JP2002530378A5 - - Google Patents
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- JP2002530378A5 JP2002530378A5 JP2000583866A JP2000583866A JP2002530378A5 JP 2002530378 A5 JP2002530378 A5 JP 2002530378A5 JP 2000583866 A JP2000583866 A JP 2000583866A JP 2000583866 A JP2000583866 A JP 2000583866A JP 2002530378 A5 JP2002530378 A5 JP 2002530378A5
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- JP
- Japan
- Prior art keywords
- formula
- compound
- alkyl
- compound according
- solvate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 description 22
- 125000000217 alkyl group Chemical group 0.000 description 10
- 150000003839 salts Chemical class 0.000 description 7
- 239000012453 solvate Substances 0.000 description 7
- 125000004432 carbon atom Chemical group C* 0.000 description 5
- 229910052739 hydrogen Inorganic materials 0.000 description 5
- 239000001257 hydrogen Substances 0.000 description 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 4
- 125000003118 aryl group Chemical group 0.000 description 4
- 229910052799 carbon Inorganic materials 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 3
- 125000006652 (C3-C12) cycloalkyl group Chemical group 0.000 description 2
- 125000003342 alkenyl group Chemical group 0.000 description 2
- 125000003545 alkoxy group Chemical group 0.000 description 2
- 125000000623 heterocyclic group Chemical group 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 125000002950 monocyclic group Chemical group 0.000 description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 description 1
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 description 1
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 description 1
- GZAINRLYQOVLRP-UHFFFAOYSA-N 2-[cyano(nitro)amino]-2-oxoacetic acid Chemical compound [N+](=O)([O-])N(C(=O)C(=O)O)C#N GZAINRLYQOVLRP-UHFFFAOYSA-N 0.000 description 1
- 125000004423 acyloxy group Chemical group 0.000 description 1
- 125000003670 adamantan-2-yl group Chemical group [H]C1([H])C(C2([H])[H])([H])C([H])([H])C3([H])C([*])([H])C1([H])C([H])([H])C2([H])C3([H])[H] 0.000 description 1
- 125000003282 alkyl amino group Chemical group 0.000 description 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 description 1
- 125000004429 atom Chemical group 0.000 description 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 description 1
- 125000000753 cycloalkyl group Chemical group 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- -1 for example Chemical group 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- 125000004129 indan-1-yl group Chemical group [H]C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])C2([H])* 0.000 description 1
- 125000004130 indan-2-yl group Chemical group [H]C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])(*)C2([H])[H] 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 125000005544 phthalimido group Chemical group 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 125000003107 substituted aryl group Chemical group 0.000 description 1
- 229940124530 sulfonamide Drugs 0.000 description 1
- 150000003456 sulfonamides Chemical class 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9825554.0 | 1998-11-20 | ||
| GBGB9825554.0A GB9825554D0 (en) | 1998-11-20 | 1998-11-20 | Novel Compounds |
| PCT/EP1999/009156 WO2000031038A1 (en) | 1998-11-20 | 1999-11-22 | Quinoline derivatives as nk-2 and nk-3 receptor ligands |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002530378A JP2002530378A (ja) | 2002-09-17 |
| JP2002530378A5 true JP2002530378A5 (enExample) | 2007-01-11 |
Family
ID=10842835
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000583866A Withdrawn JP2002530378A (ja) | 1998-11-20 | 1999-11-22 | Ｎｋ−２およびｎｋ−３受容体リガンドとしてのキノリン誘導体 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6613770B1 (enExample) |
| EP (1) | EP1131294B1 (enExample) |
| JP (1) | JP2002530378A (enExample) |
| AT (1) | ATE348813T1 (enExample) |
| DE (1) | DE69934514T2 (enExample) |
| ES (1) | ES2279645T3 (enExample) |
| GB (1) | GB9825554D0 (enExample) |
| WO (1) | WO2000031038A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7037922B1 (en) | 2000-03-10 | 2006-05-02 | Neurogen Corporation | Aryl fused 2,4-disubstituted pyridines: NK3 receptor ligands |
| GB0028964D0 (en) * | 2000-11-28 | 2001-01-10 | Smithkline Beecham Spa | Novel compounds |
| TWI243164B (en) * | 2001-02-13 | 2005-11-11 | Aventis Pharma Gmbh | Acylated indanyl amines and their use as pharmaceuticals |
| EP1385839B1 (en) * | 2001-04-11 | 2006-02-22 | GlaxoSmithKline S.p.A. | 3-substituted quinoline-4-carboxamide derivatives as nk-3 and nk-2 receptor antagonists |
| GB0109122D0 (en) * | 2001-04-11 | 2001-05-30 | Smithkline Beecham Spa | Novel compounds |
| GB0515580D0 (en) | 2005-07-29 | 2005-09-07 | Merck Sharp & Dohme | Therapeutic compounds |
| US8242134B2 (en) | 2008-09-15 | 2012-08-14 | H. Lundbeck A/S | Isoquinolinone derivatives as NK3 antagonists |
| KR101638641B1 (ko) * | 2008-09-15 | 2016-07-11 | 하. 룬드벡 아크티에셀스카브 | Ｎｋ3 길항제로서의 이소퀴놀리논 유도체 |
| EP3271334A1 (de) * | 2015-03-18 | 2018-01-24 | Bayer Pharma Aktiengesellschaft | Substituierte n-bicyclo-2-arylchinolin-4-carboxamide und ihre verwendung |
| WO2017153235A1 (de) | 2016-03-09 | 2017-09-14 | Bayer Pharma Aktiengesellschaft | Substituierte n-cyclo-3-aryl-1-naphthamide und ihre verwendung |
| WO2017153234A1 (de) | 2016-03-09 | 2017-09-14 | Bayer Pharma Aktiengesellschaft | Substituierte n-cyclo-2-arylchinolin-4-carboxamide und ihre verwendung |
| WO2017153231A1 (de) | 2016-03-09 | 2017-09-14 | Bayer Pharma Aktiengesellschaft | Substituierte n-cyclo-2-arylisochinolinon-4-carboxamide und ihre verwendung |
| PE20191616A1 (es) | 2017-04-10 | 2019-11-05 | Bayer Ag | N-ariletil-2-arilquinolina-4-carboxamidas sustituidas y su uso |
| TWI770157B (zh) | 2017-04-10 | 2022-07-11 | 德商拜耳廠股份有限公司 | 經取代之n-芳基乙基-2-胺基喹啉-4-甲醯胺及其用途 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69531458T2 (de) * | 1994-05-27 | 2004-08-05 | Glaxosmithkline S.P.A. | Chinolinderivate als tachykinin nk3 rezeptor antagonisten |
| IT1270615B (it) * | 1994-07-14 | 1997-05-07 | Smithkline Beecham Farma | Uso di derivati di chinolina |
| WO1996020509A1 (en) * | 1994-12-27 | 1996-07-04 | Ballard Power Systems Inc. | Integrated external manifold assembly for an electrochemical fuel cell stack array |
| ATE289994T1 (de) * | 1995-11-24 | 2005-03-15 | Glaxosmithkline Spa | Chinolin-derivate |
| AR004735A1 (es) * | 1995-11-24 | 1999-03-10 | Smithkline Beecham Spa | Quinoleina 4-amido sustituida, un procedimiento para su preparacion, una composicion farmaceutica que los contiene y el uso de los mismos para lapreparacion de un medicamento. |
| GB9524137D0 (en) | 1995-11-24 | 1996-01-24 | Smithkline Beecham Spa | Novel compounds |
| CN1264378A (zh) | 1997-05-23 | 2000-08-23 | 史密丝克莱恩比彻姆股份公司 | 作为nk－2和nk－3受体拮抗剂的喹啉－4－甲酰胺衍生物 |
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1998
- 1998-11-20 GB GBGB9825554.0A patent/GB9825554D0/en not_active Ceased
-
1999
- 1999-11-22 DE DE69934514T patent/DE69934514T2/de not_active Expired - Fee Related
- 1999-11-22 WO PCT/EP1999/009156 patent/WO2000031038A1/en not_active Ceased
- 1999-11-22 ES ES99959340T patent/ES2279645T3/es not_active Expired - Lifetime
- 1999-11-22 EP EP99959340A patent/EP1131294B1/en not_active Expired - Lifetime
- 1999-11-22 AT AT99959340T patent/ATE348813T1/de not_active IP Right Cessation
- 1999-11-22 US US09/856,385 patent/US6613770B1/en not_active Expired - Fee Related
- 1999-11-22 JP JP2000583866A patent/JP2002530378A/ja not_active Withdrawn