JP2004511467A5 - - Google Patents
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- Publication number
- JP2004511467A5 JP2004511467A5 JP2002534284A JP2002534284A JP2004511467A5 JP 2004511467 A5 JP2004511467 A5 JP 2004511467A5 JP 2002534284 A JP2002534284 A JP 2002534284A JP 2002534284 A JP2002534284 A JP 2002534284A JP 2004511467 A5 JP2004511467 A5 JP 2004511467A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- substituted
- phenyl
- halogen
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 22
- 229910052736 halogen Inorganic materials 0.000 claims 19
- 150000002367 halogens Chemical class 0.000 claims 19
- 125000001424 substituent group Chemical group 0.000 claims 16
- 150000001875 compounds Chemical class 0.000 claims 14
- 239000001257 hydrogen Substances 0.000 claims 13
- 229910052739 hydrogen Inorganic materials 0.000 claims 13
- 125000004093 cyano group Chemical group *C#N 0.000 claims 12
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 11
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 11
- -1 cyano, hydroxy Chemical group 0.000 claims 9
- 229910052757 nitrogen Inorganic materials 0.000 claims 9
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 8
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 7
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 6
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 6
- 229910052801 chlorine Chemical group 0.000 claims 6
- 239000000460 chlorine Chemical group 0.000 claims 6
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 125000001033 ether group Chemical group 0.000 claims 4
- 229910052731 fluorine Inorganic materials 0.000 claims 4
- 239000011737 fluorine Substances 0.000 claims 4
- 150000003839 salts Chemical group 0.000 claims 4
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 3
- 125000002252 acyl group Chemical group 0.000 claims 3
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 125000004423 acyloxy group Chemical group 0.000 claims 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 2
- 229910052794 bromium Inorganic materials 0.000 claims 2
- 125000004122 cyclic group Chemical group 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 230000002757 inflammatory effect Effects 0.000 claims 2
- 125000001624 naphthyl group Chemical group 0.000 claims 2
- 125000000962 organic group Chemical group 0.000 claims 2
- 125000004430 oxygen atom Chemical group O* 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000003341 7 membered heterocyclic group Chemical group 0.000 claims 1
- 206010027654 Allergic conditions Diseases 0.000 claims 1
- 102100024167 C-C chemokine receptor type 3 Human genes 0.000 claims 1
- 101710149862 C-C chemokine receptor type 3 Proteins 0.000 claims 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 230000000414 obstructive effect Effects 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 208000023504 respiratory system disease Diseases 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
- APEJMQOBVMLION-UHFFFAOYSA-N cinnamamide Chemical compound NC(=O)C=CC1=CC=CC=C1 APEJMQOBVMLION-UHFFFAOYSA-N 0.000 description 2
- 102000004499 CCR3 Receptors Human genes 0.000 description 1
- 108010017316 CCR3 Receptors Proteins 0.000 description 1
- 239000002464 receptor antagonist Substances 0.000 description 1
- 229940044551 receptor antagonist Drugs 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0024675A GB0024675D0 (en) | 2000-10-09 | 2000-10-09 | Organic compounds |
| GB0120549A GB0120549D0 (en) | 2001-08-23 | 2001-08-23 | Organic compounds |
| PCT/EP2001/011627 WO2002030898A1 (en) | 2000-10-09 | 2001-10-08 | N-(4-aryloxypiperidin-1-ylalkyl) cinnamic amides as ccr33 receptor antagonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004511467A JP2004511467A (ja) | 2004-04-15 |
| JP2004511467A5 true JP2004511467A5 (enExample) | 2005-04-07 |
| JP4199539B2 JP4199539B2 (ja) | 2008-12-17 |
Family
ID=26245127
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002534284A Expired - Fee Related JP4199539B2 (ja) | 2000-10-09 | 2001-10-08 | Ｃｃｒ−３受容体アンタゴニストとしてのｎ−（４−アリールオキシピペリジン−１−イルアルキル）桂皮酸アミド |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7034042B2 (enExample) |
| EP (1) | EP1330436B1 (enExample) |
| JP (1) | JP4199539B2 (enExample) |
| CN (1) | CN1209351C (enExample) |
| AT (1) | ATE472533T1 (enExample) |
| AU (1) | AU2001295601A1 (enExample) |
| BR (1) | BR0114485A (enExample) |
| CA (1) | CA2423296C (enExample) |
| DE (1) | DE60142484D1 (enExample) |
| ES (1) | ES2348290T3 (enExample) |
| PT (1) | PT1330436E (enExample) |
| WO (1) | WO2002030898A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0117387D0 (en) * | 2001-07-17 | 2001-09-05 | Novartis Ag | Organic compounds |
| US7524841B2 (en) * | 2002-04-25 | 2009-04-28 | Teijin Limited | 4,4-disubstituted piperidine derivatives having CCR3 antagonism |
| ZA200803939B (en) * | 2005-11-24 | 2009-10-28 | Eisai R&D Man Co Ltd | Morpholine type cinnamide compound |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4673684A (en) | 1984-04-04 | 1987-06-16 | Terumo Corporation | Amide derivatives and 5-lipoxygenase inhibitors containing the same as an active ingredient |
| JPH0660160B2 (ja) | 1985-12-13 | 1994-08-10 | テルモ株式会社 | アミド誘導体およびこれを含有する抗アレルギ−剤 |
| JPS63139124A (ja) | 1986-12-01 | 1988-06-10 | Terumo Corp | 腎炎治療剤 |
| JPS63179869A (ja) | 1987-01-20 | 1988-07-23 | Dainippon Pharmaceut Co Ltd | ピペリジン誘導体 |
| DE19756235A1 (de) | 1997-12-17 | 1999-07-01 | Klinge Co Chem Pharm Fab | Neue piperidinylsubstituierte Pyridylalkan- alken- und -alkincarbonsäureamide |
| EE200100502A (et) | 1999-03-26 | 2002-12-16 | Astrazeneca Ab | Ühendid |
| TWI227231B (en) * | 2000-07-12 | 2005-02-01 | Novartis Ag | 4-benzoyl-piperidine derivatives for treating conditions mediated by CCR-3 |
-
2001
- 2001-10-08 US US10/398,533 patent/US7034042B2/en not_active Expired - Fee Related
- 2001-10-08 EP EP01976285A patent/EP1330436B1/en not_active Expired - Lifetime
- 2001-10-08 AT AT01976285T patent/ATE472533T1/de active
- 2001-10-08 CA CA002423296A patent/CA2423296C/en not_active Expired - Fee Related
- 2001-10-08 PT PT01976285T patent/PT1330436E/pt unknown
- 2001-10-08 AU AU2001295601A patent/AU2001295601A1/en not_active Abandoned
- 2001-10-08 WO PCT/EP2001/011627 patent/WO2002030898A1/en not_active Ceased
- 2001-10-08 CN CNB018171028A patent/CN1209351C/zh not_active Expired - Fee Related
- 2001-10-08 BR BR0114485-5A patent/BR0114485A/pt not_active IP Right Cessation
- 2001-10-08 JP JP2002534284A patent/JP4199539B2/ja not_active Expired - Fee Related
- 2001-10-08 DE DE60142484T patent/DE60142484D1/de not_active Expired - Lifetime
- 2001-10-08 ES ES01976285T patent/ES2348290T3/es not_active Expired - Lifetime
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