JP2004512814A5 - - Google Patents
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- JP2004512814A5 JP2004512814A5 JP2001543143A JP2001543143A JP2004512814A5 JP 2004512814 A5 JP2004512814 A5 JP 2004512814A5 JP 2001543143 A JP2001543143 A JP 2001543143A JP 2001543143 A JP2001543143 A JP 2001543143A JP 2004512814 A5 JP2004512814 A5 JP 2004512814A5
- Authority
- JP
- Japan
- Prior art keywords
- epitope
- hla
- hpv
- amino acid
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001413 amino acids Chemical group 0.000 description 7
- 108090000765 processed proteins & peptides Proteins 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 102000004169 proteins and genes Human genes 0.000 description 5
- 102000004196 processed proteins & peptides Human genes 0.000 description 3
- QNAYBMKLOCPYGJ-UWTATZPHSA-N D-alanine Chemical compound C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 description 2
- QNAYBMKLOCPYGJ-UHFFFAOYSA-N D-alpha-Ala Natural products CC([NH3+])C([O-])=O QNAYBMKLOCPYGJ-UHFFFAOYSA-N 0.000 description 2
- 102000006354 HLA-DR Antigens Human genes 0.000 description 2
- 108010058597 HLA-DR Antigens Proteins 0.000 description 2
- 210000004698 lymphocyte Anatomy 0.000 description 2
- BVAUMRCGVHUWOZ-ZETCQYMHSA-N (2s)-2-(cyclohexylazaniumyl)propanoate Chemical compound OC(=O)[C@H](C)NC1CCCCC1 BVAUMRCGVHUWOZ-ZETCQYMHSA-N 0.000 description 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
- 108700028369 Alleles Proteins 0.000 description 1
- 108010035452 HLA-A1 Antigen Proteins 0.000 description 1
- 108010074032 HLA-A2 Antigen Proteins 0.000 description 1
- 102000025850 HLA-A2 Antigen Human genes 0.000 description 1
- 101800000324 Immunoglobulin A1 protease translocator Proteins 0.000 description 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- 241000223960 Plasmodium falciparum Species 0.000 description 1
- 101710132597 Protein E5 Proteins 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 108010055044 Tetanus Toxin Proteins 0.000 description 1
- 229960003767 alanine Drugs 0.000 description 1
- 229940024606 amino acid Drugs 0.000 description 1
- 125000000539 amino acid group Chemical group 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 210000002443 helper t lymphocyte Anatomy 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 210000003046 sporozoite Anatomy 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 229940118376 tetanus toxin Drugs 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17270599P | 1999-12-10 | 1999-12-10 | |
| US09/641,528 US7026443B1 (en) | 1999-12-10 | 2000-08-15 | Inducing cellular immune responses to human Papillomavirus using peptide and nucleic acid compositions |
| PCT/US2000/033549 WO2001041799A1 (en) | 1999-12-10 | 2000-12-11 | Inducing cellular immune responses to human papillomavirus using peptide and nucleic acid compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004512814A JP2004512814A (ja) | 2004-04-30 |
| JP2004512814A5 true JP2004512814A5 (enExample) | 2005-01-20 |
Family
ID=26868370
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001543143A Pending JP2004512814A (ja) | 1999-12-10 | 2000-12-11 | ペプチドおよび核酸組成物を使用する、ヒトパピローマウイルスに対する細胞性免疫応答の誘導 |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US7026443B1 (enExample) |
| EP (1) | EP1246644A4 (enExample) |
| JP (1) | JP2004512814A (enExample) |
| AU (3) | AU2258201A (enExample) |
| CA (1) | CA2393960C (enExample) |
| MX (1) | MXPA02005639A (enExample) |
| WO (1) | WO2001041799A1 (enExample) |
Families Citing this family (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL105554A (en) * | 1992-05-05 | 1999-08-17 | Univ Leiden | Peptides of human papillomavirus for use in preparations elicit a human T cell response |
| US20050100928A1 (en) * | 1999-09-16 | 2005-05-12 | Zycos Inc., A Delaware Corporation | Nucleic acids encoding polyepitope polypeptides |
| ATE536187T1 (de) | 2000-10-19 | 2011-12-15 | Epimmune Inc | Hla-klasse-i- und -klasse-ii-bindende peptide und ihre verwendungen |
| US7842480B2 (en) * | 2001-05-18 | 2010-11-30 | Mayo Foundation For Medical Education And Research | Chimeric antigen-specific t cell-activating polypeptides |
| US20060222656A1 (en) * | 2005-04-01 | 2006-10-05 | University Of Maryland, Baltimore | MAGE-A3/HPV 16 peptide vaccines for head and neck cancer |
| ATE516045T1 (de) * | 2003-01-24 | 2011-07-15 | Univ Massachusetts Medical | Identifikation von vaccinia-virus-dominanten t- zell-epitopen |
| US8067535B2 (en) * | 2003-01-24 | 2011-11-29 | The University Of Massachusetts | Identification of gene sequences and proteins involved in vaccinia virus dominant T cell epitopes |
| US7981601B2 (en) * | 2003-08-01 | 2011-07-19 | Institute Of Basic Medical Sciences | Method of preparing polyepitope chimeric gene vaccine |
| MY140664A (en) * | 2003-09-29 | 2010-01-15 | Merck Sharp & Dohme | Optimized expression of hpv 45 l1 in yeast |
| MY139500A (en) * | 2003-11-12 | 2009-10-30 | Merck Sharp & Dohme | Optimized expression of hpv 58 l1 in yeast |
| AU2005222776A1 (en) * | 2003-12-31 | 2005-09-29 | Genimmune N.V. | Inducing cellular immune responses to human papillomavirus using peptide and nucleic acid compositions |
| US10941353B2 (en) | 2004-04-28 | 2021-03-09 | Hydrocarbon Technology & Innovation, Llc | Methods and mixing systems for introducing catalyst precursor into heavy oil feedstock |
| ES2585891T3 (es) | 2004-04-28 | 2016-10-10 | Headwaters Heavy Oil, Llc | Métodos y sistemas de hidroprocesamiento en lecho en ebullición |
| WO2005104786A2 (en) * | 2004-04-28 | 2005-11-10 | Headwaters Heavy Oil, Llc | Fixed bed hydroprocessing methods and systems and methods for upgrading an existing fixed bed system |
| US8252893B2 (en) * | 2005-01-31 | 2012-08-28 | Board Of Trustees Of The University Of Arkansas | CD8 T cell epitopes in HPV 16 E6 and E7 proteins and uses thereof |
| CA2604909A1 (en) * | 2005-04-15 | 2006-10-26 | The Government Of The United States Of America, As Represented By The Se Cretary, Department Of Health And Human Services | Methods and compositions for producing an enhanced immune response to a human papillomavirus immunogen |
| CA2523032A1 (en) * | 2005-10-07 | 2007-04-07 | Immunovaccine Technologies Inc. | Vaccines for cancer therapy |
| US20070218080A1 (en) * | 2006-03-14 | 2007-09-20 | Mackay Memorial Hospital | Peptide antigen of human papillomavirus type 16 and application thereof |
| KR101710981B1 (ko) * | 2006-07-28 | 2017-02-28 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 개선된 백신 및 이의 사용 방법 |
| WO2008021296A2 (en) * | 2006-08-14 | 2008-02-21 | Thymon, L.L.C. | Compositions and methods for the treatment and prophylaxis of alzheimer's disease |
| ES2440974T3 (es) * | 2007-05-31 | 2014-01-31 | Genimmune N.V. | Constructos poliepitópicos del VPH y uso de los mismos |
| US20110097332A1 (en) * | 2007-08-06 | 2011-04-28 | Martina Buck | Composition and Method of Use for HCV Immunization |
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| US8652482B2 (en) * | 2007-10-03 | 2014-02-18 | The Board Of Trustees Of The University Of Arkansas | HPV E6 protein T cell epitopes and uses thereof |
| US8722851B2 (en) * | 2007-11-02 | 2014-05-13 | Pain Therapeutics, Inc. | Analgesia with minimal tolerance and dependence by a mu opioid receptor agonist that also binds filamin A |
| WO2009093251A2 (en) * | 2008-01-24 | 2009-07-30 | Gavish-Galilee Bio Applications Ltd | Reovirus vaccine based on sigma c protein sequence |
| KR20090103571A (ko) * | 2008-03-28 | 2009-10-01 | 바이오코아 주식회사 | 면역성 펩타이드 및 그 펩타이드를 포함하는 ｈｐｖ 관련질환 예방 또는 치료용 조성물 |
| JP2011523560A (ja) | 2008-06-02 | 2011-08-18 | ダナ−ファーバー キャンサー インスティテュート インク． | Ｘｂｐ１ペプチド、ｃｄ１３８ペプチドおよびｃｓ１ペプチド |
| AU2009253780B2 (en) | 2008-06-05 | 2014-08-14 | Immunovaccine Technologies Inc. | Compositions comprising liposomes, an antigen, a polynucleotide and a carrier comprising a continuous phase of a hydrophobic substance |
| TW201000119A (en) * | 2008-06-10 | 2010-01-01 | Oncotherapy Science Inc | MYBL2 epitope peptides and vaccines containing the same |
| TWI526219B (zh) | 2008-06-19 | 2016-03-21 | 腫瘤療法 科學股份有限公司 | Ｃｄｃａ１抗原決定位胜肽及含此胜肽的疫苗 |
| JP5707326B2 (ja) * | 2008-09-02 | 2015-04-30 | アンティジェン・エクスプレス・インコーポレーテッドＡｎｔｉｇｅｎ Ｅｘｐｒｅｓｓ，Ｉｎｃ． | ヒトパピローマウイルス／Ｉｉ−ｋｅｙのハイブリッドおよびその使用方法 |
| EP2391635B1 (en) | 2009-01-28 | 2017-04-26 | Epimmune Inc. | Pan-dr binding polypeptides and uses thereof |
| DK2993183T3 (da) * | 2010-02-16 | 2020-03-30 | Oesterreichische Akademie Der Wss | Anti-hpv e7-antistoffer |
| US20120045413A1 (en) * | 2010-04-09 | 2012-02-23 | Mayumi Nakagawa | Human papilloma virus peptide-specific T-cell response for treatment of warts |
| TWI507413B (zh) * | 2010-11-15 | 2015-11-11 | Nat Health Research Institutes | 脂質化多抗原表位疫苗 |
| US8663964B2 (en) * | 2011-07-20 | 2014-03-04 | Tamir Biotechnology, Inc. | Methods of treating human papillomavirus |
| US9790440B2 (en) | 2011-09-23 | 2017-10-17 | Headwaters Technology Innovation Group, Inc. | Methods for increasing catalyst concentration in heavy oil and/or coal resid hydrocracker |
| ES2402286B1 (es) * | 2011-09-29 | 2014-03-04 | Universidad De Valladolid | Péptido inmunogénico del gluten y sus aplicaciones. |
| CN113876945A (zh) | 2011-10-06 | 2022-01-04 | 免疫疫苗技术有限公司 | 包括激活或增加tlr2活性的佐剂的脂质体组合物及其应用 |
| US8715681B2 (en) * | 2012-02-02 | 2014-05-06 | Hengsun Pharmaceutical Technology Co. Ltd. | Minimal motifs of linear B-cell epitopes in L1 protein from human papillomavirus type 58 and their applications |
| WO2014007584A1 (en) * | 2012-07-05 | 2014-01-09 | Gwangju Institute Of Science And Technology | Decoy peptides inhibiting protein phosphatase 1-mediated dephosphorylation of phospholamban |
| JP6255593B2 (ja) | 2012-07-10 | 2018-01-10 | オンコセラピー・サイエンス株式会社 | Ｔｈ１細胞のＣＤＣＡ１エピトープペプチドおよびこれを含有するワクチン |
| US9644157B2 (en) | 2012-07-30 | 2017-05-09 | Headwaters Heavy Oil, Llc | Methods and systems for upgrading heavy oil using catalytic hydrocracking and thermal coking |
| CN105377288B (zh) | 2012-11-05 | 2019-11-15 | 达纳-法伯癌症研究所股份有限公司 | Xbp1、cd138和cs1肽的组合物制备药物的用途 |
| CN106478784B (zh) * | 2013-02-22 | 2019-10-25 | 艾托金生物医药（苏州）有限公司 | 用于检测抗人乳头瘤病毒抗体的抗原及相关免疫检测试剂盒 |
| CN104164374B (zh) * | 2013-05-17 | 2019-10-22 | 北京安百胜生物科技有限公司 | 用汉逊酵母表达系统产生hpv31 l1蛋白的方法 |
| KR101523503B1 (ko) * | 2013-09-17 | 2015-05-29 | 강원대학교산학협력단 | 아디포넥틴으로부터 유래한 펩타이드 및 이를 포함하는 조성물 |
| EP2883550A1 (en) | 2013-12-12 | 2015-06-17 | Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts | Novel promiscuous HPV16-derived T helper epitopes for immunotherapy |
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| KR101680567B1 (ko) | 2014-07-09 | 2016-11-29 | 연세대학교 산학협력단 | 인유두종바이러스 펩타이드의 자궁경부암 진단 및 치료 용도 |
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| US20180043008A1 (en) * | 2015-02-26 | 2018-02-15 | Bioventures, Llc | Recall antigen for promoting t-helper type 1 response |
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| US11414607B2 (en) | 2015-09-22 | 2022-08-16 | Hydrocarbon Technology & Innovation, Llc | Upgraded ebullated bed reactor with increased production rate of converted products |
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| CN105175498A (zh) * | 2015-10-09 | 2015-12-23 | 深圳市康尔诺生物技术有限公司 | 一种宫颈癌相关的热休克蛋白复合物及其应用 |
| US11421164B2 (en) | 2016-06-08 | 2022-08-23 | Hydrocarbon Technology & Innovation, Llc | Dual catalyst system for ebullated bed upgrading to produce improved quality vacuum residue product |
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| US11732203B2 (en) | 2017-03-02 | 2023-08-22 | Hydrocarbon Technology & Innovation, Llc | Ebullated bed reactor upgraded to produce sediment that causes less equipment fouling |
| US11118119B2 (en) | 2017-03-02 | 2021-09-14 | Hydrocarbon Technology & Innovation, Llc | Upgraded ebullated bed reactor with less fouling sediment |
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| WO2019145792A1 (en) * | 2018-01-24 | 2019-08-01 | The Council Of The Queensland Institute Of Medical Research | Hpv immunotherapy |
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| CA3057131C (en) | 2018-10-17 | 2024-04-23 | Hydrocarbon Technology And Innovation, Llc | Upgraded ebullated bed reactor with no recycle buildup of asphaltenes in vacuum bottoms |
| CN109517033B (zh) * | 2018-10-31 | 2021-02-05 | 深圳凯联健康生物科技有限公司 | 活性肽、重组载体、重组细胞、抗炎组合物及其制备方法和应用 |
| CN111440811A (zh) * | 2019-02-25 | 2020-07-24 | 武汉凯德维斯生物技术有限公司 | 同时靶向hpv16 l1及hpv16 e5e6e7的宫颈癌疫苗及其制备方法 |
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| CN111153967B (zh) * | 2019-12-16 | 2023-04-07 | 温州医科大学 | 一种对hpv16 e5蛋白特异性结合的多肽及其应用 |
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-
2000
- 2000-08-15 US US09/641,528 patent/US7026443B1/en not_active Expired - Lifetime
- 2000-12-11 WO PCT/US2000/033549 patent/WO2001041799A1/en not_active Ceased
- 2000-12-11 CA CA2393960A patent/CA2393960C/en not_active Expired - Fee Related
- 2000-12-11 JP JP2001543143A patent/JP2004512814A/ja active Pending
- 2000-12-11 EP EP00986316A patent/EP1246644A4/en not_active Ceased
- 2000-12-11 US US10/149,136 patent/US7572882B2/en not_active Expired - Lifetime
- 2000-12-11 AU AU22582/01A patent/AU2258201A/en not_active Abandoned
- 2000-12-11 MX MXPA02005639A patent/MXPA02005639A/es active IP Right Grant
-
2006
- 2006-02-16 AU AU2006200654A patent/AU2006200654C1/en not_active Ceased
-
2008
- 2008-11-14 US US12/292,281 patent/US20090214632A1/en not_active Abandoned
-
2009
- 2009-10-15 AU AU2009225354A patent/AU2009225354A1/en not_active Abandoned
-
2012
- 2012-09-14 US US13/618,996 patent/US20130017253A1/en not_active Abandoned
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