JP2004506598A - 移植における免疫応答の予防および処置に適した間葉幹細胞から獲得した上澄み - Google Patents

移植における免疫応答の予防および処置に適した間葉幹細胞から獲得した上澄み Download PDF

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JP2004506598A
JP2004506598A JP2001534394A JP2001534394A JP2004506598A JP 2004506598 A JP2004506598 A JP 2004506598A JP 2001534394 A JP2001534394 A JP 2001534394A JP 2001534394 A JP2001534394 A JP 2001534394A JP 2004506598 A JP2004506598 A JP 2004506598A
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cells
mesenchymal stem
stem cells
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JP2004506598A5 (OSRAM
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マッキントッシュ,ケビン,アール.
モスカ,ジョゼフ,ディー.
クリュシェンコバ,エレナ,エヌ.
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オシリス セラピューティクス,インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/001—Preparations to induce tolerance to non-self, e.g. prior to transplantation
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/24—Interferons [IFN]
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    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1352—Mesenchymal stem cells
    • C12N2502/1358—Bone marrow mesenchymal stem cells (BM-MSC)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Immunology (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
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  • Hematology (AREA)
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  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Mycology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2001534394A 1999-10-26 2000-10-26 移植における免疫応答の予防および処置に適した間葉幹細胞から獲得した上澄み Pending JP2004506598A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/427,333 US6368636B1 (en) 1998-03-18 1999-10-26 Mesenchymal stem cells for prevention and treatment of immune responses in transplantation
PCT/US2000/029815 WO2001032189A1 (en) 1999-10-26 2000-10-26 Supernatant from mesenchymal stem cells for prevention and treatment of immune responses in transplantation

Publications (2)

Publication Number Publication Date
JP2004506598A true JP2004506598A (ja) 2004-03-04
JP2004506598A5 JP2004506598A5 (OSRAM) 2007-12-13

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JP2001534394A Pending JP2004506598A (ja) 1999-10-26 2000-10-26 移植における免疫応答の予防および処置に適した間葉幹細胞から獲得した上澄み

Country Status (10)

Country Link
US (2) US6368636B1 (OSRAM)
EP (2) EP2269616A3 (OSRAM)
JP (1) JP2004506598A (OSRAM)
AT (1) ATE482712T1 (OSRAM)
AU (1) AU782064B2 (OSRAM)
CA (1) CA2387542C (OSRAM)
DE (1) DE60045034D1 (OSRAM)
ES (1) ES2351203T3 (OSRAM)
PT (1) PT1223956E (OSRAM)
WO (1) WO2001032189A1 (OSRAM)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007530543A (ja) * 2004-03-22 2007-11-01 オシリス セラピューティクス,インコーポレイテッド 間葉幹細胞及びその使用法
JP2010500047A (ja) * 2006-08-15 2010-01-07 エージェンシー フォー サイエンス,テクノロジー アンド リサーチ 間葉系幹細胞馴化培地
JP2010529987A (ja) * 2007-06-15 2010-09-02 ガーネット バイオセラピューティクス インコーポレイテッド invitroで培養および増殖させた自己複製性コロニー形成細胞を用いる疾患および障害の治療
JP2012176948A (ja) * 2004-03-22 2012-09-13 Osiris Therapeutics Inc 間葉幹細胞及びその使用法

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