JP2004507543A5 - - Google Patents
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- Publication number
- JP2004507543A5 JP2004507543A5 JP2002523898A JP2002523898A JP2004507543A5 JP 2004507543 A5 JP2004507543 A5 JP 2004507543A5 JP 2002523898 A JP2002523898 A JP 2002523898A JP 2002523898 A JP2002523898 A JP 2002523898A JP 2004507543 A5 JP2004507543 A5 JP 2004507543A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- group
- unsubstituted
- groups
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000000217 alkyl group Chemical group 0.000 claims 125
- 125000003118 aryl group Chemical group 0.000 claims 119
- 125000000623 heterocyclic group Chemical group 0.000 claims 104
- 125000004103 aminoalkyl group Chemical group 0.000 claims 37
- 150000001875 compounds Chemical class 0.000 claims 29
- 125000003277 amino group Chemical group 0.000 claims 18
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 12
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 10
- 125000000278 alkyl amino alkyl group Chemical group 0.000 claims 10
- 125000004985 dialkyl amino alkyl group Chemical group 0.000 claims 10
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 10
- 125000005128 aryl amino alkyl group Chemical group 0.000 claims 9
- 125000003545 alkoxy group Chemical group 0.000 claims 8
- 125000005160 aryl oxy alkyl group Chemical group 0.000 claims 8
- 125000004104 aryloxy group Chemical group 0.000 claims 8
- 229910052739 hydrogen Inorganic materials 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 6
- 229910052757 nitrogen Inorganic materials 0.000 claims 5
- 125000003342 alkenyl group Chemical group 0.000 claims 4
- 125000003282 alkyl amino group Chemical group 0.000 claims 4
- 125000001769 aryl amino group Chemical group 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 125000004432 carbon atom Chemical group C* 0.000 claims 4
- 125000004663 dialkyl amino group Chemical group 0.000 claims 4
- 125000004986 diarylamino group Chemical group 0.000 claims 4
- -1 guanidinyl groups Chemical group 0.000 claims 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 125000000304 alkynyl group Chemical group 0.000 claims 3
- 125000005844 heterocyclyloxy group Chemical group 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 102000009484 Vascular Endothelial Growth Factor Receptors Human genes 0.000 claims 2
- 125000003710 aryl alkyl group Chemical group 0.000 claims 2
- VILAVOFMIJHSJA-UHFFFAOYSA-N dicarbon monoxide Chemical group [C]=C=O VILAVOFMIJHSJA-UHFFFAOYSA-N 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 125000005429 oxyalkyl group Chemical group 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 125000004426 substituted alkynyl group Chemical group 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23182900P | 2000-09-01 | 2000-09-01 | |
| PCT/US2001/041942 WO2002018383A2 (en) | 2000-09-01 | 2001-08-30 | Aza heterocyclic derivatives and their therapeutic use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007131084A Division JP2007217427A (ja) | 2000-09-01 | 2007-05-16 | アザ複素環式誘導体およびその治療的使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004507543A JP2004507543A (ja) | 2004-03-11 |
| JP2004507543A5 true JP2004507543A5 (OSRAM) | 2005-03-17 |
| JP4341949B2 JP4341949B2 (ja) | 2009-10-14 |
Family
ID=22870779
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002523898A Expired - Fee Related JP4341949B2 (ja) | 2000-09-01 | 2001-08-30 | アザ複素環式誘導体およびその治療的使用 |
| JP2007131084A Pending JP2007217427A (ja) | 2000-09-01 | 2007-05-16 | アザ複素環式誘導体およびその治療的使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007131084A Pending JP2007217427A (ja) | 2000-09-01 | 2007-05-16 | アザ複素環式誘導体およびその治療的使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US6756383B2 (OSRAM) |
| EP (1) | EP1313734B1 (OSRAM) |
| JP (2) | JP4341949B2 (OSRAM) |
| AT (1) | ATE448226T1 (OSRAM) |
| AU (1) | AU2001293233A1 (OSRAM) |
| DE (1) | DE60140456D1 (OSRAM) |
| ES (1) | ES2334641T3 (OSRAM) |
| PT (1) | PT1313734E (OSRAM) |
| WO (1) | WO2002018383A2 (OSRAM) |
Families Citing this family (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4341949B2 (ja) | 2000-09-01 | 2009-10-14 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | アザ複素環式誘導体およびその治療的使用 |
| JP4361727B2 (ja) * | 2000-09-11 | 2009-11-11 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | チロシンキナーゼインヒビターとしてのキノリノン誘導体 |
| US20030028018A1 (en) * | 2000-09-11 | 2003-02-06 | Chiron Coporation | Quinolinone derivatives |
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| US7064215B2 (en) * | 2001-07-03 | 2006-06-20 | Chiron Corporation | Indazole benzimidazole compounds |
| CA2496164C (en) * | 2002-08-23 | 2010-11-09 | Chiron Corporation | Benzimidazole quinolinones and uses thereof |
| US7825132B2 (en) * | 2002-08-23 | 2010-11-02 | Novartis Vaccines And Diagnostics, Inc. | Inhibition of FGFR3 and treatment of multiple myeloma |
| CN100526312C (zh) * | 2002-08-23 | 2009-08-12 | 诺华疫苗和诊断公司 | 苯并咪唑喹啉酮及其应用 |
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| CA2501932C (en) * | 2002-11-13 | 2014-03-11 | Chiron Corporation | Use of benzimidazole quinolinones for treating cancer |
| WO2004063151A2 (en) * | 2003-01-03 | 2004-07-29 | Bristol-Myers Squibb Company | Novel tyrosine kinase inhibitors |
| US7329678B2 (en) * | 2003-01-28 | 2008-02-12 | Smithkline Beecham Corporation | Chemical compounds |
| EP2258365B1 (en) | 2003-03-28 | 2013-05-29 | Novartis Vaccines and Diagnostics, Inc. | Use of organic compounds for immunopotentiation |
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| FR2862969A1 (fr) * | 2003-11-28 | 2005-06-03 | Oreal | Procede de preparation de derives paraphenylenediamine a groupement pyrrolidinyle, substitue par un radical azote, et composes intermediaires |
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| US20060183750A1 (en) * | 2005-01-27 | 2006-08-17 | Chiron Corporation | Treatment of metastasized tumors |
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| SI2351772T1 (sl) | 2005-02-18 | 2016-11-30 | Glaxosmithkline Biologicals Sa | Proteini in nukleinske kisline iz Escherichia coli povezane z meningitisom/sepso |
| US7534796B2 (en) | 2005-02-18 | 2009-05-19 | Wyeth | Imidazo[4,5-b]pyridine antagonists of gonadotropin releasing hormone receptor |
| JP2008530245A (ja) | 2005-02-18 | 2008-08-07 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス, インコーポレイテッド | 尿路病原性菌株由来の抗原 |
| US7582634B2 (en) | 2005-02-18 | 2009-09-01 | Wyeth | 7-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor |
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| US7531542B2 (en) | 2005-05-18 | 2009-05-12 | Wyeth | Benzooxazole and benzothiazole antagonists of gonadotropin releasing hormone receptor |
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| US7582636B2 (en) | 2005-05-26 | 2009-09-01 | Wyeth | Piperazinylimidazopyridine and piperazinyltriazolopyridine antagonists of Gonadotropin Releasing Hormone receptor |
| EP1909564A4 (en) | 2005-07-18 | 2010-06-30 | Novartis Ag | SMALL ANIMAL MODEL FOR HCV REPLICATION |
| US7915286B2 (en) | 2005-09-16 | 2011-03-29 | Ranbaxy Laboratories Limited | Substituted pyrazolo [3,4-b] pyridines as phosphodiesterase inhibitors |
| PL2368572T3 (pl) | 2005-11-04 | 2020-11-16 | Seqirus UK Limited | Szczepionki z adjuwantem z niewirionowymi antygenami otrzymane z wirusów grypy hodowanych w hodowli komórkowej |
| ES2377884T3 (es) | 2005-11-04 | 2012-04-02 | Novartis Vaccines And Diagnostics S.R.L. | Vacunas contra la gripe que incluyen combinaciones de adyuvantes particulados e inmunopotenciadores |
| NZ567979A (en) | 2005-11-04 | 2012-02-24 | Novartis Vaccines & Diagnostic | Adjuvanted influenza vaccines including a cytokine-inducing agents which is an agonist of Toll-Like Receptor 7 |
| WO2007052155A2 (en) | 2005-11-04 | 2007-05-10 | Novartis Vaccines And Diagnostics Srl | Influenza vaccine with reduced amount of oil-in-water emulsion as adjuvant |
| BRPI0619370A2 (pt) | 2005-11-29 | 2011-09-27 | Novartis Ag | formulações de quinolinonas |
| EP2546359A1 (en) | 2005-12-08 | 2013-01-16 | Novartis AG | Effects of inhibitors of FGFR3 on gene transcription |
| BR122019013216B8 (pt) | 2006-01-27 | 2021-07-27 | Seqirus Uk Ltd | ensaio imunológico para análise de uma vacina contra influenza |
| WO2007109813A1 (en) | 2006-03-23 | 2007-09-27 | Novartis Ag | Imidazoquinoxaline compounds as immunomodulators |
| JP2009534303A (ja) | 2006-03-24 | 2009-09-24 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス ゲーエムベーハー アンド カンパニー カーゲー | 冷蔵しないインフルエンザワクチンの保存 |
| US20100285062A1 (en) | 2006-03-31 | 2010-11-11 | Novartis Ag | Combined mucosal and parenteral immunization against hiv |
| ATE522541T1 (de) | 2006-06-09 | 2011-09-15 | Novartis Ag | Bakterielle adhäsine konformere |
| GB0614471D0 (en) | 2006-07-20 | 2006-08-30 | Syngenta Ltd | Herbicidal Compounds |
| GB0614460D0 (en) | 2006-07-20 | 2006-08-30 | Novartis Ag | Vaccines |
| EP2586790A3 (en) | 2006-08-16 | 2013-08-14 | Novartis AG | Immunogens from uropathogenic Escherichia coli |
| EP3456348B1 (en) | 2006-09-11 | 2025-03-26 | Seqirus UK Limited | Making influenza virus vaccines without using eggs |
| PL2121011T3 (pl) | 2006-12-06 | 2014-10-31 | Novartis Ag | Szczepionki zawierające antygeny czterech szczepów wirusa grypy |
| GB0700562D0 (en) | 2007-01-11 | 2007-02-21 | Novartis Vaccines & Diagnostic | Modified Saccharides |
| CN101784283A (zh) | 2007-06-27 | 2010-07-21 | 诺华有限公司 | 低添加流感疫苗 |
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| GB0818453D0 (en) | 2008-10-08 | 2008-11-12 | Novartis Ag | Fermentation processes for cultivating streptococci and purification processes for obtaining cps therefrom |
| GB0800855D0 (en) * | 2008-01-17 | 2008-02-27 | Syngenta Ltd | Herbicidal compounds |
| EP2268309B1 (en) | 2008-03-18 | 2015-01-21 | Novartis AG | Improvements in preparation of influenza virus vaccine antigens |
| CN102438650A (zh) | 2009-03-06 | 2012-05-02 | 诺华有限公司 | 衣原体抗原 |
| NZ612315A (en) | 2009-04-14 | 2014-10-31 | Novartis Ag | Compositions for immunising against staphylococcus aureus |
| FR2949344A1 (fr) | 2009-04-27 | 2011-03-04 | Novartis Ag | Vaccins de protection contre la grippe |
| ES2662716T3 (es) | 2009-07-07 | 2018-04-09 | Glaxosmithkline Biologicals Sa | Inmunógenos conservados de Escherichia coli |
| TW201116294A (en) | 2009-07-15 | 2011-05-16 | Novartis Ag | RSV F protein compositions and methods for making same |
| SI2464658T1 (sl) | 2009-07-16 | 2015-02-27 | Novartis Ag | Detoksificirani imunogeni escherichie coli |
| GB0918392D0 (en) | 2009-10-20 | 2009-12-02 | Novartis Ag | Diagnostic and therapeutic methods |
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| AU2012267556B9 (en) * | 2011-06-09 | 2017-05-11 | Rhizen Pharmaceuticals Sa | Novel compounds as modulators of GPR-119 |
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| WO2013068949A1 (en) | 2011-11-07 | 2013-05-16 | Novartis Ag | Carrier molecule comprising a spr0096 and a spr2021 antigen |
| WO2013108272A2 (en) | 2012-01-20 | 2013-07-25 | International Centre For Genetic Engineering And Biotechnology | Blood stage malaria vaccine |
| CA2885625A1 (en) | 2012-10-02 | 2014-04-10 | Glaxosmithkline Biologicals S.A. | Nonlinear saccharide conjugates |
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| EP2977374A1 (en) | 2014-07-21 | 2016-01-27 | Université de Strasbourg | Molecules presenting dual emission properties |
| ES2872555T3 (es) * | 2015-06-25 | 2021-11-02 | Univ Health Network | Inhibidores de HPK1 y métodos de uso de los mismos |
| CN107935858B (zh) * | 2016-10-12 | 2020-09-08 | 利尔化学股份有限公司 | 5-氟-2-硝基苯酚的制备方法 |
| CN111655690B (zh) * | 2017-11-24 | 2023-01-10 | 詹森药业有限公司 | 吡唑并吡啶酮化合物 |
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| CN113227100B (zh) | 2018-12-26 | 2023-05-05 | 詹森药业有限公司 | 噻吩并吡啶酮化合物 |
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-
2001
- 2001-08-30 JP JP2002523898A patent/JP4341949B2/ja not_active Expired - Fee Related
- 2001-08-30 AU AU2001293233A patent/AU2001293233A1/en not_active Abandoned
- 2001-08-30 US US09/943,382 patent/US6756383B2/en not_active Expired - Fee Related
- 2001-08-30 ES ES01973678T patent/ES2334641T3/es not_active Expired - Lifetime
- 2001-08-30 PT PT01973678T patent/PT1313734E/pt unknown
- 2001-08-30 AT AT01973678T patent/ATE448226T1/de not_active IP Right Cessation
- 2001-08-30 EP EP01973678A patent/EP1313734B1/en not_active Expired - Lifetime
- 2001-08-30 DE DE60140456T patent/DE60140456D1/de not_active Expired - Lifetime
- 2001-08-30 WO PCT/US2001/041942 patent/WO2002018383A2/en not_active Ceased
-
2003
- 2003-06-02 US US10/452,786 patent/US6759417B2/en not_active Expired - Fee Related
-
2004
- 2004-04-14 US US10/823,995 patent/US7138409B2/en not_active Expired - Fee Related
-
2006
- 2006-10-11 US US11/546,814 patent/US7368459B2/en not_active Expired - Fee Related
-
2007
- 2007-05-16 JP JP2007131084A patent/JP2007217427A/ja active Pending
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