JP2004505964A5 - - Google Patents

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Publication number
JP2004505964A5
JP2004505964A5 JP2002518201A JP2002518201A JP2004505964A5 JP 2004505964 A5 JP2004505964 A5 JP 2004505964A5 JP 2002518201 A JP2002518201 A JP 2002518201A JP 2002518201 A JP2002518201 A JP 2002518201A JP 2004505964 A5 JP2004505964 A5 JP 2004505964A5
Authority
JP
Japan
Prior art keywords
alkyl
alkoxy
cyano
amino
quinoline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2002518201A
Other languages
English (en)
Japanese (ja)
Other versions
JP2004505964A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/GB2001/003553 external-priority patent/WO2002012226A1/en
Publication of JP2004505964A publication Critical patent/JP2004505964A/ja
Publication of JP2004505964A5 publication Critical patent/JP2004505964A5/ja
Pending legal-status Critical Current

Links

JP2002518201A 2000-08-09 2001-08-08 Ｖｅｇｆ阻害活性を有するキノリン誘導体 Pending JP2004505964A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00402254 2000-08-09
PCT/GB2001/003553 WO2002012226A1 (en) 2000-08-09 2001-08-08 Quinoline derivatives having vegf inhibiting activity

Publications (2)

Publication Number Publication Date
JP2004505964A JP2004505964A (ja) 2004-02-26
JP2004505964A5 true JP2004505964A5 (enExample) 2005-03-17

Family

ID=8173805

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002518201A Pending JP2004505964A (ja) 2000-08-09 2001-08-08 Ｖｅｇｆ阻害活性を有するキノリン誘導体

Country Status (14)

Country Link
US (2) US7371765B2 (enExample)
EP (1) EP1313726A1 (enExample)
JP (1) JP2004505964A (enExample)
KR (1) KR20030036686A (enExample)
CN (1) CN1315822C (enExample)
AU (2) AU7653601A (enExample)
BR (1) BR0113056A (enExample)
CA (1) CA2415469A1 (enExample)
IL (2) IL153947A0 (enExample)
MX (1) MXPA03000252A (enExample)
NO (1) NO326315B1 (enExample)
NZ (1) NZ523358A (enExample)
WO (1) WO2002012226A1 (enExample)
ZA (1) ZA200300217B (enExample)

Families Citing this family (34)

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JP3893026B2 (ja) 1999-02-10 2007-03-14 アストラゼネカ アクチボラグ 血管形成阻害剤としてのキナゾリン誘導体
ES2306306T3 (es) 1999-11-05 2008-11-01 Astrazeneca Ab Nuevos derivados de quinazolina.
DE60112268T2 (de) 2000-03-06 2006-05-24 Astrazeneca Ab Verwendung von quinazolinderivate als inhibitoren der angiogenese
ATE334973T1 (de) * 2000-04-07 2006-08-15 Astrazeneca Ab Chinazolinverbindungen
JP4608215B2 (ja) * 2002-02-01 2011-01-12 アストラゼネカ アクチボラグ キナゾリン化合物
TW200400034A (en) 2002-05-20 2004-01-01 Bristol Myers Squibb Co Pyrazolo-pyrimidine aniline compounds useful as kinase inhibitors
MXPA05004858A (es) 2002-11-04 2005-07-22 Astrazeneca Ab Derivados de quinazolina como inhibidores de cinasa de tirosina de src.
AU2004309166B2 (en) * 2003-12-23 2008-02-21 Pfizer Inc. Novel quinoline derivatives
AU2008202205B2 (en) * 2003-12-23 2009-09-10 Pfizer Inc. Novel quinoline derivatives
JP4585978B2 (ja) * 2005-03-03 2010-11-24 参天製薬株式会社 キノリルアルキルチオ基を有する新規環式化合物
US7928226B2 (en) 2005-08-08 2011-04-19 Agouron Pharmaceuticals Inc. Salts and polymorphs of a VEGF-R inhibitor
US20080190689A1 (en) * 2007-02-12 2008-08-14 Ballard Ebbin C Inserts for engine exhaust systems
JP2011526892A (ja) 2008-06-30 2011-10-20 アンジオブラスト システムズ，インコーポレーテッド 併用療法を使用した眼疾患及び過剰血管新生の治療
CN101723894B (zh) * 2009-12-03 2011-12-28 南京大学 N-喹啉酰胺类衍生物及其制法与用途
JP6026441B2 (ja) 2011-03-04 2016-11-16 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ キナーゼ阻害剤としてのアミノキノリン
TWI547494B (zh) 2011-08-18 2016-09-01 葛蘭素史克智慧財產發展有限公司 作為激酶抑制劑之胺基喹唑啉類
TW201425307A (zh) 2012-09-13 2014-07-01 Glaxosmithkline Llc 作為激酶抑制劑之胺基－喹啉類
TWI592417B (zh) 2012-09-13 2017-07-21 葛蘭素史克智慧財產發展有限公司 胺基喹唑啉激酶抑制劑之前藥
JP6669499B2 (ja) 2013-02-15 2020-03-18 カラ ファーマシューティカルズ インコーポレイテッド 治療用化合物
WO2014130612A1 (en) 2013-02-20 2014-08-28 Kala Pharmaceuticals, Inc. Therapeutic compounds and uses thereof
US9688688B2 (en) 2013-02-20 2017-06-27 Kala Pharmaceuticals, Inc. Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof
ES2654100T3 (es) 2013-02-21 2018-02-12 Glaxosmithkline Intellectual Property Development Limited Quinazolinas como inhibidores de quinasa
WO2015066482A1 (en) 2013-11-01 2015-05-07 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
US9890173B2 (en) 2013-11-01 2018-02-13 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
CN112028825B (zh) * 2015-04-07 2025-03-14 广东众生睿创生物科技有限公司 酪氨酸激酶抑制剂及包含该酪氨酸激酶抑制剂的药物组合物
WO2017139417A1 (en) 2016-02-08 2017-08-17 Vitrisa Therapeutics, Inc. Compositions with improved intravitreal half-life and uses thereof
US10253036B2 (en) 2016-09-08 2019-04-09 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
CN109688818A (zh) 2016-09-08 2019-04-26 卡拉制药公司 治疗化合物的晶型及其用途
CA3036340A1 (en) 2016-09-08 2018-03-15 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
US12343337B2 (en) 2016-09-29 2025-07-01 The Regents Of The University Of California Compounds for increasing neural plasticity
SG11202109111VA (en) 2019-02-27 2021-09-29 Univ California Azepino-indoles and other heterocycles for treating brain disorders
US12508258B2 (en) 2020-01-19 2025-12-30 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Quinoline derivative for treating rheumatoid arthritis
MX2024007221A (es) 2021-12-15 2024-08-27 Delix Therapeutics Inc Psicoplastogenos sustituidos con fenoxi y benciloxi y sus usos.
CN120289432B (zh) * 2025-06-12 2025-09-05 上海健康医学院 一种具有极光激酶b和表皮生长因子受体双重抑制作用的喹啉类化合物及用途

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US3755332A (en) * 1971-07-01 1973-08-28 Ciba Geigy Corp Substituted 4 indazolaminoquinolines
IL81307A0 (en) 1986-01-23 1987-08-31 Union Carbide Agricult Method for reducing moisture loss from plants and increasing crop yield utilizing nitrogen containing heterocyclic compounds and some novel polysubstituted pyridine derivatives
IL89029A (en) 1988-01-29 1993-01-31 Lilly Co Eli Fungicidal quinoline and cinnoline derivatives, compositions containing them, and fungicidal methods of using them
DK0584222T3 (da) 1991-05-10 1998-02-23 Rhone Poulenc Rorer Int Bis-mono- og bicycliske aryl- og heteroarylforbindelser, som inhiberer EGF- og/eller PDGF-receptor-tyrosinkinase
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WO1998002434A1 (en) 1996-07-13 1998-01-22 Glaxo Group Limited Fused heterocyclic compounds as protein tyrosine kinase inhibitors
EP0929526B1 (en) * 1996-09-25 2005-07-27 AstraZeneca AB Qinoline derivatives inhibiting the effect of growth factors such as vegf
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US6002008A (en) * 1997-04-03 1999-12-14 American Cyanamid Company Substituted 3-cyano quinolines
CA2291709A1 (en) 1997-05-30 1998-12-03 Merck & Co., Inc. Novel angiogenesis inhibitors
US6162804A (en) * 1997-09-26 2000-12-19 Merck & Co., Inc. Tyrosine kinase inhibitors
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RS49779B (sr) 1998-01-12 2008-06-05 Glaxo Group Limited, Biciklična heteroaromatična jedinjenja kao inhibitori protein tirozin kinaze
GB9800575D0 (en) 1998-01-12 1998-03-11 Glaxo Group Ltd Heterocyclic compounds
US6184226B1 (en) 1998-08-28 2001-02-06 Scios Inc. Quinazoline derivatives as inhibitors of P-38 α
CA2344169C (en) 1998-09-29 2011-07-19 American Cyanamid Company Substituted 3-cyanoquinolines as protein tyrosine kinases inhibitors
GB2345486A (en) * 1999-01-11 2000-07-12 Glaxo Group Ltd Heteroaromatic protein tyrosine kinase inhibitors
UA71945C2 (en) 1999-01-27 2005-01-17 Pfizer Prod Inc Substituted bicyclic derivatives being used as anticancer agents
JP3270834B2 (ja) 1999-01-27 2002-04-02 ファイザー・プロダクツ・インク 抗がん剤として有用なヘテロ芳香族二環式誘導体
PE20010306A1 (es) 1999-07-02 2001-03-29 Agouron Pharma Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa

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