CZ2003477A3 - Způsob přípravy N-aryl-anthranilových kyselin a jejich derivátů - Google Patents

Způsob přípravy N-aryl-anthranilových kyselin a jejich derivátů Download PDF

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Publication number
CZ2003477A3
CZ2003477A3 CZ2003477A CZ2003477A CZ2003477A3 CZ 2003477 A3 CZ2003477 A3 CZ 2003477A3 CZ 2003477 A CZ2003477 A CZ 2003477A CZ 2003477 A CZ2003477 A CZ 2003477A CZ 2003477 A3 CZ2003477 A3 CZ 2003477A3
Authority
CZ
Czechia
Prior art keywords
compound
formula
alkyl
hydrogen
pharmaceutically acceptable
Prior art date
Application number
CZ2003477A
Other languages
Czech (cs)
English (en)
Inventor
Michael Huai Gu Chen
Edward Mark Davis
Javier Magano
Thomas Norman Nanninga
Derick Dale Winkle
Original Assignee
Warner - Lambert Company Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner - Lambert Company Llc filed Critical Warner - Lambert Company Llc
Publication of CZ2003477A3 publication Critical patent/CZ2003477A3/cs

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/10—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
    • C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Indole Compounds (AREA)
CZ2003477A 2000-08-25 2001-07-20 Způsob přípravy N-aryl-anthranilových kyselin a jejich derivátů CZ2003477A3 (cs)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US22820600P 2000-08-25 2000-08-25

Publications (1)

Publication Number Publication Date
CZ2003477A3 true CZ2003477A3 (cs) 2003-10-15

Family

ID=22856235

Family Applications (1)

Application Number Title Priority Date Filing Date
CZ2003477A CZ2003477A3 (cs) 2000-08-25 2001-07-20 Způsob přípravy N-aryl-anthranilových kyselin a jejich derivátů

Country Status (31)

Country Link
EP (1) EP1313694A1 (zh)
JP (1) JP2004507518A (zh)
KR (1) KR20030059115A (zh)
CN (1) CN1458921A (zh)
AP (1) AP2001002249A0 (zh)
AR (1) AR032175A1 (zh)
AU (1) AU2001277044A1 (zh)
BG (1) BG107635A (zh)
BR (1) BR0113520A (zh)
CA (1) CA2420003A1 (zh)
CZ (1) CZ2003477A3 (zh)
DO (1) DOP2001000238A (zh)
EA (1) EA200300187A1 (zh)
GT (1) GT200100174A (zh)
HN (1) HN2001000216A (zh)
HU (1) HUP0300828A2 (zh)
IL (1) IL154507A0 (zh)
IS (1) IS6724A (zh)
MA (1) MA26949A1 (zh)
MX (1) MXPA03001654A (zh)
NO (1) NO20030844L (zh)
PA (1) PA8526501A1 (zh)
PE (1) PE20020393A1 (zh)
PL (1) PL360699A1 (zh)
SK (1) SK2072003A3 (zh)
SV (1) SV2002000601A (zh)
TN (1) TNSN01127A1 (zh)
UY (1) UY26908A1 (zh)
WO (1) WO2002018319A1 (zh)
YU (1) YU14303A (zh)
ZA (1) ZA200301182B (zh)

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KR100984613B1 (ko) 2002-03-13 2010-09-30 어레이 바이오파마 인크. Ｍｅｋ 억제제로서의 ｎ3 알킬화 벤즈이미다졸 유도체
US7235537B2 (en) 2002-03-13 2007-06-26 Array Biopharma, Inc. N3 alkylated benzimidazole derivatives as MEK inhibitors
US7144907B2 (en) 2003-09-03 2006-12-05 Array Biopharma Inc. Heterocyclic inhibitors of MEK and methods of use thereof
US7538120B2 (en) 2003-09-03 2009-05-26 Array Biopharma Inc. Method of treating inflammatory diseases
NZ546011A (en) 2003-10-21 2009-09-25 Warner Lambert Co Polymorphic form of N-[(R)-2,3-dihydroxy-propoxy]-3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-benzamide
US7517994B2 (en) 2003-11-19 2009-04-14 Array Biopharma Inc. Heterocyclic inhibitors of MEK and methods of use thereof
EP1689387B1 (en) 2003-11-19 2011-09-14 Array Biopharma, Inc. Bicyclic inhibitors of mek and methods of synthesis thereof
US7732616B2 (en) 2003-11-19 2010-06-08 Array Biopharma Inc. Dihydropyridine and dihydropyridazine derivatives as inhibitors of MEK and methods of use thereof
RU2006121990A (ru) 2003-11-21 2007-12-27 Эррэй Биофарма Инк. (Us) Ингибиторы протеинкиназ акт
UA89035C2 (ru) * 2003-12-03 2009-12-25 Лео Фарма А/С Эфиры гидроксамовых кислот и их фармацевтическое применение
MX2007012659A (es) 2005-04-13 2008-01-11 Astex Therapeutics Ltd Derivados de hidroxi-benzamida y su uso como inhibidores de hsp90.
ES2405785T3 (es) 2005-05-18 2013-06-03 Array Biopharma Inc. Inhibidores heterocíclicos de MEK y métodos de uso de los mismos
US7754725B2 (en) 2006-03-01 2010-07-13 Astex Therapeutics Ltd. Dihydroxyphenyl isoindolymethanones
US8063050B2 (en) 2006-07-06 2011-11-22 Array Biopharma Inc. Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
CN101511842B (zh) 2006-07-06 2012-10-31 阵列生物制药公司 作为akt蛋白激酶抑制剂的二氢呋喃并嘧啶
AU2007269052B2 (en) 2006-07-06 2014-10-23 Array Biopharma Inc. Cyclopenta [D] pyrimidines as AKT protein kinase inhibitors
DK2054418T3 (da) 2006-07-06 2012-02-27 Array Biopharma Inc Dihydrothieno-pyrimidiner som AKT-proteinkinase-inhibitorer
JP5410285B2 (ja) 2006-10-12 2014-02-05 アステックス、セラピューティックス、リミテッド 医薬化合物
WO2008044029A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
EP2073804B1 (en) 2006-10-12 2017-09-13 Astex Therapeutics Limited Hydroxy-substituted benzoic acid amide compounds for use in the treatment of pain
GB0620259D0 (en) 2006-10-12 2006-11-22 Astex Therapeutics Ltd Pharmaceutical compounds
EP2073807A1 (en) 2006-10-12 2009-07-01 Astex Therapeutics Limited Pharmaceutical combinations
US8916552B2 (en) 2006-10-12 2014-12-23 Astex Therapeutics Limited Pharmaceutical combinations
US9409886B2 (en) 2007-07-05 2016-08-09 Array Biopharma Inc. Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
US8846683B2 (en) 2007-07-05 2014-09-30 Array Biopharma, Inc. Pyrimidyl cyclopentanes as Akt protein kinase inhibitors
ES2533557T3 (es) 2007-07-05 2015-04-13 Array Biopharma, Inc. Pirimidil ciclopentanos como inhibidores de proteína cinasa AKT
KR20150089099A (ko) 2007-07-05 2015-08-04 어레이 바이오파마 인크. Ａｋｔ 단백질 키나제 억제제로서의 피리미딜 시클로펜탄
US8853216B2 (en) 2008-01-09 2014-10-07 Array Biopharma, Inc. Hydroxylated pyrimidyl cyclopentane as AKT protein kinase inhibitor
NZ586346A (en) 2008-01-09 2012-02-24 Array Biopharma Inc Hydroxylated pyrimidyl cyclopentanes as akt protein kinase inhibitors
GB0806527D0 (en) 2008-04-11 2008-05-14 Astex Therapeutics Ltd Pharmaceutical compounds
CN101985428B (zh) * 2009-07-29 2014-02-12 杭州民生药业有限公司 邻苯胺基苯甲酸衍生物或其药学上可接受的盐、其制备方法及其用途
CA2789361A1 (en) * 2010-02-19 2011-08-25 Jacques Mortier Method for preparing chemical compounds of interest by aromatic nucleophilic substitution
EP2536682A1 (fr) * 2010-02-19 2012-12-26 Centre National De La Recherche Scientifique Procede de preparation de composes chimiques d'interet par substitution nucleophile aromatique de derives d'acides carboxyliques aromatiques portant au moins un groupement electroattracteur
CN104586861A (zh) 2011-04-01 2015-05-06 基因泰克公司 Akt抑制剂化合物和阿比特龙的组合及使用方法
CN103841976A (zh) 2011-04-01 2014-06-04 基因泰克公司 Akt和mek抑制剂化合物的组合及其使用方法
GEP201706690B (en) * 2012-10-12 2017-06-26 Exelixis Inc Novel process for making compounds for use in treatment of cancer
CN112745237B (zh) * 2019-10-29 2023-06-20 中国科学院上海药物研究所 2-芳基胺类化合物及其制备方法和应用

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US3138636A (en) * 1960-06-23 1964-06-23 Parke Davis & Co Anthranilic acid derivatives
AU5610398A (en) * 1997-02-28 1998-09-18 Warner-Lambert Company Method of treating or preventing septic shock by administering a mek inhibitor
ATE344791T1 (de) * 1997-07-01 2006-11-15 Warner Lambert Co 2-(4-brom or 4-iod phenylamino)benzoesäurederivate und ihre anwendung als mek-inhibitoren
ATE277895T1 (de) * 1997-07-01 2004-10-15 Warner Lambert Co 4-brom or 4-iod-phenylamino- benzhydroxamsäurederivate und ihre anwendung als mek-inhibitoren
CA2348236A1 (en) * 1999-01-13 2000-07-20 Stephen Douglas Barrett 4-arylamino, 4-aryloxy, and 4-arylthio diarylamines and derivatives thereof as selective mek inhibitors
IL146056A0 (en) * 1999-04-21 2002-07-25 Warner Lambert Co Method for making 2- (n-phenylamino) benzoic acids

Also Published As

Publication number Publication date
PL360699A1 (en) 2004-09-20
WO2002018319A1 (en) 2002-03-07
SV2002000601A (es) 2002-04-03
GT200100174A (es) 2002-07-18
BR0113520A (pt) 2003-06-24
AP2001002249A0 (en) 2001-09-30
HUP0300828A2 (hu) 2003-09-29
EP1313694A1 (en) 2003-05-28
TNSN01127A1 (en) 2005-11-10
UY26908A1 (es) 2001-11-30
MA26949A1 (fr) 2004-12-20
SK2072003A3 (en) 2004-01-08
KR20030059115A (ko) 2003-07-07
PE20020393A1 (es) 2002-05-09
HN2001000216A (es) 2002-05-22
NO20030844D0 (no) 2003-02-24
IS6724A (is) 2003-02-20
ZA200301182B (en) 2004-05-12
PA8526501A1 (es) 2002-07-30
JP2004507518A (ja) 2004-03-11
CN1458921A (zh) 2003-11-26
IL154507A0 (en) 2003-09-17
CA2420003A1 (en) 2002-03-07
BG107635A (bg) 2004-09-30
EA200300187A1 (ru) 2003-08-28
DOP2001000238A (es) 2003-01-31
MXPA03001654A (es) 2004-09-10
YU14303A (sh) 2006-08-17
AR032175A1 (es) 2003-10-29
AU2001277044A1 (en) 2002-03-13
NO20030844L (no) 2003-02-25

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