JP2004507518A - N−アリール−アントラニル酸及びその誘導体の製造法 - Google Patents
N−アリール−アントラニル酸及びその誘導体の製造法 Download PDFInfo
- Publication number
- JP2004507518A JP2004507518A JP2002523437A JP2002523437A JP2004507518A JP 2004507518 A JP2004507518 A JP 2004507518A JP 2002523437 A JP2002523437 A JP 2002523437A JP 2002523437 A JP2002523437 A JP 2002523437A JP 2004507518 A JP2004507518 A JP 2004507518A
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- formula
- compound
- hydrogen
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 *c(cc1)cc(*)c1Nc1c(*)cc(*)c(F)c1F Chemical compound *c(cc1)cc(*)c1Nc1c(*)cc(*)c(F)c1F 0.000 description 13
- SGNNATAAVMUZEQ-UHFFFAOYSA-N O=C(c(ccc(F)c1F)c1NC(C=CC(C1)I)=C1Cl)NOCC1CC1 Chemical compound O=C(c(ccc(F)c1F)c1NC(C=CC(C1)I)=C1Cl)NOCC1CC1 SGNNATAAVMUZEQ-UHFFFAOYSA-N 0.000 description 1
- ZEGFMCQPAMLDCS-UHFFFAOYSA-N OC(c(cccc1)c1N(c1ccccc1)c1ccccc1)=O Chemical compound OC(c(cccc1)c1N(c1ccccc1)c1ccccc1)=O ZEGFMCQPAMLDCS-UHFFFAOYSA-N 0.000 description 1
- CQRWVZZXBUOVEA-UHFFFAOYSA-N OC(c1ccccc1N1c2ccccc2CC1)=O Chemical compound OC(c1ccccc1N1c2ccccc2CC1)=O CQRWVZZXBUOVEA-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/10—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
- C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
- C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22820600P | 2000-08-25 | 2000-08-25 | |
PCT/US2001/022948 WO2002018319A1 (en) | 2000-08-25 | 2001-07-20 | Process for making n-aryl-anthranilic acids and their derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2004507518A true JP2004507518A (ja) | 2004-03-11 |
Family
ID=22856235
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2002523437A Pending JP2004507518A (ja) | 2000-08-25 | 2001-07-20 | N−アリール−アントラニル酸及びその誘導体の製造法 |
Country Status (31)
Country | Link |
---|---|
EP (1) | EP1313694A1 (zh) |
JP (1) | JP2004507518A (zh) |
KR (1) | KR20030059115A (zh) |
CN (1) | CN1458921A (zh) |
AP (1) | AP2001002249A0 (zh) |
AR (1) | AR032175A1 (zh) |
AU (1) | AU2001277044A1 (zh) |
BG (1) | BG107635A (zh) |
BR (1) | BR0113520A (zh) |
CA (1) | CA2420003A1 (zh) |
CZ (1) | CZ2003477A3 (zh) |
DO (1) | DOP2001000238A (zh) |
EA (1) | EA200300187A1 (zh) |
GT (1) | GT200100174A (zh) |
HN (1) | HN2001000216A (zh) |
HU (1) | HUP0300828A2 (zh) |
IL (1) | IL154507A0 (zh) |
IS (1) | IS6724A (zh) |
MA (1) | MA26949A1 (zh) |
MX (1) | MXPA03001654A (zh) |
NO (1) | NO20030844L (zh) |
PA (1) | PA8526501A1 (zh) |
PE (1) | PE20020393A1 (zh) |
PL (1) | PL360699A1 (zh) |
SK (1) | SK2072003A3 (zh) |
SV (1) | SV2002000601A (zh) |
TN (1) | TNSN01127A1 (zh) |
UY (1) | UY26908A1 (zh) |
WO (1) | WO2002018319A1 (zh) |
YU (1) | YU14303A (zh) |
ZA (1) | ZA200301182B (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2013519715A (ja) * | 2010-02-19 | 2013-05-30 | センター ナショナル デ ラ リシェルシェ サイエンティフィック | 少なくとも1つの電子求引性基を有する芳香族カルボン酸誘導体の芳香族求核置換による目的の化学化合物の調製方法 |
JP2013519714A (ja) * | 2010-02-19 | 2013-05-30 | センター ナショナル デ ラ リシェルシェ サイエンティフィック | 芳香族求核置換によって目的の化学化合物を調製するための方法 |
JP2015533175A (ja) * | 2012-10-12 | 2015-11-19 | エグゼリクシス, インコーポレイテッド | 癌の処置に使用するための化合物の製造方法 |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100984613B1 (ko) | 2002-03-13 | 2010-09-30 | 어레이 바이오파마 인크. | Mek 억제제로서의 n3 알킬화 벤즈이미다졸 유도체 |
US7235537B2 (en) | 2002-03-13 | 2007-06-26 | Array Biopharma, Inc. | N3 alkylated benzimidazole derivatives as MEK inhibitors |
US7144907B2 (en) | 2003-09-03 | 2006-12-05 | Array Biopharma Inc. | Heterocyclic inhibitors of MEK and methods of use thereof |
US7538120B2 (en) | 2003-09-03 | 2009-05-26 | Array Biopharma Inc. | Method of treating inflammatory diseases |
NZ546011A (en) | 2003-10-21 | 2009-09-25 | Warner Lambert Co | Polymorphic form of N-[(R)-2,3-dihydroxy-propoxy]-3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-benzamide |
US7517994B2 (en) | 2003-11-19 | 2009-04-14 | Array Biopharma Inc. | Heterocyclic inhibitors of MEK and methods of use thereof |
EP1689387B1 (en) | 2003-11-19 | 2011-09-14 | Array Biopharma, Inc. | Bicyclic inhibitors of mek and methods of synthesis thereof |
US7732616B2 (en) | 2003-11-19 | 2010-06-08 | Array Biopharma Inc. | Dihydropyridine and dihydropyridazine derivatives as inhibitors of MEK and methods of use thereof |
RU2006121990A (ru) | 2003-11-21 | 2007-12-27 | Эррэй Биофарма Инк. (Us) | Ингибиторы протеинкиназ акт |
UA89035C2 (ru) * | 2003-12-03 | 2009-12-25 | Лео Фарма А/С | Эфиры гидроксамовых кислот и их фармацевтическое применение |
MX2007012659A (es) | 2005-04-13 | 2008-01-11 | Astex Therapeutics Ltd | Derivados de hidroxi-benzamida y su uso como inhibidores de hsp90. |
ES2405785T3 (es) | 2005-05-18 | 2013-06-03 | Array Biopharma Inc. | Inhibidores heterocíclicos de MEK y métodos de uso de los mismos |
US7754725B2 (en) | 2006-03-01 | 2010-07-13 | Astex Therapeutics Ltd. | Dihydroxyphenyl isoindolymethanones |
US8063050B2 (en) | 2006-07-06 | 2011-11-22 | Array Biopharma Inc. | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
CN101511842B (zh) | 2006-07-06 | 2012-10-31 | 阵列生物制药公司 | 作为akt蛋白激酶抑制剂的二氢呋喃并嘧啶 |
AU2007269052B2 (en) | 2006-07-06 | 2014-10-23 | Array Biopharma Inc. | Cyclopenta [D] pyrimidines as AKT protein kinase inhibitors |
DK2054418T3 (da) | 2006-07-06 | 2012-02-27 | Array Biopharma Inc | Dihydrothieno-pyrimidiner som AKT-proteinkinase-inhibitorer |
JP5410285B2 (ja) | 2006-10-12 | 2014-02-05 | アステックス、セラピューティックス、リミテッド | 医薬化合物 |
WO2008044029A1 (en) | 2006-10-12 | 2008-04-17 | Astex Therapeutics Limited | Pharmaceutical combinations |
EP2073804B1 (en) | 2006-10-12 | 2017-09-13 | Astex Therapeutics Limited | Hydroxy-substituted benzoic acid amide compounds for use in the treatment of pain |
GB0620259D0 (en) | 2006-10-12 | 2006-11-22 | Astex Therapeutics Ltd | Pharmaceutical compounds |
EP2073807A1 (en) | 2006-10-12 | 2009-07-01 | Astex Therapeutics Limited | Pharmaceutical combinations |
US8916552B2 (en) | 2006-10-12 | 2014-12-23 | Astex Therapeutics Limited | Pharmaceutical combinations |
US9409886B2 (en) | 2007-07-05 | 2016-08-09 | Array Biopharma Inc. | Pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
US8846683B2 (en) | 2007-07-05 | 2014-09-30 | Array Biopharma, Inc. | Pyrimidyl cyclopentanes as Akt protein kinase inhibitors |
ES2533557T3 (es) | 2007-07-05 | 2015-04-13 | Array Biopharma, Inc. | Pirimidil ciclopentanos como inhibidores de proteína cinasa AKT |
KR20150089099A (ko) | 2007-07-05 | 2015-08-04 | 어레이 바이오파마 인크. | Akt 단백질 키나제 억제제로서의 피리미딜 시클로펜탄 |
US8853216B2 (en) | 2008-01-09 | 2014-10-07 | Array Biopharma, Inc. | Hydroxylated pyrimidyl cyclopentane as AKT protein kinase inhibitor |
NZ586346A (en) | 2008-01-09 | 2012-02-24 | Array Biopharma Inc | Hydroxylated pyrimidyl cyclopentanes as akt protein kinase inhibitors |
GB0806527D0 (en) | 2008-04-11 | 2008-05-14 | Astex Therapeutics Ltd | Pharmaceutical compounds |
CN101985428B (zh) * | 2009-07-29 | 2014-02-12 | 杭州民生药业有限公司 | 邻苯胺基苯甲酸衍生物或其药学上可接受的盐、其制备方法及其用途 |
CN104586861A (zh) | 2011-04-01 | 2015-05-06 | 基因泰克公司 | Akt抑制剂化合物和阿比特龙的组合及使用方法 |
CN103841976A (zh) | 2011-04-01 | 2014-06-04 | 基因泰克公司 | Akt和mek抑制剂化合物的组合及其使用方法 |
CN112745237B (zh) * | 2019-10-29 | 2023-06-20 | 中国科学院上海药物研究所 | 2-芳基胺类化合物及其制备方法和应用 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3138636A (en) * | 1960-06-23 | 1964-06-23 | Parke Davis & Co | Anthranilic acid derivatives |
AU5610398A (en) * | 1997-02-28 | 1998-09-18 | Warner-Lambert Company | Method of treating or preventing septic shock by administering a mek inhibitor |
ATE344791T1 (de) * | 1997-07-01 | 2006-11-15 | Warner Lambert Co | 2-(4-brom or 4-iod phenylamino)benzoesäurederivate und ihre anwendung als mek-inhibitoren |
ATE277895T1 (de) * | 1997-07-01 | 2004-10-15 | Warner Lambert Co | 4-brom or 4-iod-phenylamino- benzhydroxamsäurederivate und ihre anwendung als mek-inhibitoren |
CA2348236A1 (en) * | 1999-01-13 | 2000-07-20 | Stephen Douglas Barrett | 4-arylamino, 4-aryloxy, and 4-arylthio diarylamines and derivatives thereof as selective mek inhibitors |
IL146056A0 (en) * | 1999-04-21 | 2002-07-25 | Warner Lambert Co | Method for making 2- (n-phenylamino) benzoic acids |
-
2001
- 2001-07-20 YU YU14303A patent/YU14303A/sh unknown
- 2001-07-20 AP APAP/P/2001/002249A patent/AP2001002249A0/en unknown
- 2001-07-20 HU HU0300828A patent/HUP0300828A2/hu unknown
- 2001-07-20 SK SK207-2003A patent/SK2072003A3/sk unknown
- 2001-07-20 JP JP2002523437A patent/JP2004507518A/ja active Pending
- 2001-07-20 MX MXPA03001654A patent/MXPA03001654A/es unknown
- 2001-07-20 CA CA002420003A patent/CA2420003A1/en not_active Abandoned
- 2001-07-20 PL PL36069901A patent/PL360699A1/xx unknown
- 2001-07-20 CZ CZ2003477A patent/CZ2003477A3/cs unknown
- 2001-07-20 CN CN01815869A patent/CN1458921A/zh active Pending
- 2001-07-20 AU AU2001277044A patent/AU2001277044A1/en not_active Abandoned
- 2001-07-20 BR BR0113520-1A patent/BR0113520A/pt not_active Application Discontinuation
- 2001-07-20 WO PCT/US2001/022948 patent/WO2002018319A1/en not_active Application Discontinuation
- 2001-07-20 EA EA200300187A patent/EA200300187A1/ru unknown
- 2001-07-20 KR KR10-2003-7002675A patent/KR20030059115A/ko not_active Application Discontinuation
- 2001-07-20 IL IL15450701A patent/IL154507A0/xx unknown
- 2001-07-20 EP EP01954824A patent/EP1313694A1/en not_active Withdrawn
- 2001-08-15 SV SV2001000601A patent/SV2002000601A/es not_active Application Discontinuation
- 2001-08-22 TN TNTNSN01127A patent/TNSN01127A1/en unknown
- 2001-08-23 PA PA20018526501A patent/PA8526501A1/es unknown
- 2001-08-24 GT GT200100174A patent/GT200100174A/es unknown
- 2001-08-24 PE PE2001000853A patent/PE20020393A1/es not_active Application Discontinuation
- 2001-08-24 DO DO2001000238A patent/DOP2001000238A/es unknown
- 2001-08-24 UY UY26908A patent/UY26908A1/es not_active Application Discontinuation
- 2001-08-24 AR ARP010104047A patent/AR032175A1/es unknown
- 2001-09-26 HN HN2001000216A patent/HN2001000216A/es unknown
-
2003
- 2003-02-12 ZA ZA200301182A patent/ZA200301182B/en unknown
- 2003-02-20 IS IS6724A patent/IS6724A/is unknown
- 2003-02-24 NO NO20030844A patent/NO20030844L/no not_active Application Discontinuation
- 2003-03-13 BG BG107635A patent/BG107635A/bg unknown
- 2003-03-14 MA MA27069A patent/MA26949A1/fr unknown
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2013519715A (ja) * | 2010-02-19 | 2013-05-30 | センター ナショナル デ ラ リシェルシェ サイエンティフィック | 少なくとも1つの電子求引性基を有する芳香族カルボン酸誘導体の芳香族求核置換による目的の化学化合物の調製方法 |
JP2013519714A (ja) * | 2010-02-19 | 2013-05-30 | センター ナショナル デ ラ リシェルシェ サイエンティフィック | 芳香族求核置換によって目的の化学化合物を調製するための方法 |
JP2015533175A (ja) * | 2012-10-12 | 2015-11-19 | エグゼリクシス, インコーポレイテッド | 癌の処置に使用するための化合物の製造方法 |
Also Published As
Publication number | Publication date |
---|---|
PL360699A1 (en) | 2004-09-20 |
WO2002018319A1 (en) | 2002-03-07 |
SV2002000601A (es) | 2002-04-03 |
GT200100174A (es) | 2002-07-18 |
BR0113520A (pt) | 2003-06-24 |
CZ2003477A3 (cs) | 2003-10-15 |
AP2001002249A0 (en) | 2001-09-30 |
HUP0300828A2 (hu) | 2003-09-29 |
EP1313694A1 (en) | 2003-05-28 |
TNSN01127A1 (en) | 2005-11-10 |
UY26908A1 (es) | 2001-11-30 |
MA26949A1 (fr) | 2004-12-20 |
SK2072003A3 (en) | 2004-01-08 |
KR20030059115A (ko) | 2003-07-07 |
PE20020393A1 (es) | 2002-05-09 |
HN2001000216A (es) | 2002-05-22 |
NO20030844D0 (no) | 2003-02-24 |
IS6724A (is) | 2003-02-20 |
ZA200301182B (en) | 2004-05-12 |
PA8526501A1 (es) | 2002-07-30 |
CN1458921A (zh) | 2003-11-26 |
IL154507A0 (en) | 2003-09-17 |
CA2420003A1 (en) | 2002-03-07 |
BG107635A (bg) | 2004-09-30 |
EA200300187A1 (ru) | 2003-08-28 |
DOP2001000238A (es) | 2003-01-31 |
MXPA03001654A (es) | 2004-09-10 |
YU14303A (sh) | 2006-08-17 |
AR032175A1 (es) | 2003-10-29 |
AU2001277044A1 (en) | 2002-03-13 |
NO20030844L (no) | 2003-02-25 |
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