JP2004505964A5 - - Google Patents

Download PDF

Info

Publication number
JP2004505964A5
JP2004505964A5 JP2002518201A JP2002518201A JP2004505964A5 JP 2004505964 A5 JP2004505964 A5 JP 2004505964A5 JP 2002518201 A JP2002518201 A JP 2002518201A JP 2002518201 A JP2002518201 A JP 2002518201A JP 2004505964 A5 JP2004505964 A5 JP 2004505964A5
Authority
JP
Japan
Prior art keywords
alkyl
alkoxy
cyano
amino
quinoline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2002518201A
Other languages
English (en)
Japanese (ja)
Other versions
JP2004505964A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/GB2001/003553 external-priority patent/WO2002012226A1/en
Publication of JP2004505964A publication Critical patent/JP2004505964A/ja
Publication of JP2004505964A5 publication Critical patent/JP2004505964A5/ja
Pending legal-status Critical Current

Links

JP2002518201A 2000-08-09 2001-08-08 Ｖｅｇｆ阻害活性を有するキノリン誘導体 Pending JP2004505964A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00402254 2000-08-09
PCT/GB2001/003553 WO2002012226A1 (en) 2000-08-09 2001-08-08 Quinoline derivatives having vegf inhibiting activity

Publications (2)

Publication Number Publication Date
JP2004505964A JP2004505964A (ja) 2004-02-26
JP2004505964A5 true JP2004505964A5 (enExample) 2005-03-17

Family

ID=8173805

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002518201A Pending JP2004505964A (ja) 2000-08-09 2001-08-08 Ｖｅｇｆ阻害活性を有するキノリン誘導体

Country Status (14)

Country Link
US (2) US7371765B2 (enExample)
EP (1) EP1313726A1 (enExample)
JP (1) JP2004505964A (enExample)
KR (1) KR20030036686A (enExample)
CN (1) CN1315822C (enExample)
AU (2) AU7653601A (enExample)
BR (1) BR0113056A (enExample)
CA (1) CA2415469A1 (enExample)
IL (2) IL153947A0 (enExample)
MX (1) MXPA03000252A (enExample)
NO (1) NO326315B1 (enExample)
NZ (1) NZ523358A (enExample)
WO (1) WO2002012226A1 (enExample)
ZA (1) ZA200300217B (enExample)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1553097T3 (da) 1999-02-10 2010-12-13 Astrazeneca Ab Quinazolinderivat som angiogeneseinhibitor og mellemprodukter dertil
PL203782B1 (pl) 1999-11-05 2009-11-30 Astrazeneca Ab Pochodne chinazoliny,sposoby ich wytwarzania,ich kompozycje farmaceutyczne oraz ich zastosowania
JP2003525897A (ja) 2000-03-06 2003-09-02 アストラゼネカ アクチボラグ 治 療
AU779695B2 (en) * 2000-04-07 2005-02-10 Astrazeneca Ab Quinazoline compounds
DK1474420T3 (da) 2002-02-01 2012-05-21 Astrazeneca Ab Quinazolinforbindelser
TW200400034A (en) 2002-05-20 2004-01-01 Bristol Myers Squibb Co Pyrazolo-pyrimidine aniline compounds useful as kinase inhibitors
NZ539408A (en) 2002-11-04 2007-09-28 Astrazeneca Ab Quinazoline derivatives as SRC tyrosine kinase inhibitors for treating solid tumours
KR100807920B1 (ko) * 2003-12-23 2008-02-27 화이자 인코포레이티드 신규한 퀴놀린 유도체
AU2008202205B2 (en) * 2003-12-23 2009-09-10 Pfizer Inc. Novel quinoline derivatives
JP4585978B2 (ja) * 2005-03-03 2010-11-24 参天製薬株式会社 キノリルアルキルチオ基を有する新規環式化合物
BRPI0614115A2 (pt) 2005-08-08 2011-03-09 Pfizer sais e polimofos de um inibidor de vergf-r, composição farmacêutica e cápsula contendo os mesmos, bem como seu uso
US20080190689A1 (en) * 2007-02-12 2008-08-14 Ballard Ebbin C Inserts for engine exhaust systems
AU2009269149B2 (en) 2008-06-30 2016-03-17 Mesoblast, Inc. Treatment of eye diseases and excessive neovascularization using a combined therapy
CN101723894B (zh) * 2009-12-03 2011-12-28 南京大学 N-喹啉酰胺类衍生物及其制法与用途
KR101940340B1 (ko) 2011-03-04 2019-01-18 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 키나제 억제제로서의 아미노-퀴놀린
TWI547494B (zh) 2011-08-18 2016-09-01 葛蘭素史克智慧財產發展有限公司 作為激酶抑制劑之胺基喹唑啉類
AR092529A1 (es) 2012-09-13 2015-04-22 Glaxosmithkline Llc Compuesto de aminoquinazolina, composicion farmaceutica que lo comprende y uso de dicho compuesto para la preparacion de un medicamento
AR092530A1 (es) 2012-09-13 2015-04-22 Glaxosmithkline Llc Compuesto de amino-quinolina, composicion farmaceutica que lo comprende y uso de dicho compuesto para la preparacion de un medicamento
HK1217092A1 (zh) 2013-02-15 2016-12-23 Kala Pharmaceuticals, Inc. 治疗性化合物及其用途
BR112015020139A2 (pt) 2013-02-20 2017-07-18 Kala Pharmaceuticals Inc compostos terapêuticos e usos dos mesmos
US9688688B2 (en) 2013-02-20 2017-06-27 Kala Pharmaceuticals, Inc. Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof
BR112015019624A2 (pt) 2013-02-21 2017-07-18 Glaxosmithkline Ip Dev Ltd quinazolinas como inibidores de quinase
US9890173B2 (en) 2013-11-01 2018-02-13 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
KR20160099084A (ko) 2013-11-01 2016-08-19 칼라 파마슈티컬스, 인크. 치료 화합물의 결정질 형태 및 그의 용도
CN112028825B (zh) * 2015-04-07 2025-03-14 广东众生睿创生物科技有限公司 酪氨酸激酶抑制剂及包含该酪氨酸激酶抑制剂的药物组合物
AU2017217677A1 (en) 2016-02-08 2018-07-26 Vitrisa Therapeutics, Inc. Compositions with improved intravitreal half-life and uses thereof
CA3036336A1 (en) 2016-09-08 2018-03-15 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
CA3036065A1 (en) 2016-09-08 2018-03-15 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
EP3509423A4 (en) 2016-09-08 2020-05-13 Kala Pharmaceuticals, Inc. CRYSTALLINE FORMS OF THERAPEUTIC COMPOUNDS AND USES THEREOF
US12343337B2 (en) 2016-09-29 2025-07-01 The Regents Of The University Of California Compounds for increasing neural plasticity
BR112021016620A2 (pt) 2019-02-27 2021-11-03 Univ California Azepino-indóis e outros heterociclos para o tratamento de distúrbios cerebrais
US12508258B2 (en) 2020-01-19 2025-12-30 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Quinoline derivative for treating rheumatoid arthritis
KR20240150417A (ko) 2021-12-15 2024-10-15 델릭스 테라퓨틱스, 인크. 페녹시 및 벤질옥시로 치환된 사이코플라스토겐 및 그의 용도
CN120289432B (zh) * 2025-06-12 2025-09-05 上海健康医学院 一种具有极光激酶b和表皮生长因子受体双重抑制作用的喹啉类化合物及用途

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US36256A (en) * 1862-08-19 Improvement in sewing-m ach ines
US3755332A (en) * 1971-07-01 1973-08-28 Ciba Geigy Corp Substituted 4 indazolaminoquinolines
IL81307A0 (en) 1986-01-23 1987-08-31 Union Carbide Agricult Method for reducing moisture loss from plants and increasing crop yield utilizing nitrogen containing heterocyclic compounds and some novel polysubstituted pyridine derivatives
IL89029A (en) 1988-01-29 1993-01-31 Lilly Co Eli Fungicidal quinoline and cinnoline derivatives, compositions containing them, and fungicidal methods of using them
AU658646B2 (en) 1991-05-10 1995-04-27 Rhone-Poulenc Rorer International (Holdings) Inc. Bis mono-and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
US5480883A (en) * 1991-05-10 1996-01-02 Rhone-Poulenc Rorer Pharmaceuticals Inc. Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
IL117620A0 (en) 1995-03-27 1996-07-23 Fujisawa Pharmaceutical Co Heterocyclic compounds processes for the preparation thereof and pharmaceutical compositions containing the same
GB9514265D0 (en) 1995-07-13 1995-09-13 Wellcome Found Hetrocyclic compounds
WO1997017329A1 (en) 1995-11-07 1997-05-15 Kirin Beer Kabushiki Kaisha Quinoline derivatives and quinazoline derivatives inhibiting autophosphorylation of growth factor receptor originating in platelet and pharmaceutical compositions containing the same
JP4386967B2 (ja) 1996-07-13 2009-12-16 グラクソ、グループ、リミテッド プロテインチロシンキナーゼ阻害剤としての縮合複素環式化合物
WO1998013350A1 (en) * 1996-09-25 1998-04-02 Zeneca Limited Qinoline derivatives inhibiting the effect of growth factors such as vegf
AU719392B2 (en) 1996-10-01 2000-05-11 Kyowa Hakko Kirin Co., Ltd. Nitrogen-containing heterocyclic compounds
US6002008A (en) * 1997-04-03 1999-12-14 American Cyanamid Company Substituted 3-cyano quinolines
AU734009B2 (en) 1997-05-30 2001-05-31 Merck & Co., Inc. Novel angiogenesis inhibitors
US6162804A (en) * 1997-09-26 2000-12-19 Merck & Co., Inc. Tyrosine kinase inhibitors
GB9721437D0 (en) 1997-10-10 1997-12-10 Glaxo Group Ltd Heteroaromatic compounds and their use in medicine
GB9800575D0 (en) 1998-01-12 1998-03-11 Glaxo Group Ltd Heterocyclic compounds
GB9800569D0 (en) 1998-01-12 1998-03-11 Glaxo Group Ltd Heterocyclic compounds
US6184226B1 (en) 1998-08-28 2001-02-06 Scios Inc. Quinazoline derivatives as inhibitors of P-38 α
PL201475B1 (pl) * 1998-09-29 2009-04-30 Wyeth Corp Podstawione 3-cyjanochinoliny jako inhibitory białkowych kinaz tyrozynowych
GB2345486A (en) 1999-01-11 2000-07-12 Glaxo Group Ltd Heteroaromatic protein tyrosine kinase inhibitors
UA71945C2 (en) 1999-01-27 2005-01-17 Pfizer Prod Inc Substituted bicyclic derivatives being used as anticancer agents
JP3270834B2 (ja) 1999-01-27 2002-04-02 ファイザー・プロダクツ・インク 抗がん剤として有用なヘテロ芳香族二環式誘導体
PE20010306A1 (es) 1999-07-02 2001-03-29 Agouron Pharma Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa

Similar Documents

Publication Publication Date Title
JP2004505964A5 (enExample)
JP6511430B2 (ja) がんの治療のための化合物および組成物
RU2004126612A (ru) Хиназолиновые соединения
RU2001124816A (ru) Производные хиназолина в качестве ингибиторов ангиогенеза
JP2004506736A5 (enExample)
RU2018134981A (ru) Конъюгаты, содержащие ингибиторы RIPK2
JP2004517894A5 (enExample)
BRPI0616630A2 (pt) compostos de pirazol substituìdos
KR960706494A (ko) 혈소판 활성화 인자 길항물질 : 이미다조피리딘 인돌(Platelet activating factor antagonists : lmidazopyridine indoles)
JP2004509113A5 (enExample)
KR20190080897A (ko) 치환된 피리디논 함유 트리시클릭 화합물, 및 그의 사용 방법
RU2005122901A (ru) Производные пиридино [2,3-] пиримидина в качестве селективных ингибиторов kdr и fgfr
JP2003521537A5 (enExample)
NO20030624L (no) Cinnolinforbindelser
NO2015020I1 (no) Ceritinib, 5-klor-N-5-metyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oksy]fenyl-N-[2-(propan-2-sulfonyl)fenyl]pyrimidine-2,4-diamin, eller et farmasøytisk akseptabelt salt derav
HUP0002208A2 (en) Use of sulphonamide derivatives for the preparation of pharmaceutical compositions potentiating glutamate receptor function
CA2422378A1 (en) Pyrazole compounds useful as protein kinase inhibitors
CN102414210A (zh) 作为β-分泌酶抑制剂的取代的咪唑并[1，2-a]吡啶衍生物、药物组合物和使用方法
JP2001525411A5 (enExample)
JP2005509622A5 (enExample)
CA2383779A1 (en) N-(indolecarbonyl)piperazine derivatives
JP2005505618A5 (enExample)
MXPA04002338A (es) Derivados de carbazol y su uso como antagonistas receptores del npy5.
WO2006069525A1 (en) Aminopyrimidine compounds and their salts, process for preparation and pharmaceutical use thereof
JP2007501210A5 (enExample)