BR0114485A - Amidas n-(4-ariloxipiperidin-1-ilalquil)cin micas como antagonistas de receptor de ccr33 - Google Patents

Amidas n-(4-ariloxipiperidin-1-ilalquil)cin micas como antagonistas de receptor de ccr33

Info

Publication number
BR0114485A
BR0114485A BR0114485-5A BR0114485A BR0114485A BR 0114485 A BR0114485 A BR 0114485A BR 0114485 A BR0114485 A BR 0114485A BR 0114485 A BR0114485 A BR 0114485A
Authority
BR
Brazil
Prior art keywords
sub
sup
alkyl
img
character
Prior art date
Application number
BR0114485-5A
Other languages
English (en)
Inventor
Gurdip Bhalay
Trevor John Howe
Darren Mark Le Grand
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0024675A external-priority patent/GB0024675D0/en
Priority claimed from GB0120549A external-priority patent/GB0120549D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BR0114485A publication Critical patent/BR0114485A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"AMIDAS N-(4-ARILOXIPIPERIDIN-1-ILALQUIL)CIN‰MICAS COMO ANTAGONISTAS DE RECEPTOR DE CCR33". Compostos da fórmula I na forma livre ou de sal, onde Ar^ 1^ é fenila substituída por um ou mais substituintes selecionados de halogênio, ciano, nitro, e C~ 1~-C~ 8~-alquila opcionalmente substituída por ciano ou halogênio, Ar^ 2^ é fenila ou naftila que é insubstituída ou substituída por um ou mais substituintes selecionados de halogênio, ciano, hidróxi, nitro, C~ 1~-C~ 8~alquila, C~ 1~-C~ 8~-haloalquila, C~ 1~-C~ 8~-alcóxi ou C~ 1~-C~ 8~-alcoxicarbonila, R^ 1^ é C~ 1~-C~ 8~-alquila substituída por hidróxi, C~ 1~-C~ 8~-alcóxi, acilóxi, -N(R^ 2^)R^ 3^, halogênio, carbóxi, C~ 1~-C~ 8~-alcoxicarbonila, fenil-C~ 1~-C~ 8~-alcoxicarbonila, -CON(R^ 4^)R^ 5^ ou por um grupo orgânico cíclico monovalente, R^ 2^ e R^ 3^ são, cada um, independentemente hidrogênio ou C~ 1~-C~ 8~alquila, ou R^ 2^ é hidrogênio e R^ 3^ é acila ou -SO~ 2~R^ 6^, ou R^ 2^ e R^ 3^ juntos com o átomo de nitrogênio ao qual eles estão ligados denotam um grupo heterocíclico de 5 ou 6 membros, R^ 4^ e R^ 5^ são, cada um, independentemente hidrogênio, C~ 1~-C~ 8~alquila opcionalmente substituída por hidróxi ou fenila, ou fenila opcionalmente substituída por C~ 1~-C~ 8~-alquila, halogênio, ciano ou C~ 1~-C~ 8~-alcóxi, ou R^ 4^ e R^ 5^ juntos com o átomo de nitrogênio ao qual eles estão ligados denotam um grupo heterocíclico de 5 ou 6 membros, R^ 6^ é C~ 1~-C~ 8~-alquila, C~ 1~-C~ 8~-haloalquila, ou fenila opcionalmente substituída por C~ 1~-C~ 8~-alquila, e n é 1, 2, 3 ou 4. Os compostos são úteis como farmacêuticos.
BR0114485-5A 2000-10-09 2001-10-08 Amidas n-(4-ariloxipiperidin-1-ilalquil)cin micas como antagonistas de receptor de ccr33 BR0114485A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0024675A GB0024675D0 (en) 2000-10-09 2000-10-09 Organic compounds
GB0120549A GB0120549D0 (en) 2001-08-23 2001-08-23 Organic compounds
PCT/EP2001/011627 WO2002030898A1 (en) 2000-10-09 2001-10-08 N-(4-aryloxypiperidin-1-ylalkyl) cinnamic amides as ccr33 receptor antagonists

Publications (1)

Publication Number Publication Date
BR0114485A true BR0114485A (pt) 2003-11-18

Family

ID=26245127

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0114485-5A BR0114485A (pt) 2000-10-09 2001-10-08 Amidas n-(4-ariloxipiperidin-1-ilalquil)cin micas como antagonistas de receptor de ccr33

Country Status (12)

Country Link
US (1) US7034042B2 (pt)
EP (1) EP1330436B1 (pt)
JP (1) JP4199539B2 (pt)
CN (1) CN1209351C (pt)
AT (1) ATE472533T1 (pt)
AU (1) AU2001295601A1 (pt)
BR (1) BR0114485A (pt)
CA (1) CA2423296C (pt)
DE (1) DE60142484D1 (pt)
ES (1) ES2348290T3 (pt)
PT (1) PT1330436E (pt)
WO (1) WO2002030898A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0117387D0 (en) * 2001-07-17 2001-09-05 Novartis Ag Organic compounds
JP4429738B2 (ja) * 2002-04-25 2010-03-10 帝人株式会社 Ｃｃｒ３拮抗作用を有する４，４−二置換ピペリジン誘導体
CN101312965B (zh) * 2005-11-24 2011-07-20 卫材R&D管理有限公司 吗啉型肉桂酰胺化合物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4673684A (en) * 1984-04-04 1987-06-16 Terumo Corporation Amide derivatives and 5-lipoxygenase inhibitors containing the same as an active ingredient
JPH0660160B2 (ja) * 1985-12-13 1994-08-10 テルモ株式会社 アミド誘導体およびこれを含有する抗アレルギ−剤
JPS63139124A (ja) * 1986-12-01 1988-06-10 Terumo Corp 腎炎治療剤
JPS63179869A (ja) * 1987-01-20 1988-07-23 Dainippon Pharmaceut Co Ltd ピペリジン誘導体
DE19756235A1 (de) * 1997-12-17 1999-07-01 Klinge Co Chem Pharm Fab Neue piperidinylsubstituierte Pyridylalkan- alken- und -alkincarbonsäureamide
PL350904A1 (en) 1999-03-26 2003-02-10 Astrazeneca Ab Novel compounds
TWI227231B (en) * 2000-07-12 2005-02-01 Novartis Ag 4-benzoyl-piperidine derivatives for treating conditions mediated by CCR-3

Also Published As

Publication number Publication date
ES2348290T3 (es) 2010-12-02
ATE472533T1 (de) 2010-07-15
CN1209351C (zh) 2005-07-06
EP1330436B1 (en) 2010-06-30
AU2001295601A1 (en) 2002-04-22
EP1330436A1 (en) 2003-07-30
JP2004511467A (ja) 2004-04-15
US20040087621A1 (en) 2004-05-06
JP4199539B2 (ja) 2008-12-17
CA2423296C (en) 2009-12-29
CN1468222A (zh) 2004-01-14
PT1330436E (pt) 2010-10-11
US7034042B2 (en) 2006-04-25
CA2423296A1 (en) 2002-04-18
WO2002030898A1 (en) 2002-04-18
DE60142484D1 (de) 2010-08-12

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Legal Events

Date Code Title Description
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 10A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2125 DE 27/09/2011.