JP2004506041A - 新規アポルフィンエステルおよび治療におけるそれらの使用 - Google Patents

新規アポルフィンエステルおよび治療におけるそれらの使用 Download PDF

Info

Publication number
JP2004506041A
JP2004506041A JP2002519422A JP2002519422A JP2004506041A JP 2004506041 A JP2004506041 A JP 2004506041A JP 2002519422 A JP2002519422 A JP 2002519422A JP 2002519422 A JP2002519422 A JP 2002519422A JP 2004506041 A JP2004506041 A JP 2004506041A
Authority
JP
Japan
Prior art keywords
substituted
aporphine
group
alkanoyl
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2002519422A
Other languages
English (en)
Japanese (ja)
Other versions
JP2004506041A5 (https=
Inventor
ビクストレム、ハカン
ディークストラ、デュルク
クレマース、トーマス
アンドレン、ペール・エリック
マルシャワ、サンドリーヌ
ユルバ、ウルリク
Original Assignee
アクソン・バイオケミカルズ・ビー・ブイ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by アクソン・バイオケミカルズ・ビー・ブイ filed Critical アクソン・バイオケミカルズ・ビー・ブイ
Publication of JP2004506041A publication Critical patent/JP2004506041A/ja
Publication of JP2004506041A5 publication Critical patent/JP2004506041A5/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/18—Ring systems of four or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Psychology (AREA)
  • Reproductive Health (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP2002519422A 2000-08-17 2001-07-20 新規アポルフィンエステルおよび治療におけるそれらの使用 Pending JP2004506041A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0002934A SE0002934D0 (sv) 2000-08-17 2000-08-17 New aporphine esters and in their use in therapy
PCT/SE2001/001658 WO2002014279A1 (en) 2000-08-17 2001-07-20 New aporphine esters and their use in therapy

Publications (2)

Publication Number Publication Date
JP2004506041A true JP2004506041A (ja) 2004-02-26
JP2004506041A5 JP2004506041A5 (https=) 2009-07-16

Family

ID=20280719

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002519422A Pending JP2004506041A (ja) 2000-08-17 2001-07-20 新規アポルフィンエステルおよび治療におけるそれらの使用

Country Status (19)

Country Link
US (3) US7238705B2 (https=)
EP (1) EP1309553A1 (https=)
JP (1) JP2004506041A (https=)
KR (1) KR100865503B1 (https=)
CN (1) CN1242991C (https=)
AU (2) AU2001271228B2 (https=)
BR (1) BR0113291A (https=)
CA (1) CA2419842C (https=)
CZ (1) CZ2003454A3 (https=)
EA (1) EA006388B1 (https=)
HU (1) HUP0301685A3 (https=)
IL (2) IL154096A0 (https=)
MX (1) MXPA03001465A (https=)
NO (1) NO324409B1 (https=)
NZ (1) NZ523893A (https=)
PL (1) PL360089A1 (https=)
SE (1) SE0002934D0 (https=)
WO (1) WO2002014279A1 (https=)
ZA (1) ZA200300828B (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005508865A (ja) * 2001-06-08 2005-04-07 アクソン・バイオケミカルズ・ビー・ブイ アポモルフィン、６ａＲ−（−）−Ｎ−プロピル−ノルアポモルフィンおよびそれらの誘導体、並びにそれらのプロドラッグを効率的に投与するための薬学的処方剤
JP2014506579A (ja) * 2011-02-11 2014-03-17 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン トリペプチド組成物および糖尿病を治療する方法
JP2014111635A (ja) * 2007-08-31 2014-06-19 H Lundbeck As カテコールアミン誘導体およびそのプロドラッグ

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0002934D0 (sv) 2000-08-17 2000-08-17 Axon Biochemicals Bv New aporphine esters and in their use in therapy
JP2006527699A (ja) * 2003-06-19 2006-12-07 美時化学製薬股▲ふん▼有限公司 アポルフィン、及び、ケトンアポルフィン化合物とその用途
US20070065463A1 (en) 2003-06-20 2007-03-22 Ronald Aung-Din Topical therapy for the treatment of migranes, muscle sprains, muscle spasms, spasticity and related conditions
US7648995B2 (en) 2004-04-13 2010-01-19 The Mclean Hospital Corporation R(—)-11-hydroxyaporphine derivatives and uses thereof
GB2437488A (en) * 2006-04-25 2007-10-31 Optinose As Pharmaceutical oily formulation for nasal or buccal administration
GB2463833B (en) * 2007-06-26 2012-02-08 Parkinson S Inst Compositions that prevent or reverse alpha-synuclein fibrillation for use in the treatment of neurological disorders
US8431591B2 (en) 2007-07-12 2013-04-30 The Mclean Hospital Corporation R(−)-2-methoxy-11-hydroxyaporphine and derivatives thereof
US20090124651A1 (en) 2007-08-31 2009-05-14 H. Lundbeck A/S Catecholamine derivatives and prodrugs thereof
ES2315203B1 (es) * 2007-09-11 2010-01-13 Universidade De Santiago De Compostela Uso de oxoisoaporfinas y sus derivados como inhibidores selectivos de la monoamino oxidasa a.
GB0721394D0 (en) * 2007-10-31 2007-12-12 Vectura Group Plc Compositions for trating parkinson's disease
JP2011526889A (ja) 2008-06-30 2011-10-20 アフギン ファーマ，エルエルシー 局所局部的神経作用療法
WO2010121159A1 (en) * 2009-04-17 2010-10-21 Somalabs, Inc. Method for the induction of a reward response by modulation of dopaminergic systems in the central nervous system
ES2699077T3 (es) 2009-06-12 2019-02-07 Sunovion Pharmaceuticals Inc Apomorfina sublingual
PT2651357T (pt) 2010-12-16 2020-06-17 Sunovion Pharmaceuticals Inc Películas sublinguais
EP4578461A3 (en) 2015-04-21 2025-09-03 Sumitomo Pharma America, Inc. Methods of treating parkinsons disease by administration of apomorphine to an oral mucosa
US10989704B2 (en) 2015-06-24 2021-04-27 Koninklijke Philips N.V. Sweat monitoring apparatus and monitoring method
CR20200225A (es) 2017-11-24 2020-07-25 H Lundbeck As Nuevos fármacos de catecolamina para uso en el tratamiento de la enfermedad de parkinson
SI3740190T1 (sl) * 2018-01-18 2025-03-31 Leukos Biotech, S.L. Kristalinična oblika trdnih delcev kokristala apomorfina palmitinske kisline
EP3781149A4 (en) * 2018-04-20 2022-03-16 The General Hospital Corporation ACETYLATED PRODRUGS FOR ADMINISTRATION ACROSS THE BLOOD-BRAIN BARRIER
US11111263B2 (en) 2019-05-20 2021-09-07 H. Lundbeck A/S Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
US11168056B2 (en) 2019-05-20 2021-11-09 H. Lundbeck A/S Process for the manufacturing of (6aR,10aR)-7-propyl-6,6a,7,8,9,10,10a,11-octahydro-[1,3]dioxolo[4′,5′:5,6]benzo[1,2-G]quinoline and (4aR,10aR)-1-propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[G]quinoline-6,7-diol
US11130775B2 (en) 2019-05-20 2021-09-28 H. Lundbeck A/S Solid forms of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
JP7641234B2 (ja) 2019-05-21 2025-03-06 ハー・ルンドベック・アクチエゼルスカベット パーキンソン病の治療に使用するための新規なカテコールアミンプロドラッグ
WO2020234277A1 (en) 2019-05-21 2020-11-26 H. Lundbeck A/S Catecholamine carbamate prodrugs for use in the treatment of parkinson s disease
EP3972971A1 (en) 2019-05-21 2022-03-30 H. Lundbeck A/S New catecholamine prodrugs for use in the treatment of parkinson's diseases
WO2020234276A1 (en) 2019-05-21 2020-11-26 H. Lundbeck A/S New catecholamine prodrugs for use in the treatment of parkinson's disease

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5392777A (en) * 1976-12-13 1978-08-15 Sterling Drug Inc Nnpropylnorapomorphine diester and method for its production
WO1990012574A1 (en) * 1989-04-25 1990-11-01 Northeastern University Dopamine agonist compounds

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4080456A (en) * 1971-10-26 1978-03-21 Schering Aktiengesellschaft Diacylapomorphines
DE2717001C2 (de) 1977-04-18 1984-06-20 Karl O. Helm Ag, 2000 Hamburg Arzneimittel mit antithrombotischer Wirkung
US4353912A (en) * 1980-05-08 1982-10-12 Northeastern University N-Haloalkyl nor apomorphines and method of inactivating dopamine receptor sites and enhancing dopaminergic activity therewith
DE3171561D1 (en) * 1980-05-08 1985-09-05 Univ Northeastern N-substituted aporphines, a method of inducing emesis and a method of controlling psychosis utilising the same
GB9517062D0 (en) 1995-08-18 1995-10-25 Scherer Ltd R P Pharmaceutical compositions
GB9700878D0 (en) 1997-01-17 1997-03-05 Scherer Ltd R P Dosage forms and method for ameliorating male erectile dysfunction
US6403605B1 (en) 1998-05-29 2002-06-11 Queen's University At Kingston Methods for the normalization of sexual response and amelioration of long term genital tissue degradation
IT1299566B1 (it) 1998-07-17 2000-03-16 Ifi Istituto Farmacoterapico I Cerotto transdermico e composizioni farmaceutiche comprendenti r (-)- norapropilapomorfina cloridrato e/o s (+) - norapropilapomorfina
WO2000069416A1 (en) 1999-05-13 2000-11-23 Unihart Corporation Pharmaceutical compositions comprising apocodeine and/or its derivatives
MXPA02009904A (es) * 2000-04-07 2004-09-06 Tap Pharmaceutical Prod Inc Derivados de apomorfina y metodos para su uso.
SE0002934D0 (sv) 2000-08-17 2000-08-17 Axon Biochemicals Bv New aporphine esters and in their use in therapy
SE0102036D0 (sv) * 2001-06-08 2001-06-08 Axon Biochemicals Bv Pharmaceutical formulation for the efficient administration of apomorphine, 6aR- (-) -N- Propyl- norapomorphine and their derivatives and pro-drugs thereof
EP1950203A1 (en) 2007-01-24 2008-07-30 Laboratorios del Dr. Esteve S.A. Substituted pyrazoline compounds with ACAT, their preparation and use as medicaments

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5392777A (en) * 1976-12-13 1978-08-15 Sterling Drug Inc Nnpropylnorapomorphine diester and method for its production
WO1990012574A1 (en) * 1989-04-25 1990-11-01 Northeastern University Dopamine agonist compounds

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005508865A (ja) * 2001-06-08 2005-04-07 アクソン・バイオケミカルズ・ビー・ブイ アポモルフィン、６ａＲ−（−）−Ｎ−プロピル−ノルアポモルフィンおよびそれらの誘導体、並びにそれらのプロドラッグを効率的に投与するための薬学的処方剤
JP2014111635A (ja) * 2007-08-31 2014-06-19 H Lundbeck As カテコールアミン誘導体およびそのプロドラッグ
JP2014506579A (ja) * 2011-02-11 2014-03-17 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン トリペプチド組成物および糖尿病を治療する方法

Also Published As

Publication number Publication date
KR20030036703A (ko) 2003-05-09
CN1447792A (zh) 2003-10-08
HUP0301685A3 (en) 2010-03-29
IL154096A0 (en) 2003-07-31
CA2419842A1 (en) 2002-02-21
AU7122801A (en) 2002-02-25
SE0002934D0 (sv) 2000-08-17
NO324409B1 (no) 2007-10-08
CA2419842C (en) 2011-10-18
EA006388B1 (ru) 2005-12-29
US20040018956A1 (en) 2004-01-29
NO20030677L (no) 2003-03-05
NZ523893A (en) 2003-10-31
AU2001271228B2 (en) 2006-02-02
PL360089A1 (en) 2004-09-06
US7238705B2 (en) 2007-07-03
HUP0301685A2 (hu) 2003-08-28
CN1242991C (zh) 2006-02-22
CZ2003454A3 (cs) 2003-06-18
EA200300266A1 (ru) 2003-08-28
IL154096A (en) 2009-11-18
EP1309553A1 (en) 2003-05-14
ZA200300828B (en) 2004-05-17
US20050143408A1 (en) 2005-06-30
MXPA03001465A (es) 2004-12-13
US7332503B2 (en) 2008-02-19
NO20030677D0 (no) 2003-02-11
US20080119504A1 (en) 2008-05-22
WO2002014279A1 (en) 2002-02-21
BR0113291A (pt) 2004-01-06
KR100865503B1 (ko) 2008-10-28

Similar Documents

Publication Publication Date Title
JP2004506041A (ja) 新規アポルフィンエステルおよび治療におけるそれらの使用
KR102398194B1 (ko) 신규한 조성물 및 방법
AU2001271228A1 (en) New aporphine esters and their use in therapy
JP3350061B2 (ja) エレトリプタンヘミスルフェートおよびカフェインを含有する医薬組成物
JP6196986B2 (ja) 麻酔化合物および関連する使用方法
CN100553633C (zh) 包含有酮咯酸的酯衍生物的可注射的长效镇痛剂组合物
KR20120115380A (ko) 마이봄선 기능 장애의 치료 방법
KR101430626B1 (ko) 부프레노르핀 유도체 및 이들의 용도
JP2019529543A (ja) ブプレノルフィン徐放性製剤
EP0499882B1 (en) Pharmaceutical compositions containing N-acetyl-cysteine derivatives useful for the treatment of cataracts
TW202038910A (zh) 納曲酮注射型緩釋製劑
TWI342210B (en) 2-aminobenzoyl derivatives
CN106946866A (zh) 一种预防和治疗脑卒中的药物及其制备方法
KR101325058B1 (ko) 신규한 케르세틴 유도체, 3',4'-디플루오로케르세틴, 그 제조방법 및 그 용도
BR102013008990A2 (pt) Composições farmacêuticas compreendendo kisspeptina ou seus derivados
KR101261006B1 (ko) Ｃ형 간염 바이러스의 활성을 억제하는 신규 5,6-디히드록시크로몬 유도체 및 그 제조방법
KR100384346B1 (ko) 엘레트립탄 헤미술페이트 및 카페인을 포함하는 약제학적조성물
WO2017161093A1 (en) Caffeic acid derivatives and uses thereof
HK40047988A (en) Naltrexone injectable sustained release formulation
JPH0376302B2 (https=)

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20080718

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20090529

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20111004

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20120306