc. | Pharmaceutical products for the treatment of viral eye infections |
| US11414608B2 (en) | 2015-09-22 | 2022-08-16 | Hydrocarbon Technology & Innovation, Llc | Upgraded ebullated bed reactor used with opportunity feedstocks |
| US11414607B2 (en) | 2015-09-22 | 2022-08-16 | Hydrocarbon Technology & Innovation, Llc | Upgraded ebullated bed reactor with increased production rate of converted products |
| CN105175498A (zh) * | 2015-10-09 | 2015-12-23 | 深圳市康尔诺生物技术有限公司 | 一种宫颈癌相关的热休克蛋白复合物及其应用 |
| US11421164B2 (en) | 2016-06-08 | 2022-08-23 | Hydrocarbon Technology & Innovation, Llc | Dual catalyst system for ebullated bed upgrading to produce improved quality vacuum residue product |
| US20190209669A1 (en) | 2016-08-23 | 2019-07-11 | Oncopep, Inc. | Peptide vaccines and durvalumab for treating breast cancer |
| WO2018039203A1 (en) | 2016-08-23 | 2018-03-01 | Oncopep, Inc. | Peptide vaccines and durvalumab for treating multiple myeloma |
| US11732203B2 (en) | 2017-03-02 | 2023-08-22 | Hydrocarbon Technology & Innovation, Llc | Ebullated bed reactor upgraded to produce sediment that causes less equipment fouling |
| MX2018002577A (es) | 2017-03-02 | 2018-11-09 | Hydrocarbon Tech & Innovation Llc | Reactor de lecho en ebullicion mejorado con menos sedimento de ensuciamiento. |
| US12303561B2 (en) * | 2017-04-03 | 2025-05-20 | Biontech Us Inc. | Protein antigens and uses thereof |
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| CN111655280B (zh) | 2017-09-01 | 2025-01-14 | 达纳-法伯癌症研究所股份有限公司 | 用于治疗癌症的bcma和taci抗原特异的免疫原性肽 |
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| US20210046114A1 (en) * | 2018-01-24 | 2021-02-18 | The Council Of The Queensland Institute Of Medical Research | Hpv immunotherapy |
| TW202023581A (zh) | 2018-08-02 | 2020-07-01 | 日商腫瘤療法 科學股份有限公司 | 來自cdca1的胜肽及含有此的疫苗 |
| CA3057131C (en) | 2018-10-17 | 2024-04-23 | Hydrocarbon Technology And Innovation, Llc | Upgraded ebullated bed reactor with no recycle buildup of asphaltenes in vacuum bottoms |
| CN109517033B (zh) * | 2018-10-31 | 2021-02-05 | 深圳凯联健康生物科技有限公司 | 活性肽、重组载体、重组细胞、抗炎组合物及其制备方法和应用 |
| CN111440811A (zh) * | 2019-02-25 | 2020-07-24 | 武汉凯德维斯生物技术有限公司 | 同时靶向hpv16 l1及hpv16 e5e6e7的宫颈癌疫苗及其制备方法 |
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| CN111153967B (zh) * | 2019-12-16 | 2023-04-07 | 温州医科大学 | 一种对hpv16 e5蛋白特异性结合的多肽及其应用 |
| EP4125949A4 (en) * | 2020-03-23 | 2024-05-22 | The Council of the Queensland Institute of Medical Research | COMPOSITIONS AND METHODS FOR TARGETING HPV-INFECTED CELLS |
| CN113984947B (zh) * | 2020-07-27 | 2024-05-17 | 中国食品药品检定研究院 | 测定9价hpv疫苗中抗原蛋白含量的特异性肽段及方法 |
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-
2000
- 2000-08-15 US US09/641,528 patent/US7026443B1/en not_active Expired - Lifetime
- 2000-12-11 AU AU22582/01A patent/AU2258201A/en not_active Abandoned
- 2000-12-11 MX MXPA02005639A patent/MXPA02005639A/es active IP Right Grant
- 2000-12-11 CA CA2393960A patent/CA2393960C/en not_active Expired - Fee Related
- 2000-12-11 US US10/149,136 patent/US7572882B2/en not_active Expired - Lifetime
- 2000-12-11 JP JP2001543143A patent/JP2004512814A/ja active Pending
- 2000-12-11 WO PCT/US2000/033549 patent/WO2001041799A1/en not_active Ceased
- 2000-12-11 EP EP00986316A patent/EP1246644A4/en not_active Ceased
-
2006
- 2006-02-16 AU AU2006200654A patent/AU2006200654C1/en not_active Ceased
-
2008
- 2008-11-14 US US12/292,281 patent/US20090214632A1/en not_active Abandoned
-
2009
- 2009-10-15 AU AU2009225354A patent/AU2009225354A1/en not_active Abandoned
-
2012
- 2012-09-14 US US13/618,996 patent/US20130017253A1/en not_active Abandoned
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