JP2002530378A - Ｎｋ−２およびｎｋ−３受容体リガンドとしてのキノリン誘導体 - Google Patents
Ｎｋ−２およびｎｋ−３受容体リガンドとしてのキノリン誘導体Info
- Publication number
- JP2002530378A JP2002530378A JP2000583866A JP2000583866A JP2002530378A JP 2002530378 A JP2002530378 A JP 2002530378A JP 2000583866 A JP2000583866 A JP 2000583866A JP 2000583866 A JP2000583866 A JP 2000583866A JP 2002530378 A JP2002530378 A JP 2002530378A
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- Japan
- Prior art keywords
- formula
- compound
- alkyl
- group
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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- 108010040716 Neurokinin-3 Receptors Proteins 0.000 title abstract description 6
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- 125000000217 alkyl group Chemical group 0.000 claims abstract description 45
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
- C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9825554.0 | 1998-11-20 | ||
| GBGB9825554.0A GB9825554D0 (en) | 1998-11-20 | 1998-11-20 | Novel Compounds |
| PCT/EP1999/009156 WO2000031038A1 (en) | 1998-11-20 | 1999-11-22 | Quinoline derivatives as nk-2 and nk-3 receptor ligands |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002530378A true JP2002530378A (ja) | 2002-09-17 |
| JP2002530378A5 JP2002530378A5 (enExample) | 2007-01-11 |
Family
ID=10842835
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000583866A Withdrawn JP2002530378A (ja) | 1998-11-20 | 1999-11-22 | Ｎｋ−２およびｎｋ−３受容体リガンドとしてのキノリン誘導体 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6613770B1 (enExample) |
| EP (1) | EP1131294B1 (enExample) |
| JP (1) | JP2002530378A (enExample) |
| AT (1) | ATE348813T1 (enExample) |
| DE (1) | DE69934514T2 (enExample) |
| ES (1) | ES2279645T3 (enExample) |
| GB (1) | GB9825554D0 (enExample) |
| WO (1) | WO2000031038A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2018512404A (ja) * | 2015-03-18 | 2018-05-17 | バイエル ファーマ アクチエンゲゼルシャフト | 置換ｎ−ビシクロ−２−アリール−キノリン−４−カルボキサミドおよびその使用 |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7037922B1 (en) | 2000-03-10 | 2006-05-02 | Neurogen Corporation | Aryl fused 2,4-disubstituted pyridines: NK3 receptor ligands |
| GB0028964D0 (en) * | 2000-11-28 | 2001-01-10 | Smithkline Beecham Spa | Novel compounds |
| TWI243164B (en) * | 2001-02-13 | 2005-11-11 | Aventis Pharma Gmbh | Acylated indanyl amines and their use as pharmaceuticals |
| EP1385839B1 (en) * | 2001-04-11 | 2006-02-22 | GlaxoSmithKline S.p.A. | 3-substituted quinoline-4-carboxamide derivatives as nk-3 and nk-2 receptor antagonists |
| GB0109122D0 (en) * | 2001-04-11 | 2001-05-30 | Smithkline Beecham Spa | Novel compounds |
| GB0515580D0 (en) | 2005-07-29 | 2005-09-07 | Merck Sharp & Dohme | Therapeutic compounds |
| US8242134B2 (en) | 2008-09-15 | 2012-08-14 | H. Lundbeck A/S | Isoquinolinone derivatives as NK3 antagonists |
| KR101638641B1 (ko) * | 2008-09-15 | 2016-07-11 | 하. 룬드벡 아크티에셀스카브 | Ｎｋ3 길항제로서의 이소퀴놀리논 유도체 |
| WO2017153235A1 (de) | 2016-03-09 | 2017-09-14 | Bayer Pharma Aktiengesellschaft | Substituierte n-cyclo-3-aryl-1-naphthamide und ihre verwendung |
| WO2017153234A1 (de) | 2016-03-09 | 2017-09-14 | Bayer Pharma Aktiengesellschaft | Substituierte n-cyclo-2-arylchinolin-4-carboxamide und ihre verwendung |
| WO2017153231A1 (de) | 2016-03-09 | 2017-09-14 | Bayer Pharma Aktiengesellschaft | Substituierte n-cyclo-2-arylisochinolinon-4-carboxamide und ihre verwendung |
| PE20191616A1 (es) | 2017-04-10 | 2019-11-05 | Bayer Ag | N-ariletil-2-arilquinolina-4-carboxamidas sustituidas y su uso |
| TWI770157B (zh) | 2017-04-10 | 2022-07-11 | 德商拜耳廠股份有限公司 | 經取代之n-芳基乙基-2-胺基喹啉-4-甲醯胺及其用途 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69531458T2 (de) * | 1994-05-27 | 2004-08-05 | Glaxosmithkline S.P.A. | Chinolinderivate als tachykinin nk3 rezeptor antagonisten |
| IT1270615B (it) * | 1994-07-14 | 1997-05-07 | Smithkline Beecham Farma | Uso di derivati di chinolina |
| WO1996020509A1 (en) * | 1994-12-27 | 1996-07-04 | Ballard Power Systems Inc. | Integrated external manifold assembly for an electrochemical fuel cell stack array |
| ATE289994T1 (de) * | 1995-11-24 | 2005-03-15 | Glaxosmithkline Spa | Chinolin-derivate |
| AR004735A1 (es) * | 1995-11-24 | 1999-03-10 | Smithkline Beecham Spa | Quinoleina 4-amido sustituida, un procedimiento para su preparacion, una composicion farmaceutica que los contiene y el uso de los mismos para lapreparacion de un medicamento. |
| GB9524137D0 (en) | 1995-11-24 | 1996-01-24 | Smithkline Beecham Spa | Novel compounds |
| CN1264378A (zh) | 1997-05-23 | 2000-08-23 | 史密丝克莱恩比彻姆股份公司 | 作为nk－2和nk－3受体拮抗剂的喹啉－4－甲酰胺衍生物 |
-
1998
- 1998-11-20 GB GBGB9825554.0A patent/GB9825554D0/en not_active Ceased
-
1999
- 1999-11-22 DE DE69934514T patent/DE69934514T2/de not_active Expired - Fee Related
- 1999-11-22 WO PCT/EP1999/009156 patent/WO2000031038A1/en not_active Ceased
- 1999-11-22 ES ES99959340T patent/ES2279645T3/es not_active Expired - Lifetime
- 1999-11-22 EP EP99959340A patent/EP1131294B1/en not_active Expired - Lifetime
- 1999-11-22 AT AT99959340T patent/ATE348813T1/de not_active IP Right Cessation
- 1999-11-22 US US09/856,385 patent/US6613770B1/en not_active Expired - Fee Related
- 1999-11-22 JP JP2000583866A patent/JP2002530378A/ja not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2018512404A (ja) * | 2015-03-18 | 2018-05-17 | バイエル ファーマ アクチエンゲゼルシャフト | 置換ｎ−ビシクロ−２−アリール−キノリン−４−カルボキサミドおよびその使用 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1131294B1 (en) | 2006-12-20 |
| EP1131294A1 (en) | 2001-09-12 |
| ATE348813T1 (de) | 2007-01-15 |
| DE69934514D1 (de) | 2007-02-01 |
| ES2279645T3 (es) | 2007-08-16 |
| GB9825554D0 (en) | 1999-01-13 |
| US6613770B1 (en) | 2003-09-02 |
| DE69934514T2 (de) | 2007-05-16 |
| WO2000031038A1 (en) | 2000-06-02 |
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